{"id":"https://openalex.org/W2011809273","doi":"https://doi.org/10.1021/bc200138d","title":"Design of Acid-Activated Cell Penetrating Peptide for Delivery of Active Molecules into Cancer Cells","display_name":"Design of Acid-Activated Cell Penetrating Peptide for Delivery of Active Molecules into Cancer Cells","publication_year":2011,"publication_date":"2011-06-13","ids":{"openalex":"https://openalex.org/W2011809273","doi":"https://doi.org/10.1021/bc200138d","mag":"2011809273","pmid":"https://pubmed.ncbi.nlm.nih.gov/21663318"},"language":"en","primary_location":{"id":"doi:10.1021/bc200138d","doi":"https://doi.org/10.1021/bc200138d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc200138d","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://ir.lzu.edu.cn/handle/262010/121493","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100441778","display_name":"Wei Zhang","orcid":"https://orcid.org/0009-0009-2508-8428","observed_orcids":["https://orcid.org/0009-0009-2508-8428"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014609023","display_name":"Jingjing Song","orcid":"https://orcid.org/0000-0003-3641-8954","observed_orcids":["https://orcid.org/0000-0003-3641-8954"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Song","raw_affiliation_strings":["Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043314594","display_name":"Bangzhi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bangzhi Zhang","raw_affiliation_strings":["Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100786345","display_name":"Liwei Liu","orcid":"https://orcid.org/0000-0002-4593-665X","observed_orcids":["https://orcid.org/0000-0002-4593-665X"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liwei Liu","raw_affiliation_strings":["Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032684202","display_name":"Kairong Wang","orcid":"https://orcid.org/0000-0003-0749-9214","observed_orcids":["https://orcid.org/0000-0003-0749-9214"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kairong Wang","raw_affiliation_strings":["Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100431254","display_name":"Rui Wang","orcid":"https://orcid.org/0000-0002-4719-9921","observed_orcids":["https://orcid.org/0000-0002-4719-9921","https://orcid.org/0009-0003-7191-7828"]},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"Rui Wang","raw_affiliation_strings":["Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China","State Key Laboratory of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, China","institution_ids":["https://openalex.org/I76214153"]},{"raw_affiliation_string":"State Key Laboratory of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong","institution_ids":["https://openalex.org/I14243506"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100431254"],"corresponding_institution_ids":["https://openalex.org/I14243506","https://openalex.org/I76214153"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.5679,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.90595778,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"22","issue":"7","first_page":"1410","last_page":"1415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":0.9169999957084656},{"id":"https://openalex.org/keywords/transportan-10","display_name":"transportan 10","score":0.777999997138977},{"id":"https://openalex.org/keywords/histidine-substitution","display_name":"histidine substitution","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.4749999940395355},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5929999947547913},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7609999775886536},{"id":"https://openalex.org/keywords/peptide-toxicity","display_name":"peptide toxicity","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9705743789672852},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6227138638496399},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5226694941520691},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5179494619369507},{"id":"https://openalex.org/C2776929087","wikidata":"https://www.wikidata.org/wiki/Q189096","display_name":"Cell-penetrating peptide","level":3,"score":0.4892556667327881},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38566091656684875},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35335347056388855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34971141815185547},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3404087424278259},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1825236976146698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06067770719528198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057846","descriptor_name":"Cell-Penetrating Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/bc200138d","doi":"https://doi.org/10.1021/bc200138d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc200138d","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:21663318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21663318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/121493","doi":null,"is_oa":true,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/121493","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:ira.lib.polyu.edu.hk:10397/28774","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10397/28774","pdf_url":null,"source":{"id":"https://openalex.org/S4306400205","display_name":"PolyU Institutional Research Archive (Hong Kong Polytechnic University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I14243506","host_organization_name":"Hong Kong Polytechnic University","host_organization_lineage":["https://openalex.org/I14243506"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal/Magazine Article"}],"best_oa_location":{"id":"pmh:oai:ir.lzu.edu.cn/:262010/121493","doi":null,"is_oa":true,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/121493","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1488083143","https://openalex.org/W1948560807","https://openalex.org/W1956944003","https://openalex.org/W1975059067","https://openalex.org/W1975148998","https://openalex.org/W1978498174","https://openalex.org/W1979146520","https://openalex.org/W1985613060","https://openalex.org/W1987898644","https://openalex.org/W2018547804","https://openalex.org/W2019889336","https://openalex.org/W2026314821","https://openalex.org/W2048864215","https://openalex.org/W2053622564","https://openalex.org/W2054087967","https://openalex.org/W2055991021","https://openalex.org/W2057443193","https://openalex.org/W2067848116","https://openalex.org/W2070280888","https://openalex.org/W2070986221","https://openalex.org/W2073847499","https://openalex.org/W2076531479","https://openalex.org/W2084973104","https://openalex.org/W2086353181","https://openalex.org/W2088627129","https://openalex.org/W2089421206","https://openalex.org/W2099132605","https://openalex.org/W2137584261","https://openalex.org/W2163235231","https://openalex.org/W2332193194"],"related_works":["https://openalex.org/W2623946955","https://openalex.org/W2943931971","https://openalex.org/W4408014930","https://openalex.org/W3172989780","https://openalex.org/W4225405814","https://openalex.org/W3121051340","https://openalex.org/W7035300433","https://openalex.org/W2554377221","https://openalex.org/W6907773448","https://openalex.org/W7033383180"],"abstract_inverted_index":{"TP10-5":[0],"(TK)":[1],"was":[2],"screened":[3],"as":[4],"the":[5,10,87,100],"most":[6],"promising":[7],"candidate":[8],"among":[9],"designed":[11],"analogues":[12],"of":[13,31,50,56,59,89,102,109,116],"transportan":[14],"10":[15],"(TP10),":[16],"a":[17,47,130,142],"cell":[18],"penetrating":[19],"peptide":[20],"(CPP)":[21],"with":[22,61,134,156],"remarkable":[23,124],"capacity":[24],"for":[25,40,95],"membrane":[26],"translocation.":[27],"However,":[28],"low":[29],"levels":[30],"specificity":[32],"and":[33,70,137],"high":[34],"toxicity":[35,101],"limit":[36],"its":[37],"successful":[38],"use":[39],"drug":[41],"delivery":[42],"applications.":[43],"Here,":[44],"we":[45],"developed":[46],"new":[48,143],"type":[49],"acid-activated":[51],"CPP":[52],"(TH)":[53],"by":[54],"replacement":[55],"all":[57],"lysines":[58],"TK":[60,90,110],"histidines.":[62],"As":[63],"expected,":[64],"histidine-containing":[65],"TH":[66,103],"can":[67],"be":[68],"activated":[69],"subsequently":[71],"enter":[72,150],"cells":[73,128,151],"at":[74,82],"pH":[75,83,97],"6.0,":[76],"whereas":[77],"it":[78],"is":[79,104],"less":[80],"active":[81],"7.4.":[84],"In":[85],"contrast,":[86],"uptake":[88,159],"has":[91],"no":[92],"significant":[93],"difference":[94],"both":[96],"values.":[98],"Importantly,":[99],"significantly":[105],"lower":[106],"than":[107],"that":[108,148],"under":[111],"physiological":[112],"conditions.":[113],"After":[114],"attachment":[115],"camptothecin":[117],"(CPT)":[118],"to":[119,126,145],"TH,":[120],"this":[121],"conjugate":[122],"exhibited":[123],"cytotoxicity":[125],"cancer":[127],"in":[129,152,160],"pH-dependent":[131],"manner":[132],"compared":[133],"free":[135],"CPT":[136],"TK-CPT.":[138],"This":[139],"study":[140],"opens":[141],"avenue":[144],"design":[146],"CPPs":[147],"preferentially":[149],"acidic":[153],"solid":[154],"tumors,":[155],"minimal":[157],"cellular":[158],"normal":[161],"tissues.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
