{"id":"https://openalex.org/W2011821683","doi":"https://doi.org/10.1074/jbc.m608834200","title":"A Three-dimensional Model of Human Organic Anion Transporter 1","display_name":"A Three-dimensional Model of Human Organic Anion Transporter 1","publication_year":2006,"publication_date":"2006-10-13","ids":{"openalex":"https://openalex.org/W2011821683","doi":"https://doi.org/10.1074/jbc.m608834200","mag":"2011821683","pmid":"https://pubmed.ncbi.nlm.nih.gov/17038320","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1847411"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m608834200","doi":"https://doi.org/10.1074/jbc.m608834200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m608834200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m608834200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029408100","display_name":"Jennifer L. Perry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Perry","raw_affiliation_strings":["Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041308528","display_name":"Neetu Dembla-Rajpal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neetu Dembla-Rajpal","raw_affiliation_strings":["Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028641868","display_name":"Laura A. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura A. Hall","raw_affiliation_strings":["Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103582364","display_name":"John B. Pritchard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John B. Pritchard","raw_affiliation_strings":["Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103582364"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.0988,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.91413801,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"281","issue":"49","first_page":"38071","last_page":"38079"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oat1","display_name":"OAT1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hoat1","display_name":"hOAT1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/three-dimensional-structural-model","display_name":"3D structural model","score":0.796999990940094},{"id":"https://openalex.org/keywords/major-facilitator-superfamily","display_name":"major facilitator superfamily","score":0.9290000200271606},{"id":"https://openalex.org/keywords/protein-fold-recognition","display_name":"protein fold recognition","score":0.578000009059906},{"id":"https://openalex.org/keywords/active-site","display_name":"active site","score":0.652999997138977},{"id":"https://openalex.org/keywords/cidofovir","display_name":"cidofovir","score":0.8489999771118164},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.7070000171661377},{"id":"https://openalex.org/keywords/xenopus-oocyte-expression-system","display_name":"Xenopus oocyte expression","score":0.859000027179718},{"id":"https://openalex.org/keywords/membrane-protein-expression","display_name":"membrane protein expression","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C62465871","wikidata":"https://www.wikidata.org/wiki/Q1886097","display_name":"Major facilitator superfamily","level":4,"score":0.6802688837051392},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6646655201911926},{"id":"https://openalex.org/C123584848","wikidata":"https://www.wikidata.org/wiki/Q18034026","display_name":"Organic anion transporter 1","level":4,"score":0.6622604131698608},{"id":"https://openalex.org/C121421483","wikidata":"https://www.wikidata.org/wiki/Q43457632","display_name":"Organic anion","level":3,"score":0.558999240398407},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.515347421169281},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4804517924785614},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4335530400276184},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.40138325095176697},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.3838246464729309},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36236104369163513},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14501920342445374},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024322","descriptor_name":"Amino Acids, Aromatic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D027362","descriptor_name":"Organic Anion Transport Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027362","descriptor_name":"Organic Anion Transport Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027362","descriptor_name":"Organic Anion Transport Protein 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m608834200","doi":"https://doi.org/10.1074/jbc.m608834200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m608834200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17038320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17038320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1847411","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1847411","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m608834200","doi":"https://doi.org/10.1074/jbc.m608834200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m608834200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G258321565","display_name":"Role Of Membrane Transport In The Effectiveness And Toxicity Of Aids Therapeutic","funder_award_id":"1z01es048014-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4577068194","display_name":null,"funder_award_id":"Z01 ES048014-06","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6442384163","display_name":"Role Of Altered Membrane Function In Xenobiotic Toxicity","funder_award_id":"Z01ES080031","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1517566065","https://openalex.org/W1588849194","https://openalex.org/W1970728251","https://openalex.org/W1980170383","https://openalex.org/W1980374511","https://openalex.org/W1985818354","https://openalex.org/W1991758707","https://openalex.org/W2000123189","https://openalex.org/W2005002354","https://openalex.org/W2012497777","https://openalex.org/W2015642465","https://openalex.org/W2022232632","https://openalex.org/W2042100725","https://openalex.org/W2047711332","https://openalex.org/W2051860402","https://openalex.org/W2054828628","https://openalex.org/W2059709001","https://openalex.org/W2064203680","https://openalex.org/W2065283382","https://openalex.org/W2071416115","https://openalex.org/W2076036695","https://openalex.org/W2079748137","https://openalex.org/W2082188851","https://openalex.org/W2094271698","https://openalex.org/W2099384461","https://openalex.org/W2105828315","https://openalex.org/W2106189131","https://openalex.org/W2111575755","https://openalex.org/W2114232878","https://openalex.org/W2114520383","https://openalex.org/W2121335499","https://openalex.org/W2130381741","https://openalex.org/W2130422352","https://openalex.org/W2131124255","https://openalex.org/W2141783940","https://openalex.org/W2144103325","https://openalex.org/W2145608698","https://openalex.org/W2147241123","https://openalex.org/W2149675876","https://openalex.org/W2159832606","https://openalex.org/W2170380669","https://openalex.org/W2298286985"],"related_works":["https://openalex.org/W3033035301","https://openalex.org/W6926857767","https://openalex.org/W2000123189","https://openalex.org/W1525638107","https://openalex.org/W1970728251","https://openalex.org/W4319079584","https://openalex.org/W2102866872","https://openalex.org/W2152416112","https://openalex.org/W1988869301","https://openalex.org/W2033250114"],"abstract_inverted_index":{"Organic":[0],"anion":[1],"transporters":[2],"(OATs)":[3],"play":[4],"a":[5,39,142],"critical":[6],"role":[7],"in":[8,34,141,207],"the":[9,26,54,58,104,154,158,181,190,217,235],"handling":[10,208],"of":[11,57,127,169,209],"endogenous":[12],"and":[13,19,67,89,106,120,122,133,160,211,245],"exogenous":[14],"organic":[15],"anions":[16],"by":[17,109,138],"excretory":[18],"barrier":[20],"tissues.":[21],"Little":[22,220],"is":[23,107],"known":[24],"about":[25],"OAT":[27],"three-dimensional":[28,41],"structure":[29,56],"or":[30],"substrate/protein":[31,251],"interactions":[32],"involved":[33],"transport.":[35],"In":[36,188],"this":[37],"investigation,":[38],"theoretical":[40],"model":[42,81,238],"was":[43,150,165,200,222,229],"generated":[44],"for":[45,115,153,180,197,204,216,224,250],"human":[46],"OAT1":[47],"(hOAT1)":[48],"based":[49],"on":[50,130],"fold":[51],"recognition":[52],"to":[53,103,231],"crystal":[55],"glycerol":[59],"3-phosphate":[60],"transporter":[61],"(GlpT)":[62],"from":[63],"Escherichia":[64],"coli.":[65],"GlpT":[66],"hOAT1":[68,80,171,236],"share":[69],"several":[70],"sequence":[71],"motifs":[72],"as":[73],"major":[74],"facilitator":[75],"superfamily":[76],"members.":[77],"The":[78,100],"structural":[79,237],"shows":[82],"that":[83],"helices":[84],"5,":[85],"7,":[86],"8,":[87],"10,":[88],"11":[90],"surround":[91],"an":[92,194],"electronegative":[93],"putative":[94],"active":[95],"site":[96,101],"(":[97],"approximately":[98],"830A(3)).":[99],"opens":[102],"cytoplasm":[105],"surrounded":[108],"three":[110],"residues":[111,129],"not":[112,201],"previously":[113],"examined":[114],"function":[116],"(Tyr(230)":[117],"(domain":[118,124],"5)":[119],"Lys(431)":[121],"Phe(438)":[123],"10)).":[125],"Effects":[126],"these":[128],"p-aminohippurate":[131],"(PAH)":[132],"cidofovir":[134,198,212],"transport":[135],"were":[136,213],"assessed":[137],"point":[139],"mutations":[140],"Xenopus":[143],"oocyte":[144],"expression":[145,149,175],"system.":[146],"Membrane":[147],"protein":[148,174,186],"severely":[151],"limited":[152],"Y230A":[155],"mutant.":[156,219],"For":[157],"K431A":[159],"F438A":[161,182,191],"mutants,":[162],"[(3)H]PAH":[163],"uptake":[164,172,221,228],"less":[166],"than":[167],"30%":[168],"wild-type":[170,232],"after":[173],"correction.":[176],"Reduced":[177],"V(max)":[178],"values":[179],"mutant":[183,192],"confirmed":[184],"lower":[185],"expression.":[187],"addition,":[189],"exhibited":[193],"increased":[195],"affinity":[196],"but":[199],"significantly":[202],"different":[203],"PAH.":[205],"Differences":[206],"PAH":[210,227],"also":[214],"observed":[215],"Y230F":[218],"determined":[223],"cidofovir,":[225],"whereas":[226],"similar":[230],"hOAT1.":[233],"Therefore,":[234],"has":[239],"identified":[240],"two":[241],"new":[242],"residues,":[243],"Tyr(230)":[244],"Phe(438),":[246],"which":[247],"are":[248],"important":[249],"interactions.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
