{"id":"https://openalex.org/W2011646445","doi":"https://doi.org/10.1016/j.crvi.2003.09.014","title":"High-throughput classification of images of cells transfected with cDNA clones","display_name":"High-throughput classification of images of cells transfected with cDNA clones","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W2011646445","doi":"https://doi.org/10.1016/j.crvi.2003.09.014","mag":"2011646445","pmid":"https://pubmed.ncbi.nlm.nih.gov/14744106"},"language":"en","primary_location":{"id":"doi:10.1016/j.crvi.2003.09.014","doi":"https://doi.org/10.1016/j.crvi.2003.09.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.crvi.2003.09.014","pdf_url":null,"source":{"id":"https://openalex.org/S119003425","display_name":"Comptes Rendus Biologies","issn_l":"1631-0691","issn":["1631-0691","1768-3238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ddh","doaj","dongbi-d","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4404678052","host_organization_name":"Acad\u00e9mie des sciences","host_organization_lineage":["https://openalex.org/P4404678052"],"host_organization_lineage_names":["Acad\u00e9mie des sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comptes Rendus. Biologies","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088470124","display_name":"Reiko Minamikawa\u2010Tachino","orcid":"https://orcid.org/0000-0001-8337-6115","observed_orcids":["https://orcid.org/0000-0001-8337-6115"]},"institutions":[{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Minamikawa-Tachino","raw_affiliation_strings":["The Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan. tachino@rinshoken.or.jp","The Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613,#N#Japan#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan. tachino@rinshoken.or.jp","institution_ids":["https://openalex.org/I4210098918"]},{"raw_affiliation_string":"The Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613,#N#Japan#N#","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055121199","display_name":"Noriko Kabuyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180203408","display_name":"Yokohama National University","ror":"https://ror.org/03zyp6p76","country_code":"JP","type":"education","lineage":["https://openalex.org/I180203408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko Kabuyama","raw_affiliation_strings":["Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan","institution_ids":["https://openalex.org/I180203408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074462117","display_name":"Toshiyuki Gotoh","orcid":"https://orcid.org/0000-0003-2209-854X","observed_orcids":["https://orcid.org/0000-0003-2209-854X"]},"institutions":[{"id":"https://openalex.org/I180203408","display_name":"Yokohama National University","ror":"https://ror.org/03zyp6p76","country_code":"JP","type":"education","lineage":["https://openalex.org/I180203408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Gotoh","raw_affiliation_strings":["Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan","institution_ids":["https://openalex.org/I180203408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007943920","display_name":"Seiichiro Kagei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180203408","display_name":"Yokohama National University","ror":"https://ror.org/03zyp6p76","country_code":"JP","type":"education","lineage":["https://openalex.org/I180203408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiichiro Kagei","raw_affiliation_strings":["Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan","institution_ids":["https://openalex.org/I180203408"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masatoshi Naruse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2252096349","display_name":"Fujitsu (Japan)","ror":"https://ror.org/038e2g226","country_code":"JP","type":"company","lineage":["https://openalex.org/I2252096349"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatoshi Naruse","raw_affiliation_strings":["Fujitsu Oita Software Laboratories Limited, Oita 870-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujitsu Oita Software Laboratories Limited, Oita 870-8551, Japan","institution_ids":["https://openalex.org/I2252096349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035430285","display_name":"Yasutomo Kisu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasutomo Kisu","raw_affiliation_strings":["Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085961370","display_name":"Takushi Togashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takushi Togashi","raw_affiliation_strings":["The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan ,","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056627631","display_name":"Sumio Sugano","orcid":"https://orcid.org/0000-0001-8058-2861","observed_orcids":["https://orcid.org/0000-0001-8058-2861"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sumio Sugano","raw_affiliation_strings":["The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan ,","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110418356","display_name":"Hitohide Usami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2252096349","display_name":"Fujitsu (Japan)","ror":"https://ror.org/038e2g226","country_code":"JP","type":"company","lineage":["https://openalex.org/I2252096349"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitohide Usami","raw_affiliation_strings":["Computational Science and Engineering Center, Fujitsu Limited, Chiba, 261\u20108588 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Science and Engineering Center, Fujitsu Limited, Chiba, 261\u20108588 Japan","institution_ids":["https://openalex.org/I2252096349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105524003","display_name":"Nobuo Nomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuo Nomura","raw_affiliation_strings":["Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan","institution_ids":["https://openalex.org/I73613424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.576,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.63636364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"326","issue":"10-11","first_page":"993","last_page":"1001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdna-clones","display_name":"cDNA clones","score":0.652999997138977},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cell-image-classification","display_name":"cell image classification","score":0.5899999737739563},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.652999997138977},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.503000020980835},{"id":"https://openalex.org/keywords/automated-image-analysis","display_name":"automated image analysis","score":0.5450000166893005},{"id":"https://openalex.org/keywords/gene-function-analysis","display_name":"gene function analysis","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.8231462240219116},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7392410039901733},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6211641430854797},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5696932077407837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5572404265403748},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4932085871696472},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4796638786792755},{"id":"https://openalex.org/C2911029443","wikidata":"https://www.wikidata.org/wiki/Q21296145","display_name":"Human proteins","level":3,"score":0.45633381605148315},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.4393717050552368},{"id":"https://openalex.org/C149034497","wikidata":"https://www.wikidata.org/wiki/Q1384835","display_name":"Expressed sequence tag","level":4,"score":0.4331935942173004},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.4267650544643402},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37167611718177795},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3698996901512146}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.crvi.2003.09.014","doi":"https://doi.org/10.1016/j.crvi.2003.09.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.crvi.2003.09.014","pdf_url":null,"source":{"id":"https://openalex.org/S119003425","display_name":"Comptes Rendus Biologies","issn_l":"1631-0691","issn":["1631-0691","1768-3238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ddh","doaj","dongbi-d","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4404678052","host_organization_name":"Acad\u00e9mie des sciences","host_organization_lineage":["https://openalex.org/P4404678052"],"host_organization_lineage_names":["Acad\u00e9mie des sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comptes Rendus. Biologies","raw_type":"journal-article"},{"id":"pmid:14744106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14744106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comptes rendus biologies","raw_type":"Journal Article"},{"id":"pmh:oai:centre-mersenne.org:CRBIOL_2003__326_10-11_993_0","doi":null,"is_oa":false,"landing_page_url":"https://comptes-rendus.academie-sciences.fr/biologies/articles/10.1016/j.crvi.2003.09.014/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196241","display_name":"Biology Reports","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1564660545","https://openalex.org/W1622620102","https://openalex.org/W1861706286","https://openalex.org/W1963771790","https://openalex.org/W1984643873","https://openalex.org/W2004841938","https://openalex.org/W2035333992","https://openalex.org/W2132549764","https://openalex.org/W2145752049","https://openalex.org/W2149198894","https://openalex.org/W2799061466","https://openalex.org/W4206738201","https://openalex.org/W4230946174"],"related_works":["https://openalex.org/W1553703108","https://openalex.org/W1981624003","https://openalex.org/W2538734069","https://openalex.org/W1487944143","https://openalex.org/W2159053176","https://openalex.org/W7100396839","https://openalex.org/W7096585134","https://openalex.org/W2026439693","https://openalex.org/W1969862475","https://openalex.org/W2003639420"],"abstract_inverted_index":{"The":[0,9],"sequence":[1],"of":[2,17,23,39,66,69,75,93],"the":[3,15,18,36,62,70,73,80],"human":[4,27],"genome":[5],"has":[6],"been":[7],"determined.":[8],"next":[10],"task":[11],"is":[12,30],"to":[13,55],"determine":[14],"function":[16],"genes.":[19,44],"Classifying":[20],"cellular":[21],"forms":[22,76,89],"proteins":[24,40,86],"encoded":[25],"by":[26,87],"cDNA":[28],"clones":[29],"a":[31,91],"primary":[32],"step":[33],"toward":[34],"understanding":[35],"biological":[37],"role":[38],"and":[41,72],"their":[42,88],"coding":[43],"We":[45],"report":[46],"here":[47],"our":[48],"ongoing":[49],"work":[50],"on":[51],"an":[52],"automatic":[53],"system":[54,60,83],"facilitate":[56],"this":[57],"classification.":[58],"Our":[59,82],"handles":[61],"transfection,":[63],"incubation,":[64],"acquisition":[65],"microscopic":[67],"images":[68],"cells,":[71],"classification":[74],"there":[77],"appearing":[78],"in":[79,95],"images.":[81],"correctly":[84],"classified":[85],"at":[90],"rate":[92],"90%":[94],"feasibility":[96],"studies.":[97]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}