{"id":"https://openalex.org/W2011807810","doi":"https://doi.org/10.1016/j.yrtph.2003.11.003","title":"A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins","display_name":"A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins","publication_year":2004,"publication_date":"2004-02-06","ids":{"openalex":"https://openalex.org/W2011807810","doi":"https://doi.org/10.1016/j.yrtph.2003.11.003","mag":"2011807810","pmid":"https://pubmed.ncbi.nlm.nih.gov/15041142"},"language":"en","primary_location":{"id":"doi:10.1016/j.yrtph.2003.11.003","doi":"https://doi.org/10.1016/j.yrtph.2003.11.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2003.11.003","pdf_url":null,"source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018638337","display_name":"Karluss Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089683","display_name":"International Life Sciences Institute","ror":"https://ror.org/006x8s867","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089683"]},{"id":"https://openalex.org/I4210147691","display_name":"Health and Environmental Sciences Institute","ror":"https://ror.org/04bqs3e84","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147691"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Thomas","raw_affiliation_strings":["ILSI Health and Environmental Sciences Institute, Washington, DC, USA. kthomas@ilsi.org","ILSI Health and Environmental Sciences Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ILSI Health and Environmental Sciences Institute, Washington, DC, USA. kthomas@ilsi.org","institution_ids":["https://openalex.org/I4210089683","https://openalex.org/I4210147691"]},{"raw_affiliation_string":"ILSI Health and Environmental Sciences Institute","institution_ids":["https://openalex.org/I4210089683","https://openalex.org/I4210147691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062229157","display_name":"Marja Aalbers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. Aalbers","raw_affiliation_strings":["Sanquin Research, Amsterdam, Netherlands","Sanquin Blood Supply Foundation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanquin Research, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I3020210244"]},{"raw_affiliation_string":"Sanquin Blood Supply Foundation;","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030363417","display_name":"Gary Anthony Bannon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295346377","display_name":"Monsanto (United States)","ror":"https://ror.org/00j83wy46","country_code":"US","type":"company","lineage":["https://openalex.org/I1295346377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.A. Bannon","raw_affiliation_strings":["Monsanto Co., St.Louis, MO, USA","Monsanto Company"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monsanto Co., St.Louis, MO, USA","institution_ids":["https://openalex.org/I1295346377"]},{"raw_affiliation_string":"Monsanto Company","institution_ids":["https://openalex.org/I1295346377"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Bartels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Bartels","raw_affiliation_strings":["The Dow Chemical Co., Midland, MI, USA","DOW Chemical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Co., Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]},{"raw_affiliation_string":"DOW Chemical","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039090860","display_name":"Rebecca Jane Dearman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]},{"id":"https://openalex.org/I4387155952","display_name":"Syngenta (France)","ror":"https://ror.org/0310sdb05","country_code":"FR","type":"company","lineage":["https://openalex.org/I4387155952","https://openalex.org/I89199228"]},{"id":"https://openalex.org/I89199228","display_name":"Syngenta (Switzerland)","ror":"https://ror.org/05fqg8t87","country_code":"CH","type":"company","lineage":["https://openalex.org/I89199228"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"R.J. Dearman","raw_affiliation_strings":["Syngenta Central Toxicology Laboratory, Alderley Park, UK","Syngenta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Central Toxicology Laboratory, Alderley Park, UK","institution_ids":["https://openalex.org/I4210087094"]},{"raw_affiliation_string":"Syngenta","institution_ids":["https://openalex.org/I4387155952","https://openalex.org/I89199228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076569468","display_name":"David J. Esdaile","orcid":"https://orcid.org/0000-0002-8110-2193","observed_orcids":["https://orcid.org/0000-0002-8110-2193"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D.J. Esdaile","raw_affiliation_strings":["Bayer CropScience, Sophia Antipolis, France","Bayer AG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer CropScience, Sophia Antipolis, France","institution_ids":[]},{"raw_affiliation_string":"Bayer AG","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025304040","display_name":"Tong\u2010Jen Fu","orcid":"https://orcid.org/0000-0001-6584-8721","observed_orcids":["https://orcid.org/0000-0001-6584-8721"]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.J. Fu","raw_affiliation_strings":["US Food and Drug Administration National Center for Food Safety and Technology, Summit Argo, IL, USA","U.S. Food/Drug Administration"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"US Food and Drug Administration National Center for Food Safety and Technology, Summit Argo, IL, USA","institution_ids":["https://openalex.org/I1320320070"]},{"raw_affiliation_string":"U.S. Food/Drug Administration","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057763129","display_name":"Christine M. Glatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316910977","display_name":"DuPont (United States)","ror":"https://ror.org/03g3m1w62","country_code":"US","type":"company","lineage":["https://openalex.org/I1316910977"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.M. Glatt","raw_affiliation_strings":["DuPont Co., Newark, DE,USA","DuPont"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DuPont Co., Newark, DE,USA","institution_ids":["https://openalex.org/I1316910977"]},{"raw_affiliation_string":"DuPont","institution_ids":["https://openalex.org/I1316910977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088206727","display_name":"N. Hadfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]},{"id":"https://openalex.org/I4387155952","display_name":"Syngenta (France)","ror":"https://ror.org/0310sdb05","country_code":"FR","type":"company","lineage":["https://openalex.org/I4387155952","https://openalex.org/I89199228"]},{"id":"https://openalex.org/I89199228","display_name":"Syngenta (Switzerland)","ror":"https://ror.org/05fqg8t87","country_code":"CH","type":"company","lineage":["https://openalex.org/I89199228"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"N. Hadfield","raw_affiliation_strings":["Syngenta Central Toxicology Laboratory, Alderley Park, UK","Syngenta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Central Toxicology Laboratory, Alderley Park, UK","institution_ids":["https://openalex.org/I4210087094"]},{"raw_affiliation_string":"Syngenta","institution_ids":["https://openalex.org/I4387155952","https://openalex.org/I89199228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041266664","display_name":"Catherine Hatzos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Hatzos","raw_affiliation_strings":["US Food and Drug Administration National Center for Food Safety and Technology, Summit Argo, IL, USA","U.S. Food/Drug Administration"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"US Food and Drug Administration National Center for Food Safety and Technology, Summit Argo, IL, USA","institution_ids":["https://openalex.org/I1320320070"]},{"raw_affiliation_string":"U.S. Food/Drug Administration","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111538920","display_name":"Susan L. Hefle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.L. Hefle","raw_affiliation_strings":["University of Nebraska, Lincoln, NE, USA","#N##TAB##TAB##TAB##TAB# University of Nebraska-Lincoln#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# University of Nebraska-Lincoln#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091535852","display_name":"Jon R. Heylings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]},{"id":"https://openalex.org/I4387155952","display_name":"Syngenta (France)","ror":"https://ror.org/0310sdb05","country_code":"FR","type":"company","lineage":["https://openalex.org/I4387155952","https://openalex.org/I89199228"]},{"id":"https://openalex.org/I89199228","display_name":"Syngenta (Switzerland)","ror":"https://ror.org/05fqg8t87","country_code":"CH","type":"company","lineage":["https://openalex.org/I89199228"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"J.R. Heylings","raw_affiliation_strings":["Syngenta Central Toxicology Laboratory, Alderley Park, UK","Syngenta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Central Toxicology Laboratory, Alderley Park, UK","institution_ids":["https://openalex.org/I4210087094"]},{"raw_affiliation_string":"Syngenta","institution_ids":["https://openalex.org/I4387155952","https://openalex.org/I89199228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037302086","display_name":"Richard E. Goodman","orcid":"https://orcid.org/0000-0001-8243-2285","observed_orcids":["https://orcid.org/0000-0001-8243-2285"]},"institutions":[{"id":"https://openalex.org/I1295346377","display_name":"Monsanto (United States)","ror":"https://ror.org/00j83wy46","country_code":"US","type":"company","lineage":["https://openalex.org/I1295346377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.E. Goodman","raw_affiliation_strings":["Monsanto Co., St.Louis, MO, USA","Monsanto Company"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monsanto Co., St.Louis, MO, USA","institution_ids":["https://openalex.org/I1295346377"]},{"raw_affiliation_string":"Monsanto Company","institution_ids":["https://openalex.org/I1295346377"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. Henry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Henry","raw_affiliation_strings":["Bayer CropScience, Research Triangle Park, NC, USA","Bayer AG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer CropScience, Research Triangle Park, NC, USA","institution_ids":[]},{"raw_affiliation_string":"Bayer AG","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075962664","display_name":"Corinne H\u00e9rouet-Guicheney","orcid":"https://orcid.org/0000-0001-7764-4021","observed_orcids":["https://orcid.org/0000-0001-7764-4021"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Herouet","raw_affiliation_strings":["Bayer CropScience, Sophia Antipolis, France","Bayer AG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer CropScience, Sophia Antipolis, France","institution_ids":[]},{"raw_affiliation_string":"Bayer AG","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030047327","display_name":"Michael P. Holsapple","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089683","display_name":"International Life Sciences Institute","ror":"https://ror.org/006x8s867","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089683"]},{"id":"https://openalex.org/I4210147691","display_name":"Health and Environmental Sciences Institute","ror":"https://ror.org/04bqs3e84","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147691"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Holsapple","raw_affiliation_strings":["ILSI Health and Environmental Sciences Institute, Washington, DC, USA","ILSI Health and Environmental Sciences Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ILSI Health and Environmental Sciences Institute, Washington, DC, USA","institution_ids":["https://openalex.org/I4210147691"]},{"raw_affiliation_string":"ILSI Health and Environmental Sciences Institute","institution_ids":["https://openalex.org/I4210089683","https://openalex.org/I4210147691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031406472","display_name":"Gregory S. Ladics","orcid":"https://orcid.org/0000-0002-9021-6328","observed_orcids":["https://orcid.org/0000-0002-9021-6328"]},"institutions":[{"id":"https://openalex.org/I1316910977","display_name":"DuPont (United States)","ror":"https://ror.org/03g3m1w62","country_code":"US","type":"company","lineage":["https://openalex.org/I1316910977"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.S. Ladics","raw_affiliation_strings":["DuPont Co., Newark, DE,USA","DuPont"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DuPont Co., Newark, DE,USA","institution_ids":["https://openalex.org/I1316910977"]},{"raw_affiliation_string":"DuPont","institution_ids":["https://openalex.org/I1316910977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108407277","display_name":"Tim Landry","orcid":"https://orcid.org/0009-0002-2755-1884","observed_orcids":["https://orcid.org/0009-0002-2755-1884"]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.D. Landry","raw_affiliation_strings":["The Dow Chemical Co., Midland, MI, USA","DOW Chemical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Co., Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]},{"raw_affiliation_string":"DOW Chemical","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110178144","display_name":"Susan C. Macintosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S.C. MacIntosh","raw_affiliation_strings":["Bayer CropScience, Research Triangle Park, NC, USA","Bayer AG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer CropScience, Research Triangle Park, NC, USA","institution_ids":[]},{"raw_affiliation_string":"Bayer AG","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053640083","display_name":"Elena A. Rice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295346377","display_name":"Monsanto (United States)","ror":"https://ror.org/00j83wy46","country_code":"US","type":"company","lineage":["https://openalex.org/I1295346377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.A. Rice","raw_affiliation_strings":["Monsanto Co., St.Louis, MO, USA","Monsanto Company"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monsanto Co., St.Louis, MO, USA","institution_ids":["https://openalex.org/I1295346377"]},{"raw_affiliation_string":"Monsanto Company","institution_ids":["https://openalex.org/I1295346377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027055595","display_name":"Laura Privalle","orcid":"https://orcid.org/0000-0001-7704-8131","observed_orcids":["https://orcid.org/0000-0001-7704-8131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L.S. Privalle","raw_affiliation_strings":["Syngenta Biotechnology Inc., Research Triangle Park NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Biotechnology Inc., Research Triangle Park NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"H.Y. Steiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155952","display_name":"Syngenta (France)","ror":"https://ror.org/0310sdb05","country_code":"FR","type":"company","lineage":["https://openalex.org/I4387155952","https://openalex.org/I89199228"]},{"id":"https://openalex.org/I89199228","display_name":"Syngenta (Switzerland)","ror":"https://ror.org/05fqg8t87","country_code":"CH","type":"company","lineage":["https://openalex.org/I89199228"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"H.Y. Steiner","raw_affiliation_strings":["Syngenta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta","institution_ids":["https://openalex.org/I4387155952","https://openalex.org/I89199228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061529680","display_name":"Reiko Teshima","orcid":"https://orcid.org/0000-0003-4310-6430","observed_orcids":["https://orcid.org/0000-0003-4310-6430"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Teshima","raw_affiliation_strings":["National Institute of Health Sciences Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Health Sciences Tokyo","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035034281","display_name":"Ronald van Ree","orcid":"https://orcid.org/0000-0003-0767-0894","observed_orcids":["https://orcid.org/0000-0003-0767-0894"]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. van Ree","raw_affiliation_strings":["Sanquin Blood Supply Foundation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanquin Blood Supply Foundation;","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109131674","display_name":"Michael R. Woolhiser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Woolhiser","raw_affiliation_strings":["DOW Chemical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOW Chemical","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006015165","display_name":"J. Zawodny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155952","display_name":"Syngenta (France)","ror":"https://ror.org/0310sdb05","country_code":"FR","type":"company","lineage":["https://openalex.org/I4387155952","https://openalex.org/I89199228"]},{"id":"https://openalex.org/I89199228","display_name":"Syngenta (Switzerland)","ror":"https://ror.org/05fqg8t87","country_code":"CH","type":"company","lineage":["https://openalex.org/I89199228"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"J. Zawodny","raw_affiliation_strings":["Syngenta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta","institution_ids":["https://openalex.org/I4387155952","https://openalex.org/I89199228"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5018638337"],"corresponding_institution_ids":["https://openalex.org/I4210089683","https://openalex.org/I4210147691"],"apc_list":{"value":4210,"currency":"USD","value_usd":4210},"apc_paid":null,"fwci":5.517,"has_fulltext":false,"cited_by_count":281,"citation_normalized_percentile":{"value":0.96191301,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"39","issue":"2","first_page":"87","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.7113999724388123,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.7113999724388123,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11426","display_name":"Genetically Modified Organisms Research","score":0.2502000033855438,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-digestibility","display_name":"protein digestibility","score":0.9449999928474426},{"id":"https://openalex.org/keywords/simulated-gastric-fluid","display_name":"simulated gastric fluid","score":0.7039999961853027},{"id":"https://openalex.org/keywords/genetically-modified-foods","display_name":"genetically modified foods","score":0.5979999899864197},{"id":"https://openalex.org/keywords/food-allergenicity","display_name":"food allergenicity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/assay-reproducibility","display_name":"assay reproducibility","score":0.8460000157356262},{"id":"https://openalex.org/keywords/interlaboratory-agreement","display_name":"interlaboratory agreement","score":0.6669999957084656},{"id":"https://openalex.org/keywords/assay-standardization","display_name":"assay standardization","score":0.6259999871253967},{"id":"https://openalex.org/keywords/ara-h-2","display_name":"Ara h 2","score":0.902999997138977},{"id":"https://openalex.org/keywords/ovomucoid","display_name":"ovomucoid","score":0.7609999775886536},{"id":"https://openalex.org/keywords/phosphinothricin-acetyltransferase","display_name":"phosphinothricin acetyltransferase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ribulose-diphosphate-carboxylase","display_name":"ribulose diphosphate carboxylase","score":0.9089999794960022},{"id":"https://openalex.org/keywords/soybean-trypsin-inhibitor","display_name":"soybean trypsin inhibitor","score":0.8859999775886536},{"id":"https://openalex.org/keywords/beta-lactoglobulin","display_name":"\u03b2-lactoglobulin","score":0.777999997138977},{"id":"https://openalex.org/keywords/peanut-allergens","display_name":"peanut allergens","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C16311235","wikidata":"https://www.wikidata.org/wiki/Q190265","display_name":"Pepsin","level":3,"score":0.9168418645858765},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6738754510879517},{"id":"https://openalex.org/C2781357212","wikidata":"https://www.wikidata.org/wiki/Q5275608","display_name":"Digestion (alchemy)","level":2,"score":0.6410551071166992},{"id":"https://openalex.org/C160845552","wikidata":"https://www.wikidata.org/wiki/Q247562","display_name":"Bradford protein assay","level":2,"score":0.598750114440918},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.5621950626373291},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5463895201683044},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5020430088043213},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.4732518792152405},{"id":"https://openalex.org/C2781283633","wikidata":"https://www.wikidata.org/wiki/Q7157196","display_name":"Pea protein","level":2,"score":0.44532740116119385},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2762683629989624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1863858699798584},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004063","descriptor_name":"Digestion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019411","descriptor_name":"Clinical Laboratory Techniques","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.yrtph.2003.11.003","doi":"https://doi.org/10.1016/j.yrtph.2003.11.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2003.11.003","pdf_url":null,"source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:15041142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15041142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory toxicology and pharmacology : RTP","raw_type":"Comparative Study"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/de76d5ab-e953-463f-a128-0e071410af2c","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/a-multilaboratory-evaluation-of-a-common-in-vitro-pepsin-digestion-assay-protocol-used-in-assessing-the-safety-of-novel-proteins(de76d5ab-e953-463f-a128-0e071410af2c).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Regulatory toxicology and pharmacology, 39(2), 87 - 98. Academic Press Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/e07b100c-ebcf-426c-a040-6de90b87946b","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/e07b100c-ebcf-426c-a040-6de90b87946b","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/70ad4fb5-44fd-43c1-a29a-f43de24624d9","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/70ad4fb5-44fd-43c1-a29a-f43de24624d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W90532991","https://openalex.org/W99295644","https://openalex.org/W1504546383","https://openalex.org/W1535579925","https://openalex.org/W1573723390","https://openalex.org/W1931782913","https://openalex.org/W1966943019","https://openalex.org/W1967653096","https://openalex.org/W1969011088","https://openalex.org/W1972717477","https://openalex.org/W1974078294","https://openalex.org/W1975085160","https://openalex.org/W1975107332","https://openalex.org/W1982405838","https://openalex.org/W1999138282","https://openalex.org/W2005532431","https://openalex.org/W2009834810","https://openalex.org/W2011344289","https://openalex.org/W2020845503","https://openalex.org/W2024747783","https://openalex.org/W2028230976","https://openalex.org/W2037414308","https://openalex.org/W2040800520","https://openalex.org/W2046606047","https://openalex.org/W2047172713","https://openalex.org/W2048110827","https://openalex.org/W2055995740","https://openalex.org/W2060330690","https://openalex.org/W2062820033","https://openalex.org/W2066741083","https://openalex.org/W2068283466","https://openalex.org/W2075056431","https://openalex.org/W2076059990","https://openalex.org/W2086316039","https://openalex.org/W2089407496","https://openalex.org/W2090136358","https://openalex.org/W2090373831","https://openalex.org/W2091870229","https://openalex.org/W2097629282","https://openalex.org/W2100837269","https://openalex.org/W2471859669","https://openalex.org/W3206231916","https://openalex.org/W4239393922"],"related_works":["https://openalex.org/W2089002048","https://openalex.org/W2883994022","https://openalex.org/W4284885970","https://openalex.org/W1990621507","https://openalex.org/W3034303396","https://openalex.org/W2587950959","https://openalex.org/W2088644987","https://openalex.org/W4288104382","https://openalex.org/W2309003927","https://openalex.org/W4288376382"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
