{"id":"https://openalex.org/W201163518","doi":null,"title":"[Regulation of melanogenesis: the role of cAMP and MITF].","display_name":"[Regulation of melanogenesis: the role of cAMP and MITF].","publication_year":2012,"publication_date":"2012-01-30","ids":{"openalex":"https://openalex.org/W201163518","mag":"201163518","pmid":"https://pubmed.ncbi.nlm.nih.gov/22371403"},"language":"pl","primary_location":{"id":"pmid:22371403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22371403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postepy higieny i medycyny doswiadczalnej (Online)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013111720","display_name":"Micha\u0142 Otr\u0119ba","orcid":"https://orcid.org/0000-0002-7523-7737","observed_orcids":["https://orcid.org/0000-0002-7523-7737"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Micha\u0142 Otr\u0119ba","raw_affiliation_strings":["\u015al\u0105ski Uniwersytet Medyczny w Katowicach, Wydzia\u0142 Farmaceutyczny z Oddzia\u0142em Medycyny Laboratoryjnej, Katedra i Zak\u0142ad Chemii i Analizy Lek\u00f3w, ul. Jagiello\u0144ska 4, Sosnowiec"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u015al\u0105ski Uniwersytet Medyczny w Katowicach, Wydzia\u0142 Farmaceutyczny z Oddzia\u0142em Medycyny Laboratoryjnej, Katedra i Zak\u0142ad Chemii i Analizy Lek\u00f3w, ul. Jagiello\u0144ska 4, Sosnowiec","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068203931","display_name":"Jakub Rok","orcid":"https://orcid.org/0000-0002-8260-4339","observed_orcids":["https://orcid.org/0000-0002-8260-4339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jakub Rok","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031198019","display_name":"Ewa Buszman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewa Buszman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053419079","display_name":"Dorota Ma\u0142gorzata Wrze\u015bniok","orcid":"https://orcid.org/0000-0002-6918-3330","observed_orcids":["https://orcid.org/0000-0002-6918-3330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dorota Wrze\u015bniok","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0245,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.84782748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"66","issue":null,"first_page":"33","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/trp-1","display_name":"TRP-1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tyrosinase-related-protein-2","display_name":"tyrosinase-related protein 2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/melanosome-maturation","display_name":"melanosome maturation","score":0.5640000104904175},{"id":"https://openalex.org/keywords/melanocyte-proliferation","display_name":"melanocyte proliferation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6159999966621399},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.7149999737739563},{"id":"https://openalex.org/keywords/melanocortin-receptors","display_name":"melanocortin receptors","score":0.859000027179718},{"id":"https://openalex.org/keywords/gtp-cyclohydrolase-i","display_name":"GTP cyclohydrolase I","score":0.7870000004768372},{"id":"https://openalex.org/keywords/phenylalanine-hydroxylase","display_name":"phenylalanine hydroxylase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mccune-albright-syndrome","display_name":"McCune-Albright syndrome","score":0.8169999718666077},{"id":"https://openalex.org/keywords/carney-syndrome","display_name":"Carney syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/waardenburg-syndrome-type-ii","display_name":"Waardenburg syndrome type II","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.9596841335296631},{"id":"https://openalex.org/C87554066","wikidata":"https://www.wikidata.org/wiki/Q85942926","display_name":"Tyrosinase","level":3,"score":0.7793759107589722},{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.5925107002258301},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5520093441009521},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4812697768211365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45438656210899353},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4159083664417267},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40214860439300537},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.37153780460357666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36755889654159546},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3327752351760864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31201183795928955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1213752031326294},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07352250814437866}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22371403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22371403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postepy higieny i medycyny doswiadczalnej (Online)","raw_type":"Journal Article"},{"id":"mag:201163518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22371403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010684135","https://openalex.org/W2002918515","https://openalex.org/W1860078110","https://openalex.org/W2162997202","https://openalex.org/W3030559811","https://openalex.org/W2016138208","https://openalex.org/W2064480241","https://openalex.org/W4240557590","https://openalex.org/W2077979194","https://openalex.org/W2128963294"],"abstract_inverted_index":{"The":[0,41,119],"article":[1],"presents":[2],"the":[3,7,44,78,87,91,109,113,150,165,228],"melanogenesis":[4,26,195],"pathway":[5],"and":[6,14,39,56,61,68,83,112,131,158,188,201,215,222,239],"role":[8],"of":[9,21,25,36,46,65,74,116,144,164,176,198,208,227],"cyclic":[10],"adenosine":[11,99],"monophosphate":[12],"(cAMP)":[13],"microphthalmia":[15],"transcription":[16,69,130,169,192],"factor":[17,193],"(MITF)":[18],"in":[19,32,72,90,182],"regulation":[20,73],"this":[22],"process.":[23],"Products":[24],"are":[27,81,179],"eu-":[28],"and/or":[29],"pheomelanins":[30],"synthesized":[31,97],"a":[33],"multistage":[34],"process":[35],"tyrosine":[37,51],"oxidation":[38],"polymerization.":[40],"conversions":[42],"require":[43],"presence":[45],"tyrosinase":[47,57],"(TYR,":[48],"key":[49],"enzyme),":[50],"hydroxylase":[52,133],"isoform":[53],"I":[54,128],"(THI)":[55],"related":[58],"proteins":[59,147],"(TRP1":[60],"TRP2).":[62],"Many":[63],"types":[64],"signal":[66,93,120,152],"molecules":[67],"factors":[70,170,210],"participate":[71],"melanin":[75],"synthesis,":[76],"but":[77,181],"most":[79,166],"important":[80,167],"cAMP":[82,85,122,151],"MITF.":[84],"is":[86,96,162],"second":[88],"messenger":[89],"intracellular":[92],"cascade,":[94],"which":[95],"from":[98],"triphosphate":[100],"(ATP)":[101],"by":[102,108,138,196],"adenylyl":[103],"cyclase,":[104],"activated":[105],"among":[106],"others":[107],"melanocortin":[110],"receptor":[111],"\u03b1S":[114],"subunit":[115],"G":[117],"protein.":[118],"molecule":[121],"regulates":[123,194,219],"MITF,":[124],"TYR,":[125],"THI,":[126],"GTP-cyclohydroxylase":[127],"(GTP-CHI)":[129],"phenylalanine":[132],"(PAH)":[134],"phosphorylation":[135],"at":[136],"Ser16":[137],"protein":[139],"kinase":[140],"A":[141],"(PKA).":[142],"Mutations":[143,226],"genes":[145],"encoding":[146],"belonging":[148],"to":[149,156,233],"cascade":[153],"may":[154,231],"lead":[155,232],"McCune-Albright":[157],"Carney":[159],"syndromes.":[160,241],"MITF":[161,178,191,229],"one":[163],"nuclear":[168],"regulating":[171,211],"melanogenesis.":[172],"Currently":[173],"10":[174],"isoforms":[175],"human":[177],"known,":[180],"melanocytes":[183],"only":[184],"MITF-M,":[185],"MITF-Mdel,":[186],"MITF-A":[187],"MITF-H":[189],"occur.":[190],"activation":[197],"tyrosinase,":[199],"TRP1":[200],"TRP2":[202],"transcription.":[203],"It":[204],"also":[205],"affects":[206],"expression":[207],"other":[209],"melanosome":[212],"maturation,":[213],"biogenesis":[214],"transport.":[216],"Moreover,":[217],"it":[218],"melanocyte":[220],"proliferation":[221],"protection":[223],"against":[224],"apoptosis.":[225],"gene":[230],"hereditary":[234],"diseases:":[235],"Waardenburg":[236],"type":[237],"II":[238],"Tietz":[240]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}