{"id":"https://openalex.org/W2011978404","doi":"https://doi.org/10.1016/j.juro.2011.11.090","title":"Detection of Prostate Cancer in an Ethnically Diverse, Disadvantaged Population With Multiple Prostate Specific Antigen Measurements Before Biopsy","display_name":"Detection of Prostate Cancer in an Ethnically Diverse, Disadvantaged Population With Multiple Prostate Specific Antigen Measurements Before Biopsy","publication_year":2012,"publication_date":"2012-02-14","ids":{"openalex":"https://openalex.org/W2011978404","doi":"https://doi.org/10.1016/j.juro.2011.11.090","mag":"2011978404","pmid":"https://pubmed.ncbi.nlm.nih.gov/22335862"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2011.11.090","doi":"https://doi.org/10.1016/j.juro.2011.11.090","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2011.11.090","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089094298","display_name":"A. Ari Hakimi","orcid":"https://orcid.org/0000-0002-0930-8824","observed_orcids":["https://orcid.org/0000-0002-0930-8824","https://orcid.org/0000-0001-7504-6044","https://orcid.org/0000-0003-0329-3921"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Ari Hakimi","raw_affiliation_strings":["Department of Urology, Albert Einstein College of Medicine, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Albert Einstein College of Medicine, Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053234667","display_name":"Ilir Agalliu","orcid":"https://orcid.org/0000-0002-6248-5790","observed_orcids":["https://orcid.org/0000-0002-6248-5790"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilir Agalliu","raw_affiliation_strings":["Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111965532","display_name":"Gloria Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gloria Y. Ho","raw_affiliation_strings":["Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006864691","display_name":"Reza Ghavamian","orcid":"https://orcid.org/0009-0009-7002-196X","observed_orcids":["https://orcid.org/0009-0009-7002-196X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reza Ghavamian","raw_affiliation_strings":["Department of Urology, Albert Einstein College of Medicine, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Albert Einstein College of Medicine, Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018963148","display_name":"Chaghong Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaghong Yu","raw_affiliation_strings":["Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054374857","display_name":"Michael W. Kattan","orcid":"https://orcid.org/0000-0002-3840-4161","observed_orcids":["https://orcid.org/0000-0002-3840-4161"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Kattan","raw_affiliation_strings":["Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030714353","display_name":"Farhang Rabbani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farhang Rabbani","raw_affiliation_strings":["Department of Urology, Albert Einstein College of Medicine, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Albert Einstein College of Medicine, Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"187","issue":"4","first_page":"1234","last_page":"1240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7459999918937683},{"id":"https://openalex.org/keywords/prostate-specific-antigen-velocity","display_name":"prostate-specific antigen velocity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/high-grade-prostate-cancer","display_name":"high-grade prostate cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.9670000076293945},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.7549999952316284},{"id":"https://openalex.org/keywords/black-men","display_name":"Black men","score":0.6729999780654907},{"id":"https://openalex.org/keywords/hispanic-men","display_name":"Hispanic men","score":1.0},{"id":"https://openalex.org/keywords/age-as-risk-factor","display_name":"age as risk factor","score":0.5519999861717224},{"id":"https://openalex.org/keywords/cancer-risk-prediction","display_name":"cancer risk prediction","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7990796566009521},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.6188247203826904},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5946942567825317},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5423865914344788},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5225783586502075},{"id":"https://openalex.org/C2775941076","wikidata":"https://www.wikidata.org/wiki/Q7250979","display_name":"Prostate cancer screening","level":5,"score":0.4912394881248474},{"id":"https://openalex.org/C2780623907","wikidata":"https://www.wikidata.org/wiki/Q106394435","display_name":"Disadvantaged","level":2,"score":0.46284645795822144},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4014095962047577},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.35148757696151733},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.34674280881881714},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2867419719696045},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2603222727775574},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001741","descriptor_name":"Black or African American","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006630","descriptor_name":"Hispanic or Latino","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D035862","descriptor_name":"Vulnerable Populations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.juro.2011.11.090","doi":"https://doi.org/10.1016/j.juro.2011.11.090","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2011.11.090","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:22335862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22335862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W80256803","https://openalex.org/W1976692516","https://openalex.org/W1978177793","https://openalex.org/W1992963194","https://openalex.org/W1999011921","https://openalex.org/W2001375816","https://openalex.org/W2044210477","https://openalex.org/W2061261260","https://openalex.org/W2067615588","https://openalex.org/W2073134737","https://openalex.org/W2078720457","https://openalex.org/W2085756391","https://openalex.org/W2093197441","https://openalex.org/W2093307117","https://openalex.org/W2109046819","https://openalex.org/W2123369557","https://openalex.org/W2129080434","https://openalex.org/W2142072350","https://openalex.org/W2143858821","https://openalex.org/W2148454896"],"related_works":["https://openalex.org/W2315971339","https://openalex.org/W2053548642","https://openalex.org/W2082053935","https://openalex.org/W2765406369","https://openalex.org/W2147707434","https://openalex.org/W846826746","https://openalex.org/W2069687446","https://openalex.org/W4238985588","https://openalex.org/W2034169832","https://openalex.org/W2080602929"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1,31,77],"assessed":[2],"the":[3,62,83,95,147,170],"predictive":[4],"effect":[5],"of":[6,16,64,69,115,172,203,233],"prostate":[7,19,40,45,65,72,90,97,105,110,116,121,127,144,149,165,173,179,184,190,195,234,239,247,252,265,269,295],"specific":[8,20,41,48,91,98,128,150,166,185,226,248,270,291,296],"antigen":[9,21,42,49,92,99,129,151,167,186,227,249,271,297],"velocity":[10,50,93,130,168,187,228],"for":[11,85,264],"men":[12,242,275],"with":[13,61,125,143,243],"a":[14,24,230],"minimum":[15],"3":[17,37,244],"pre-biopsy":[18],"measurements":[22],"in":[23,205,214,241],"racially":[25],"diverse":[26],"population.":[27],"MATERIALS":[28],"AND":[29],"METHODS:":[30],"identified":[32],"795":[33],"patients":[34,136,157,209,216,257],"who":[35],"underwent":[36],"or":[38,94,245],"more":[39,138,246],"tests":[43,250],"before":[44,101,251],"biopsy.":[46,253],"Prostate":[47,225],"was":[51,210],"calculated":[52],"by":[53,199],"linear":[54,161],"regression":[55],"and":[56,68,81,107,118,155,169,176,192,207,218,236,255,286,289],"used":[57],"to":[58,103,140,188,259,293],"assess":[59,294],"associations":[60,162],"risk":[63,114,171,263],"cancer":[66,73,106,117,122,174,191,196,235,240,266],"overall":[67,175],"high":[70,108,119,177,193,237],"grade":[71,109,120,178,194,238],"(Gleason":[74],"score":[75],"7-10).":[76],"created":[78],"ROC":[79,181],"curves":[80,182],"determined":[82],"AUC":[84,202],"several":[86],"models,":[87],"including":[88],"only":[89],"last":[96],"measurement":[100],"biopsy,":[102],"predict":[104,189],"cancer.":[111,180],"RESULTS:":[112],"The":[113,201],"increased":[123,262],"linearly":[124],"increasing":[126,164],"quartiles":[131],"(each":[132],"p":[133],"trend<0.001).":[134],"Older":[135],"were":[137,159],"likely":[139],"be":[141,260],"diagnosed":[142],"cancer,":[145],"given":[146],"same":[148],"velocity.":[152,298],"In":[153],"black":[154,206],"Hispanic":[156,208,256],"there":[158],"strong":[160],"between":[163],"incorporating":[183],"varied":[197],"significantly":[198,211],"race.":[200],"models":[204],"higher":[212,268],"than":[213,277],"white":[215],"(0.62":[217],"0.64,":[219],"respectively,":[220],"vs":[221],"0.47,":[222],"p=0.03).":[223],"CONCLUSIONS:":[224],"is":[229],"significant":[231],"predictor":[232],"Black":[254],"appear":[258],"at":[261,267],"velocity,":[272],"as":[273],"are":[274],"older":[276],"60":[278],"years.":[279],"Further":[280],"studies":[281],"should":[282],"confirm":[283],"these":[284],"results":[285],"create":[287],"age":[288],"race":[290],"guidelines":[292]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}