{"id":"https://openalex.org/W2011629034","doi":"https://doi.org/10.1590/s0047-20852009000100009","title":"Imunologia do transtorno bipolar","display_name":"Imunologia do transtorno bipolar","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2011629034","doi":"https://doi.org/10.1590/s0047-20852009000100009","mag":"2011629034"},"language":"pt","primary_location":{"id":"doi:10.1590/s0047-20852009000100009","doi":"https://doi.org/10.1590/s0047-20852009000100009","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0047-20852009000100009","pdf_url":"https://www.scielo.br/j/jbpsiq/a/WD8cD9VNFpWLv5dkJCGd86q/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S177969571","display_name":"Jornal Brasileiro de Psiquiatria","issn_l":"0047-2085","issn":["0047-2085","1982-0208"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312367","host_organization_name":"Federal University of Rio de Janeiro","host_organization_lineage":["https://openalex.org/P4310312367"],"host_organization_lineage_names":["Federal University of Rio de Janeiro"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jornal Brasileiro de Psiquiatria","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/jbpsiq/a/WD8cD9VNFpWLv5dkJCGd86q/?lang=pt&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036060079","display_name":"Izabela Guimar\u00e3es Barbosa","orcid":"https://orcid.org/0000-0002-4480-0195","observed_orcids":["https://orcid.org/0000-0002-4480-0195"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Izabela Guimar\u00e3es Barbosa","raw_affiliation_strings":["Universidade Federal de Minas Gerais","Universidade Federal de Minas Gerais#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Minas Gerais","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Universidade Federal de Minas Gerais#TAB#","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061267614","display_name":"Rodrigo Barreto Huguet","orcid":"https://orcid.org/0000-0002-6525-2327","observed_orcids":["https://orcid.org/0000-0002-6525-2327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodrigo Barreto Huguet","raw_affiliation_strings":["Instituto dos Servidores do Estado de Minas Gerais","Instituto dos Servidores do Estado de Minas Gerais, Belo Horizonte"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto dos Servidores do Estado de Minas Gerais","institution_ids":[]},{"raw_affiliation_string":"Instituto dos Servidores do Estado de Minas Gerais, Belo Horizonte","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008042437","display_name":"Fernando Silva Neves","orcid":"https://orcid.org/0000-0002-7474-9052","observed_orcids":["https://orcid.org/0000-0002-7474-9052"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando Silva Neves","raw_affiliation_strings":["Universidade Federal de Minas Gerais","Universidade Federal de Minas Gerais#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Minas Gerais","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Universidade Federal de Minas Gerais#TAB#","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055496175","display_name":"Mois\u00e9s Evandro Bauer","orcid":"https://orcid.org/0000-0003-2957-1352","observed_orcids":["https://orcid.org/0000-0003-2957-1352"]},"institutions":[{"id":"https://openalex.org/I45643870","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","ror":"https://ror.org/025vmq686","country_code":"BR","type":"education","lineage":["https://openalex.org/I45643870"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mois\u00e9s Evandro Bauer","raw_affiliation_strings":["Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","institution_ids":["https://openalex.org/I45643870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040845311","display_name":"Ant\u00f4nio L\u00facio Teixeira","orcid":"https://orcid.org/0000-0002-9621-5422","observed_orcids":["https://orcid.org/0000-0002-9621-5422"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ant\u00f4nio L\u00facio Teixeira","raw_affiliation_strings":["Universidade Federal de Minas Gerais","Universidade Federal de Minas Gerais#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Minas Gerais","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Universidade Federal de Minas Gerais#TAB#","institution_ids":["https://openalex.org/I110200422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4125,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.66757028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"58","issue":"1","first_page":"52","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":1.0},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9049999713897705},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9660000205039978},{"id":"https://openalex.org/keywords/interleukins","display_name":"interleukins","score":0.9089999794960022},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9549999833106995},{"id":"https://openalex.org/keywords/immune-response-genes","display_name":"immune response genes","score":0.8320000171661377},{"id":"https://openalex.org/keywords/leukocyte-populations","display_name":"leukocyte populations","score":0.6629999876022339},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7590000033378601},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mania","display_name":"mania","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.6245084404945374},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.46509113907814026},{"id":"https://openalex.org/C3020774429","wikidata":"https://www.wikidata.org/wiki/Q1201886","display_name":"Web of science","level":3,"score":0.4560615122318268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4413125216960907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35749369859695435},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3485645651817322},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.21348345279693604},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.1736747920513153}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1590/s0047-20852009000100009","doi":"https://doi.org/10.1590/s0047-20852009000100009","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0047-20852009000100009","pdf_url":"https://www.scielo.br/j/jbpsiq/a/WD8cD9VNFpWLv5dkJCGd86q/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S177969571","display_name":"Jornal Brasileiro de Psiquiatria","issn_l":"0047-2085","issn":["0047-2085","1982-0208"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312367","host_organization_name":"Federal University of Rio de Janeiro","host_organization_lineage":["https://openalex.org/P4310312367"],"host_organization_lineage_names":["Federal University of Rio de Janeiro"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jornal Brasileiro de Psiquiatria","raw_type":"journal-article"},{"id":"pmh:oai:scielo:S0047-20852009000100009","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852009000100009","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jornal Brasileiro de Psiquiatria v.58 n.1 2009","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2394254","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852009000100009","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jornal Brasileiro de Psiquiatria v.58 n.1 2009","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:b98a4a40cd194cbfafd91fbbcf4592f0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b98a4a40cd194cbfafd91fbbcf4592f0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jornal Brasileiro de Psiquiatria, Vol 58, Iss 1, Pp 52-59 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/s0047-20852009000100009","doi":"https://doi.org/10.1590/s0047-20852009000100009","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0047-20852009000100009","pdf_url":"https://www.scielo.br/j/jbpsiq/a/WD8cD9VNFpWLv5dkJCGd86q/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S177969571","display_name":"Jornal Brasileiro de Psiquiatria","issn_l":"0047-2085","issn":["0047-2085","1982-0208"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312367","host_organization_name":"Federal University of Rio de Janeiro","host_organization_lineage":["https://openalex.org/P4310312367"],"host_organization_lineage_names":["Federal University of Rio de Janeiro"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jornal Brasileiro de Psiquiatria","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011629034.pdf","grobid_xml":"https://content.openalex.org/works/W2011629034.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W94993519","https://openalex.org/W1506124301","https://openalex.org/W1958990516","https://openalex.org/W1964778832","https://openalex.org/W1971295949","https://openalex.org/W1977674187","https://openalex.org/W1978480599","https://openalex.org/W1979038244","https://openalex.org/W1989684475","https://openalex.org/W1990830377","https://openalex.org/W1992868687","https://openalex.org/W1993490510","https://openalex.org/W1998520631","https://openalex.org/W1999182152","https://openalex.org/W2000171400","https://openalex.org/W2006585084","https://openalex.org/W2010493158","https://openalex.org/W2034226072","https://openalex.org/W2039723887","https://openalex.org/W2045300503","https://openalex.org/W2048866565","https://openalex.org/W2049078005","https://openalex.org/W2053221584","https://openalex.org/W2059467700","https://openalex.org/W2067466132","https://openalex.org/W2073175406","https://openalex.org/W2083547165","https://openalex.org/W2083833696","https://openalex.org/W2087184916","https://openalex.org/W2087214416","https://openalex.org/W2089216562","https://openalex.org/W2089327465","https://openalex.org/W2089760657","https://openalex.org/W2090291829","https://openalex.org/W2105659365","https://openalex.org/W2110793335","https://openalex.org/W2110964571","https://openalex.org/W2116994483","https://openalex.org/W2119349901","https://openalex.org/W2128322831","https://openalex.org/W2131826740","https://openalex.org/W2131942594","https://openalex.org/W2144357933","https://openalex.org/W2150413247","https://openalex.org/W2151692644","https://openalex.org/W2159838806","https://openalex.org/W2163384841","https://openalex.org/W2169838584","https://openalex.org/W2411784323","https://openalex.org/W2522691423","https://openalex.org/W2907548682","https://openalex.org/W2907578283","https://openalex.org/W4253487572"],"related_works":["https://openalex.org/W210609365","https://openalex.org/W3007003792","https://openalex.org/W7047749434","https://openalex.org/W2413585289","https://openalex.org/W4406364351","https://openalex.org/W2238358981","https://openalex.org/W2620878481","https://openalex.org/W7042761373","https://openalex.org/W2028131345","https://openalex.org/W7030020161"],"abstract_inverted_index":{"OBJETIVO:":[0],"Pesquisas":[1],"recentes":[2],"t\u00eam":[3],"implicado":[4],"fatores":[5],"imunes":[6,84],"na":[7,122],"patog\u00eanese":[8],"de":[9,62,72,114,146,158,163],"diversos":[10],"transtornos":[11],"neuropsiqui\u00e1tricos.":[12],"O":[13,136],"objetivo":[14],"do":[15],"presente":[16],"trabalho":[17],"\u00e9":[18],"revisar":[19],"os":[20,70,131],"trabalhos":[21,80],"que":[22,36,81],"investigaram":[23,92],"a":[24,128,142],"associa\u00e7\u00e3o":[25],"entre":[26,69],"transtorno":[27,88,126,137],"bipolar":[28,127,138],"e":[29,48,67,74,111,161],"altera\u00e7\u00f5es":[30,83,129],"em":[31,54,85],"par\u00e2metros":[32,164],"imunes.":[33],"M\u00c9TODOS:":[34],"Artigos":[35],"inclu\u00edam":[37],"as":[38],"palavras-chave:":[39],"\"bipolar":[40],"disorder\",":[41],"\"mania\",":[42],"\"immunology\",":[43],"\"cytokines\",":[44],"\"chemokines\",":[45],"\"interleukins\",":[46],"\"interferon\"":[47],"\"tumor":[49],"necrosis":[50],"factor\"":[51],"foram":[52,65],"selecionados":[53],"uma":[55],"revis\u00e3o":[56],"sistem\u00e1tica":[57],"da":[58],"literatura.":[59],"As":[60],"bases":[61],"dados":[63,132],"avaliadas":[64],"MedLine":[66],"Scopus,":[68],"anos":[71],"1980":[73],"2008.":[75],"RESULTADOS:":[76],"Foram":[77],"identificados":[78],"28":[79],"estudaram":[82],"pacientes":[86,115],"com":[87,156],"bipolar.":[89],"Seis":[90],"artigos":[91],"genes":[93],"relacionados":[94],"\u00e0":[95,108,151,153],"resposta":[96,109],"imune;":[97],"cinco,":[98],"autoanticorpos;":[99],"quatro,":[100],"popula\u00e7\u00f5es":[101],"leucocit\u00e1rias;":[102],"13,":[103],"citocinas":[104,159],"e/ou":[105],"mol\u00e9culas":[106],"relacionadas":[107],"imune":[110,155],"seis,":[112],"leuc\u00f3citos":[113],"in":[116],"vitro.":[117],"CONCLUS\u00d5ES:":[118],"Embora":[119],"haja":[120],"evid\u00eancias":[121],"literatura":[123],"correlacionando":[124],"o":[125],"imunes,":[130],"n\u00e3o":[133],"s\u00e3o":[134],"conclusivos.":[135],"parece":[139],"estar":[140],"associado":[141],"n\u00edveis":[143],"mais":[144],"elevados":[145],"autoanticorpos":[147],"circulantes,":[148],"assim":[149],"como":[150],"tend\u00eancia":[152],"ativa\u00e7\u00e3o":[154],"produ\u00e7\u00e3o":[157],"pr\u00f3-inflamat\u00f3rias":[160],"redu\u00e7\u00e3o":[162],"anti-inflamat\u00f3rios.":[165]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2016-06-24T00:00:00"}