{"id":"https://openalex.org/W2011955653","doi":"https://doi.org/10.1371/journal.pone.0049043","title":"Cyanobacteria Produce N-(2-Aminoethyl)Glycine, a Backbone for Peptide Nucleic Acids Which May Have Been the First Genetic Molecules for Life on Earth","display_name":"Cyanobacteria Produce N-(2-Aminoethyl)Glycine, a Backbone for Peptide Nucleic Acids Which May Have Been the First Genetic Molecules for Life on Earth","publication_year":2012,"publication_date":"2012-11-07","ids":{"openalex":"https://openalex.org/W2011955653","doi":"https://doi.org/10.1371/journal.pone.0049043","mag":"2011955653","pmid":"https://pubmed.ncbi.nlm.nih.gov/23145061","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3492184"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0049043","doi":"https://doi.org/10.1371/journal.pone.0049043","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049043","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049043&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049043&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064487941","display_name":"Sandra Anne Banack","orcid":"https://orcid.org/0000-0001-5183-2702","observed_orcids":["https://orcid.org/0000-0001-5183-2702"]},"institutions":[{"id":"https://openalex.org/I4210122304","display_name":"Institute for EthnoMedicine","ror":"https://ror.org/02rrpz836","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210122304"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Anne Banack","raw_affiliation_strings":["Institute for Ethnomedicine, Jackson, WY, USA","Institute for Ethnomedicine, Jackson, Wyoming, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Ethnomedicine, Jackson, WY, USA","institution_ids":["https://openalex.org/I4210122304"]},{"raw_affiliation_string":"Institute for Ethnomedicine, Jackson, Wyoming, United States of America","institution_ids":["https://openalex.org/I4210122304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068231881","display_name":"James S. Metcalf","orcid":"https://orcid.org/0000-0003-3011-3973","observed_orcids":["https://orcid.org/0000-0003-3011-3973"]},"institutions":[{"id":"https://openalex.org/I4210122304","display_name":"Institute for EthnoMedicine","ror":"https://ror.org/02rrpz836","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210122304"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James S. Metcalf","raw_affiliation_strings":["Institute for Ethnomedicine, Jackson, Wyoming, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Ethnomedicine, Jackson, Wyoming, United States of America","institution_ids":["https://openalex.org/I4210122304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101529446","display_name":"Liying Jiang","orcid":"https://orcid.org/0000-0002-9118-9907","observed_orcids":["https://orcid.org/0000-0002-9118-9907"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Liying Jiang","raw_affiliation_strings":["Department of Analytical Chemistry, Stockholm University, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Stockholm University, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016764805","display_name":"Derek J. Craighead","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derek Craighead","raw_affiliation_strings":["Craighead Beringia South, Kelly, Wyoming, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Craighead Beringia South, Kelly, Wyoming, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062207006","display_name":"Leopold L. Ilag","orcid":"https://orcid.org/0000-0003-3678-7100","observed_orcids":["https://orcid.org/0000-0003-3678-7100"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Leopold L. Ilag","raw_affiliation_strings":["Department of Analytical Chemistry, Stockholm University, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Stockholm University, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018425320","display_name":"Paul Alan Cox","orcid":"https://orcid.org/0000-0001-6401-2981","observed_orcids":["https://orcid.org/0000-0001-6401-2981"]},"institutions":[{"id":"https://openalex.org/I4210122304","display_name":"Institute for EthnoMedicine","ror":"https://ror.org/02rrpz836","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210122304"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul Alan Cox","raw_affiliation_strings":["Institute for Ethnomedicine, Jackson, Wyoming, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Ethnomedicine, Jackson, Wyoming, United States of America","institution_ids":["https://openalex.org/I4210122304"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018425320"],"corresponding_institution_ids":["https://openalex.org/I4210122304"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.2303,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.90779501,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"11","first_page":"e49043","last_page":"e49043"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.09939999878406525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide-nucleic-acid","display_name":"peptide nucleic acid","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cyanobacteria","display_name":"cyanobacteria","score":0.996999979019165},{"id":"https://openalex.org/keywords/origin-of-life","display_name":"origin of life","score":0.8429999947547913},{"id":"https://openalex.org/keywords/rna-world-hypothesis","display_name":"RNA world","score":0.5429999828338623},{"id":"https://openalex.org/keywords/prebiotic-chemistry","display_name":"prebiotic chemistry","score":0.656000018119812},{"id":"https://openalex.org/keywords/amino-acid-biosynthesis","display_name":"amino acid biosynthesis","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2779669040","wikidata":"https://www.wikidata.org/wiki/Q93315","display_name":"Cyanobacteria","level":3,"score":0.8322961926460266},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7822649478912354},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5863070487976074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5786990523338318},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5440770983695984},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.5097948908805847},{"id":"https://openalex.org/C2778265057","wikidata":"https://www.wikidata.org/wiki/Q537299","display_name":"Axenic","level":3,"score":0.4853624105453491},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4489969313144684},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.44345542788505554},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37351155281066895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34249764680862427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2901025712490082},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1887706220149994}],"mesh":[{"descriptor_ui":"D000458","descriptor_name":"Cyanobacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000458","descriptor_name":"Cyanobacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018534","descriptor_name":"Earth, Planet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020135","descriptor_name":"Peptide Nucleic Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020135","descriptor_name":"Peptide Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0049043","doi":"https://doi.org/10.1371/journal.pone.0049043","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049043","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049043&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2492262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3492184","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23145061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23145061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3492184","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3492184/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8bfd372a7c054fe28779a4fa5d9082b3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8bfd372a7c054fe28779a4fa5d9082b3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 11, p e49043 (2012)","raw_type":"article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/f68e49f4-50df-46ef-a300-36ce9479b58d","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/f68e49f4-50df-46ef-a300-36ce9479b58d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Banack, S A, Metcalf, J S, Jiang, L, Craighead, D, Ilag, L L & Cox, P A 2012, 'Cyanobacteria produce N-(2-aminoethyl) glycine, a backbone for peptide nucleic acids which may have been the first genetic molecules for life on earth', PLOS One, vol. 7, no. 11, pp. e49043. https://doi.org/10.1371/journal.pone.0049043","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0049043","doi":"https://doi.org/10.1371/journal.pone.0049043","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049043","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049043&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011955653.pdf","grobid_xml":"https://content.openalex.org/works/W2011955653.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1856770580","https://openalex.org/W1920681646","https://openalex.org/W1991122925","https://openalex.org/W1994714652","https://openalex.org/W1995115284","https://openalex.org/W2000643475","https://openalex.org/W2019818589","https://openalex.org/W2020741558","https://openalex.org/W2025541331","https://openalex.org/W2032178581","https://openalex.org/W2035868601","https://openalex.org/W2037837681","https://openalex.org/W2045974535","https://openalex.org/W2048083582","https://openalex.org/W2048304974","https://openalex.org/W2052429917","https://openalex.org/W2078723261","https://openalex.org/W2080791625","https://openalex.org/W2083367765","https://openalex.org/W2099553504","https://openalex.org/W2116276518","https://openalex.org/W2139217432","https://openalex.org/W2155025987","https://openalex.org/W2163006245","https://openalex.org/W2164701497"],"related_works":["https://openalex.org/W1990020604","https://openalex.org/W1995115284","https://openalex.org/W2987897897","https://openalex.org/W2045873472","https://openalex.org/W1501796863","https://openalex.org/W4319812194","https://openalex.org/W2164701497","https://openalex.org/W7220854751","https://openalex.org/W4234906207","https://openalex.org/W1975529757"],"abstract_inverted_index":{"Prior":[0],"to":[1,35,107],"the":[2,20,40,131],"evolution":[3,132],"of":[4,43,66,72,82,112,117,133],"DNA-based":[5],"organisms":[6,26],"on":[7,45,135],"earth":[8],"over":[9],"3.5":[10],"billion":[11],"years":[12],"ago":[13],"it":[14],"is":[15],"hypothesized":[16],"that":[17,49,120],"RNA":[18],"was":[19],"primary":[21],"genetic":[22,37],"molecule.":[23],"Before":[24],"RNA-based":[25],"arose,":[27],"peptide":[28,57],"nucleic":[29,58],"acids":[30],"may":[31,122],"have":[32],"been":[33],"used":[34],"transmit":[36],"information":[38],"by":[39,98,114],"earliest":[41],"forms":[42],"life":[44,134],"earth.":[46,136],"We":[47,60,75],"discovered":[48],"cyanobacteria":[50,67,83,118],"produce":[51],"N-(2-aminoethyl)glycine":[52],"(AEG),":[53],"a":[54,86,93,124],"backbone":[55],"for":[56],"acids.":[59],"detected":[61,77,106],"AEG":[62,78,113,121],"in":[63,79,130],"axenic":[64],"strains":[65],"with":[68],"an":[69],"average":[70],"concentration":[71],"1":[73],"\u00b5g/g.":[74,109],"also":[76],"environmental":[80],"samples":[81],"as":[84],"both":[85],"free":[87],"or":[88],"weakly":[89],"bound":[90,95],"molecule":[91],"and":[92],"tightly":[94],"form":[96],"released":[97],"acid":[99],"hydrolysis,":[100],"at":[101],"concentrations":[102],"ranging":[103],"from":[104],"not":[105],"34":[108],"The":[110],"production":[111],"diverse":[115],"taxa":[116],"suggests":[119],"be":[123],"primitive":[125],"feature":[126],"which":[127],"arose":[128],"early":[129]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}