{"id":"https://openalex.org/W2011877516","doi":"https://doi.org/10.1097/jsm.0b013e318235151e","title":"Severe Physical Exertion, Oxidative Stress, and Acute Lung Injury","display_name":"Severe Physical Exertion, Oxidative Stress, and Acute Lung Injury","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2011877516","doi":"https://doi.org/10.1097/jsm.0b013e318235151e","mag":"2011877516","pmid":"https://pubmed.ncbi.nlm.nih.gov/22064719"},"language":"en","primary_location":{"id":"doi:10.1097/jsm.0b013e318235151e","doi":"https://doi.org/10.1097/jsm.0b013e318235151e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/jsm.0b013e318235151e","pdf_url":null,"source":{"id":"https://openalex.org/S19541889","display_name":"Clinical Journal of Sport Medicine","issn_l":"1050-642X","issn":["1050-642X","1536-3724"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Journal of Sport Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101904303","display_name":"Nikunj R. Shah","orcid":"https://orcid.org/0000-0002-1959-2750","observed_orcids":["https://orcid.org/0000-0002-1959-2750"]},"institutions":[{"id":"https://openalex.org/I2801227293","display_name":"Watford General Hospital","ror":"https://ror.org/01v13p275","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800621266","https://openalex.org/I2801227293"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nikunj R. Shah","raw_affiliation_strings":["Department of Cardiology, Watford General Hospital, Hertfordshire, United Kingdom. nikunjravshah@hotmail.com","Cardiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Watford General Hospital, Hertfordshire, United Kingdom. nikunjravshah@hotmail.com","institution_ids":["https://openalex.org/I2801227293"]},{"raw_affiliation_string":"Cardiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101657995","display_name":"M. Bilal Iqbal","orcid":"https://orcid.org/0000-0002-7864-7782","observed_orcids":["https://orcid.org/0000-0002-7864-7782"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M. Bilal Iqbal","raw_affiliation_strings":["Cardiology","The concept of the article was developed by N. Shah and M. B. Iqbal. N. Shah is the primary author. M. B. Iqbal, N. Shah, A. Barlow, and J. Bayliss contributed to all sections. J. Bayliss reviewed the final manuscript and is the guarantor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology","institution_ids":[]},{"raw_affiliation_string":"The concept of the article was developed by N. Shah and M. B. Iqbal. N. Shah is the primary author. M. B. Iqbal, N. Shah, A. Barlow, and J. Bayliss contributed to all sections. J. Bayliss reviewed the final manuscript and is the guarantor","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109838299","display_name":"Andrew Bryan Timothy Barlow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801227293","display_name":"Watford General Hospital","ror":"https://ror.org/01v13p275","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800621266","https://openalex.org/I2801227293"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Barlow","raw_affiliation_strings":["Respiratory Medicine, Watford General Hospital, Hertfordshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Medicine, Watford General Hospital, Hertfordshire, United Kingdom","institution_ids":["https://openalex.org/I2801227293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109260997","display_name":"John M. Bayliss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John Bayliss","raw_affiliation_strings":["Cardiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101657995","https://openalex.org/A5101904303","https://openalex.org/A5109260997"],"corresponding_institution_ids":["https://openalex.org/I2801227293"],"apc_list":null,"apc_paid":null,"fwci":0.2168,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.57335776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"21","issue":"6","first_page":"537","last_page":"538"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7730000019073486},{"id":"https://openalex.org/keywords/exercise-induced-lung-injury","display_name":"exercise-induced lung injury","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ironman-triathlon","display_name":"Ironman triathlon","score":0.8700000047683716},{"id":"https://openalex.org/keywords/athletes","display_name":"athletes","score":0.4699999988079071},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.871999979019165},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.800000011920929},{"id":"https://openalex.org/keywords/exercise-physiology","display_name":"exercise physiology","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9060324430465698},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7980818748474121},{"id":"https://openalex.org/C2778310968","wikidata":"https://www.wikidata.org/wiki/Q14536140","display_name":"Exertion","level":2,"score":0.6778212785720825},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.48212766647338867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4509276747703552},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.42579758167266846},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4155965745449066},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3929176926612854},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3631260097026825}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004417","descriptor_name":"Dyspnea","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005082","descriptor_name":"Physical Exertion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/jsm.0b013e318235151e","doi":"https://doi.org/10.1097/jsm.0b013e318235151e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/jsm.0b013e318235151e","pdf_url":null,"source":{"id":"https://openalex.org/S19541889","display_name":"Clinical Journal of Sport Medicine","issn_l":"1050-642X","issn":["1050-642X","1536-3724"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Journal of Sport Medicine","raw_type":"journal-article"},{"id":"pmid:22064719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22064719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1994610317","https://openalex.org/W2083963420","https://openalex.org/W2100289338","https://openalex.org/W2110102530","https://openalex.org/W2117866456","https://openalex.org/W4240573145"],"related_works":["https://openalex.org/W2004143343","https://openalex.org/W2127333943","https://openalex.org/W7007916026","https://openalex.org/W3217209742","https://openalex.org/W2364819685","https://openalex.org/W2955487336","https://openalex.org/W2395012387","https://openalex.org/W2089063213","https://openalex.org/W2054731030","https://openalex.org/W85625969"],"abstract_inverted_index":{"We":[0],"report":[1],"the":[2,110,127,132,142,172],"case":[3,117],"of":[4,82,91,134,145,152],"a":[5,35,80],"27-year-old":[6],"male":[7],"athlete":[8],"presenting":[9],"with":[10,47],"severe":[11,71,123],"dyspnoea":[12],"24":[13],"hours":[14],"after":[15],"completing":[16],"an":[17,28,103],"\"Ironman":[18],"Triathlon.\"":[19],"Subsequent":[20],"chest":[21],"radiology":[22],"excluded":[23],"pulmonary":[24],"embolus":[25],"but":[26],"confirmed":[27],"acute":[29,173],"lung":[30],"injury":[31],"(ALI).":[32],"Echocardiography":[33],"corroborated":[34],"normal":[36],"brain":[37],"natriuretic":[38],"peptide":[39],"level":[40],"by":[41],"demonstrating":[42],"good":[43],"biventricular":[44],"systolic":[45],"function":[46],"no":[48],"regional":[49],"wall":[50],"motion":[51],"abnormalities.":[52],"He":[53],"recovered":[54],"well,":[55],"without":[56],"requiring":[57],"ventilatory":[58],"support,":[59],"on":[60],"supplemental":[61],"oxygen":[62],"therapy":[63,163],"and":[64],"empirical":[65],"antibiotics.":[66],"To":[67],"date,":[68],"ALI":[69],"following":[70],"physical":[72,124],"exertion":[73,125],"has":[74],"never":[75],"been":[76],"described.":[77],"Exercise":[78],"is":[79,100],"form":[81],"physiological":[83],"stress":[84,88,106,120],"resulting":[85],"in":[86,131,171],"oxidative":[87,105,119,147],"through":[89],"generation":[90],"reactive":[92],"oxygen/nitrogen":[93],"species.":[94],"In":[95],"its":[96],"extreme":[97],"form,":[98],"there":[99],"potential":[101,168],"for":[102],"excessive":[104],"response--one":[107],"that":[108],"overwhelms":[109],"body's":[111],"protective":[112],"antioxidant":[113,162],"mechanisms.":[114],"As":[115],"our":[116],"demonstrated,":[118],"secondary":[121],"to":[122,140,159],"was":[126],"most":[128],"likely":[129],"factor":[130],"pathogenesis":[133],"ALI.":[135],"Further":[136],"studies":[137],"are":[138],"necessary":[139],"explore":[141],"pathological":[143],"consequences":[144],"exercise-induced":[146],"stress.":[148],"Although":[149],"unproven":[150],"as":[151],"yet,":[153],"further":[154],"research":[155],"may":[156],"be":[157],"needed":[158],"demonstrate":[160],"if":[161],"can":[164],"prevent":[165],"or":[166],"ameliorate":[167],"life-threatening":[169],"complications":[170],"setting.":[174]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}