{"id":"https://openalex.org/W2011636652","doi":"https://doi.org/10.3748/wjg.v19.i21.3189","title":"E2F transcription factors and digestive system malignancies: How much do we know?","display_name":"E2F transcription factors and digestive system malignancies: How much do we know?","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2011636652","doi":"https://doi.org/10.3748/wjg.v19.i21.3189","mag":"2011636652","pmid":"https://pubmed.ncbi.nlm.nih.gov/23745020","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3671070"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.v19.i21.3189","doi":"https://doi.org/10.3748/wjg.v19.i21.3189","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v19.i21.3189","pdf_url":"https://www.wjgnet.com/1007-9327/full/v19/i21/3189.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1007-9327/full/v19/i21/3189.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035946466","display_name":"Athanasios I. Xanthoulis","orcid":"https://orcid.org/0000-0001-9667-922X","observed_orcids":["https://orcid.org/0000-0001-9667-922X"]},"institutions":[{"id":"https://openalex.org/I2800375777","display_name":"Levanger Hospital","ror":"https://ror.org/029nzwk08","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800375777"]},{"id":"https://openalex.org/I4405269086","display_name":"Helse Nord-Tr\u00f8ndelag HF","ror":"https://ror.org/0319bc948","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4405269086"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Athanasios Xanthoulis","raw_affiliation_strings":["Department of Surgery, Section of Gastroenterological Surgery, Levanger Hospital, Nord-Tr\u00f8ndelag Hospital Trust, 7600 Levanger, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Section of Gastroenterological Surgery, Levanger Hospital, Nord-Tr\u00f8ndelag Hospital Trust, 7600 Levanger, Norway","institution_ids":["https://openalex.org/I2800375777","https://openalex.org/I4405269086"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035946466"],"corresponding_institution_ids":["https://openalex.org/I2800375777","https://openalex.org/I4405269086"],"apc_list":null,"apc_paid":null,"fwci":0.8829,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.68322981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"19","issue":"21","first_page":"3189","last_page":"3189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e2f-transcription-factors","display_name":"E2F transcription factors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/e2f2","display_name":"E2F2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/e2f4","display_name":"E2F4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/e2f8","display_name":"E2F8","score":1.0},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.8859999775886536},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/colorectal-adenocarcinoma","display_name":"colorectal adenocarcinoma","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6389999985694885},{"id":"https://openalex.org/keywords/tumor-promoters","display_name":"tumor promoters","score":0.7490000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6570342183113098},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6095044016838074},{"id":"https://openalex.org/C83258922","wikidata":"https://www.wikidata.org/wiki/Q24771933","display_name":"E2F","level":4,"score":0.5928247570991516},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5653772354125977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5262157917022705},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49864983558654785},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4808695912361145},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4553719758987427},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4450902044773102},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4286684989929199},{"id":"https://openalex.org/C183022183","wikidata":"https://www.wikidata.org/wiki/Q15333016","display_name":"E2F1","level":4,"score":0.419445663690567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36395853757858276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3345833122730255}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004067","descriptor_name":"Digestive System Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004067","descriptor_name":"Digestive System Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004067","descriptor_name":"Digestive System Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D004067","descriptor_name":"Digestive System Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004067","descriptor_name":"Digestive System Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050684","descriptor_name":"E2F Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050684","descriptor_name":"E2F Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3748/wjg.v19.i21.3189","doi":"https://doi.org/10.3748/wjg.v19.i21.3189","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v19.i21.3189","pdf_url":"https://www.wjgnet.com/1007-9327/full/v19/i21/3189.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2672366","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3671070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3671070","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3671070","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastroenterol","raw_type":"Text"},{"id":"pmid:23745020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23745020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastroenterology","raw_type":"Journal Article"},{"id":"doi:10.25405/ncl.34207749","doi":"https://doi.org/10.25405/ncl.34207749","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34207749","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34207749.v1","doi":"https://doi.org/10.25405/ncl.34207749.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34207749.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"mag:3140128076","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/84123X/201321/1005603516.html","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e16\u754c\u80c3\u80a0\u75c5\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248\uff08\u7535\u5b50\u7248\uff09","raw_type":null}],"best_oa_location":{"id":"doi:10.3748/wjg.v19.i21.3189","doi":"https://doi.org/10.3748/wjg.v19.i21.3189","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v19.i21.3189","pdf_url":"https://www.wjgnet.com/1007-9327/full/v19/i21/3189.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323149","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011636652.pdf","grobid_xml":"https://content.openalex.org/works/W2011636652.grobid-xml"},"referenced_works_count":135,"referenced_works":["https://openalex.org/W39686604","https://openalex.org/W92652176","https://openalex.org/W94167612","https://openalex.org/W133487162","https://openalex.org/W972698465","https://openalex.org/W1497286120","https://openalex.org/W1521333964","https://openalex.org/W1550253130","https://openalex.org/W1563049522","https://openalex.org/W1604429067","https://openalex.org/W1606907359","https://openalex.org/W1665024321","https://openalex.org/W1713437946","https://openalex.org/W1834185815","https://openalex.org/W1839839171","https://openalex.org/W1873059808","https://openalex.org/W1885235228","https://openalex.org/W1896073557","https://openalex.org/W1919210158","https://openalex.org/W1957295278","https://openalex.org/W1967724582","https://openalex.org/W1969083778","https://openalex.org/W1972295452","https://openalex.org/W1972713988","https://openalex.org/W1974226434","https://openalex.org/W1979374055","https://openalex.org/W1980807416","https://openalex.org/W1981981304","https://openalex.org/W1983287898","https://openalex.org/W1983294080","https://openalex.org/W1983831266","https://openalex.org/W1984252723","https://openalex.org/W1985626007","https://openalex.org/W1993651018","https://openalex.org/W1995979905","https://openalex.org/W1998052021","https://openalex.org/W1998492363","https://openalex.org/W1999470160","https://openalex.org/W2003354259","https://openalex.org/W2003414599","https://openalex.org/W2003543763","https://openalex.org/W2006195578","https://openalex.org/W2007618242","https://openalex.org/W2007644982","https://openalex.org/W2008942114","https://openalex.org/W2010112859","https://openalex.org/W2011370737","https://openalex.org/W2019160859","https://openalex.org/W2020288787","https://openalex.org/W2021744259","https://openalex.org/W2023356125","https://openalex.org/W2029120481","https://openalex.org/W2031897237","https://openalex.org/W2034277114","https://openalex.org/W2035762638","https://openalex.org/W2037870474","https://openalex.org/W2038768356","https://openalex.org/W2046085471","https://openalex.org/W2046150468","https://openalex.org/W2050951620","https://openalex.org/W2051886117","https://openalex.org/W2052181152","https://openalex.org/W2053422998","https://openalex.org/W2053425283","https://openalex.org/W2055162988","https://openalex.org/W2055270107","https://openalex.org/W2059884945","https://openalex.org/W2061349698","https://openalex.org/W2061941936","https://openalex.org/W2063418926","https://openalex.org/W2064113174","https://openalex.org/W2070512450","https://openalex.org/W2078239183","https://openalex.org/W2080758883","https://openalex.org/W2082611751","https://openalex.org/W2084953766","https://openalex.org/W2085312521","https://openalex.org/W2086137470","https://openalex.org/W2086642593","https://openalex.org/W2088142356","https://openalex.org/W2088789697","https://openalex.org/W2090258042","https://openalex.org/W2093634273","https://openalex.org/W2098203177","https://openalex.org/W2103446533","https://openalex.org/W2107097909","https://openalex.org/W2108874380","https://openalex.org/W2110266019","https://openalex.org/W2110453029","https://openalex.org/W2110846453","https://openalex.org/W2116464970","https://openalex.org/W2116738722","https://openalex.org/W2116933755","https://openalex.org/W2118498323","https://openalex.org/W2118740126","https://openalex.org/W2119958264","https://openalex.org/W2122462438","https://openalex.org/W2122511750","https://openalex.org/W2129113161","https://openalex.org/W2131368686","https://openalex.org/W2132244795","https://openalex.org/W2133609791","https://openalex.org/W2134597949","https://openalex.org/W2137433289","https://openalex.org/W2140522709","https://openalex.org/W2141449051","https://openalex.org/W2141463740","https://openalex.org/W2145363003","https://openalex.org/W2148719100","https://openalex.org/W2148902511","https://openalex.org/W2150539701","https://openalex.org/W2158091235","https://openalex.org/W2160541843","https://openalex.org/W2162465088","https://openalex.org/W2163359063","https://openalex.org/W2164848514","https://openalex.org/W2168459422","https://openalex.org/W2169073626","https://openalex.org/W2170659948","https://openalex.org/W2170851763","https://openalex.org/W2187211519","https://openalex.org/W2322812254","https://openalex.org/W2323769589","https://openalex.org/W2324510594","https://openalex.org/W2324515322","https://openalex.org/W2327945916","https://openalex.org/W2334898564","https://openalex.org/W2398186073","https://openalex.org/W2398689688","https://openalex.org/W2413721750","https://openalex.org/W2415876980","https://openalex.org/W4210738594","https://openalex.org/W4235166365","https://openalex.org/W6684835484","https://openalex.org/W6686491395"],"related_works":["https://openalex.org/W3046818554","https://openalex.org/W3173068861","https://openalex.org/W3197733324","https://openalex.org/W4214859514","https://openalex.org/W3207829124","https://openalex.org/W2903224192","https://openalex.org/W1999188831","https://openalex.org/W6995918368","https://openalex.org/W1983294080","https://openalex.org/W3196505084"],"abstract_inverted_index":{"E2F":[0,181,226],"family":[1],"of":[2,51,137,180,224,230],"transcription":[3],"factors":[4],"regulates":[5],"various":[6],"cellular":[7,234],"functions":[8,235],"related":[9],"to":[10,42,176,185,204],"cell":[11,102],"cycle":[12],"and":[13,24,40,57,64,72,86,89,99,123,131,161],"apoptosis.":[14],"Its":[15],"individual":[16],"members":[17],"have":[18],"traditionally":[19],"been":[20,117,144,194],"classified":[21],"into":[22,219],"activators":[23],"repressors,":[25],"based":[26],"on":[27,48],"in":[28,34,53,83,90,95,128,146,158,170,196,233,236,243],"vitro":[29],"studies.":[30,198],"However":[31],"their":[32,241],"contribution":[33,232],"human":[35,171],"cancer":[36,188],"is":[37,134,152,164,167],"more":[38],"complicated":[39],"difficult":[41],"predict.":[43],"We":[44],"review":[45],"current":[46],"knowledge":[47],"the":[49,67,73,110,221],"expression":[50,115],"E2Fs":[52],"digestive":[54],"system":[55],"malignancies":[56],"its":[58,150],"clinical":[59],"implications":[60],"for":[61,190],"patient":[62,125,139],"prognosis":[63],"treatment.":[65],"E2F1,":[66],"most":[68],"extensively":[69],"studied":[70,145],"member":[71],"only":[74,143],"one":[75],"with":[76,119],"prognostic":[77],"value,":[78],"exhibits":[79],"a":[80,107,135],"tumor-suppressing":[81],"activity":[82],"esophageal,":[84,129],"gastric":[85,130,160],"colorectal":[87,132,147],"adenocarcinoma,":[88],"hepatocellular":[91],"carcinoma":[92,103],"(HCC),":[93],"whereas":[94,127],"pancreatic":[96,187],"ductal":[97],"adenocarcinoma":[98],"esophageal":[100],"squamous":[101],"may":[104],"function":[105,223],"as":[106,182],"tumor-promoter.":[108],"In":[109],"latter":[111],"malignancies,":[112],"E2F1":[113],"immunohistochemical":[114],"has":[116,142,193],"correlated":[118],"higher":[120],"tumor":[121],"grade":[122],"worse":[124],"survival,":[126],"adenocarcinomas":[133],"marker":[136],"increased":[138],"survival.":[140],"E2F2":[141],"cancer,":[148],"where":[149],"role":[151,157,242],"not":[153],"considered":[154],"significant.":[155],"E2F4's":[156],"colorectal,":[159],"hepatic":[162],"carcinogenesis":[163],"tumor-promoting.":[165],"E2F8":[166],"strongly":[168],"upregulated":[169],"HCC,":[172],"thus":[173],"possibly":[174],"contributing":[175],"hepatocarcinogenesis.":[177],"Adenoviral":[178],"transfer":[179],"gene":[183],"therapy":[184],"sensitize":[186],"cells":[189],"chemotherapeutic":[191],"agents":[192],"used":[195],"experimental":[197],"Other":[199],"therapeutic":[200],"strategies":[201],"are":[202],"yet":[203],"be":[205],"developed,":[206],"but":[207],"it":[208],"appears":[209],"that":[210],"targeted":[211],"approaches":[212],"using":[213],"E2F-agonists":[214],"or":[215],"antagonists":[216],"should":[217],"take":[218],"account":[220],"tissue-dependent":[222],"each":[225],"member.":[227],"Further":[228],"understanding":[229],"E2Fs'":[231],"vivo":[237],"would":[238],"help":[239],"clarify":[240],"carcinogenesis.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
