{"id":"https://openalex.org/W2011716630","doi":"https://doi.org/10.3109/00365528209181056","title":"Effect of Cimetidine on the Absorption of Vitamin B12","display_name":"Effect of Cimetidine on the Absorption of Vitamin B12","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2011716630","doi":"https://doi.org/10.3109/00365528209181056","mag":"2011716630","pmid":"https://pubmed.ncbi.nlm.nih.gov/7134827"},"language":"en","primary_location":{"id":"doi:10.3109/00365528209181056","doi":"https://doi.org/10.3109/00365528209181056","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365528209181056","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110196466","display_name":"Ira L. Salom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. L. Salom","raw_affiliation_strings":["Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York; and the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA","Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York","the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York; and the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408","https://openalex.org/I63190737"]},{"raw_affiliation_string":"Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111676722","display_name":"S.E. Silvis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. E. Silvis","raw_affiliation_strings":["Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York; and the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA","Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York","the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York; and the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408","https://openalex.org/I63190737"]},{"raw_affiliation_string":"Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009968477","display_name":"Alfred Doscherholmen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Doscherholmen","raw_affiliation_strings":["Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York; and the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA","Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York","the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York; and the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408","https://openalex.org/I63190737"]},{"raw_affiliation_string":"Gastroenterology Section, State University of New York at Buffalo, Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"the Dept. of Medicine and Special Diagnostic and Treatment Unit. Veterans Administration Medical Center, and Dept. of Medicine. University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0108,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.93948483,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"1","first_page":"129","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cimetidine","display_name":"cimetidine","score":1.0},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.8809999823570251},{"id":"https://openalex.org/keywords/egg-yolk","display_name":"egg yolk","score":0.7739999890327454},{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":0.796999990940094},{"id":"https://openalex.org/keywords/hypochlorhydria","display_name":"hypochlorhydria","score":0.9079999923706055},{"id":"https://openalex.org/keywords/h2-receptor-antagonists","display_name":"H2 receptor antagonists","score":0.8949999809265137},{"id":"https://openalex.org/keywords/schilling-test","display_name":"Schilling test","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2780719153","wikidata":"https://www.wikidata.org/wiki/Q409492","display_name":"Cimetidine","level":2,"score":0.9834535121917725},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.8223254680633545},{"id":"https://openalex.org/C2780439177","wikidata":"https://www.wikidata.org/wiki/Q1442923","display_name":"Malabsorption","level":2,"score":0.7122001051902771},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.6428989171981812},{"id":"https://openalex.org/C2777569460","wikidata":"https://www.wikidata.org/wiki/Q410153","display_name":"Intrinsic factor","level":3,"score":0.6197382807731628},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49895620346069336},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49736717343330383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46244341135025024},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4120599031448364},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3605877757072449},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3331340551376343},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3033485412597656},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07525894045829773},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002927","descriptor_name":"Cimetidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002927","descriptor_name":"Cimetidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004530","descriptor_name":"Egg Yolk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014806","descriptor_name":"Vitamin B 12 Deficiency","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/00365528209181056","doi":"https://doi.org/10.3109/00365528209181056","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365528209181056","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:7134827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7134827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1564039364","https://openalex.org/W1658953272","https://openalex.org/W1965413028","https://openalex.org/W2001151298","https://openalex.org/W2014367193","https://openalex.org/W2019397877","https://openalex.org/W2020518181","https://openalex.org/W2028036430","https://openalex.org/W2030946615","https://openalex.org/W2033662357","https://openalex.org/W2054629139","https://openalex.org/W2065620284","https://openalex.org/W2077022152","https://openalex.org/W2087211521","https://openalex.org/W2095897100","https://openalex.org/W2191397678","https://openalex.org/W2410245936","https://openalex.org/W4256620390","https://openalex.org/W4300077112"],"related_works":["https://openalex.org/W2014367193","https://openalex.org/W2061953551","https://openalex.org/W1900351220","https://openalex.org/W1520754042","https://openalex.org/W2416548722","https://openalex.org/W1968275561","https://openalex.org/W2041742798","https://openalex.org/W2008203963","https://openalex.org/W2404596541","https://openalex.org/W2465025775"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,7,39,49,60,68],"cimetidine":[3,79],"on":[4],"the":[5,37,52,72,104],"absorption":[6,70],"orally":[8],"administered":[9],"crystalline":[10,25],"or":[11,24],"food":[12],"(egg":[13],"yolk-bound)":[14],"vitamin":[15],"B12":[16,26,41,69,82,97],"(B12)":[17],"was":[18,27],"studied":[19],"in":[20,43,88],"13":[21],"patients.":[22],"Absorption":[23],"normal":[28],"and":[29],"not":[30,100],"significantly":[31],"changed":[32],"by":[33,103],"cimetidine.":[34],"In":[35],"contrast,":[36],"uptake":[38],"food-bound":[40],"decreased":[42],"all":[44],"patients,":[45],"from":[46],"a":[47,58],"mean":[48],"5.3%":[50],"without":[51],"drug":[53],"to":[54,85],"2.5%":[55],"after":[56],"it,":[57],"fall":[59],"53%":[61],"(p":[62],"less":[63],"than":[64],"0.0001).":[65],"This":[66],"impairment":[67],"raises":[71],"possibility":[73],"that":[74,86,95],"long-term,":[75],"full-dose":[76],"therapy":[77],"with":[78],"may":[80],"produce":[81],"deficiency":[83],"similar":[84],"seen":[87],"other":[89],"hypochlorhydric":[90],"states.":[91],"Our":[92],"data":[93],"indicate":[94],"cimetidine-induced":[96],"malabsorption":[98],"would":[99],"be":[101],"detected":[102],"standard":[105],"Schilling":[106],"test.":[107]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}