{"id":"https://openalex.org/W2011989170","doi":"https://doi.org/10.1111/j.1432-2277.2000.tb02057.x","title":"Conversion from cyclosporine A to tacrolimus after kidney transplantation due to hyperlipidemia","display_name":"Conversion from cyclosporine A to tacrolimus after kidney transplantation due to hyperlipidemia","publication_year":2000,"publication_date":"2000-04-28","ids":{"openalex":"https://openalex.org/W2011989170","doi":"https://doi.org/10.1111/j.1432-2277.2000.tb02057.x","mag":"2011989170","pmid":"https://pubmed.ncbi.nlm.nih.gov/11112029"},"language":"en","primary_location":{"id":"doi:10.1111/j.1432-2277.2000.tb02057.x","doi":"https://doi.org/10.1111/j.1432-2277.2000.tb02057.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-2277.2000.tb02057.x","pdf_url":null,"source":{"id":"https://openalex.org/S121647140","display_name":"Transplant International","issn_l":"0934-0874","issn":["0934-0874","1432-2277"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010250434","display_name":"Matthias Kohnle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Kohnle","raw_affiliation_strings":["Nierentransplantationsambulanz, Universit\u00e4tsklinikum Essen, Medizinische Klinik, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nierentransplantationsambulanz, Universit\u00e4tsklinikum Essen, Medizinische Klinik, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109283531","display_name":"US Zimmermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Zimmermann","raw_affiliation_strings":["Nierentransplantationsambulanz, Universit\u00e4tsklinikum Essen, Medizinische Klinik, Hufelandstrasse 55, D\u201045147 Essen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nierentransplantationsambulanz, Universit\u00e4tsklinikum Essen, Medizinische Klinik, Hufelandstrasse 55, D\u201045147 Essen","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071485077","display_name":"Peter L\u00fctkes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. L\u00fctkes","raw_affiliation_strings":["Nierentransplantationsambulanz, Universit\u00e4tsklinikum Essen, Medizinische Klinik, Hufelandstrasse 55, D\u201045147 Essen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nierentransplantationsambulanz, Universit\u00e4tsklinikum Essen, Medizinische Klinik, Hufelandstrasse 55, D\u201045147 Essen","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111649240","display_name":"K Albrecht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K.-H. Albrecht","raw_affiliation_strings":["K.\u2010H. Albrecht Department of Surgery, University Hospital Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K.\u2010H. Albrecht Department of Surgery, University Hospital Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113580572","display_name":"T Philipp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Philipp","raw_affiliation_strings":["Nierentransplantationsambulanz, Universit\u00e4tsklinikum Essen, Medizinische Klinik, Hufelandstrasse 55, D\u201045147 Essen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nierentransplantationsambulanz, Universit\u00e4tsklinikum Essen, Medizinische Klinik, Hufelandstrasse 55, D\u201045147 Essen","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028813168","display_name":"Uwe W. Heemann","orcid":"https://orcid.org/0000-0002-3886-2517","observed_orcids":["https://orcid.org/0000-0002-3886-2517"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Heemann","raw_affiliation_strings":["Nierentransplantationsambulanz, Universit\u00e4tsklinikum Essen, Medizinische Klinik, Hufelandstrasse 55, D\u201045147 Essen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nierentransplantationsambulanz, Universit\u00e4tsklinikum Essen, Medizinische Klinik, Hufelandstrasse 55, D\u201045147 Essen","institution_ids":["https://openalex.org/I4210119759"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210119759"],"apc_list":{"value":2700,"currency":"EUR","value_usd":3051},"apc_paid":null,"fwci":1.0803,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.76145152,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13","issue":"0","first_page":"S345","last_page":"S348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.5569999814033508},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9950000047683716},{"id":"https://openalex.org/keywords/renal-allograft-function","display_name":"renal allograft function","score":0.7450000047683716},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.640999972820282},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.9351323843002319},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9232606291770935},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.8243032693862915},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6786257028579712},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6171645522117615},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.616465151309967},{"id":"https://openalex.org/C2779528694","wikidata":"https://www.wikidata.org/wiki/Q367700","display_name":"Ciclosporin","level":3,"score":0.5718613862991333},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5520027875900269},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.5445842742919922},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5099033117294312},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.4559316337108612},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4492453932762146},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3957308530807495},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3745979070663452},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2099604606628418},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.10584509372711182}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1432-2277.2000.tb02057.x","doi":"https://doi.org/10.1111/j.1432-2277.2000.tb02057.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-2277.2000.tb02057.x","pdf_url":null,"source":{"id":"https://openalex.org/S121647140","display_name":"Transplant International","issn_l":"0934-0874","issn":["0934-0874","1432-2277"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant International","raw_type":"journal-article"},{"id":"doi:10.1007/s001470050358","doi":"https://doi.org/10.1007/s001470050358","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s001470050358","pdf_url":null,"source":{"id":"https://openalex.org/S121647140","display_name":"Transplant International","issn_l":"0934-0874","issn":["0934-0874","1432-2277"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant International","raw_type":"journal-article"},{"id":"pmid:11112029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11112029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant international : official journal of the European Society for Organ Transplantation","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W38500840","https://openalex.org/W1996764051","https://openalex.org/W2001285551","https://openalex.org/W2013755756","https://openalex.org/W2029549907","https://openalex.org/W2042598295","https://openalex.org/W2044600432","https://openalex.org/W2054016827","https://openalex.org/W2055211491","https://openalex.org/W2058757441","https://openalex.org/W2060789833","https://openalex.org/W2063642389","https://openalex.org/W2093162411","https://openalex.org/W2104149174","https://openalex.org/W2167839140","https://openalex.org/W2409200729","https://openalex.org/W2419319660","https://openalex.org/W2525900412","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2060789833","https://openalex.org/W2051775402","https://openalex.org/W1986922812","https://openalex.org/W4324262906","https://openalex.org/W2120851931","https://openalex.org/W2005186599","https://openalex.org/W2055032443","https://openalex.org/W2059812333","https://openalex.org/W3030369835","https://openalex.org/W1985497664"],"abstract_inverted_index":{"As":[0],"more":[1,21,23,124],"than":[2],"90%":[3],"of":[4,17,34,46,67,158],"renal":[5,13,47,161],"grafts":[6],"retain":[7],"their":[8,68],"function":[9,54],"1":[10,74],"year":[11],"after":[12,160],"transplantation,":[14],"side":[15],"effects":[16,33],"immunosuppressive":[18],"therapy":[19,70],"gain":[20],"and":[22,71,80,142],"importance.":[24],"In":[25],"a":[26,153],"randomised":[27],"prospective":[28],"study,":[29,119],"we":[30],"investigated":[31],"the":[32,92,100,117,130],"conversion":[35,62],"from":[36],"cyclosporine":[37,57,85,113],"A":[38,148],"to":[39,42,61,63,97,102,150],"tacrolimus":[40,64,93,115,131,151],"due":[41],"hyperlipidemia":[43,159],"in":[44,91,99,129,136,156],"recipients":[45],"allografts.":[48],"Fifty-seven":[49],"patients":[50,77,82,108],"with":[51,56],"stable":[52,141],"graft":[53],"treated":[55],"were":[58,78,109],"randomly":[59],"assigned":[60],"or":[65,114],"continuation":[66],"current":[69],"followed":[72],"for":[73],"year.":[75],"Twenty-seven":[76],"switched":[79],"30":[81],"remained":[83,140],"on":[84],"A.":[86],"Cholesterol":[87],"levels":[88,127,139],"decreased":[89,128],"significantly":[90],"group":[94],"as":[95],"compared":[96],"controls":[98],"intent":[101],"treat":[103],"analysis.":[104],"When":[105],"only":[106],"those":[107],"evaluated":[110],"who":[111],"received":[112],"during":[116],"whole":[118],"statistical":[120],"significance":[121],"was":[122,146],"even":[123],"pronounced.":[125],"Triglyceride":[126],"group,":[132],"whereas":[133],"they":[134],"increased":[135],"controls.":[137],"Creatinine":[138],"no":[143],"acute":[144],"rejection":[145],"observed.":[147],"switch":[149],"is":[152],"safe":[154],"alternative":[155],"cases":[157],"transplantation.":[162]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}