{"id":"https://openalex.org/W2011554131","doi":"https://doi.org/10.1159/000207767","title":"Benign Sickle Cell Anemia in Israeli-Arabs with High Red Cell 2,3 Diphosphoglycerate","display_name":"Benign Sickle Cell Anemia in Israeli-Arabs with High Red Cell 2,3 Diphosphoglycerate","publication_year":2009,"publication_date":"2009-03-03","ids":{"openalex":"https://openalex.org/W2011554131","doi":"https://doi.org/10.1159/000207767","mag":"2011554131","pmid":"https://pubmed.ncbi.nlm.nih.gov/417546"},"language":"en","primary_location":{"id":"doi:10.1159/000207767","doi":"https://doi.org/10.1159/000207767","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000207767","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102057265","display_name":"Eugene F. Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Eugene F. Roth","raw_affiliation_strings":["Division of Hematology, Albert Einstein College of Medicine, Bronx, N. Y. and the Department of Hematology, Hadassah University Hospital, Hebrew University- Hadassah Medical School, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Albert Einstein College of Medicine, Bronx, N. Y. and the Department of Hematology, Hadassah University Hospital, Hebrew University- Hadassah Medical School, Jerusalem","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113576353","display_name":"Eliezer A. Rachmilewitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Eliezer H. Rachmilewitz","raw_affiliation_strings":["Division of Hematology, Albert Einstein College of Medicine, Bronx, N. Y. and the Department of Hematology, Hadassah University Hospital, Hebrew University- Hadassah Medical School, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Albert Einstein College of Medicine, Bronx, N. Y. and the Department of Hematology, Hadassah University Hospital, Hebrew University- Hadassah Medical School, Jerusalem","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051746192","display_name":"Alicia Schifter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Alicia Schifter","raw_affiliation_strings":["Division of Hematology, Albert Einstein College of Medicine, Bronx, N. Y. and the Department of Hematology, Hadassah University Hospital, Hebrew University- Hadassah Medical School, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Albert Einstein College of Medicine, Bronx, N. Y. and the Department of Hematology, Hadassah University Hospital, Hebrew University- Hadassah Medical School, Jerusalem","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113607632","display_name":"Ronald L. Nagel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald L. Nagel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2303,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.52561876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":"4","first_page":"237","last_page":"245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hemoglobin-s","display_name":"hemoglobin S","score":0.8629999756813049},{"id":"https://openalex.org/keywords/2-3-bisphosphoglycerate","display_name":"2,3-diphosphoglycerate","score":0.9079999923706055},{"id":"https://openalex.org/keywords/arab-citizens-of-israel","display_name":"Arab citizens of Israel","score":0.703000009059906},{"id":"https://openalex.org/keywords/hemoglobin-beta-chain","display_name":"hemoglobin beta chain","score":0.5920000076293945},{"id":"https://openalex.org/keywords/hemoglobin-solubility","display_name":"hemoglobin solubility","score":0.8069999814033508},{"id":"https://openalex.org/keywords/fetal-hemoglobin","display_name":"fetal hemoglobin","score":0.609000027179718},{"id":"https://openalex.org/keywords/red-blood-cell-indices","display_name":"red blood cell indices","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2909111029","wikidata":"https://www.wikidata.org/wiki/Q5279760","display_name":"Diphosphoglycerate","level":3,"score":0.9721486568450928},{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.5671864151954651},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.5475406050682068},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5433462858200073},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.4842047691345215},{"id":"https://openalex.org/C2779668550","wikidata":"https://www.wikidata.org/wiki/Q1642147","display_name":"Hemoglobinopathy","level":3,"score":0.4695473313331604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4144817292690277},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.4141424894332886},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.3487370014190674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3235829770565033},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30670690536499023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2978343963623047},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2461172640323639}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D004163","descriptor_name":"Diphosphoglyceric Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006451","descriptor_name":"Hemoglobin, Sickle","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007557","descriptor_name":"Israel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012529","descriptor_name":"Saudi Arabia","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044383","descriptor_name":"Black People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000207767","doi":"https://doi.org/10.1159/000207767","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000207767","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},{"id":"pmid:417546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/417546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta haematologica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038869801","https://openalex.org/W1990307587","https://openalex.org/W2024486972","https://openalex.org/W2033139535","https://openalex.org/W1973453090","https://openalex.org/W1983573023","https://openalex.org/W2055432091","https://openalex.org/W2000934279","https://openalex.org/W2094784616","https://openalex.org/W1982418092"],"abstract_inverted_index":{"Arabs":[0],"living":[1],"near":[2],"the":[3,35,42],"Sea":[4],"of":[5,16,34,41,54],"Galilee":[6],"were":[7,87],"found":[8,46],"to":[9],"be":[10],"homozygous":[11],"for":[12],"hemoglobin":[13,36,43,49,69],"S.":[14],"Studies":[15],"solubility,":[17],"mechanical":[18],"precipitability,":[19],"electrophoretic":[20],"mobility":[21],"on":[22],"starch-gel":[23],"and":[24,31,104],"citrate":[25],"agar":[26],"media,":[27],"minimum":[28],"gelling":[29],"concentration,":[30],"peptide":[32],"mapping":[33],"beta-chain":[37],"confirmed":[38],"complete":[39],"identity":[40],"with":[44,59],"that":[45],"in":[47,68,80,91,94,102,106],"Afro-American":[48,60],"S":[50,57,62],"homozygotes.":[51],"A":[52],"comparison":[53],"Arab":[55,81],"Hb":[56,61,76],"homozygotes":[58],"patients":[63],"showed":[64],"no":[65],"significant":[66],"differences":[67],"levels,":[70],"red":[71],"cell":[72],"indices":[73],"or":[74],"morphology.":[75],"F":[77],"averaged":[78],"4.4%":[79],"patients.":[82],"The":[83],"2,3":[84],"diphosphoglycerate":[85],"levels":[86],"increased":[88,98],"approximately":[89],"twofold":[90],"Arabs,":[92],"whereas":[93],"Afro-Americans,":[95],"it":[96],"was":[97],"by":[99],"only":[100],"7%":[101],"females":[103],"20%":[105],"males.":[107]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
