{"id":"https://openalex.org/W2011593282","doi":"https://doi.org/10.1111/j.0954-6820.1983.tb03721.x","title":"Interferon Therapy in Recurrent Renal Carcinoma","display_name":"Interferon Therapy in Recurrent Renal Carcinoma","publication_year":1983,"publication_date":"1983-01-12","ids":{"openalex":"https://openalex.org/W2011593282","doi":"https://doi.org/10.1111/j.0954-6820.1983.tb03721.x","mag":"2011593282","pmid":"https://pubmed.ncbi.nlm.nih.gov/6189369"},"language":"en","primary_location":{"id":"doi:10.1111/j.0954-6820.1983.tb03721.x","doi":"https://doi.org/10.1111/j.0954-6820.1983.tb03721.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.0954-6820.1983.tb03721.x","pdf_url":null,"source":{"id":"https://openalex.org/S91099313","display_name":"Acta Medica Scandinavica","issn_l":"0001-6101","issn":["0001-6101"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Medica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078406849","display_name":"Kjartan G. Magn\u00fasson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Kjartan Magnusson","raw_affiliation_strings":["Departments of Oncology and Radiotherapy, Urology, and Radiology, Herlev University Hospital, Herlev, and the Department of Clinical Chemistry, Gentofte University Hospital, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncology and Radiotherapy, Urology, and Radiology, Herlev University Hospital, Herlev, and the Department of Clinical Chemistry, Gentofte University Hospital, Gentofte, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802582725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113815083","display_name":"Ivan Str\u00f8yer Christophersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ivan Str\u00f8yer Christophersen","raw_affiliation_strings":["Departments of Oncology and Radiotherapy, Urology, and Radiology, Herlev University Hospital, Herlev, and the Department of Clinical Chemistry, Gentofte University Hospital, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncology and Radiotherapy, Urology, and Radiology, Herlev University Hospital, Herlev, and the Department of Clinical Chemistry, Gentofte University Hospital, Gentofte, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802582725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087929944","display_name":"Robert Jordal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Robert Jordal","raw_affiliation_strings":["Departments of Oncology and Radiotherapy, Urology, and Radiology, Herlev University Hospital, Herlev, and the Department of Clinical Chemistry, Gentofte University Hospital, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncology and Radiotherapy, Urology, and Radiology, Herlev University Hospital, Herlev, and the Department of Clinical Chemistry, Gentofte University Hospital, Gentofte, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802582725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114032067","display_name":"Hans Henrik Holm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hans Henrik Holm","raw_affiliation_strings":["Departments of Oncology and Radiotherapy, Urology, and Radiology, Herlev University Hospital, Herlev, and the Department of Clinical Chemistry, Gentofte University Hospital, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncology and Radiotherapy, Urology, and Radiology, Herlev University Hospital, Herlev, and the Department of Clinical Chemistry, Gentofte University Hospital, Gentofte, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802582725"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109971135","display_name":"Thorkild Mygind","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Thorkild Mygind","raw_affiliation_strings":["Departments of Oncology and Radiotherapy, Urology, and Radiology, Herlev University Hospital, Herlev, and the Department of Clinical Chemistry, Gentofte University Hospital, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncology and Radiotherapy, Urology, and Radiology, Herlev University Hospital, Herlev, and the Department of Clinical Chemistry, Gentofte University Hospital, Gentofte, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802582725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078406849"],"corresponding_institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802582725"],"apc_list":null,"apc_paid":null,"fwci":1.6575,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83520201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"213","issue":"3","first_page":"221","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.75},{"id":"https://openalex.org/keywords/recurrent-renal-cell-carcinoma","display_name":"recurrent renal cell carcinoma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/leukocyte-interferon","display_name":"leukocyte interferon","score":0.8029999732971191},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.6480000019073486},{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.574999988079071},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.5}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9413998126983643},{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.8628154397010803},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.7036890387535095},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.6165433526039124},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5759439468383789},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5248910188674927},{"id":"https://openalex.org/C2993968704","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal carcinoma","level":3,"score":0.5195789337158203},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44659700989723206},{"id":"https://openalex.org/C2781228144","wikidata":"https://www.wikidata.org/wiki/Q6046441","display_name":"Interferon alfa","level":4,"score":0.4352940320968628},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41739022731781006},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.38815000653266907},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.37349483370780945},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35198861360549927},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.3337988257408142},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27490729093551636}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.0954-6820.1983.tb03721.x","doi":"https://doi.org/10.1111/j.0954-6820.1983.tb03721.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.0954-6820.1983.tb03721.x","pdf_url":null,"source":{"id":"https://openalex.org/S91099313","display_name":"Acta Medica Scandinavica","issn_l":"0001-6101","issn":["0001-6101"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Medica Scandinavica","raw_type":"journal-article"},{"id":"pmid:6189369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6189369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1550310038","https://openalex.org/W1996882245","https://openalex.org/W2008854654","https://openalex.org/W2015391851","https://openalex.org/W2019282640","https://openalex.org/W2026486028","https://openalex.org/W2032641453","https://openalex.org/W2051780676","https://openalex.org/W2053665669","https://openalex.org/W2089186622","https://openalex.org/W2107619962","https://openalex.org/W2115881864","https://openalex.org/W2130766162","https://openalex.org/W2144360148","https://openalex.org/W2396514826","https://openalex.org/W2408102278","https://openalex.org/W2411777204","https://openalex.org/W2412149830","https://openalex.org/W2418617209","https://openalex.org/W2915241199"],"related_works":["https://openalex.org/W7207951541","https://openalex.org/W2428596843","https://openalex.org/W1912348852","https://openalex.org/W2085719231","https://openalex.org/W2418203333","https://openalex.org/W2038260901","https://openalex.org/W2061199186","https://openalex.org/W1854251458","https://openalex.org/W7208644181","https://openalex.org/W1988415837"],"abstract_inverted_index":{"Seven":[0],"patients":[1,27,52],"with":[2,11,20],"recurrent":[3],"renal":[4],"carcinoma,":[5],"who":[6],"had":[7],"previously":[8],"been":[9],"treated":[10,19],"progesterone":[12],"and":[13],"vinblastine":[14],"for":[15],"progressive":[16],"disease,":[17],"were":[18,63],"human":[21],"leukocyte":[22],"interferon":[23],"(HuIFN":[24],"alpha).":[25],"Five":[26],"received":[28,53],"daily":[29],"escalating":[30],"i.m.":[31],"IFN":[32],"doses":[33],"from":[34],"4":[35,48],"X":[36,41,57],"10":[37],"up":[38],"to":[39],"16":[40],"10(6)":[42,58],"U":[43],"during":[44],"a":[45],"minimum":[46],"of":[47,72],"weeks,":[49],"while":[50],"two":[51],"intralesional":[54],"IFN,":[55],"20":[56],"U/dose.":[59],"No":[60,65],"serious":[61],"side-effects":[62],"observed.":[64],"tumor":[66],"response":[67],"was":[68],"found":[69],"in":[70],"any":[71],"these":[73],"patients.":[74]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}