{"id":"https://openalex.org/W2011751998","doi":"https://doi.org/10.1006/jmbi.2001.5290","title":"Structure and mechanism of action of a cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus with broad specificity phosphatase activity","display_name":"Structure and mechanism of action of a cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus with broad specificity phosphatase activity","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2011751998","doi":"https://doi.org/10.1006/jmbi.2001.5290","mag":"2011751998","pmid":"https://pubmed.ncbi.nlm.nih.gov/11827481"},"language":"en","primary_location":{"id":"doi:10.1006/jmbi.2001.5290","doi":"https://doi.org/10.1006/jmbi.2001.5290","is_oa":false,"landing_page_url":"https://doi.org/10.1006/jmbi.2001.5290","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009636964","display_name":"Daniel John Rigden","orcid":"https://orcid.org/0000-0002-7565-8937","observed_orcids":["https://orcid.org/0000-0002-7565-8937"]},"institutions":[{"id":"https://openalex.org/I199691007","display_name":"Embrapa","ror":"https://ror.org/0482b5b22","country_code":"BR","type":"government","lineage":["https://openalex.org/I199691007"]},{"id":"https://openalex.org/I4405284811","display_name":"Embrapa Recursos Gen\u00e9ticos e Biotecnologia","ror":"https://ror.org/047y8rp84","country_code":"BR","type":"government","lineage":["https://openalex.org/I199691007","https://openalex.org/I4405284811"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniel J Rigden","raw_affiliation_strings":["National Centre of Genetic Resources and Biotechnology, Cenargen/Embrapa, S.A.I.N. Parque Rural, Final W5, Asa Norte, Bras\u00edlia, 70770-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre of Genetic Resources and Biotechnology, Cenargen/Embrapa, S.A.I.N. Parque Rural, Final W5, Asa Norte, Bras\u00edlia, 70770-900, Brazil","institution_ids":["https://openalex.org/I199691007","https://openalex.org/I4405284811"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048124538","display_name":"Luciane Vieira Mello","orcid":"https://orcid.org/0000-0002-8632-1678","observed_orcids":["https://orcid.org/0000-0002-8632-1678"]},"institutions":[{"id":"https://openalex.org/I199691007","display_name":"Embrapa","ror":"https://ror.org/0482b5b22","country_code":"BR","type":"government","lineage":["https://openalex.org/I199691007"]},{"id":"https://openalex.org/I4405284811","display_name":"Embrapa Recursos Gen\u00e9ticos e Biotecnologia","ror":"https://ror.org/047y8rp84","country_code":"BR","type":"government","lineage":["https://openalex.org/I199691007","https://openalex.org/I4405284811"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciane V Mello","raw_affiliation_strings":["National Centre of Genetic Resources and Biotechnology, Cenargen/Embrapa, S.A.I.N. Parque Rural, Final W5, Asa Norte, 70770-900 Bras\u0131\u0301lia, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre of Genetic Resources and Biotechnology, Cenargen/Embrapa, S.A.I.N. Parque Rural, Final W5, Asa Norte, 70770-900 Bras\u0131\u0301lia, Brazil","institution_ids":["https://openalex.org/I199691007","https://openalex.org/I4405284811"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042833634","display_name":"Peter Setlow","orcid":"https://orcid.org/0000-0003-3119-2669","observed_orcids":["https://orcid.org/0000-0003-3119-2669"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Setlow","raw_affiliation_strings":["Resources and Biotechnology Department of Biochemistry University of Connecticut Health Center, Farmington CT 06032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resources and Biotechnology Department of Biochemistry University of Connecticut Health Center, Farmington CT 06032, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110221615","display_name":"Mark J. Jedrzejas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mark J Jedrzejas","raw_affiliation_strings":["Children\u2019s Hospital Oakland Research Institute, Oakland, CA 94609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Oakland Research Institute, Oakland, CA 94609, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110221615"],"corresponding_institution_ids":[],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":1.9684,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.85325362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"315","issue":"5","first_page":"1129","last_page":"1143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phoe","display_name":"PhoE","score":0.9100000262260437},{"id":"https://openalex.org/keywords/geobacillus-stearothermophilus","display_name":"Bacillus stearothermophilus","score":0.9369999766349792},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7689999938011169},{"id":"https://openalex.org/keywords/active-site-cleft","display_name":"active site cleft","score":0.7839999794960022},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.5960000157356262},{"id":"https://openalex.org/keywords/3-phosphoglycerate","display_name":"3-phosphoglycerate","score":0.9660000205039978},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.9039999842643738},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.4440000057220459},{"id":"https://openalex.org/keywords/fructose-2-6-bisphosphatase","display_name":"fructose-2,6-bisphosphatase","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C91754966","wikidata":"https://www.wikidata.org/wiki/Q415490","display_name":"Phosphoglycerate mutase","level":4,"score":0.93402099609375},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.689059853553772},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6127836108207703},{"id":"https://openalex.org/C2779150676","wikidata":"https://www.wikidata.org/wiki/Q2091405","display_name":"Bacillus (shape)","level":2,"score":0.6116316318511963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5543757677078247},{"id":"https://openalex.org/C2777552656","wikidata":"https://www.wikidata.org/wiki/Q118009","display_name":"Mutase","level":3,"score":0.5294187664985657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4541941285133362},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4369666874408722},{"id":"https://openalex.org/C2777932965","wikidata":"https://www.wikidata.org/wiki/Q149098","display_name":"Bacillaceae","level":4,"score":0.4153212010860443},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.41413021087646484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4028926193714142},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4016238749027252},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.20577287673950195},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1529671549797058},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1384248435497284},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.07820859551429749},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001411","descriptor_name":"Geobacillus stearothermophilus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010736","descriptor_name":"Phosphoglycerate Mutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010736","descriptor_name":"Phosphoglycerate Mutase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/jmbi.2001.5290","doi":"https://doi.org/10.1006/jmbi.2001.5290","is_oa":false,"landing_page_url":"https://doi.org/10.1006/jmbi.2001.5290","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:11827481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11827481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1197907232","display_name":null,"funder_award_id":"AI 44079","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3891165741","display_name":"STRUCTURAL STUDIES OF BACTERIAL HYALURONATE LYASE ENZYME","funder_award_id":"R01AI044079","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W139332744","https://openalex.org/W1539796472","https://openalex.org/W1560083437","https://openalex.org/W1561202599","https://openalex.org/W1563191931","https://openalex.org/W1566946038","https://openalex.org/W1964042511","https://openalex.org/W1966834633","https://openalex.org/W1968960032","https://openalex.org/W1980467950","https://openalex.org/W1983011713","https://openalex.org/W1986191025","https://openalex.org/W1992532108","https://openalex.org/W1993404146","https://openalex.org/W1995017064","https://openalex.org/W1995180700","https://openalex.org/W1996607909","https://openalex.org/W1999921589","https://openalex.org/W2001575235","https://openalex.org/W2001641653","https://openalex.org/W2008294923","https://openalex.org/W2013083986","https://openalex.org/W2020481171","https://openalex.org/W2027249579","https://openalex.org/W2028231353","https://openalex.org/W2038908554","https://openalex.org/W2042783465","https://openalex.org/W2043329863","https://openalex.org/W2047173579","https://openalex.org/W2051942624","https://openalex.org/W2055043387","https://openalex.org/W2055989425","https://openalex.org/W2060067160","https://openalex.org/W2060421754","https://openalex.org/W2062177449","https://openalex.org/W2077701177","https://openalex.org/W2078163944","https://openalex.org/W2083211222","https://openalex.org/W2084925740","https://openalex.org/W2085277871","https://openalex.org/W2087293973","https://openalex.org/W2090906760","https://openalex.org/W2091969321","https://openalex.org/W2096726561","https://openalex.org/W2097493124","https://openalex.org/W2099031446","https://openalex.org/W2100882223","https://openalex.org/W2103924432","https://openalex.org/W2106882534","https://openalex.org/W2109072224","https://openalex.org/W2109310563","https://openalex.org/W2125289895","https://openalex.org/W2126924068","https://openalex.org/W2127432350","https://openalex.org/W2132351632","https://openalex.org/W2132589721","https://openalex.org/W2137234426","https://openalex.org/W2141839673","https://openalex.org/W2141885858","https://openalex.org/W2141920771","https://openalex.org/W2150460982","https://openalex.org/W2154665416","https://openalex.org/W2155479906","https://openalex.org/W2155785386","https://openalex.org/W2160788362","https://openalex.org/W2160951461","https://openalex.org/W2161579456","https://openalex.org/W2171462702","https://openalex.org/W2953060674","https://openalex.org/W3199943451","https://openalex.org/W4241496951","https://openalex.org/W4252166161","https://openalex.org/W6800717233"],"related_works":["https://openalex.org/W2029797858","https://openalex.org/W2030949721","https://openalex.org/W2008294923","https://openalex.org/W2127078413","https://openalex.org/W2038908554","https://openalex.org/W2160788362","https://openalex.org/W2000123492","https://openalex.org/W2160754382","https://openalex.org/W1964042511","https://openalex.org/W2162647129"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}