{"id":"https://openalex.org/W2011536910","doi":"https://doi.org/10.1039/j39680002564","title":"Cyto-active amino-acids and peptides. Part XV. The synthesis of p-di-(2-chloroethyl)aminophenyl-L-alanine (melphalan) labelled with tritium","display_name":"Cyto-active amino-acids and peptides. Part XV. The synthesis of p-di-(2-chloroethyl)aminophenyl-L-alanine (melphalan) labelled with tritium","publication_year":1968,"publication_date":"1968-01-01","ids":{"openalex":"https://openalex.org/W2011536910","doi":"https://doi.org/10.1039/j39680002564","mag":"2011536910","pmid":"https://pubmed.ncbi.nlm.nih.gov/5693590"},"language":"en","primary_location":{"id":"doi:10.1039/j39680002564","doi":"https://doi.org/10.1039/j39680002564","is_oa":false,"landing_page_url":"https://doi.org/10.1039/j39680002564","pdf_url":null,"source":{"id":"https://openalex.org/S4210199992","display_name":"Journal of the Chemical Society C Organic","issn_l":"0022-4952","issn":["0022-4952","2050-5604"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Chemical Society C: Organic","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103387495","display_name":"Roy Wade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roy Wade","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076106994","display_name":"T. Srinivasa Murthy","orcid":"https://orcid.org/0000-0002-2422-7766","observed_orcids":["https://orcid.org/0000-0002-2422-7766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Srinivasa Murthy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6504,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.61353383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":null,"first_page":"2564","last_page":"2564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tritium-labeling","display_name":"tritium labeling","score":0.8180000185966492},{"id":"https://openalex.org/keywords/amino-acid-synthesis","display_name":"amino acid synthesis","score":0.5669999718666077},{"id":"https://openalex.org/keywords/l-alanine-derivatives","display_name":"L-alanine derivatives","score":0.7799999713897705},{"id":"https://openalex.org/keywords/radiolabeled-amino-acids","display_name":"radiolabeled amino acids","score":0.6690000295639038},{"id":"https://openalex.org/keywords/metabolic-research","display_name":"metabolic studies","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C62538594","wikidata":"https://www.wikidata.org/wiki/Q54389","display_name":"Tritium","level":2,"score":0.7806015610694885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7388869524002075},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.718332827091217},{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.7060778141021729},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6189961433410645},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.5482242703437805},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.4984431266784668},{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.43063926696777344},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4106699824333191},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.4012581408023834},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22261810302734375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17070245742797852},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.06732168793678284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05825766921043396},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007455","descriptor_name":"Iodine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008558","descriptor_name":"Melphalan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/j39680002564","doi":"https://doi.org/10.1039/j39680002564","is_oa":false,"landing_page_url":"https://doi.org/10.1039/j39680002564","pdf_url":null,"source":{"id":"https://openalex.org/S4210199992","display_name":"Journal of the Chemical Society C Organic","issn_l":"0022-4952","issn":["0022-4952","2050-5604"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Chemical Society C: Organic","raw_type":"journal-article"},{"id":"pmid:5693590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5693590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Chemical Society. Perkin transactions 1","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2094458407","https://openalex.org/W1964345013","https://openalex.org/W2046359188","https://openalex.org/W1967481654","https://openalex.org/W2056145004","https://openalex.org/W1893097720","https://openalex.org/W2126831588","https://openalex.org/W2162243011","https://openalex.org/W2138048682","https://openalex.org/W1989553829"],"abstract_inverted_index":{"Experiments":[0],"aimed":[1],"at":[2],"the":[3,9,18,24,29],"preparation":[4],"of":[5,12,20,28,37,49],"ring-tritiated":[6],"melphalan":[7],"by":[8],"catalytic":[10],"replacement":[11],"iodine":[13],"are":[14],"described.":[15],"Owing":[16],"to":[17,23],"lability":[19],"tritium":[21],"ortho":[22],"amino":[25],"ring-substituent":[26],"much":[27],"incorporated":[30],"radioactivity":[31],"was":[32],"subsequently":[33],"lost.":[34],"Nevertheless":[35],"products":[36],"high":[38],"specific":[39],"activity":[40],"were":[41],"obtained,":[42],"suitable":[43],"for":[44],"most":[45],"metabolic":[46],"and":[47],"mechanism":[48],"action":[50],"studies.":[51]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
