{"id":"https://openalex.org/W2011663058","doi":"https://doi.org/10.1016/0305-0491(88)90021-1","title":"Degradation of extracellular thymidine by cultured hepatocytes from rainbow trout (Salmo gairdneri)","display_name":"Degradation of extracellular thymidine by cultured hepatocytes from rainbow trout (Salmo gairdneri)","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2011663058","doi":"https://doi.org/10.1016/0305-0491(88)90021-1","mag":"2011663058","pmid":"https://pubmed.ncbi.nlm.nih.gov/3233930"},"language":"en","primary_location":{"id":"doi:10.1016/0305-0491(88)90021-1","doi":"https://doi.org/10.1016/0305-0491(88)90021-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0305-0491(88)90021-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210171413","display_name":"Comparative Biochemistry and Physiology Part B Comparative Biochemistry","issn_l":"0305-0491","issn":["0305-0491"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative Biochemistry and Physiology Part B: Comparative Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036061525","display_name":"Trudy E. Kocal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"T.E. Kocal","raw_affiliation_strings":["Department of Pathology, University of Guelph, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Guelph, Ontario, Canada","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012559911","display_name":"T.L. Crane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"T.L. Crane","raw_affiliation_strings":["Department of Pathology, University of Guelph, Guelph, Ontario, Canada N1GZ 2W1 (Tel: 519-823-8800)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Guelph, Guelph, Ontario, Canada N1GZ 2W1 (Tel: 519-823-8800)","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111666950","display_name":"Bette Anne Quinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B.A. Quinn","raw_affiliation_strings":["Department of Pathology, University of Guelph, Guelph, Ontario, Canada N1GZ 2W1 (Tel: 519-823-8800)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Guelph, Guelph, Ontario, Canada N1GZ 2W1 (Tel: 519-823-8800)","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109193941","display_name":"H. W. Ferguson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"H.W. Ferguson","raw_affiliation_strings":["Department of Pathology, University of Guelph, Guelph, Ontario, Canada N1GZ 2W1 (Tel: 519-823-8800)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Guelph, Guelph, Ontario, Canada N1GZ 2W1 (Tel: 519-823-8800)","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105523435","display_name":"M. Anthony Hayes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"M.A. Hayes","raw_affiliation_strings":["Department of Pathology, University of Guelph, Guelph, Ontario, Canada N1GZ 2W1 (Tel: 519-823-8800)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Guelph, Guelph, Ontario, Canada N1GZ 2W1 (Tel: 519-823-8800)","institution_ids":["https://openalex.org/I79817857"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5105523435"],"corresponding_institution_ids":["https://openalex.org/I79817857"],"apc_list":null,"apc_paid":null,"fwci":0.223,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.40885499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"91","issue":"3","first_page":"557","last_page":"561"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.6352999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.6352999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.13699999451637268,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.09440000355243683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rainbow-trout","display_name":"rainbow trout","score":0.5429999828338623},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.6019999980926514},{"id":"https://openalex.org/keywords/thymidine-metabolism","display_name":"thymidine metabolism","score":0.5979999899864197},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.4950000047683716},{"id":"https://openalex.org/keywords/dna-repair-synthesis","display_name":"DNA repair synthesis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2994167347","wikidata":"https://www.wikidata.org/wiki/Q187986","display_name":"Rainbow trout","level":3,"score":0.8417590856552124},{"id":"https://openalex.org/C2779363728","wikidata":"https://www.wikidata.org/wiki/Q2258881","display_name":"Trout","level":3,"score":0.8386045098304749},{"id":"https://openalex.org/C2777940460","wikidata":"https://www.wikidata.org/wiki/Q310436","display_name":"Salmo","level":3,"score":0.8201943635940552},{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.6990921497344971},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.5925162434577942},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5864861011505127},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5386236906051636},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.5270866751670837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5128009915351868},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49232280254364014},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.45917466282844543},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43044519424438477},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.42877405881881714},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39963361620903015},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3331325650215149},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15364030003547668},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.14700087904930115},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.14117729663848877}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012487","descriptor_name":"Salmonidae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014337","descriptor_name":"Trout","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0305-0491(88)90021-1","doi":"https://doi.org/10.1016/0305-0491(88)90021-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0305-0491(88)90021-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210171413","display_name":"Comparative Biochemistry and Physiology Part B Comparative Biochemistry","issn_l":"0305-0491","issn":["0305-0491"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative Biochemistry and Physiology Part B: Comparative Biochemistry","raw_type":"journal-article"},{"id":"pmid:3233930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3233930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative biochemistry and physiology. B, Comparative biochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W185414759","https://openalex.org/W1587797128","https://openalex.org/W1779916050","https://openalex.org/W1808665011","https://openalex.org/W1836748004","https://openalex.org/W1876317263","https://openalex.org/W1892296408","https://openalex.org/W1968922526","https://openalex.org/W1974384202","https://openalex.org/W1974526001","https://openalex.org/W1978046552","https://openalex.org/W1986968769","https://openalex.org/W1993536852","https://openalex.org/W2049623337","https://openalex.org/W2052550891","https://openalex.org/W2061478756","https://openalex.org/W2067915504","https://openalex.org/W2127369296","https://openalex.org/W2138087109","https://openalex.org/W2145357420","https://openalex.org/W2154448040","https://openalex.org/W2161810778","https://openalex.org/W2285285564","https://openalex.org/W2410023486","https://openalex.org/W6682692543","https://openalex.org/W6683787425"],"related_works":["https://openalex.org/W1660588146","https://openalex.org/W2414954639","https://openalex.org/W2038015679","https://openalex.org/W185414759","https://openalex.org/W2415529245","https://openalex.org/W7043850263","https://openalex.org/W2314556455","https://openalex.org/W2090898338","https://openalex.org/W2061482770","https://openalex.org/W2283246374"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}