{"id":"https://openalex.org/W2011711071","doi":"https://doi.org/10.1089/pho.2008.2398","title":"Phototherapy Improves Healing of Chronic Venous Ulcers","display_name":"Phototherapy Improves Healing of Chronic Venous Ulcers","publication_year":2009,"publication_date":"2009-02-01","ids":{"openalex":"https://openalex.org/W2011711071","doi":"https://doi.org/10.1089/pho.2008.2398","mag":"2011711071","pmid":"https://pubmed.ncbi.nlm.nih.gov/19196110"},"language":"en","primary_location":{"id":"doi:10.1089/pho.2008.2398","doi":"https://doi.org/10.1089/pho.2008.2398","is_oa":false,"landing_page_url":"https://doi.org/10.1089/pho.2008.2398","pdf_url":null,"source":{"id":"https://openalex.org/S188121330","display_name":"Photomedicine and Laser Surgery","issn_l":"1549-5418","issn":["1549-5418","1557-8550"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photomedicine and Laser Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035511861","display_name":"Kelly Steinkopf Caetano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Kelly Steinkopf Caetano","raw_affiliation_strings":["Department of Bioengineering, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001221222","display_name":"Marco Andrey Cipriani Frade","orcid":"https://orcid.org/0000-0003-2700-5971","observed_orcids":["https://orcid.org/0000-0003-2700-5971"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marco Andrey Cipriani Frade","raw_affiliation_strings":["Department of Dermatology, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002256632","display_name":"D\u00e9bora Garbin Minatel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62885914","display_name":"Universidade Federal do Amazonas","ror":"https://ror.org/02263ky35","country_code":"BR","type":"education","lineage":["https://openalex.org/I62885914"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"D\u00e9bora Garbin Minatel","raw_affiliation_strings":["Department of Biotechnology, Federal University of the Amazon, Manaus, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Federal University of the Amazon, Manaus, Brazil","institution_ids":["https://openalex.org/I62885914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015820389","display_name":"Lu\u00edsiane de \u00c1vila Santana","orcid":"https://orcid.org/0000-0003-1338-3920","observed_orcids":["https://orcid.org/0000-0003-1338-3920"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luisiane \u00c1vila Santana","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103506114","display_name":"Chukuka Samuel Enwemeka","orcid":"https://orcid.org/0000-0001-9405-9529","observed_orcids":["https://orcid.org/0000-0001-9405-9529"]},"institutions":[{"id":"https://openalex.org/I4210104314","display_name":"New York Institute of Technology","ror":"https://ror.org/01bghzb51","country_code":"US","type":"education","lineage":["https://openalex.org/I4210104314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chukuka S. Enwemeka","raw_affiliation_strings":["School of Health Professions, Behavioral and Life Sciences, New York Institute of Technology, Old Westbury, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health Professions, Behavioral and Life Sciences, New York Institute of Technology, Old Westbury, New York","institution_ids":["https://openalex.org/I4210104314"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2163,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.96776747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"27","issue":"1","first_page":"111","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.18850000202655792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.06809999793767929,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phototherapy","display_name":"phototherapy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/led-phototherapy","display_name":"LED phototherapy","score":0.7730000019073486},{"id":"https://openalex.org/keywords/venous-leg-ulcers","display_name":"venous leg ulcers","score":0.9210000038146973},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ulcer-size","display_name":"ulcer size","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9538042545318604},{"id":"https://openalex.org/C2776532303","wikidata":"https://www.wikidata.org/wiki/Q420984","display_name":"Silver sulfadiazine","level":3,"score":0.7903677821159363},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7669914364814758},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5240883231163025},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5059632658958435},{"id":"https://openalex.org/C3017583242","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Placebo group","level":4,"score":0.4454609751701355},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.34905654191970825},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000891","descriptor_name":"Anti-Infective Agents, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010789","descriptor_name":"Phototherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012837","descriptor_name":"Silver Sulfadiazine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014647","descriptor_name":"Varicose Ulcer","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014647","descriptor_name":"Varicose Ulcer","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014647","descriptor_name":"Varicose Ulcer","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1089/pho.2008.2398","doi":"https://doi.org/10.1089/pho.2008.2398","is_oa":false,"landing_page_url":"https://doi.org/10.1089/pho.2008.2398","pdf_url":null,"source":{"id":"https://openalex.org/S188121330","display_name":"Photomedicine and Laser Surgery","issn_l":"1549-5418","issn":["1549-5418","1557-8550"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photomedicine and Laser Surgery","raw_type":"journal-article"},{"id":"pmid:19196110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19196110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photomedicine and laser surgery","raw_type":"Journal Article"},{"id":"pmh:oai:www.producao.usp.br:BDPI/15374","doi":null,"is_oa":false,"landing_page_url":"http://producao.usp.br/handle/BDPI/15374","pdf_url":null,"source":{"id":"https://openalex.org/S4306401373","display_name":"Scientific Electronic Library Online (S\u00e3o Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2982035970","host_organization_name":"Costa Rican Department of Social Security","host_organization_lineage":["https://openalex.org/I2982035970"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W101324012","https://openalex.org/W1486527173","https://openalex.org/W1639343909","https://openalex.org/W1964563074","https://openalex.org/W1968578768","https://openalex.org/W1971204131","https://openalex.org/W1982990141","https://openalex.org/W1984224424","https://openalex.org/W1985443914","https://openalex.org/W1987687871","https://openalex.org/W1998753924","https://openalex.org/W1999943258","https://openalex.org/W2000869511","https://openalex.org/W2003950143","https://openalex.org/W2004129060","https://openalex.org/W2006525806","https://openalex.org/W2018045405","https://openalex.org/W2019303851","https://openalex.org/W2025790443","https://openalex.org/W2026152380","https://openalex.org/W2026404392","https://openalex.org/W2026907647","https://openalex.org/W2027569270","https://openalex.org/W2028690103","https://openalex.org/W2030294879","https://openalex.org/W2031968135","https://openalex.org/W2035138987","https://openalex.org/W2041633166","https://openalex.org/W2041757934","https://openalex.org/W2046975278","https://openalex.org/W2049555299","https://openalex.org/W2056231500","https://openalex.org/W2056388320","https://openalex.org/W2059121155","https://openalex.org/W2059590451","https://openalex.org/W2064802106","https://openalex.org/W2067050531","https://openalex.org/W2074316198","https://openalex.org/W2075128218","https://openalex.org/W2075640812","https://openalex.org/W2076091115","https://openalex.org/W2078908623","https://openalex.org/W2079581261","https://openalex.org/W2101000272","https://openalex.org/W2122592422","https://openalex.org/W2131979542","https://openalex.org/W2133220560","https://openalex.org/W2133958699","https://openalex.org/W2147788860","https://openalex.org/W2155101368","https://openalex.org/W2161353253","https://openalex.org/W2164755655","https://openalex.org/W2166585511","https://openalex.org/W2181012382","https://openalex.org/W2325183966","https://openalex.org/W2326452536","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2025790443","https://openalex.org/W7120573300","https://openalex.org/W1535264294","https://openalex.org/W2611240832","https://openalex.org/W1558682921","https://openalex.org/W2485960262","https://openalex.org/W1562493078","https://openalex.org/W2112240091","https://openalex.org/W4401917265","https://openalex.org/W1983547237"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1,56],"tested":[2],"the":[3,81,110,128,193,218,227],"hypothesis":[4],"that":[5,20,264],"LED":[6],"phototherapy":[7,96,104,118,163,213],"with":[8,71,86,94,135,143,162,236],"combined":[9],"660-nm":[10],"and":[11,37,92,133,146,182,188,199,230],"890-nm":[12],"light":[13],"will":[14],"promote":[15],"healing":[16,156,241,255],"of":[17,27,33,67,122,212,221,240,256],"venous":[18,44,258],"ulcers":[19,74,82,111,129,140,195,223,232,248,263],"failed":[21],"to":[22,24,42,49,63,268],"respond":[23,267],"other":[25],"forms":[26],"treatment.":[28,270],"BACKGROUND":[29],"DATA:":[30],"A":[31],"variety":[32],"dressings,":[34],"growth":[35],"factors,":[36],"adjunct":[38],"therapies":[39],"are":[40],"used":[41,57],"treat":[43],"ulcers,":[45,259],"but":[46,115,204],"none":[47],"seems":[48],"yield":[50],"satisfactory":[51],"results.":[52],"MATERIALS":[53],"AND":[54],"METHODS:":[55],"a":[58,65,100],"randomized":[59],"placebo-controlled":[60],"double-blind":[61],"study":[62],"compare":[64],"total":[66],"20":[68],"patients":[69],"divided":[70],"32":[72],"chronic":[73,257],"into":[75],"three":[76],"groups.":[77],"In":[78,107,124],"group":[79,108,125],"1":[80],"were":[83,112,130,141],"cleaned,":[84],"dressed":[85,134],"1%":[87],"silver":[88],"sulfadiazine":[89],"(SDZ)":[90],"cream,":[91],"treated":[93,113,161],"placebo":[95,245],"(<.03":[97],"J/cm(-3))":[98],"using":[99],"Dynatron":[101],"Solaris":[102],"705":[103],"research":[105],"device.":[106],"2":[109],"similarly":[114,189],"received":[116],"real":[117],"(3":[119],"J/cm(-2))":[120],"instead":[121],"placebo.":[123],"3":[126],"(controls),":[127],"simply":[131],"cleaned":[132],"SDZ":[136],"without":[137],"phototherapy.":[138],"The":[139,209],"evaluated":[142],"digital":[144],"photography":[145],"computer":[147],"image":[148],"analysis":[149],"over":[150],"90":[151,184,200],"d":[152],"or":[153,246],"until":[154],"full":[155],"was":[157,214,224],"attained.":[158],"RESULTS:":[159],"Ulcers":[160],"healed":[164,190,233],"significantly":[165,234],"faster":[166,191,235],"than":[167,192,244],"controls":[168],"when":[169,217],"compared":[170],"at":[171,196,206],"day":[172,177,183,207],"30":[173,198],"(p":[174,179,185,201,249],"+/-":[175,180,186,202,250],"0.01),":[176,203],"60":[178],"0.05),":[181],"0.001),":[187],"placebo-treated":[194],"days":[197],"not":[205,266],"60.":[208],"beneficial":[210],"effect":[211,220],"more":[215],"pronounced":[216],"confounding":[219],"small-sized":[222],"removed":[225],"from":[226],"analysis.":[228],"Medium-":[229],"large-sized":[231],"treatment":[237],"(>or=40%":[238],"rate":[239],"per":[242],"month)":[243],"control":[247],"0.05).":[251],"CONCLUSION:":[252],"Phototherapy":[253],"promotes":[254],"particularly":[260],"large":[261],"recalcitrant":[262],"do":[265],"conventional":[269]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}