{"id":"https://openalex.org/W201160628","doi":null,"title":"Telomeres and Telomerase in Aging, Longevity, and Health","display_name":"Telomeres and Telomerase in Aging, Longevity, and Health","publication_year":2009,"publication_date":"2009-12-14","ids":{"openalex":"https://openalex.org/W201160628","mag":"201160628"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/37184","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/37184","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dspace.library.uu.nl:8080/handle/1874/37184","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032542388","display_name":"Georges E. Janssens","orcid":"https://orcid.org/0000-0003-2104-8145","observed_orcids":["https://orcid.org/0000-0003-2104-8145"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Georges E. Janssens","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2104-8145","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5032542388"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":1.0},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":1.0},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9399999976158142},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.9700000286102295},{"id":"https://openalex.org/keywords/end-replication-problem","display_name":"end-replication problem","score":0.8429999947547913},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tumor-biology","display_name":"tumor biology","score":0.7020000219345093},{"id":"https://openalex.org/keywords/exonuclease-activity","display_name":"exonuclease activity","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9197568893432617},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.9154443144798279},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.8988929986953735},{"id":"https://openalex.org/C2908780919","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Cellular Aging","level":4,"score":0.5667588710784912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44643861055374146},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3933763802051544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3525369465351105},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3507012724876404},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3311704397201538},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3272862434387207},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.10980173945426941},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06594571471214294}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/37184","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/37184","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},{"id":"mag:201160628","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/bitstream/1874/37184/1/G_Janssens_Telomeres_Telomerase_Aging_v2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/37184","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/37184","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1211988174","https://openalex.org/W1497143641","https://openalex.org/W1520725469","https://openalex.org/W1648785664","https://openalex.org/W1964235601","https://openalex.org/W1966347199","https://openalex.org/W1966432404","https://openalex.org/W1966908647","https://openalex.org/W1969645714","https://openalex.org/W1972192032","https://openalex.org/W1973063382","https://openalex.org/W1979369962","https://openalex.org/W1983298684","https://openalex.org/W1989289507","https://openalex.org/W1989635874","https://openalex.org/W1990198677","https://openalex.org/W1992324036","https://openalex.org/W1992842240","https://openalex.org/W2000492199","https://openalex.org/W2003409493","https://openalex.org/W2003446723","https://openalex.org/W2004740296","https://openalex.org/W2008320117","https://openalex.org/W2009273592","https://openalex.org/W2011882274","https://openalex.org/W2014231393","https://openalex.org/W2019958076","https://openalex.org/W2021264577","https://openalex.org/W2021489383","https://openalex.org/W2023270609","https://openalex.org/W2029456327","https://openalex.org/W2032694449","https://openalex.org/W2033053950","https://openalex.org/W2035375803","https://openalex.org/W2040466227","https://openalex.org/W2043204829","https://openalex.org/W2044444301","https://openalex.org/W2049566430","https://openalex.org/W2050159685","https://openalex.org/W2050166933","https://openalex.org/W2053556250","https://openalex.org/W2063914679","https://openalex.org/W2069073149","https://openalex.org/W2074781636","https://openalex.org/W2076473351","https://openalex.org/W2077302783","https://openalex.org/W2079784664","https://openalex.org/W2086095857","https://openalex.org/W2088926897","https://openalex.org/W2105637995","https://openalex.org/W2106206232","https://openalex.org/W2110009378","https://openalex.org/W2113168077","https://openalex.org/W2116490988","https://openalex.org/W2117912210","https://openalex.org/W2123504399","https://openalex.org/W2124967403","https://openalex.org/W2129198998","https://openalex.org/W2130609411","https://openalex.org/W2131797682","https://openalex.org/W2134390575","https://openalex.org/W2145859123","https://openalex.org/W2160812540","https://openalex.org/W2175325490","https://openalex.org/W2417511905","https://openalex.org/W7095856360"],"related_works":["https://openalex.org/W2217315069","https://openalex.org/W1827409831","https://openalex.org/W2010802168","https://openalex.org/W1996384141","https://openalex.org/W6996949628","https://openalex.org/W4251824337","https://openalex.org/W2161108082","https://openalex.org/W7096377680","https://openalex.org/W7162420371","https://openalex.org/W7127253373"],"abstract_inverted_index":{"Drs.":[0],"J.":[1],"Watson":[2],"and":[3,67,98,111,121,133],"A.":[4],"M.":[5],"Olovnikov":[6],"described":[7,132],"the":[8,17,23,41,53,57,63,78,93,96,106,123,125,128],"natural":[9],"phenomenon":[10],"of":[11,25,40,43,51,59,95,127],"an":[12,100],"\u201cend":[13],"replication":[14,65],"problem\u201d":[15],"in":[16,36,77,108,112,119,122,137],"1970s.":[18],"The":[19,49],"problem":[20,66],"arises":[21],"from":[22],"inability":[24],"a":[26,32,37,75,82],"polymerase":[27],"enzyme":[28,101],"to":[29,62,73,104],"fully":[30],"replicate":[31],"linearized":[33],"chromosome,":[34],"resulting":[35],"cumulative":[38],"erosion":[39],"ends":[42,58],"chromosomes":[44],"during":[45],"each":[46],"cell":[47],"division.":[48],"shortening":[50],"telomeres,":[52,107],"protective":[54],"caps":[55],"at":[56,115],"chromosomes,":[60],"due":[61],"end":[64],"exonuclease":[68],"activity":[69],"has":[70],"been":[71],"hypothesized":[72],"play":[74],"role":[76,94,126],"aging":[79,138],"process,":[80],"as":[81],"'senescence'":[83],"setpoint":[84],"is":[85],"progressively":[86],"impinged":[87],"upon.":[88],"This":[89],"thesis":[90],"will":[91,130,139],"review":[92],"telomeres":[97,129],"telomerase,":[99],"which":[102],"acts":[103],"elongate":[105],"cancer":[109],"biology":[110],"aging.":[113],"Looked":[114],"through":[116],"examples":[117],"both":[118],"nature":[120],"laboratory,":[124],"be":[131,140],"their":[134],"possible":[135],"roles":[136],"discerned.":[141]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}