{"id":"https://openalex.org/W2011725341","doi":"https://doi.org/10.1016/0027-5107(87)90100-x","title":"DNA methods for detecting and analyzing mutations in vivo","display_name":"DNA methods for detecting and analyzing mutations in vivo","publication_year":1987,"publication_date":"1987-12-01","ids":{"openalex":"https://openalex.org/W2011725341","doi":"https://doi.org/10.1016/0027-5107(87)90100-x","mag":"2011725341","pmid":"https://pubmed.ncbi.nlm.nih.gov/2825007"},"language":"en","primary_location":{"id":"doi:10.1016/0027-5107(87)90100-x","doi":"https://doi.org/10.1016/0027-5107(87)90100-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0027-5107(87)90100-x","pdf_url":null,"source":{"id":"https://openalex.org/S4394735698","display_name":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","issn_l":"0027-5107","issn":["0027-5107","1386-1964","1873-135X","1879-2871"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.82135/tno-230432","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010451011","display_name":"P.H.M. Lohman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"P.H.M. Lohman","raw_affiliation_strings":["TNO, Medical Biological Laboratory, Rijswijk, The Netherlands","TNO - Medical Biological Laboratory, P.O. Box 45, 2280 AA Rijswijk The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO, Medical Biological Laboratory, Rijswijk, The Netherlands","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"TNO - Medical Biological Laboratory, P.O. Box 45, 2280 AA Rijswijk The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012398734","display_name":"Jan Vijg","orcid":"https://orcid.org/0000-0002-8457-9595","observed_orcids":["https://orcid.org/0000-0002-8457-9595"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. Vijg","raw_affiliation_strings":["TNO - Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO - Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031530236","display_name":"Andr\u00e9 Gerardus Uitterlinden","orcid":"https://orcid.org/0000-0002-7276-3387","observed_orcids":["https://orcid.org/0000-0002-7276-3387"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A.G. Uitterlinden","raw_affiliation_strings":["TNO - Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO - Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071478025","display_name":"P. Eline Slagboom","orcid":"https://orcid.org/0000-0002-2875-4723","observed_orcids":["https://orcid.org/0000-0002-2875-4723"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. Slagboom","raw_affiliation_strings":["TNO - Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO - Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013488003","display_name":"Jan A. Gossen","orcid":"https://orcid.org/0000-0002-5614-0411","observed_orcids":["https://orcid.org/0000-0002-5614-0411"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.A. Gossen","raw_affiliation_strings":["TNO - Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk The Netherlands","TNO - Medical Biological Laboratory, P.O. Box 45, 2280 AA Rijswijk The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO - Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk The Netherlands","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"TNO - Medical Biological Laboratory, P.O. Box 45, 2280 AA Rijswijk The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041979853","display_name":"Frits Berends","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F. Berends","raw_affiliation_strings":["TNO - Medical Biological Laboratory, P.O. Box 45, 2280 AA Rijswijk The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO - Medical Biological Laboratory, P.O. Box 45, 2280 AA Rijswijk The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010451011"],"corresponding_institution_ids":["https://openalex.org/I148297040"],"apc_list":{"value":3380,"currency":"USD","value_usd":3380},"apc_paid":null,"fwci":0.6392,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.58730159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"181","issue":"2","first_page":"227","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-toxicology","display_name":"genetic toxicology","score":0.9089999794960022},{"id":"https://openalex.org/keywords/uv-induced-dna-repair","display_name":"UV-induced DNA repair","score":0.7900000214576721},{"id":"https://openalex.org/keywords/xeroderma-pigmentosum","display_name":"xeroderma pigmentosum","score":0.996999979019165},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.7149999737739563},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.5490000247955322},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C2778378917","wikidata":"https://www.wikidata.org/wiki/Q612693","display_name":"Xeroderma pigmentosum","level":4,"score":0.8883105516433716},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6834442615509033},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6522535085678101},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6117901802062988},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5343517661094666},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5016369819641113},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4698697030544281},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46776339411735535},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.45206934213638306},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43941208720207214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39405113458633423},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37734681367874146},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32114097476005554},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/0027-5107(87)90100-x","doi":"https://doi.org/10.1016/0027-5107(87)90100-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0027-5107(87)90100-x","pdf_url":null,"source":{"id":"https://openalex.org/S4394735698","display_name":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","issn_l":"0027-5107","issn":["0027-5107","1386-1964","1873-135X","1879-2871"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research","raw_type":"journal-article"},{"id":"pmid:2825007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2825007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation research","raw_type":"Journal Article"},{"id":"pmh:oai:oai-pmh.tno.nl:86597","doi":null,"is_oa":false,"landing_page_url":"https://resolver.tno.nl/uuid:9965fd84-9bb4-4ec3-aead-f82f2dd95cc6","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mutation Research, 181(2), pp. 227-234.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/f303520b-2012-46eb-b6f7-46e4cd573ce3","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/f303520b-2012-46eb-b6f7-46e4cd573ce3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lohman , P H M , Vijg , J , Uitterlinden , A G , Slagboom , P , Gossen , J A & Berends , F 1987 , ' DNA methods for detecting and analyzing mutations in vivo ' , Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol. 181 , no. 2 , pp. 227-234 . https://doi.org/10.1016/0027-5107(87)90100-X","raw_type":"article"},{"id":"doi:10.82135/tno-230432","doi":"https://doi.org/10.82135/tno-230432","is_oa":true,"landing_page_url":"https://doi.org/10.82135/tno-230432","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.82135/tno-230432","doi":"https://doi.org/10.82135/tno-230432","is_oa":true,"landing_page_url":"https://doi.org/10.82135/tno-230432","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W93302532","https://openalex.org/W560852019","https://openalex.org/W1968458490","https://openalex.org/W1970502777","https://openalex.org/W1977634176","https://openalex.org/W1979000139","https://openalex.org/W1979604597","https://openalex.org/W1980944646","https://openalex.org/W1987802717","https://openalex.org/W1987803067","https://openalex.org/W1992368452","https://openalex.org/W1994239961","https://openalex.org/W1996729627","https://openalex.org/W2001695665","https://openalex.org/W2015369033","https://openalex.org/W2019226265","https://openalex.org/W2024921638","https://openalex.org/W2039456492","https://openalex.org/W2041148981","https://openalex.org/W2041963065","https://openalex.org/W2046775765","https://openalex.org/W2048066539","https://openalex.org/W2050036403","https://openalex.org/W2050077019","https://openalex.org/W2050717506","https://openalex.org/W2053631253","https://openalex.org/W2053906706","https://openalex.org/W2066287900","https://openalex.org/W2069647602","https://openalex.org/W2080266123","https://openalex.org/W2081608552","https://openalex.org/W2085534722","https://openalex.org/W2086834887","https://openalex.org/W2153683703","https://openalex.org/W2167016213","https://openalex.org/W2172960123","https://openalex.org/W4253663860","https://openalex.org/W4285719527","https://openalex.org/W6603822081"],"related_works":["https://openalex.org/W2086834887","https://openalex.org/W2418684461","https://openalex.org/W2060412665","https://openalex.org/W2002889765","https://openalex.org/W7095612538","https://openalex.org/W2084223129","https://openalex.org/W189364574","https://openalex.org/W4379513459","https://openalex.org/W2059506261","https://openalex.org/W4388298492"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}