{"id":"https://openalex.org/W2011696186","doi":"https://doi.org/10.1110/ps.052016406","title":"Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri Tip","display_name":"Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri Tip","publication_year":2006,"publication_date":"2006-09-28","ids":{"openalex":"https://openalex.org/W2011696186","doi":"https://doi.org/10.1110/ps.052016406","mag":"2011696186","pmid":"https://pubmed.ncbi.nlm.nih.gov/17008721","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2242400"},"language":"en","primary_location":{"id":"doi:10.1110/ps.052016406","doi":"https://doi.org/10.1110/ps.052016406","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.052016406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.052016406","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.052016406","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026266291","display_name":"David D. Weis","orcid":"https://orcid.org/0000-0003-3032-1211","observed_orcids":["https://orcid.org/0000-0003-3032-1211"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David D. Weis","raw_affiliation_strings":["Department of Chemistry, University, of New Mexico, Albuquerque, New Mexico 87131, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University, of New Mexico, Albuquerque, New Mexico 87131, USA","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029465126","display_name":"Peter Kjell\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kjellen","raw_affiliation_strings":["Molecular Cell and Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell and Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053274271","display_name":"Bartholomew M. Sefton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bartholomew M. Sefton","raw_affiliation_strings":["Molecular Cell and Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell and Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082763070","display_name":"John R. Engen","orcid":"https://orcid.org/0000-0002-6918-9476","observed_orcids":["https://orcid.org/0000-0002-6918-9476"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]},{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John R. Engen","raw_affiliation_strings":["Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131, USA","The Barnett Institute, 341 Mugar Life Sciences, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA; fax: (617) 373\u20102855"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131, USA","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"The Barnett Institute, 341 Mugar Life Sciences, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA; fax: (617) 373\u20102855","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082763070"],"corresponding_institution_ids":["https://openalex.org/I12912129","https://openalex.org/I169521973"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":1.2226,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.75190579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"15","issue":"10","first_page":"2402","last_page":"2410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7239999771118164},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.6000000238418579},{"id":"https://openalex.org/keywords/partial-unfolding","display_name":"partial unfolding","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hydrogen-exchange","display_name":"hydrogen exchange","score":0.6460000276565552},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.5960000157356262},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.4269999861717224},{"id":"https://openalex.org/keywords/deuterium-labeling","display_name":"deuterium labeling","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.8188232183456421},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.46114641427993774},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4323950409889221},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.41680753231048584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3808007836341858},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36130625009536743},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33964258432388306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3133453130722046},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.22216108441352844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13527756929397583},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06748142838478088}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006567","descriptor_name":"Herpesvirus 2, Saimiriine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019860","descriptor_name":"Lymphocyte Specific Protein Tyrosine Kinase p56(lck)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019860","descriptor_name":"Lymphocyte Specific Protein Tyrosine Kinase p56(lck)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D041961","descriptor_name":"Deuterium Exchange Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1110/ps.052016406","doi":"https://doi.org/10.1110/ps.052016406","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.052016406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.052016406","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2242400","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2242400","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmid:17008721","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17008721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1110/ps.052016406","doi":"https://doi.org/10.1110/ps.052016406","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.052016406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.052016406","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8872309832","display_name":"Structural Dynamics of Src-Family Kinase Activation","funder_award_id":"R01GM070590","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011696186.pdf","grobid_xml":"https://content.openalex.org/works/W2011696186.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W77973074","https://openalex.org/W1892578325","https://openalex.org/W1923801572","https://openalex.org/W1953752063","https://openalex.org/W1964396270","https://openalex.org/W1969249762","https://openalex.org/W1971855594","https://openalex.org/W1972636814","https://openalex.org/W1972862814","https://openalex.org/W1974811607","https://openalex.org/W1981772486","https://openalex.org/W1982063067","https://openalex.org/W1984428716","https://openalex.org/W1985861538","https://openalex.org/W1994167992","https://openalex.org/W1996117928","https://openalex.org/W1998266346","https://openalex.org/W2002473468","https://openalex.org/W2008818819","https://openalex.org/W2016207825","https://openalex.org/W2019842618","https://openalex.org/W2033300775","https://openalex.org/W2043348527","https://openalex.org/W2053465303","https://openalex.org/W2057934025","https://openalex.org/W2062972508","https://openalex.org/W2063555581","https://openalex.org/W2068043800","https://openalex.org/W2090167935","https://openalex.org/W2090538255","https://openalex.org/W2093878568","https://openalex.org/W2100903140","https://openalex.org/W2101257013","https://openalex.org/W2128635872","https://openalex.org/W2131918208","https://openalex.org/W2137526291","https://openalex.org/W2141196514","https://openalex.org/W2147024375","https://openalex.org/W2155549197","https://openalex.org/W2157005876","https://openalex.org/W2158175056","https://openalex.org/W2164215595","https://openalex.org/W2166032271","https://openalex.org/W2420643526","https://openalex.org/W2468123769","https://openalex.org/W2474650212","https://openalex.org/W4210984919","https://openalex.org/W4249388593"],"related_works":["https://openalex.org/W7099959158","https://openalex.org/W2057934025","https://openalex.org/W1971855594","https://openalex.org/W7134473101","https://openalex.org/W1972862814","https://openalex.org/W2121845085","https://openalex.org/W3173434004","https://openalex.org/W2090538255","https://openalex.org/W7037417672","https://openalex.org/W2068043800"],"abstract_inverted_index":{"The":[0,43,153],"Tip":[1,124],"protein":[2,53],"from":[3,11],"Herpesvirus":[4],"saimiri":[5],"interacts":[6],"with":[7,69,117],"the":[8,12,58,65,139,143,177,191],"SH3":[9,24,60,76,87,100,135,160,171,182,187],"domain":[10,61,66,140],"Src-family":[13,22],"kinase":[14,23],"Lck":[15,28,59,75,99,134,159,181],"via":[16],"a":[17,118,149],"proline-containing":[18],"sequence":[19,178],"termed":[20],"LBD1.":[21],"domains":[25,88,172,188],"related":[26,186],"to":[27,32,79,95,163,166,196],"have":[29],"been":[30],"shown":[31],"be":[33,80,164,197],"dynamic":[34,82],"in":[35,83,133,158],"solution":[36],"and":[37,72,141,183],"partially":[38,174],"unfold":[39],"under":[40],"physiological":[41],"conditions.":[42],"rate":[44,144],"of":[45,120,145,151,155],"such":[46],"partial":[47,109,146,156],"unfolding":[48,110,147,157],"is":[49,189],"reduced":[50,142],"by":[51,148],"viral":[52],"binding.":[54],"To":[55],"determine":[56],"if":[57],"displayed":[62],"similar":[63,165],"behavior,":[64],"was":[67,77,115,161],"investigated":[68],"hydrogen":[70],"exchange":[71],"mass":[73],"spectrometry.":[74],"found":[78,162],"highly":[81],"solution.":[84],"While":[85],"other":[86,170,184],"require":[89],"as":[90,92],"much":[91],"10,000":[93],"sec":[94],"become":[96],"totally":[97],"deuterated,":[98],"became":[101],"almost":[102],"completely":[103],"labeled":[104],"within":[105],"200":[106],"sec.":[107,123],"A":[108],"event":[111],"involving":[112],"8-10":[113],"residues":[114],"observed":[116],"half-life":[119],"approximately":[121],"10":[122],"LBD1":[125],"binding":[126],"did":[127],"not":[128,194],"cause":[129],"gross":[130],"structural":[131],"changes":[132],"but":[136],"globally":[137],"stabilized":[138],"factor":[150],"five.":[152],"region":[154],"that":[167,173],"identified":[168],"for":[169],"unfold.":[175],"Although":[176],"conservation":[179],"between":[180],"closely":[185],"high,":[190],"dynamics":[192],"do":[193],"appear":[195],"conserved.":[198]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}