{"id":"https://openalex.org/W201176646","doi":"https://doi.org/10.1021/bi201157t","title":"Two Distinct Catalytic Strategies in the Hepatitis Delta Virus Ribozyme Cleavage Reaction","display_name":"Two Distinct Catalytic Strategies in the Hepatitis Delta Virus Ribozyme Cleavage Reaction","publication_year":2011,"publication_date":"2011-10-17","ids":{"openalex":"https://openalex.org/W201176646","doi":"https://doi.org/10.1021/bi201157t","mag":"201176646","pmid":"https://pubmed.ncbi.nlm.nih.gov/22003985","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3220057"},"language":"en","primary_location":{"id":"doi:10.1021/bi201157t","doi":"https://doi.org/10.1021/bi201157t","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi201157t","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3220057","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090853950","display_name":"Barbara L. Golden","orcid":"https://orcid.org/0000-0002-9741-882X","observed_orcids":["https://orcid.org/0000-0002-9741-882X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Barbara L. Golden","raw_affiliation_strings":["Department of Biochemistry, Purdue University, 175 South University Street, West\rLafayette, Indiana 47907-2063,\rUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Purdue University, 175 South University Street, West\rLafayette, Indiana 47907-2063,\rUnited States","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090853950"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.8196,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.8402272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"50","issue":"44","first_page":"9424","last_page":"9433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-delta-virus-ribozyme","display_name":"hepatitis delta virus ribozyme","score":0.9879999756813049},{"id":"https://openalex.org/keywords/rna-self-cleavage","display_name":"RNA self-cleavage","score":0.859000027179718},{"id":"https://openalex.org/keywords/ribozyme-catalysis","display_name":"ribozyme catalysis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/divalent-metal-ions","display_name":"divalent metal ions","score":0.6899999976158142},{"id":"https://openalex.org/keywords/magnesium-ion-catalysis","display_name":"magnesium ion catalysis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/lewis-acid-catalysis","display_name":"Lewis acid catalysis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/general-acid-catalysis","display_name":"general acid catalysis","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.857715368270874},{"id":"https://openalex.org/C2908824246","wikidata":"https://www.wikidata.org/wiki/Q327281","display_name":"HEPATITIS DELTA","level":4,"score":0.801153302192688},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.7286384105682373},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5374935269355774},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5192692279815674},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5106697678565979},{"id":"https://openalex.org/C30951146","wikidata":"https://www.wikidata.org/wiki/Q6745754","display_name":"Mammalian CPEB3 ribozyme","level":5,"score":0.45862194895744324},{"id":"https://openalex.org/C5072461","wikidata":"https://www.wikidata.org/wiki/Q49506","display_name":"Delta","level":2,"score":0.4518848657608032},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4399823248386383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3425399661064148},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.21626797318458557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20782968401908875},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1649286150932312},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.16250410676002502},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0609307587146759},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003597","descriptor_name":"Cytosine Nucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003597","descriptor_name":"Cytosine Nucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003597","descriptor_name":"Cytosine Nucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003597","descriptor_name":"Cytosine Nucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017412","descriptor_name":"Ribonucleoprotein, U1 Small Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017412","descriptor_name":"Ribonucleoprotein, U1 Small Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017412","descriptor_name":"Ribonucleoprotein, U1 Small Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017412","descriptor_name":"Ribonucleoprotein, U1 Small Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017412","descriptor_name":"Ribonucleoprotein, U1 Small Nuclear","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017412","descriptor_name":"Ribonucleoprotein, U1 Small Nuclear","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017412","descriptor_name":"Ribonucleoprotein, U1 Small Nuclear","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017412","descriptor_name":"Ribonucleoprotein, U1 Small Nuclear","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/bi201157t","doi":"https://doi.org/10.1021/bi201157t","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi201157t","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:22003985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22003985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:2490017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3220057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3220057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3220057","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2490017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3220057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6627270897","display_name":"Coupling of structure and dynamics in RNA catalysis","funder_award_id":"R01GM095923","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W124204487","https://openalex.org/W1642023497","https://openalex.org/W1678644792","https://openalex.org/W1876847843","https://openalex.org/W1881326155","https://openalex.org/W1965897089","https://openalex.org/W1967565706","https://openalex.org/W1968052494","https://openalex.org/W1969590246","https://openalex.org/W1969669203","https://openalex.org/W1974000520","https://openalex.org/W1974732040","https://openalex.org/W1981167137","https://openalex.org/W1981253739","https://openalex.org/W1983744996","https://openalex.org/W1984649012","https://openalex.org/W1984990168","https://openalex.org/W1985012591","https://openalex.org/W1985119561","https://openalex.org/W1986221874","https://openalex.org/W1986492966","https://openalex.org/W1989961446","https://openalex.org/W1991346026","https://openalex.org/W1994958501","https://openalex.org/W2004672687","https://openalex.org/W2004721956","https://openalex.org/W2006521039","https://openalex.org/W2008151075","https://openalex.org/W2008797142","https://openalex.org/W2014733573","https://openalex.org/W2015869768","https://openalex.org/W2018562898","https://openalex.org/W2029998151","https://openalex.org/W2034847127","https://openalex.org/W2035140491","https://openalex.org/W2035530213","https://openalex.org/W2038708776","https://openalex.org/W2039282510","https://openalex.org/W2043951259","https://openalex.org/W2046385606","https://openalex.org/W2047683652","https://openalex.org/W2049289210","https://openalex.org/W2050956602","https://openalex.org/W2055688390","https://openalex.org/W2055832088","https://openalex.org/W2064592675","https://openalex.org/W2069348762","https://openalex.org/W2070213115","https://openalex.org/W2073459948","https://openalex.org/W2074240228","https://openalex.org/W2074312400","https://openalex.org/W2082968605","https://openalex.org/W2086708241","https://openalex.org/W2087211235","https://openalex.org/W2088764843","https://openalex.org/W2090349687","https://openalex.org/W2104040152","https://openalex.org/W2104214639","https://openalex.org/W2104689448","https://openalex.org/W2105120377","https://openalex.org/W2109115256","https://openalex.org/W2110473615","https://openalex.org/W2118039681","https://openalex.org/W2120883316","https://openalex.org/W2125074270","https://openalex.org/W2127279316","https://openalex.org/W2132466716","https://openalex.org/W2135058126","https://openalex.org/W2143654339","https://openalex.org/W2143970011","https://openalex.org/W2144759995","https://openalex.org/W2148503018","https://openalex.org/W2149081982","https://openalex.org/W2151088029","https://openalex.org/W2154378035","https://openalex.org/W2158158767","https://openalex.org/W2159946246","https://openalex.org/W2164166224","https://openalex.org/W2165143835","https://openalex.org/W2165759309","https://openalex.org/W2169751581","https://openalex.org/W2171563376"],"related_works":["https://openalex.org/W2163151016","https://openalex.org/W2257474662","https://openalex.org/W7206206090","https://openalex.org/W2082968605","https://openalex.org/W2055832088","https://openalex.org/W7132851536","https://openalex.org/W2159946246","https://openalex.org/W1538577407","https://openalex.org/W4210330855","https://openalex.org/W1966015273"],"abstract_inverted_index":{"The":[0,108],"hepatitis":[1],"delta":[2],"virus":[3],"(HDV)":[4],"ribozyme":[5,20,87,113,147,159,243],"and":[6,30,79,126,182,202,238],"related":[7],"RNAs":[8],"are":[9,37],"widely":[10],"dispersed":[11],"in":[12,50,114,138,156,228,233,249],"nature.":[13],"This":[14,61,220],"RNA":[15],"is":[16,75,128,151],"a":[17,27,31,65,91,94,100,133,152,194],"small":[18,35,73,239],"nucleolytic":[19],"that":[21,64,84,97,132,149,171],"self-cleaves":[22],"to":[23,103,235],"generate":[24],"products":[25],"with":[26,93,178],"2',3'-cyclic":[28],"phosphate":[29,181],"free":[32],"5'-hydroxyl.":[33],"Although":[34],"ribozymes":[36,74],"dependent":[38],"on":[39],"divalent":[40,54],"metal":[41,55,153,173],"ions":[42,56],"under":[43],"biologically":[44],"relevant":[45],"buffer":[46],"conditions,":[47],"they":[48],"function":[49],"the":[51,69,85,105,111,120,123,145,157,164,168,179,183,188,200,204,207,214,217,241],"absence":[52],"of":[53,72,110,122,144,163,199,206,213],"at":[57,216],"high":[58],"ionic":[59],"strengths.":[60],"characteristic":[62],"suggests":[63],"functional":[66],"group":[67],"within":[68],"covalent":[70],"structure":[71,143,169],"facilitating":[76,197],"catalysis.":[77,139],"Structural":[78],"mechanistic":[80],"analyses":[81],"have":[82],"demonstrated":[83],"HDV":[86,112,146,158,242],"active":[88,160],"site":[89,166,209],"contains":[90],"cytosine":[92],"perturbed":[95],"pK(a)":[96],"serves":[98],"as":[99,193],"general":[101],"acid":[102],"protonate":[104],"leaving":[106],"group.":[107],"reaction":[109],"monovalent":[115],"cations":[116],"alone":[117],"never":[118],"approaches":[119],"velocity":[121],"Mg(2+)-dependent":[124],"reaction,":[125],"there":[127,150],"significant":[129],"biochemical":[130],"evidence":[131],"Mg(2+)":[134,189],"ion":[135,174,190],"participates":[136],"directly":[137,177],"A":[140],"recent":[141],"crystal":[142],"revealed":[148],"binding":[154],"pocket":[155],"site.":[161],"Modeling":[162],"cleavage":[165,208,251],"into":[167],"suggested":[170],"this":[172,186],"can":[175,191],"interact":[176],"scissile":[180,218],"nucleophile.":[184],"In":[185],"manner,":[187],"serve":[192],"Lewis":[195],"acid,":[196],"deprotonation":[198],"nucleophile":[201,215],"stabilizing":[203],"conformation":[205],"for":[210],"in-line":[211],"attack":[212],"phosphate.":[219],"catalytic":[221,247],"strategy":[222],"had":[223],"previously":[224],"been":[225],"observed":[226],"only":[227],"much":[229],"larger":[230],"ribozymes.":[231],"Thus,":[232],"contrast":[234],"most":[236],"large":[237],"ribozymes,":[240],"uses":[244],"two":[245],"distinct":[246],"strategies":[248],"its":[250],"reaction.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}