{"id":"https://openalex.org/W2011541677","doi":"https://doi.org/10.1055/s-2007-967239","title":"The Interleukin 13 Receptor System: A Novel Pathogenetic Mechanism in Pulmonary Arterial Hypertension","display_name":"The Interleukin 13 Receptor System: A Novel Pathogenetic Mechanism in Pulmonary Arterial Hypertension","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2011541677","doi":"https://doi.org/10.1055/s-2007-967239","mag":"2011541677"},"language":"en","primary_location":{"id":"doi:10.1055/s-2007-967239","doi":"https://doi.org/10.1055/s-2007-967239","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-967239","pdf_url":null,"source":{"id":"https://openalex.org/S111957458","display_name":"Pneumologie","issn_l":"0934-8387","issn":["0934-8387","1438-8790"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pneumologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102798194","display_name":"Matthias Hecker","orcid":"https://orcid.org/0000-0003-0614-5967","observed_orcids":["https://orcid.org/0000-0003-0614-5967"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Hecker","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016018148","display_name":"Gra\u017cyna Kwapiszewska","orcid":"https://orcid.org/0000-0003-0518-9079","observed_orcids":["https://orcid.org/0000-0003-0518-9079"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Kwapiszewska","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008982767","display_name":"Anna Zakrzewicz","orcid":"https://orcid.org/0000-0001-9004-3706","observed_orcids":["https://orcid.org/0000-0001-9004-3706"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Zakrzewicz","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020015230","display_name":"Leigh Matthew Marsh","orcid":"https://orcid.org/0000-0002-1754-9249","observed_orcids":["https://orcid.org/0000-0002-1754-9249"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Marsh","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004431838","display_name":"Ulrike Seay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U Seay","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017189713","display_name":"Daniel Sedding","orcid":"https://orcid.org/0000-0001-7312-5216","observed_orcids":["https://orcid.org/0000-0001-7312-5216"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D Sedding","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057524424","display_name":"Norbert Wei\u00dfmann","orcid":"https://orcid.org/0000-0003-2675-3871","observed_orcids":["https://orcid.org/0000-0003-2675-3871"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N Weissmann","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018388032","display_name":"Walter Klepetko","orcid":"https://orcid.org/0000-0003-4174-6071","observed_orcids":["https://orcid.org/0000-0003-4174-6071"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"W Klepetko","raw_affiliation_strings":["Department of Cardiothoracic Surgery, University of Vienna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, University of Vienna","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016511599","display_name":"Werner Seeger","orcid":"https://orcid.org/0000-0003-1946-0894","observed_orcids":["https://orcid.org/0000-0003-1946-0894"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W Seeger","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009672774","display_name":"Oliver Eickelberg","orcid":"https://orcid.org/0000-0001-7170-0360","observed_orcids":["https://orcid.org/0000-0001-7170-0360"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O Eickelberg","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5743,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.73791391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":"01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.8730000257492065},{"id":"https://openalex.org/keywords/il-13-receptor-alpha-2","display_name":"IL-13 receptor alpha 2","score":0.7369999885559082},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.968999981880188},{"id":"https://openalex.org/keywords/pulmonary-artery-smooth-muscle-cells","display_name":"pulmonary artery smooth muscle cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/smooth-muscle-cell-proliferation","display_name":"smooth muscle cell proliferation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8159999847412109},{"id":"https://openalex.org/keywords/monocrotaline","display_name":"monocrotaline","score":0.9129999876022339},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/stat6-phosphorylation","display_name":"STAT6 phosphorylation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/g0-g1-cell-cycle-arrest","display_name":"G0/G1 cell cycle arrest","score":0.9300000071525574},{"id":"https://openalex.org/keywords/il-4-receptor","display_name":"IL-4 receptor","score":0.8159999847412109},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5885654091835022},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5835744142532349},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.5502960681915283},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.5089385509490967},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4871463477611542},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47563982009887695},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.4720348119735718},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44441384077072144},{"id":"https://openalex.org/C32046619","wikidata":"https://www.wikidata.org/wiki/Q14878303","display_name":"Interleukin 13","level":4,"score":0.4331355094909668},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4324970841407776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39683079719543457},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3708155155181885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36974766850471497},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.348031222820282},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29764795303344727},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.273587703704834},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08441361784934998},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2007-967239","doi":"https://doi.org/10.1055/s-2007-967239","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-967239","pdf_url":null,"source":{"id":"https://openalex.org/S111957458","display_name":"Pneumologie","issn_l":"0934-8387","issn":["0934-8387","1438-8790"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pneumologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6907590275","https://openalex.org/W2154944989","https://openalex.org/W2918977091","https://openalex.org/W2765440609","https://openalex.org/W2070288105","https://openalex.org/W7098253771","https://openalex.org/W4291284655","https://openalex.org/W3031219215","https://openalex.org/W4388535230","https://openalex.org/W2795700422"],"abstract_inverted_index":{"Interleukin":[0],"(IL)-13":[1],"controls":[2,65],"airway":[3,6],"hyperresponsiveness":[4],"and":[5,30,47,88,98,135,139,164,202],"smooth":[7],"muscle":[8],"cell":[9,132],"(SMC)":[10],"hypertrophy,":[11],"but":[12],"its":[13],"effect":[14,125,201],"on":[15,162,186],"pulmonary":[16,37],"artery":[17],"SMC":[18],"has":[19],"not":[20],"been":[21],"investigated":[22],"thus":[23,169],"far.":[24],"Here,":[25],"we":[26,52],"examined":[27],"the":[28,33,42,182,208],"expression":[29,55,161],"activity":[31],"of":[32,56,60,86,104,126,137,146,159,181,198,210],"IL-13":[34,117,127,172],"system":[35],"in":[36,58,74,84,178,188],"arterial":[38],"hypertension":[39],"(PAH),":[40],"including":[41],"receptor":[43,184],"isotypes":[44],"IL-4R,":[45,76],"IL-13RA1,":[46],"IL-13RA2.":[48,147],"Using":[49],"quantitative":[50],"RT-PCR,":[51],"detected":[53],"increased":[54],"IL-13RA2":[57,105,160,185],"lungs":[59,85],"PAH":[61,189],"patients":[62],"compared":[63],"with":[64],"(transplant":[66],"donors).":[67],"In":[68,148],"contrast,":[69],"no":[70],"differences":[71],"were":[72,82],"observed":[73],"IL-13,":[75],"or":[77,93,190],"IL-13RA1":[78],"expression.":[79],"Similar":[80],"results":[81],"obtained":[83],"mice":[87],"rats":[89],"subjected":[90,151],"to":[91,106,130,152,195],"hypoxia-":[92],"monocrotaline-induced":[94],"PAH,":[95],"respectively.":[96],"Immunohistochemical":[97],"microdissection":[99],"analysis":[100],"demonstrated":[101],"selective":[102],"localization":[103],"paSMC.":[107,179],"Freshly":[108],"isolated":[109],"paSMC":[110,150,187,205],"displayed":[111,155],"a":[112,156,174,196],"dose-dependent":[113],"growth":[114],"inhibition":[115],"upon":[116],"treatment,":[118],"without":[119],"inducing":[120],"apoptotic":[121],"effects.":[122],"The":[123],"antiproliferative":[124,176,200],"was":[128,142],"due":[129],"G0/G1":[131],"cycle":[133],"arrest":[134],"phosphorylation":[136],"STAT3":[138],"STAT6,":[140],"which":[141],"diminished":[143],"by":[144],"overexpression":[145],"addition,":[149],"hypoxia":[153,191],"(24h)":[154],"significant":[157],"up-regulation":[158],"mRNA":[163],"protein":[165],"level.":[166],"Our":[167],"studies":[168],"demonstrate":[170],"that":[171],"is":[173],"potent":[175],"factor":[177],"Upregulation":[180],"decoy":[183],"may":[192],"therefore":[193,203],"lead":[194],"loss":[197],"this":[199,211],"enhanced":[204],"proliferation":[206],"during":[207],"pathogenesis":[209],"disease.":[212]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
