{"id":"https://openalex.org/W2011723947","doi":"https://doi.org/10.1371/journal.pgen.1000865","title":"Role of RecA and the SOS Response in Thymineless Death in Escherichia coli","display_name":"Role of RecA and the SOS Response in Thymineless Death in Escherichia coli","publication_year":2010,"publication_date":"2010-03-04","ids":{"openalex":"https://openalex.org/W2011723947","doi":"https://doi.org/10.1371/journal.pgen.1000865","mag":"2011723947","pmid":"https://pubmed.ncbi.nlm.nih.gov/20221259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2832678"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1000865","doi":"https://doi.org/10.1371/journal.pgen.1000865","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1000865","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000865&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000865&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084108439","display_name":"Natalie C. Fonville","orcid":"https://orcid.org/0000-0002-0172-0961","observed_orcids":["https://orcid.org/0000-0002-0172-0961"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie C. Fonville","raw_affiliation_strings":["Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA","Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America","Interdepartmental Graduate Program in Cellular and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Interdepartmental Graduate Program in Cellular and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000421887","display_name":"David B. Bates","orcid":"https://orcid.org/0000-0002-0870-055X","observed_orcids":["https://orcid.org/0000-0002-0870-055X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Bates","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America","Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America","Interdepartmental Graduate Program in Cellular and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Interdepartmental Graduate Program in Cellular and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068732023","display_name":"P. J. Hastings","orcid":"https://orcid.org/0000-0002-6196-3893","observed_orcids":["https://orcid.org/0000-0002-6196-3893"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. J. Hastings","raw_affiliation_strings":["Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003203263","display_name":"Philip C. Hanawalt","orcid":"https://orcid.org/0000-0003-2331-0768","observed_orcids":["https://orcid.org/0000-0003-2331-0768"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip C. Hanawalt","raw_affiliation_strings":["Department of Biological Sciences, Stanford University, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026001356","display_name":"Susan M. Rosenberg","orcid":"https://orcid.org/0000-0003-1444-473X","observed_orcids":["https://orcid.org/0000-0003-1444-473X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4390039366","display_name":"Dan L Duncan Comprehensive Cancer Center","ror":"https://ror.org/02nre0x31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4390039366"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan M. Rosenberg","raw_affiliation_strings":["Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America","Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America","Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America","Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America","Interdepartmental Graduate Program in Cellular and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Interdepartmental Graduate Program in Cellular and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026001356"],"corresponding_institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":2.1848,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.87292922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"6","issue":"3","first_page":"e1000865","last_page":"e1000865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.25119999051094055,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymineless-death","display_name":"thymineless death","score":1.0},{"id":"https://openalex.org/keywords/reca","display_name":"RecA","score":0.9070000052452087},{"id":"https://openalex.org/keywords/sos-response","display_name":"SOS response","score":0.9660000205039978},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9240000247955322},{"id":"https://openalex.org/keywords/sula","display_name":"Sula","score":0.847000002861023},{"id":"https://openalex.org/keywords/cell-division-inhibition","display_name":"cell division inhibition","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cell-cycle-checkpoints","display_name":"cell cycle checkpoints","score":0.7710000276565552},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8960000276565552},{"id":"https://openalex.org/keywords/replication-fork-stalling","display_name":"replication fork stalling","score":0.6800000071525574},{"id":"https://openalex.org/keywords/single-stranded-dna","display_name":"single-stranded DNA","score":0.7540000081062317},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7911023497581482},{"id":"https://openalex.org/C2780852648","wikidata":"https://www.wikidata.org/wiki/Q143584","display_name":"SOS response","level":4,"score":0.7273574471473694},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6515613794326782},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6504349708557129},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5291279554367065},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.523283064365387},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4863915741443634},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.46457964181900024},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.46413180232048035},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4277753233909607},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37012290954589844},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35771477222442627},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22098946571350098},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11747339367866516}],"mesh":[{"descriptor_ui":"D002876","descriptor_name":"Chromosomes, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011938","descriptor_name":"Rec A Recombinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013014","descriptor_name":"SOS Response, Genetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020090","descriptor_name":"Chromosome Segregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045566","descriptor_name":"DNA, Cruciform","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050296","descriptor_name":"Microbial Viability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pgen.1000865","doi":"https://doi.org/10.1371/journal.pgen.1000865","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1000865","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000865&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2832678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2832678","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:20221259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20221259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.355.9995","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.9995","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/37/cd/PLoS_Genet_2010_Mar_5_6(3)_e1000865.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:2887138b44fb481892b7720cf225765e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2887138b44fb481892b7720cf225765e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 6, Iss 3, p e1000865 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/144350","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Role_of_RecA_and_the_SOS_Response_in_Thymineless_Death_in_Escherichia_coli_/144350","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1000865","doi":"https://doi.org/10.1371/journal.pgen.1000865","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1000865","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000865&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3362254120","display_name":"Mechanisms of Adaptive Amplification","funder_award_id":"R01GM064022","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5962130342","display_name":"DNA Repair and Replication Re-start in vivo","funder_award_id":"R01CA085777","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011723947.pdf","grobid_xml":"https://content.openalex.org/works/W2011723947.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1489688558","https://openalex.org/W1491876634","https://openalex.org/W1540831008","https://openalex.org/W1560500509","https://openalex.org/W1668171824","https://openalex.org/W1708342446","https://openalex.org/W1735673569","https://openalex.org/W1845219395","https://openalex.org/W1896075455","https://openalex.org/W1896670299","https://openalex.org/W1965789286","https://openalex.org/W1966965753","https://openalex.org/W1972932327","https://openalex.org/W1984328540","https://openalex.org/W1984580584","https://openalex.org/W1989798735","https://openalex.org/W1995239650","https://openalex.org/W1997437286","https://openalex.org/W1997572817","https://openalex.org/W2002544649","https://openalex.org/W2012152649","https://openalex.org/W2012690739","https://openalex.org/W2016506997","https://openalex.org/W2017550427","https://openalex.org/W2029997311","https://openalex.org/W2030444324","https://openalex.org/W2039751418","https://openalex.org/W2040092826","https://openalex.org/W2045515333","https://openalex.org/W2058236414","https://openalex.org/W2072343802","https://openalex.org/W2073511864","https://openalex.org/W2074775871","https://openalex.org/W2075109594","https://openalex.org/W2078883324","https://openalex.org/W2081122054","https://openalex.org/W2099958026","https://openalex.org/W2114965792","https://openalex.org/W2131232623","https://openalex.org/W2136381527","https://openalex.org/W2137358848","https://openalex.org/W2137360548","https://openalex.org/W2138826967","https://openalex.org/W2139412554","https://openalex.org/W2151546745","https://openalex.org/W7015003088"],"related_works":["https://openalex.org/W2037207750","https://openalex.org/W2105822168","https://openalex.org/W2075109594","https://openalex.org/W1495170549","https://openalex.org/W2522051926","https://openalex.org/W2012690739","https://openalex.org/W2290315298","https://openalex.org/W2757037223","https://openalex.org/W2023837893","https://openalex.org/W1984580584"],"abstract_inverted_index":{"Thymineless":[0],"death":[1],"(TLD)":[2],"is":[3],"a":[4,97,209],"classic":[5],"and":[6,13,37,74,90,121,178,191,213,217,229,234],"enigmatic":[7],"phenomenon,":[8],"documented":[9],"in":[10,59,171,237],"bacterial,":[11],"yeast,":[12],"human":[14],"cells,":[15],"whereby":[16],"cells":[17,172],"lose":[18],"viability":[19],"rapidly":[20],"when":[21],"deprived":[22],"of":[23,31,33,48,76,100,106,117,123,135,143,153,168,202,226],"thymine.":[24],"Despite":[25],"its":[26],"being":[27],"the":[28,45,70,77,91,107,118,124,169,183,186,192,195,224],"essential":[29],"mode":[30],"action":[32],"important":[34],"chemotherapeutic":[35],"agents,":[36],"despite":[38],"having":[39],"been":[40],"studied":[41],"extensively":[42],"for":[43,65,96,139],"decades,":[44],"basic":[46],"mechanisms":[47],"TLD":[49,113,154,174,233],"have":[50],"remained":[51],"elusive.":[52],"In":[53],"Escherichia":[54],"coli,":[55],"several":[56],"proteins":[57,109,127],"involved":[58],"homologous":[60],"recombination":[61],"(HR)":[62],"are":[63,94,219],"required":[64,95],"TLD,":[66],"however,":[67],"surprisingly,":[68],"RecA,":[69],"central":[71],"HR":[72,218,230],"protein":[73],"activator":[75],"SOS":[78,92,119,145],"DNA-damage":[79],"response":[80,93,120],"was":[81],"reported":[82],"not":[83],"to":[84,162,232],"be.":[85],"We":[86,102],"demonstrate":[87],"that":[88,104,151],"RecA":[89],"substantial":[98],"fraction":[99],"TLD.":[101,147],"show":[103],"some":[105],"Rec":[108],"implicated":[110],"previously":[111],"promote":[112],"via":[114],"facilitating":[115],"activation":[116],"that,":[122],"roughly":[125],"40":[126],"upregulated":[128],"by":[129],"SOS,":[130],"SulA,":[131],"an":[132,157],"SOS-inducible":[133],"inhibitor":[134],"cell":[136,164,211],"division,":[137],"accounts":[138],"most":[140],"or":[141],"all":[142],"how":[144],"causes":[146],"The":[148,221],"data":[149,222],"imply":[150],"much":[152],"results":[155],"from":[156],"irreversible":[158],"cell-cycle":[159],"checkpoint":[160],"due":[161],"blocked":[163,176,206],"division.":[165],"FISH":[166],"analyses":[167],"DNA":[170,180,204,215,227],"undergoing":[173],"reveal":[175],"replication":[177,187,207],"apparent":[179],"loss":[181],"with":[182],"region":[184,193],"near":[185,194],"origin":[188],"underrepresented":[189],"initially":[190],"terminus":[196],"lost":[197],"later.":[198],"Models":[199],"implicating":[200],"formation":[201],"single-strand":[203],"at":[205],"forks,":[208],"SulA-blocked":[210],"cycle,":[212],"RecQ/RecJ-catalyzed":[214],"degradation":[216],"discussed.":[220],"predict":[223],"importance":[225],"damage-response":[228],"networks":[231],"chemotherapy":[235],"resistance":[236],"humans.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
