{"id":"https://openalex.org/W2011886993","doi":"https://doi.org/10.1080/10826070903187981","title":"Countercurrent Chromatographic Separation of Lipophilic Ascorbic Acid Derivatives and Extract from Kadsura coccinea Using Hydrophobic Organic-Aqueous Two-Phase Solvent Systems","display_name":"Countercurrent Chromatographic Separation of Lipophilic Ascorbic Acid Derivatives and Extract from Kadsura coccinea Using Hydrophobic Organic-Aqueous Two-Phase Solvent Systems","publication_year":2009,"publication_date":"2009-09-04","ids":{"openalex":"https://openalex.org/W2011886993","doi":"https://doi.org/10.1080/10826070903187981","mag":"2011886993","pmid":"https://pubmed.ncbi.nlm.nih.gov/20046934","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2759759"},"language":"en","primary_location":{"id":"doi:10.1080/10826070903187981","doi":"https://doi.org/10.1080/10826070903187981","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10826070903187981","pdf_url":null,"source":{"id":"https://openalex.org/S123147032","display_name":"Journal of Liquid Chromatography & Related Technologies","issn_l":"1082-6076","issn":["1082-6076","1520-572X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Liquid Chromatography & Related Technologies","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2759759","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063156265","display_name":"Kazufusa Shinomiya","orcid":"https://orcid.org/0000-0001-7897-6546","observed_orcids":["https://orcid.org/0000-0001-7897-6546"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazufusa Shinomiya","raw_affiliation_strings":["a  College of Pharmacy, Nihon University , Funabashi-shi, Chiba,  Japan","College of Pharmacy, Nihon University , Funabashi-shi, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  College of Pharmacy, Nihon University , Funabashi-shi, Chiba,  Japan","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"College of Pharmacy, Nihon University , Funabashi-shi, Chiba, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013906211","display_name":"Heran Li","orcid":"https://orcid.org/0000-0002-2254-6552","observed_orcids":["https://orcid.org/0000-0002-2254-6552"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Heran Li","raw_affiliation_strings":["a  College of Pharmacy, Nihon University , Funabashi-shi, Chiba,  Japan","College of Pharmacy, Nihon University , Funabashi-shi, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  College of Pharmacy, Nihon University , Funabashi-shi, Chiba,  Japan","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"College of Pharmacy, Nihon University , Funabashi-shi, Chiba, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113824826","display_name":"Susumu Kitanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Kitanaka","raw_affiliation_strings":["a  College of Pharmacy, Nihon University , Funabashi-shi, Chiba,  Japan","College of Pharmacy, Nihon University , Funabashi-shi, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  College of Pharmacy, Nihon University , Funabashi-shi, Chiba,  Japan","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"College of Pharmacy, Nihon University , Funabashi-shi, Chiba, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029128268","display_name":"Yoichiro Ito","orcid":"https://orcid.org/0000-0001-9018-295X","observed_orcids":["https://orcid.org/0000-0001-9018-295X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoichiro Ito","raw_affiliation_strings":["b  Bioseparation Technology Laboratory, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland,  USA","Bioseparation Technology Laboratory, Biochemistry and Biophysics Center, National Heart , Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b  Bioseparation Technology Laboratory, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland,  USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Bioseparation Technology Laboratory, Biochemistry and Biophysics Center, National Heart , Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063156265"],"corresponding_institution_ids":["https://openalex.org/I104946051"],"apc_list":null,"apc_paid":null,"fwci":0.9735,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.74832018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"32","issue":"16","first_page":"2361","last_page":"2371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/countercurrent-chromatography","display_name":"countercurrent chromatography","score":0.9629999995231628},{"id":"https://openalex.org/keywords/kadsura-coccinea","display_name":"Kadsura coccinea","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ascorbic-acid-derivatives","display_name":"ascorbic acid derivatives","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lignans","display_name":"lignans","score":0.8999999761581421},{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":1.0},{"id":"https://openalex.org/keywords/beta-sitosterol","display_name":"\u03b2-sitosterol","score":0.9670000076293945},{"id":"https://openalex.org/keywords/natural-product-separation","display_name":"natural product separation","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9469197988510132},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.754904568195343},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.7380201816558838},{"id":"https://openalex.org/C63258622","wikidata":"https://www.wikidata.org/wiki/Q1498317","display_name":"Countercurrent chromatography","level":3,"score":0.7041612863540649},{"id":"https://openalex.org/C2780112151","wikidata":"https://www.wikidata.org/wiki/Q412033","display_name":"Trifluoroacetic acid","level":2,"score":0.6806077361106873},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.578795313835144},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.5477818250656128},{"id":"https://openalex.org/C149556010","wikidata":"https://www.wikidata.org/wiki/Q4782870","display_name":"Aqueous two-phase system","level":3,"score":0.4458228647708893},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.37354302406311035},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.35952621698379517},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1080/10826070903187981","doi":"https://doi.org/10.1080/10826070903187981","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10826070903187981","pdf_url":null,"source":{"id":"https://openalex.org/S123147032","display_name":"Journal of Liquid Chromatography & Related Technologies","issn_l":"1082-6076","issn":["1082-6076","1520-572X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Liquid Chromatography & Related Technologies","raw_type":"journal-article"},{"id":"pmid:20046934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20046934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of liquid chromatography & related technologies","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2759759","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2759759","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Liq Chromatogr Relat Technol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2759759","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2759759","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Liq Chromatogr Relat Technol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4705346009","display_name":null,"funder_award_id":"Z99 HL999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320326853","display_name":"Peking Union Medical College","ror":"https://ror.org/02drdmm93"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W72307602","https://openalex.org/W619665994","https://openalex.org/W2002848726","https://openalex.org/W2011886993","https://openalex.org/W2046370062","https://openalex.org/W2061228323","https://openalex.org/W2065361732","https://openalex.org/W2070059667","https://openalex.org/W2080383522","https://openalex.org/W2091049953","https://openalex.org/W2097217766","https://openalex.org/W2129291078","https://openalex.org/W2164702363","https://openalex.org/W2828401711","https://openalex.org/W2895340958","https://openalex.org/W2950553336","https://openalex.org/W4244455167","https://openalex.org/W4249745463"],"related_works":["https://openalex.org/W2082891889","https://openalex.org/W2606305103","https://openalex.org/W1984974146","https://openalex.org/W2129291078","https://openalex.org/W2100925176","https://openalex.org/W2886273138","https://openalex.org/W1930263567","https://openalex.org/W2091940132","https://openalex.org/W2093144593","https://openalex.org/W2097388795"],"abstract_inverted_index":{"Countercurrent":[0],"chromatographic":[1],"(CCC)":[2],"separation":[3,102,183],"of":[4,33,43,61,103,131,184],"lipophilic":[5,52],"ascorbic":[6,53],"acid":[7,38,54,153,156],"derivatives":[8,55],"and":[9,66,78,125,144,148,158,186],"the":[10,19,40,59,71,75,85,89,100,104,114,132,136,149,167,175,181,190],"crude":[11],"extract":[12,105,115],"from":[13,107],"Kadsura":[14],"Coccinea":[15],"was":[16,81,96,116,178],"performed":[17],"using":[18],"type-J":[20],"multilayer":[21],"coil":[22],"planet":[23],"centrifuge":[24],"with":[25],"a":[26],"hydrophobic":[27,168],"organic-aqueous":[28,169],"two-phase":[29,170],"solvent":[30,94,171],"system":[31,95,172],"composed":[32],"n-hexane/ethyl":[34],"acetate/ethanol/aqueous":[35],"0.1%":[36],"trifluoroacetic":[37],"at":[39,88],"volume":[41],"ratio":[42],"(5":[44],":":[45,47,49],"5":[46],"6":[48],"2).":[50],"The":[51,92,128,162],"were":[56],"separated":[57,82,118],"in":[58,174,189],"order":[60],"L-ascrobyl":[62],"2,6-dibutyrate,":[63],"L-ascorbyl":[64,67,79],"6-palmitate":[65],"6-stearate":[68],"by":[69,83],"eluting":[70,84],"lower":[72,111],"phase":[73,87,112],"as":[74,146,160],"mobile":[76],"phase,":[77],"2,6-dipalmitate":[80],"upper":[86],"opposite":[90],"direction.":[91],"above":[93],"then":[97],"applied":[98],"to":[99,123],"CCC":[101,182],"prepared":[106],"K.":[108],"coccinea.":[109],"With":[110],"mobile,":[113],"mainly":[117],"into":[119],"two":[120],"peaks":[121],"corresponding":[122],"lignans":[124,185],"triterpenoids":[126,187],"accordingly.":[127],"HPLC":[129],"analysis":[130],"fractions":[133],"showed":[134],"that":[135,166],"former":[137],"peak":[138],"contained":[139],"Kadsulignan":[140],"N,":[141],"Schizandrin":[142],"H":[143],"Neokadsuranin":[145],"lignans,":[147],"latter":[150],"peak,":[151],"Micranoic":[152],"A,":[154],"Neokadsuranic":[155],"B":[157],"beta-Sitosterol":[159],"triterpenoids.":[161],"overall":[163],"results":[164],"indicate":[165],"used":[173],"present":[176,188],"studies":[177],"useful":[179],"for":[180],"natural":[191],"products.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}