{"id":"https://openalex.org/W2011923581","doi":"https://doi.org/10.1172/jci114321","title":"Augmented bicarbonate reabsorption by both the proximal and distal nephron maintains chloride-deplete metabolic alkalosis in rats.","display_name":"Augmented bicarbonate reabsorption by both the proximal and distal nephron maintains chloride-deplete metabolic alkalosis in rats.","publication_year":1989,"publication_date":"1989-11-01","ids":{"openalex":"https://openalex.org/W2011923581","doi":"https://doi.org/10.1172/jci114321","mag":"2011923581","pmid":"https://pubmed.ncbi.nlm.nih.gov/2808701","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/304010"},"language":"en","primary_location":{"id":"doi:10.1172/jci114321","doi":"https://doi.org/10.1172/jci114321","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114321","pdf_url":"http://www.jci.org/articles/view/114321/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/114321/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019935894","display_name":"Donald E. Wesson","orcid":"https://orcid.org/0009-0007-7952-7401","observed_orcids":["https://orcid.org/0009-0007-7952-7401"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D E Wesson","raw_affiliation_strings":["Veterans Administration Medical Center, Baylor College of Medicine, Houston, Texas 77211"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Administration Medical Center, Baylor College of Medicine, Houston, Texas 77211","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019935894"],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":1.191,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.78169477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"84","issue":"5","first_page":"1460","last_page":"1469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bicarbonate-reabsorption","display_name":"bicarbonate reabsorption","score":0.9509999752044678},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.9039999842643738},{"id":"https://openalex.org/keywords/distal-nephron","display_name":"distal nephron","score":0.9309999942779541},{"id":"https://openalex.org/keywords/renal-tubular-epithelium","display_name":"renal tubular epithelium","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.8809283971786499},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.8427834510803223},{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.7784925699234009},{"id":"https://openalex.org/C2777068682","wikidata":"https://www.wikidata.org/wiki/Q512654","display_name":"Alkalosis","level":3,"score":0.7476136088371277},{"id":"https://openalex.org/C2779539245","wikidata":"https://www.wikidata.org/wiki/Q1428362","display_name":"Metabolic alkalosis","level":2,"score":0.7393432259559631},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7214764952659607},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6942931413650513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6822808384895325},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.5181738138198853},{"id":"https://openalex.org/C2778437025","wikidata":"https://www.wikidata.org/wiki/Q7850936","display_name":"Tubular fluid","level":4,"score":0.47530731558799744},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.4591052532196045},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.40259623527526855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20049437880516052},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.14002791047096252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.117095947265625}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000471","descriptor_name":"Alkalosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000471","descriptor_name":"Alkalosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007444","descriptor_name":"Inulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007686","descriptor_name":"Kidney Tubules, Distal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci114321","doi":"https://doi.org/10.1172/jci114321","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114321","pdf_url":"http://www.jci.org/articles/view/114321/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:304010","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/304010","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:2808701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2808701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci114321","doi":"https://doi.org/10.1172/jci114321","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114321","pdf_url":"http://www.jci.org/articles/view/114321/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G462414336","display_name":null,"funder_award_id":"RR 05425","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011923581.pdf","grobid_xml":"https://content.openalex.org/works/W2011923581.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1964403626","https://openalex.org/W1974950598","https://openalex.org/W1978701376","https://openalex.org/W1996594976","https://openalex.org/W2002747837","https://openalex.org/W2005300265","https://openalex.org/W2013672909","https://openalex.org/W2017969703","https://openalex.org/W2021053546","https://openalex.org/W2026596960","https://openalex.org/W2042403734","https://openalex.org/W2042792085","https://openalex.org/W2044842531","https://openalex.org/W2048819252","https://openalex.org/W2060183868","https://openalex.org/W2076704072","https://openalex.org/W2077750345","https://openalex.org/W2079184110","https://openalex.org/W2141595052","https://openalex.org/W2257737402","https://openalex.org/W2321945384","https://openalex.org/W2336635005","https://openalex.org/W2342449315","https://openalex.org/W2394941990","https://openalex.org/W2412024284","https://openalex.org/W2429587076","https://openalex.org/W2469908289"],"related_works":["https://openalex.org/W7097642480","https://openalex.org/W2409887329","https://openalex.org/W2167759319","https://openalex.org/W2283775893","https://openalex.org/W2410696169","https://openalex.org/W2044842531","https://openalex.org/W2398132370","https://openalex.org/W2467325257","https://openalex.org/W2074423981","https://openalex.org/W2021053546"],"abstract_inverted_index":{"Whether":[0],"augmented":[1,148],"bicarbonate":[2,26,91,129,149,172],"reabsorption":[3,27,61,87,150,173,180],"by":[4,28,151],"renal":[5],"tubular":[6,92],"epithelium":[7],"contributes":[8,158],"to":[9,24,40,58,94,159],"the":[10,48,77,80,90,99,105,109,133,153,161,175,182],"maintenance":[11],"of":[12,36,47,68,79,83,112,163,171],"chloride-deplete":[13],"metabolic":[14],"alkalosis":[15,38,162],"is":[16],"not":[17],"clear.":[18],"This":[19],"study":[20],"used":[21],"free-flow":[22],"micropuncture":[23],"investigate":[25],"surface":[29],"nephron":[30,46,157,177],"segments":[31],"in":[32,174,181],"a":[33,116,127],"rat":[34],"model":[35],"diuretic-induced":[37],"compared":[39],"control.":[41],"The":[42,65,144,166],"proximal":[43,66,101,154,183],"and":[44,59,70,88,126,155,178],"distal":[45,110,135,156,176],"alkalotic":[49,69,113],"animals":[50,72,114],"had":[51,73],"higher":[52],"values":[53,75],"for":[54,76,89,108],"both":[55,152],"delivered":[56,84],"load":[57,85],"absolute":[60],"from":[62],"these":[63],"segments.":[64],"tubules":[67],"control":[71],"similar":[74],"slopes":[78],"linear":[81],"regression":[82],"vs.":[86,120,138],"fluid":[93],"plasma":[95],"(TF/P)":[96],"ratio":[97,131],"at":[98,132],"late":[100,134],"tubule.":[102,184],"By":[103],"contrast,":[104],"corresponding":[106],"analysis":[107],"segment":[111],"revealed":[115],"greater":[117],"slope":[118],"(0.98":[119],"0.81,":[121],"P":[122,140],"less":[123,141],"than":[124,142],"0.003)":[125],"smaller":[128],"TF/P":[130],"tubule":[136],"(0.10":[137],"0.16,":[139],"0.006).":[143],"data":[145,167],"indicate":[146],"that":[147],"maintaining":[160],"this":[164],"model.":[165],"suggest":[168],"primary":[169],"stimulation":[170],"load-dependent":[179]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
