{"id":"https://openalex.org/W2011793441","doi":"https://doi.org/10.1095/biolreprod35.2.425","title":"The Effects of Ethylene Dimethane Suiphonate (EDS) on Rat Leydig Cells: Evidence to Support a Connective Tissue Origin of Leydig Cells1","display_name":"The Effects of Ethylene Dimethane Suiphonate (EDS) on Rat Leydig Cells: Evidence to Support a Connective Tissue Origin of Leydig Cells1","publication_year":1986,"publication_date":"1986-09-01","ids":{"openalex":"https://openalex.org/W2011793441","doi":"https://doi.org/10.1095/biolreprod35.2.425","mag":"2011793441","pmid":"https://pubmed.ncbi.nlm.nih.gov/3021249"},"language":"en","primary_location":{"id":"doi:10.1095/biolreprod35.2.425","doi":"https://doi.org/10.1095/biolreprod35.2.425","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod35.2.425","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006672846","display_name":"Anne E. Jackson","orcid":"https://orcid.org/0000-0001-5329-1292","observed_orcids":["https://orcid.org/0000-0001-5329-1292"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"A. E. Jackson","raw_affiliation_strings":["Department of Anatomy Monash University Melbourne, Victoria 3168 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy Monash University Melbourne, Victoria 3168 Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045559304","display_name":"Peter C. O'Leary","orcid":"https://orcid.org/0000-0001-9375-0801","observed_orcids":["https://orcid.org/0000-0001-9375-0801"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"P. C. O\u2019Leary","raw_affiliation_strings":["Department of Anatomy Monash University Melbourne, Victoria 3168 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy Monash University Melbourne, Victoria 3168 Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111648708","display_name":"M. M. Ayers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. M. Ayers","raw_affiliation_strings":["Department of Anatomy Monash University Melbourne, Victoria 3168 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy Monash University Melbourne, Victoria 3168 Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111410222","display_name":"D. M. DE KRETSER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"D. M. de Kretser","raw_affiliation_strings":["Department of Anatomy Monash University Melbourne, Victoria 3168 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy Monash University Melbourne, Victoria 3168 Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111410222"],"corresponding_institution_ids":["https://openalex.org/I56590836"],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":6.4274,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.97738425,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"2","first_page":"425","last_page":"437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/leydig-cell-degeneration","display_name":"Leydig cell degeneration","score":0.7990000247955322},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.628000020980835},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9169999957084656},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leydig-cell-differentiation","display_name":"Leydig cell differentiation","score":0.718999981880188},{"id":"https://openalex.org/keywords/fetal-leydig-cells","display_name":"fetal Leydig cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/testicular-macrophages","display_name":"testicular macrophages","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.8479231595993042},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7854764461517334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7765545845031738},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.7224900722503662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6751464009284973},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.6646546721458435},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.652742862701416},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4582902193069458},{"id":"https://openalex.org/C2779066085","wikidata":"https://www.wikidata.org/wiki/Q9384","display_name":"Testicle","level":2,"score":0.4114062190055847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08892160654067993},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003238","descriptor_name":"Connective Tissue","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008698","descriptor_name":"Mesylates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1095/biolreprod35.2.425","doi":"https://doi.org/10.1095/biolreprod35.2.425","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod35.2.425","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},{"id":"pmid:3021249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3021249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of reproduction","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1984063971","https://openalex.org/W2004543369","https://openalex.org/W2025247756","https://openalex.org/W2027076894","https://openalex.org/W2036523229","https://openalex.org/W2050337369","https://openalex.org/W2068691378","https://openalex.org/W2131889623","https://openalex.org/W2169798916","https://openalex.org/W2402393700"],"related_works":["https://openalex.org/W2169798916","https://openalex.org/W2145082047","https://openalex.org/W2063134547","https://openalex.org/W1991841212","https://openalex.org/W2036119676","https://openalex.org/W2103955423","https://openalex.org/W1993113295","https://openalex.org/W1984353630","https://openalex.org/W2090266069","https://openalex.org/W2463686307"],"abstract_inverted_index":{"Ethylene":[0],"dimethane":[1],"sulphonate":[2],"(DS)":[3],"administered":[4],"to":[5,95,119,194,232],"adult":[6,202],"male":[7],"rats":[8,203],"in":[9,19,27,35,76,115,122],"a":[10,20,32,132,160,217],"single":[11],"dose":[12],"of":[13,23,37,55,80,89,103,107,135,162,187,200,210,219,222],"75":[14],"mg/kg":[15],"body":[16],"weight":[17],"results":[18,75],"rapid":[21],"destruction":[22],"Leydig":[24,49,66,81,136,154,176,189,197,212],"cells":[25,50,67,82,137,155,165,171,198,213],"which,":[26],"turn,":[28],"is":[29,214],"associated":[30,215],"with":[31,45,99,216],"marked":[33],"decline":[34],"levels":[36,102,106,120,145,221],"serum":[38,104,116],"testosterone.":[39],"For":[40],"24-72":[41],"h":[42],"after":[43],"treatment":[44],"EDS":[46],"(post-EDS)":[47],"the":[48,69,77,87,100,153,185],"undergo":[51],"degenerative":[52],"changes":[53],"consisting":[54],"chromatin":[56],"condensation":[57],"and":[58,61,86,111,126,142,172,229,237],"cytoplasmic":[59],"vacuolation,":[60],"testicular":[62],"macrophages":[63],"progressively":[64],"remove":[65],"from":[68,139,159],"intertubular":[70],"tissue":[71,164],"by":[72,146,157],"phagocytosis.":[73],"This":[74],"total":[78],"absence":[79,88],"on":[83],"Days":[84],"7-14":[85],"any":[90],"detectable":[91],"specific":[92],"125I-hCG":[93,127],"binding":[94,128],"testis":[96],"homogenates.":[97],"Associated":[98],"low":[101],"testosterone,":[105],"luteinizing":[108],"hormone":[109,113],"(LH)":[110],"follicle-stimulating":[112],"(FSH)":[114],"rise,":[117],"LH":[118,228],"found":[121],"castrate":[123],"rats.":[124],"Morphometric":[125],"studies":[129],"indicate":[130],"that":[131,152,166],"new":[133,175,211],"generation":[134],"develop":[138],"Day":[140,147,181],"21":[141,182,224],"reach":[143],"control":[144],"49.":[148],"Morphologic":[149],"observations":[150],"suggest":[151],"arise":[156],"differentiation":[158,209],"pool":[161],"connective":[163],"includes":[167],"fibroblasts,":[168],"lymphatic":[169],"endothelial":[170],"pericytes.":[173],"The":[174,191,208],"cells,":[177],"which":[178],"appear":[179,193],"around":[180],"post-EDS,":[183],"have":[184],"features":[186],"fetal":[188],"cells.":[190],"latter":[192],"transform":[195],"into":[196],"typical":[199],"normal":[201,220,233],"between":[204],"35-49":[205],"days":[206,225,236,239],"post-EDS.":[207,226],"reestablishment":[218],"testosterone":[223],"Serum":[227],"FSH":[230],"return":[231],"at":[234],"28":[235],"49":[238],"respectively.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}