{"id":"https://openalex.org/W2011787638","doi":"https://doi.org/10.1016/j.biortech.2008.10.022","title":"Response surface methodology: Synthesis of short chain fructooligosaccharides with a fructosyltransferase from Aspergillus aculeatus","display_name":"Response surface methodology: Synthesis of short chain fructooligosaccharides with a fructosyltransferase from Aspergillus aculeatus","publication_year":2008,"publication_date":"2008-11-23","ids":{"openalex":"https://openalex.org/W2011787638","doi":"https://doi.org/10.1016/j.biortech.2008.10.022","mag":"2011787638","pmid":"https://pubmed.ncbi.nlm.nih.gov/19028090"},"language":"en","primary_location":{"id":"doi:10.1016/j.biortech.2008.10.022","doi":"https://doi.org/10.1016/j.biortech.2008.10.022","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biortech.2008.10.022","pdf_url":null,"source":{"id":"https://openalex.org/S21442059","display_name":"Bioresource Technology","issn_l":"0960-8524","issn":["0960-8524","1873-2976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioresource Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039874321","display_name":"A. Nemukula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203238179","display_name":"Rhodes University","ror":"https://ror.org/016sewp10","country_code":"ZA","type":"education","lineage":["https://openalex.org/I203238179"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"A. Nemukula","raw_affiliation_strings":["Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa","institution_ids":["https://openalex.org/I203238179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020121218","display_name":"Taurai Mutanda","orcid":"https://orcid.org/0000-0002-9539-9231","observed_orcids":["https://orcid.org/0000-0002-9539-9231"]},"institutions":[{"id":"https://openalex.org/I203238179","display_name":"Rhodes University","ror":"https://ror.org/016sewp10","country_code":"ZA","type":"education","lineage":["https://openalex.org/I203238179"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"T. Mutanda","raw_affiliation_strings":["Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa","institution_ids":["https://openalex.org/I203238179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037365118","display_name":"Brendan Wilhelmi","orcid":"https://orcid.org/0000-0002-7854-891X","observed_orcids":["https://orcid.org/0000-0002-7854-891X"]},"institutions":[{"id":"https://openalex.org/I203238179","display_name":"Rhodes University","ror":"https://ror.org/016sewp10","country_code":"ZA","type":"education","lineage":["https://openalex.org/I203238179"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"B.S. Wilhelmi","raw_affiliation_strings":["Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa","institution_ids":["https://openalex.org/I203238179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022462837","display_name":"C.G. Whiteley","orcid":"https://orcid.org/0000-0001-8956-1338","observed_orcids":["https://orcid.org/0000-0001-8956-1338"]},"institutions":[{"id":"https://openalex.org/I203238179","display_name":"Rhodes University","ror":"https://ror.org/016sewp10","country_code":"ZA","type":"education","lineage":["https://openalex.org/I203238179"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"C.G. Whiteley","raw_affiliation_strings":["Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa","institution_ids":["https://openalex.org/I203238179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022462837"],"corresponding_institution_ids":["https://openalex.org/I203238179"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":2.2162,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.86109642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"100","issue":"6","first_page":"2040","last_page":"2045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fructooligosaccharides","display_name":"fructooligosaccharides","score":0.9449999928474426},{"id":"https://openalex.org/keywords/aspergillus-aculeatus","display_name":"Aspergillus aculeatus","score":0.9210000038146973},{"id":"https://openalex.org/keywords/fructosyltransferase","display_name":"fructosyltransferase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.6970000267028809},{"id":"https://openalex.org/keywords/transfructosylation","display_name":"transfructosylation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/sucrose","display_name":"sucrose","score":0.7480000257492065},{"id":"https://openalex.org/keywords/response-surface-methodology","display_name":"response surface methodology","score":0.7059999704360962},{"id":"https://openalex.org/keywords/oligosaccharide-synthesis","display_name":"oligosaccharide synthesis","score":0.781000018119812},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.6449999809265137},{"id":"https://openalex.org/keywords/incubation-time","display_name":"incubation time","score":0.699999988079071},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7523945569992065},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.6912676095962524},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.6737895607948303},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6053981184959412},{"id":"https://openalex.org/C150077022","wikidata":"https://www.wikidata.org/wiki/Q3136137","display_name":"Response surface methodology","level":2,"score":0.586752712726593},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5817681550979614},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5769975781440735},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.45979663729667664},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.4589120149612427},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.43881574273109436},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.41402700543403625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3954077363014221},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006602","descriptor_name":"Hexosyltransferases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006602","descriptor_name":"Hexosyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biortech.2008.10.022","doi":"https://doi.org/10.1016/j.biortech.2008.10.022","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biortech.2008.10.022","pdf_url":null,"source":{"id":"https://openalex.org/S21442059","display_name":"Bioresource Technology","issn_l":"0960-8524","issn":["0960-8524","1873-2976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioresource Technology","raw_type":"journal-article"},{"id":"pmid:19028090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19028090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioresource technology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W64160500","https://openalex.org/W207776502","https://openalex.org/W1576919957","https://openalex.org/W1975708850","https://openalex.org/W1976910934","https://openalex.org/W1982618462","https://openalex.org/W1999175064","https://openalex.org/W2010666346","https://openalex.org/W2023459508","https://openalex.org/W2033509028","https://openalex.org/W2037302321","https://openalex.org/W2053197517","https://openalex.org/W2056333275","https://openalex.org/W2062682990","https://openalex.org/W2075393018","https://openalex.org/W2082477816","https://openalex.org/W2082801762","https://openalex.org/W2100837269","https://openalex.org/W2120536847","https://openalex.org/W2128635872","https://openalex.org/W2161638490","https://openalex.org/W2301086946","https://openalex.org/W2971042176"],"related_works":["https://openalex.org/W2183878015","https://openalex.org/W2082477816","https://openalex.org/W4375865801","https://openalex.org/W2497868104","https://openalex.org/W2010084937","https://openalex.org/W2009317106","https://openalex.org/W2913980377","https://openalex.org/W2093608400","https://openalex.org/W2990014476","https://openalex.org/W2255558087"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}