{"id":"https://openalex.org/W2011586590","doi":"https://doi.org/10.1136/jnnp.56.6.679","title":"Skeletal muscle bioenergetics in the chronic fatigue syndrome.","display_name":"Skeletal muscle bioenergetics in the chronic fatigue syndrome.","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W2011586590","doi":"https://doi.org/10.1136/jnnp.56.6.679","mag":"2011586590","pmid":"https://pubmed.ncbi.nlm.nih.gov/8509783","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/489619"},"language":"en","primary_location":{"id":"doi:10.1136/jnnp.56.6.679","doi":"https://doi.org/10.1136/jnnp.56.6.679","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp.56.6.679","pdf_url":"https://jnnp.bmj.com/content/jnnp/56/6/679.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery & Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnnp.bmj.com/content/jnnp/56/6/679.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"P R Barnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P R Barnes","raw_affiliation_strings":["MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112796302","display_name":"D.J. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D J Taylor","raw_affiliation_strings":["MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082908640","display_name":"Graham John Kemp","orcid":"https://orcid.org/0000-0002-8324-9666","observed_orcids":["https://orcid.org/0000-0002-8324-9666"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G J Kemp","raw_affiliation_strings":["MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108105469","display_name":"G. K. Radda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G K Radda","raw_affiliation_strings":["MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK","institution_ids":["https://openalex.org/I2802742124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802742124"],"apc_list":null,"apc_paid":null,"fwci":3.8903,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.92986811,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"56","issue":"6","first_page":"679","last_page":"683"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-fatigue-syndrome","display_name":"chronic fatigue syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/skeletal-muscle-bioenergetics","display_name":"skeletal muscle bioenergetics","score":0.9890000224113464},{"id":"https://openalex.org/keywords/intracellular-ph-regulation","display_name":"intracellular pH regulation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.7429999709129333},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.949999988079071},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C2778626300","wikidata":"https://www.wikidata.org/wiki/Q1984607","display_name":"Phosphocreatine","level":3,"score":0.9562667012214661},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.8782132863998413},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7418663501739502},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7116385698318481},{"id":"https://openalex.org/C2779566273","wikidata":"https://www.wikidata.org/wiki/Q209733","display_name":"Chronic fatigue syndrome","level":2,"score":0.678830087184906},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.5981143712997437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5802266001701355},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5252853631973267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4718261659145355},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.4658803343772888},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.3981872797012329},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.39472582936286926},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.39293769001960754},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3894007205963135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33326712250709534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33028891682624817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2217261791229248},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06189283728599548}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015673","descriptor_name":"Fatigue Syndrome, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015673","descriptor_name":"Fatigue Syndrome, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1136/jnnp.56.6.679","doi":"https://doi.org/10.1136/jnnp.56.6.679","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp.56.6.679","pdf_url":"https://jnnp.bmj.com/content/jnnp/56/6/679.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery & Psychiatry","raw_type":"journal-article"},{"id":"pmid:8509783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8509783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology, neurosurgery, and psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:489619","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC489619/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurol Neurosurg Psychiatry","raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:jnnp:56/6/679","doi":null,"is_oa":false,"landing_page_url":"http://jnnp.bmj.com/cgi/content/short/56/6/679","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"mag:2189067509","doi":null,"is_oa":false,"landing_page_url":"http://jnnp.bmj.com/content/56/6/679.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1136/jnnp.56.6.679","doi":"https://doi.org/10.1136/jnnp.56.6.679","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp.56.6.679","pdf_url":"https://jnnp.bmj.com/content/jnnp/56/6/679.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery & Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011586590.pdf","grobid_xml":"https://content.openalex.org/works/W2011586590.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W198241781","https://openalex.org/W212358581","https://openalex.org/W1481283116","https://openalex.org/W1538919177","https://openalex.org/W1586233686","https://openalex.org/W1841699391","https://openalex.org/W1964035003","https://openalex.org/W1996691305","https://openalex.org/W1998891861","https://openalex.org/W2030175300","https://openalex.org/W2046563319","https://openalex.org/W2067964782","https://openalex.org/W2069166971","https://openalex.org/W2085453623","https://openalex.org/W2097521339","https://openalex.org/W2142168650","https://openalex.org/W2150889540","https://openalex.org/W2174552657","https://openalex.org/W2183387493","https://openalex.org/W2272690666","https://openalex.org/W2398178093","https://openalex.org/W2921858060"],"related_works":["https://openalex.org/W2009291774","https://openalex.org/W2086660587","https://openalex.org/W1491141584","https://openalex.org/W2011395190","https://openalex.org/W2085453623","https://openalex.org/W2040514402","https://openalex.org/W2284303138","https://openalex.org/W1999226341","https://openalex.org/W2067964782","https://openalex.org/W2766330091"],"abstract_inverted_index":{"Skeletal":[0],"muscle":[1],"bioenergetics":[2],"and":[3,33,76],"control":[4],"of":[5,37,48,68,127],"intracellular":[6],"pH":[7,53,75],"have":[8,25],"been":[9,26],"investigated":[10],"in":[11,57,66,116,124],"46":[12,70],"patients":[13,38,71,89],"with":[14,28,39],"chronic":[15],"fatigue":[16,115],"syndrome":[17,118],"by":[18],"phosphorus":[19],"magnetic":[20],"resonance":[21],"spectroscopy.":[22],"The":[23],"results":[24],"compared":[27],"those":[29],"from":[30,34],"healthy":[31],"controls":[32],"a":[35,63,125],"group":[36,59],"mitochondrial":[40,50],"cytopathies":[41],"affecting":[42],"skeletal":[43],"muscle.":[44],"No":[45],"consistent":[46],"abnormalities":[47,120],"glycolysis,":[49],"metabolism":[51],"or":[52],"regulation":[54],"were":[55],"identified":[56],"the":[58,69,72,83,107],"when":[60],"taken":[61],"as":[62],"whole,":[64],"although":[65,119],"12":[67],"relationship":[73],"between":[74],"phosphocreatine":[77,95],"utilisation":[78],"during":[79],"exercise":[80],"fell":[81],"outside":[82],"normal":[84],"range.":[85],"Of":[86],"these,":[87],"6":[88,98],"showed":[90,99],"increased":[91],"acidification":[92],"relative":[93],"to":[94],"depletion":[96],"while":[97],"reduced":[100],"acidification.":[101],"These":[102],"findings":[103],"do":[104],"not":[105],"support":[106],"hypothesis":[108],"that":[109],"any":[110],"specific":[111],"metabolic":[112],"abnormality":[113],"underlies":[114],"this":[117],"may":[121],"be":[122],"present":[123],"minority":[126],"patients.":[128]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}