{"id":"https://openalex.org/W2011920826","doi":"https://doi.org/10.1128/aac.00809-09","title":"Susceptibilities of Human Cytomegalovirus Clinical Isolates and Other Herpesviruses to New Acetylated, Tetrahalogenated Benzimidazole d -Ribonucleosides","display_name":"Susceptibilities of Human Cytomegalovirus Clinical Isolates and Other Herpesviruses to New Acetylated, Tetrahalogenated Benzimidazole d -Ribonucleosides","publication_year":2009,"publication_date":"2009-09-29","ids":{"openalex":"https://openalex.org/W2011920826","doi":"https://doi.org/10.1128/aac.00809-09","mag":"2011920826","pmid":"https://pubmed.ncbi.nlm.nih.gov/19786605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2786319"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00809-09","doi":"https://doi.org/10.1128/aac.00809-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.00809-09","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2786319","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082119228","display_name":"Jae-Seon Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jae-Seon Hwang","raw_affiliation_strings":["Institute of Virology, Charite\u0301 Universita\u0308tsmedizin Berlin, Charite\u0301 Campus Mitte, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Charite\u0301 Universita\u0308tsmedizin Berlin, Charite\u0301 Campus Mitte, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051660603","display_name":"Rita Schilf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rita Schilf","raw_affiliation_strings":["Institute of Virology, Charite\u0301 Universita\u0308tsmedizin Berlin, Charite\u0301 Campus Mitte, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Charite\u0301 Universita\u0308tsmedizin Berlin, Charite\u0301 Campus Mitte, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110073621","display_name":"John C. Drach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Drach","raw_affiliation_strings":["Department of Biologic and Materials Sciences, School of Dentistry","Interdepartmental Graduate Program in Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, School of Dentistry","institution_ids":[]},{"raw_affiliation_string":"Interdepartmental Graduate Program in Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103853042","display_name":"Leroy B. Townsend","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leroy B. Townsend","raw_affiliation_strings":["Interdepartmental Graduate Program in Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdepartmental Graduate Program in Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077085499","display_name":"Elke Bogner","orcid":"https://orcid.org/0000-0001-7622-2900","observed_orcids":["https://orcid.org/0000-0001-7622-2900"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Elke Bogner","raw_affiliation_strings":["Institute of Virology, Charite\u0301 Universita\u0308tsmedizin Berlin, Charite\u0301 Campus Mitte, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Charite\u0301 Universita\u0308tsmedizin Berlin, Charite\u0301 Campus Mitte, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077085499"],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":null,"apc_paid":null,"fwci":1.8377,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.85748241,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"53","issue":"12","first_page":"5095","last_page":"5101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ganciclovir-resistance","display_name":"ganciclovir resistance","score":0.7770000100135803},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/murine-cytomegalovirus","display_name":"murine cytomegalovirus","score":0.9589999914169312},{"id":"https://openalex.org/keywords/rat-cytomegalovirus","display_name":"rat cytomegalovirus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/varicella-zoster-virus","display_name":"varicella-zoster virus","score":1.0},{"id":"https://openalex.org/keywords/viral-replication-kinetics","display_name":"viral replication kinetics","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.8543422222137451},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.729603111743927},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7092949151992798},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6572830080986023},{"id":"https://openalex.org/C2778484023","wikidata":"https://www.wikidata.org/wiki/Q415190","display_name":"Benzimidazole","level":2,"score":0.6422812938690186},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6225361824035645},{"id":"https://openalex.org/C2777965375","wikidata":"https://www.wikidata.org/wiki/Q417640","display_name":"Ganciclovir","level":4,"score":0.5438734292984009},{"id":"https://openalex.org/C70913881","wikidata":"https://www.wikidata.org/wiki/Q2296803","display_name":"Virus quantification","level":3,"score":0.5299402475357056},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5090279579162598},{"id":"https://openalex.org/C2776159415","wikidata":"https://www.wikidata.org/wiki/Q6868","display_name":"Varicella zoster virus","level":3,"score":0.5069749355316162},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.49834251403808594},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.4976702034473419},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47922971844673157},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.47429874539375305},{"id":"https://openalex.org/C17133392","wikidata":"https://www.wikidata.org/wiki/Q5158263","display_name":"Concatemer","level":4,"score":0.41586899757385254},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20348316431045532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16668203473091125},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.09059768915176392},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006562","descriptor_name":"Herpes Zoster","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006846","descriptor_name":"Hydrocarbons, Halogenated","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006846","descriptor_name":"Hydrocarbons, Halogenated","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006846","descriptor_name":"Hydrocarbons, Halogenated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014645","descriptor_name":"Herpesvirus 3, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016521","descriptor_name":"Electrophoresis, Gel, Pulsed-Field","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.00809-09","doi":"https://doi.org/10.1128/aac.00809-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.00809-09","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2786319","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2786319","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:19786605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19786605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.846.4652","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.846.4652","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://aac.asm.org/content/53/12/5095.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2786319","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2786319","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310707","display_name":"Wilhelm Sander-Stiftung","ror":"https://ror.org/02q83sc19"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1774396824","https://openalex.org/W1898707643","https://openalex.org/W1926456818","https://openalex.org/W1966562440","https://openalex.org/W1966581323","https://openalex.org/W1969840763","https://openalex.org/W1970323210","https://openalex.org/W1998777238","https://openalex.org/W2002040141","https://openalex.org/W2048177512","https://openalex.org/W2067406484","https://openalex.org/W2068392260","https://openalex.org/W2094659754","https://openalex.org/W2096682430","https://openalex.org/W2100635589","https://openalex.org/W2106227497","https://openalex.org/W2128353822","https://openalex.org/W2134955152","https://openalex.org/W2148244720","https://openalex.org/W2148869484","https://openalex.org/W2153568126","https://openalex.org/W2164301614","https://openalex.org/W2166315380","https://openalex.org/W2168531806","https://openalex.org/W2248336029","https://openalex.org/W2950125885","https://openalex.org/W4249086574"],"related_works":["https://openalex.org/W2100635589","https://openalex.org/W1882658935","https://openalex.org/W2555387465","https://openalex.org/W2096682430","https://openalex.org/W791489068","https://openalex.org/W4240047866","https://openalex.org/W7096950031","https://openalex.org/W2123918019","https://openalex.org/W2147902854","https://openalex.org/W2752130405"],"abstract_inverted_index":{"Recently":[0],"we":[1],"characterized":[2],"two":[3],"inhibitors":[4],"targeting":[5],"the":[6,22,27,130,173,207],"human":[7],"cytomegalovirus":[8,90],"(HCMV)":[9],"terminase,":[10,48],"2-bromo-4,5,6-trichloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)":[11],"benzimidazole":[12,16,63],"(BTCRB)":[13],"and":[14,26,92,108,116,125,150,200,215,219],"2,4,5,6-tetrachloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)":[15],"(Cl(4)RB).":[17],"The":[18,193],"terminase":[19],"consists":[20],"of":[21,43,81,102,163],"ATP-hydrolyzing":[23],"subunit":[24,28],"pUL56":[25],"pUL89":[29],"required":[30],"for":[31],"duplex":[32],"nicking.":[33],"Because":[34],"mammalian":[35],"cell":[36],"DNA":[37,45,165],"replication":[38],"does":[39],"not":[40],"involve":[41],"cleavage":[42,162],"concatemeric":[44],"by":[46,100,109,134],"a":[47],"these":[49,60],"compounds":[50,209],"represent":[51],"attractive":[52],"alternative":[53],"HCMV":[54,74],"antivirals.":[55],"We":[56],"now":[57],"have":[58],"tested":[59,191],"previously":[61],"identified":[62],"ribonucleosides":[64],"in":[65,122,140,168,182],"order":[66],"to":[67],"determine":[68],"if":[69],"they":[70],"are":[71,210],"active":[72,188,212,221],"against":[73,189,213,222],"clinical":[75,127,169,217],"isolates":[76,218],"as":[77,79],"well":[78],"those":[80],"herpes":[82],"simplex":[83],"virus":[84,94],"type":[85],"1,":[86],"mouse":[87],"cytomegalovirus,":[88],"rat":[89],"(RCMV),":[91],"varicella-zoster":[93],"(VZV).":[95],"Antiviral":[96],"activity":[97],"was":[98,166,179,187],"quantified":[99],"measurement":[101],"viral":[103,110],"plaque":[104,183],"formation":[105],"(plaque":[106],"reduction)":[107],"growth":[111],"kinetics.":[112],"Interestingly,":[113,181],"both":[114],"BTCRB":[115,186],"Cl(4)RB":[117],"had":[118],"an":[119],"inhibitory":[120],"effect":[121,132,175],"ganciclovir":[123],"(GCV)-sensitive":[124],"GCV-resistant":[126,146,214],"isolates,":[128,147],"with":[129,143],"best":[131,194],"produced":[133],"Cl(4)RB.":[135],"Electron":[136],"microscopy":[137],"revealed":[138],"that":[139,161,206],"cells":[141],"infected":[142],"GCV-sensitive":[144,216],"or":[145],"B":[148],"capsids":[149],"dense":[151],"bodies":[152],"were":[153,196],"formed":[154],"mainly.":[155],"Furthermore,":[156],"pulsed-field":[157],"gel":[158],"electrophoresis":[159],"showed":[160],"concatenated":[164],"inhibited":[167],"isolates.":[170],"In":[171],"addition,":[172],"antiviral":[174],"on":[176,198],"other":[177,223],"herpesviruses":[178],"determined.":[180],"reduction":[184],"assays,":[185],"all":[190],"herpesviruses.":[192,224],"effects":[195],"observed":[197],"VZV-":[199],"RCMV-infected":[201],"cells.":[202],"These":[203],"results":[204],"demonstrate":[205],"new":[208],"highly":[211],"slightly":[220]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}