{"id":"https://openalex.org/W2011567971","doi":"https://doi.org/10.1002/jcp.1041580218","title":"DNA strand breakage during physiological apoptosis of the embryonic chick lens: Free 3' OH end single strand breaks do not accumulate even in the presence of a cation\u2010independent deoxyribonuclease","display_name":"DNA strand breakage during physiological apoptosis of the embryonic chick lens: Free 3' OH end single strand breaks do not accumulate even in the presence of a cation\u2010independent deoxyribonuclease","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W2011567971","doi":"https://doi.org/10.1002/jcp.1041580218","mag":"2011567971","pmid":"https://pubmed.ncbi.nlm.nih.gov/8106572"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.1041580218","doi":"https://doi.org/10.1002/jcp.1041580218","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041580218","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110602699","display_name":"E. Chaudun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Chaudun","raw_affiliation_strings":["Unit\u00e9 de Recherches G\u00e9rontologiques 118 INSERM, UA 630 CRNS, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Recherches G\u00e9rontologiques 118 INSERM, UA 630 CRNS, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023089203","display_name":"Cristina Arruti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"C. Arruti","raw_affiliation_strings":["Laboratorio de Cultivo de Tejidos, Departamento de Histologia y Embryologia, Facultad de Medicina, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Cultivo de Tejidos, Departamento de Histologia y Embryologia, Facultad de Medicina, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036188179","display_name":"Yves Courtois","orcid":"https://orcid.org/0000-0002-6341-2120","observed_orcids":["https://orcid.org/0000-0002-6341-2120"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Y. Courtois","raw_affiliation_strings":["Unite\u0301 de Recherches Ge\u0301rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","Unit\u00e9 de Recherches G\u00e9rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Recherches Ge\u0301rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Unit\u00e9 de Recherches G\u00e9rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034248882","display_name":"Fatima Ferrag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Ferrag","raw_affiliation_strings":["Unite\u0301 de Recherches Ge\u0301rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","Unit\u00e9 de Recherches G\u00e9rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Recherches Ge\u0301rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Unit\u00e9 de Recherches G\u00e9rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110046801","display_name":"J.C. Jeanny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. C. Jeanny","raw_affiliation_strings":["Unite\u0301 de Recherches Ge\u0301rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","Unit\u00e9 de Recherches G\u00e9rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Recherches Ge\u0301rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Unit\u00e9 de Recherches G\u00e9rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022155428","display_name":"Bhartiben N. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. N. Patel","raw_affiliation_strings":["Department of Biochemistry and Physiology, University of Reading, Reading RG6 2AJ, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Physiology, University of Reading, Reading RG6 2AJ, England","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002182140","display_name":"CHRISTOPHER J. SKIDMORE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Skidmore","raw_affiliation_strings":["Department of Biochemistry and Physiology, University of Reading, Reading RG6 2AJ, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Physiology, University of Reading, Reading RG6 2AJ, England","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097989457","display_name":"A. Torriclia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Torriclia","raw_affiliation_strings":["Unite\u0301 de Recherches Ge\u0301rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Recherches Ge\u0301rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111748739","display_name":"Marie France Counis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"M. F. Counis","raw_affiliation_strings":["Unite\u0301 de Recherches Ge\u0301rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","Unit\u00e9 de Recherches G\u00e9rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Recherches Ge\u0301rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Unit\u00e9 de Recherches G\u00e9rontologiques 118 INSERM, UA 630 CRNS, Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111748739"],"corresponding_institution_ids":["https://openalex.org/I154526488"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":0.9555,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.7198954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"158","issue":"2","first_page":"354","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.24560000002384186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.9639999866485596},{"id":"https://openalex.org/keywords/single-strand-breaks","display_name":"single-strand breaks","score":0.7730000019073486},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.40799999237060547},{"id":"https://openalex.org/keywords/lens-fiber-cells","display_name":"lens fiber cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lens-epithelium","display_name":"lens epithelium","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nick-translation","display_name":"nick translation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/dnase-i","display_name":"DNase I","score":0.6520000100135803},{"id":"https://openalex.org/keywords/nuclease-p1","display_name":"nuclease P1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/adp-ribosyltransferase","display_name":"ADP-ribosyltransferase","score":0.906000018119812},{"id":"https://openalex.org/keywords/adp-ribosylation","display_name":"ADP-ribosylation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.7059999704360962},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2778659741","wikidata":"https://www.wikidata.org/wiki/Q420690","display_name":"Deoxyribonuclease","level":3,"score":0.7371844053268433},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6910520195960999},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5688750147819519},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5509077310562134},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5363990068435669},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.4936886727809906},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4871053695678711},{"id":"https://openalex.org/C3017648133","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Single strand","level":3,"score":0.47472083568573},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4620157480239868},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4499533772468567},{"id":"https://openalex.org/C2779015675","wikidata":"https://www.wikidata.org/wiki/Q92796261","display_name":"Breakage","level":2,"score":0.4441388249397278},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4416024684906006},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42458438873291016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3054738938808441},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07715648412704468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000246","descriptor_name":"Adenosine Diphosphate Ribose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003851","descriptor_name":"Deoxyribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015719","descriptor_name":"Single-Strand Specific DNA and RNA Endonucleases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jcp.1041580218","doi":"https://doi.org/10.1002/jcp.1041580218","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041580218","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:8106572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8106572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-00768345v1","doi":null,"is_oa":false,"landing_page_url":"https://inserm.hal.science/inserm-00768345","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cellular Physiology, 1994, 158 (2), pp.354-64. ⟨10.1002/jcp.1041580218⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W186308413","https://openalex.org/W1538805645","https://openalex.org/W1559184092","https://openalex.org/W1585111054","https://openalex.org/W1892554314","https://openalex.org/W1925019465","https://openalex.org/W1964045300","https://openalex.org/W1965201547","https://openalex.org/W1965538605","https://openalex.org/W1965956246","https://openalex.org/W1966038446","https://openalex.org/W1974292158","https://openalex.org/W1976312800","https://openalex.org/W1976338865","https://openalex.org/W1988232110","https://openalex.org/W1988886218","https://openalex.org/W1990710462","https://openalex.org/W1992760474","https://openalex.org/W2006604431","https://openalex.org/W2011476357","https://openalex.org/W2011634180","https://openalex.org/W2012994890","https://openalex.org/W2016788008","https://openalex.org/W2021048148","https://openalex.org/W2042423036","https://openalex.org/W2045958900","https://openalex.org/W2048582059","https://openalex.org/W2049226608","https://openalex.org/W2050089067","https://openalex.org/W2061947498","https://openalex.org/W2068202223","https://openalex.org/W2072090854","https://openalex.org/W2073757281","https://openalex.org/W2074586011","https://openalex.org/W2078067923","https://openalex.org/W2080617777","https://openalex.org/W2083489709","https://openalex.org/W2084570691","https://openalex.org/W2084609653","https://openalex.org/W2089480619","https://openalex.org/W2094092090","https://openalex.org/W2094141502","https://openalex.org/W2101115544","https://openalex.org/W2128442121","https://openalex.org/W2129625403","https://openalex.org/W2143484830","https://openalex.org/W2160929782","https://openalex.org/W7074184880"],"related_works":["https://openalex.org/W1992760474","https://openalex.org/W2101115544","https://openalex.org/W2054675593","https://openalex.org/W1964045300","https://openalex.org/W2080617777","https://openalex.org/W2048582059","https://openalex.org/W2045958900","https://openalex.org/W2051039145","https://openalex.org/W2416530244","https://openalex.org/W89503280"],"abstract_inverted_index":{"Epithelial":[0],"cells":[1,74,93,104,186],"from":[2,75],"the":[3,12,17,51,54,111,117,129,138,154,220,253],"lens":[4,91,161,185,295],"equator":[5],"differentiate":[6],"into":[7,25,259],"elongated":[8],"fiber":[9,71,92,122,195,222],"cells.":[10,123],"In":[11],"final":[13],"steps":[14],"of":[15,41,57,83,113,116,128,131,141,148,157,167,184,244,287],"differentiation,":[16],"chromatin":[18,23],"appears":[19],"quite":[20],"condensed":[21],"and":[22,43,53,67,72,176,205,268,290],"breakdown":[24],"nucleosomes":[26],"occurs.":[27],"DNA":[28,132,180],"breaks":[29,85,133,149,261],"due":[30],"to":[31,36,175],"an":[32,114],"endodeoxyribonuclease":[33],"activity":[34,140,280],"corresponding":[35],"at":[37,164],"least":[38],"two":[39],"polypeptides":[40],"30":[42],"40":[44],"kDa":[45],"have":[46,256],"been":[47,257],"identified.":[48],"To":[49],"identify":[50],"nature":[52],"developmental":[55],"appearance":[56],"initial":[58],"breaks,":[59],"nick":[60,118,276],"translation":[61,119],"reaction":[62,120],"was":[63],"followed":[64],"both":[65,203],"biochemically":[66],"in":[68,70,90,102,121,160,187,194,202,212,214,219,227,246,252,294],"situ":[69],"epithelial":[73],"chick":[76],"embryonic":[77,95,168],"lenses.":[78],"There":[79],"is":[80,144,150,177,285],"no":[81,270],"accumulation":[82],"single-strand":[84],"(SSB)":[86],"with":[87,107,134,199],"3'OH":[88,200],"ends":[89,201],"during":[94],"development.":[96],"Such":[97],"damage":[98],"can":[99],"be":[100,292],"increased":[101],"these":[103,233],"by":[105,153,179],"treatment":[106],"DNAase":[108],"I":[109],"indicating":[110],"absence":[112],"inhibitor":[115],"However,":[124],"there":[125],"are":[126,225],"indications":[127],"presence":[130,147],"blocked":[135],"termini":[136],"when":[137],"phosphatase":[139],"nuclease":[142,279],"P1":[143],"used.":[145],"The":[146,250,278],"also":[151],"indicated":[152],"large":[155],"amounts":[156],"(ADP-ribose)n":[158],"found":[159],"fibers":[162,254],"particularly":[163],"11":[165],"days":[166],"development":[169],"(E11)":[170],"as":[171,265,273],"ADP-ribosyl":[172],"transferase":[173],"binds":[174],"activated":[178],"strand":[181],"breaks.":[182],"Incubation":[183,207],"vitro,":[188],"which":[189,224],"causes":[190],"nucleosomal":[191,266],"fragmentation":[192],"only":[193],"cells,":[196],"produces":[197],"SSB":[198,217,234,245,251,283],"epithelia":[204,247],"fibers.":[206,249],"for":[208,275,282],"short":[209],"periods,":[210],"observed":[211],"experiments":[213],"situ,":[215],"induces":[216],"first":[218],"central":[221],"nuclei,":[223],"late":[226],"differentiation.":[228,297],"This":[229],"may":[230,255],"indicate":[231],"that":[232],"play":[235],"a":[236],"physiological":[237],"role.":[238],"Long":[239],"incubations":[240],"produce":[241],"larger":[242],"numbers":[243],"than":[248],"converted":[258],"double-strand":[260],"(D":[262],"SB),":[263],"seen":[264],"fragments,":[267],"therefore":[269],"longer":[271],"act":[272],"substrates":[274],"translation.":[277],"responsible":[281],"production":[284],"independent":[286],"divalent":[288],"cations":[289],"could":[291],"implicated":[293],"terminal":[296]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}