{"id":"https://openalex.org/W2011527151","doi":"https://doi.org/10.1089/clo.2005.7.82","title":"Challenges of Primate Embryonic Stem Cell Research","display_name":"Challenges of Primate Embryonic Stem Cell Research","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2011527151","doi":"https://doi.org/10.1089/clo.2005.7.82","mag":"2011527151","pmid":"https://pubmed.ncbi.nlm.nih.gov/15971982"},"language":"en","primary_location":{"id":"doi:10.1089/clo.2005.7.82","doi":"https://doi.org/10.1089/clo.2005.7.82","is_oa":false,"landing_page_url":"https://doi.org/10.1089/clo.2005.7.82","pdf_url":null,"source":{"id":"https://openalex.org/S136641558","display_name":"Cloning and Stem Cells","issn_l":"1536-2302","issn":["1536-2302","1557-7457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cloning and Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112009101","display_name":"Barry D. Bavister","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192396691","display_name":"LSU New Orleans","ror":"https://ror.org/034mtvk83","country_code":"US","type":"education","lineage":["https://openalex.org/I192396691"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry D. Bavister","raw_affiliation_strings":["Department of Biological Sciences, University of New Orleans, New Orleans, Louisiana","Department of Biological Sciences, University of New Orleans, Louisiana 70148-2960, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of New Orleans, New Orleans, Louisiana","institution_ids":["https://openalex.org/I192396691"]},{"raw_affiliation_string":"Department of Biological Sciences, University of New Orleans, Louisiana 70148-2960, USA","institution_ids":["https://openalex.org/I192396691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069135894","display_name":"Don P. Wolf","orcid":"https://orcid.org/0000-0001-6900-2045","observed_orcids":["https://orcid.org/0000-0001-6900-2045"]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Don P. Wolf","raw_affiliation_strings":["Division of Reproductive Biology/Behavior, Oregon National Primate Research Center, Beaverton, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Biology/Behavior, Oregon National Primate Research Center, Beaverton, Oregon","institution_ids":["https://openalex.org/I102507086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103463009","display_name":"Carol A. Brenner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192396691","display_name":"LSU New Orleans","ror":"https://ror.org/034mtvk83","country_code":"US","type":"education","lineage":["https://openalex.org/I192396691"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol A. Brenner","raw_affiliation_strings":["Department of Biological Sciences, University of New Orleans, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of New Orleans, New Orleans, Louisiana","institution_ids":["https://openalex.org/I192396691"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3843,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.87951701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"2","first_page":"82","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primate-embryonic-stem-cells","display_name":"primate embryonic stem cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/mitochondrial-dna-defects","display_name":"mitochondrial DNA defects","score":0.9879999756813049},{"id":"https://openalex.org/keywords/in-vivo-derived-embryos","display_name":"in vivo-derived embryos","score":0.6480000019073486},{"id":"https://openalex.org/keywords/directed-differentiation","display_name":"directed differentiation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/stem-cell-ethics","display_name":"stem cell research ethics","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8012959957122803},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7839621305465698},{"id":"https://openalex.org/C2780509455","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Primate","level":2,"score":0.6336442828178406},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.529571533203125},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4206470251083374},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3517093360424042},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3317837119102478},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27726441621780396},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.23249846696853638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11907210946083069}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/clo.2005.7.82","doi":"https://doi.org/10.1089/clo.2005.7.82","is_oa":false,"landing_page_url":"https://doi.org/10.1089/clo.2005.7.82","pdf_url":null,"source":{"id":"https://openalex.org/S136641558","display_name":"Cloning and Stem Cells","issn_l":"1536-2302","issn":["1536-2302","1557-7457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cloning and Stem Cells","raw_type":"journal-article"},{"id":"pmid:15971982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15971982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cloning and stem cells","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1643110960","display_name":"Characterization of Monkey Embryonic Stem Cells","funder_award_id":"R21RR021881","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6290476456","display_name":"Chromosomal anomalies in macaque monkey oocytes","funder_award_id":"R03HD046553","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W1529934215","https://openalex.org/W1539549165","https://openalex.org/W1558721825","https://openalex.org/W1653639829","https://openalex.org/W1963715201","https://openalex.org/W1974129023","https://openalex.org/W1974663927","https://openalex.org/W1979794741","https://openalex.org/W1981045803","https://openalex.org/W1981395111","https://openalex.org/W1982966949","https://openalex.org/W1986574885","https://openalex.org/W1988865085","https://openalex.org/W1988866108","https://openalex.org/W1992469810","https://openalex.org/W1998998975","https://openalex.org/W2008375975","https://openalex.org/W2011827930","https://openalex.org/W2014073178","https://openalex.org/W2016621987","https://openalex.org/W2023921091","https://openalex.org/W2024423008","https://openalex.org/W2025962847","https://openalex.org/W2027149632","https://openalex.org/W2028452487","https://openalex.org/W2034763955","https://openalex.org/W2037388456","https://openalex.org/W2040596075","https://openalex.org/W2041844029","https://openalex.org/W2056483443","https://openalex.org/W2056707698","https://openalex.org/W2059317606","https://openalex.org/W2064745146","https://openalex.org/W2066413879","https://openalex.org/W2070672203","https://openalex.org/W2088048329","https://openalex.org/W2089319709","https://openalex.org/W2093677350","https://openalex.org/W2094557730","https://openalex.org/W2097055795","https://openalex.org/W2100088611","https://openalex.org/W2101863334","https://openalex.org/W2103246764","https://openalex.org/W2103709866","https://openalex.org/W2105314351","https://openalex.org/W2105593951","https://openalex.org/W2106115330","https://openalex.org/W2106124311","https://openalex.org/W2113591374","https://openalex.org/W2116715929","https://openalex.org/W2117790117","https://openalex.org/W2120121992","https://openalex.org/W2120533079","https://openalex.org/W2121230264","https://openalex.org/W2123079503","https://openalex.org/W2123405901","https://openalex.org/W2124643989","https://openalex.org/W2129534940","https://openalex.org/W2129844850","https://openalex.org/W2133501984","https://openalex.org/W2142221613","https://openalex.org/W2143086647","https://openalex.org/W2144142672","https://openalex.org/W2146651194","https://openalex.org/W2147172760","https://openalex.org/W2147447147","https://openalex.org/W2151487778","https://openalex.org/W2154040966","https://openalex.org/W2155143410","https://openalex.org/W2157942965","https://openalex.org/W2161682861","https://openalex.org/W2162410711","https://openalex.org/W2164469054","https://openalex.org/W2168407561","https://openalex.org/W2196804939","https://openalex.org/W2252785585","https://openalex.org/W2267144837","https://openalex.org/W2285972583","https://openalex.org/W2415801324","https://openalex.org/W2549448970","https://openalex.org/W2588514930","https://openalex.org/W4244200550"],"related_works":["https://openalex.org/W1992469810","https://openalex.org/W4210247538","https://openalex.org/W2321385315","https://openalex.org/W2409975567","https://openalex.org/W2013973099","https://openalex.org/W2086446960","https://openalex.org/W2020532383","https://openalex.org/W2388965077","https://openalex.org/W1485225722","https://openalex.org/W2100088611"],"abstract_inverted_index":{"Embryonic":[0],"stem":[1,166,178],"(ES)":[2],"cells":[3,28,100,179],"hold":[4],"great":[5],"promise":[6],"for":[7,64,136,147,185],"treating":[8],"degenerative":[9],"diseases,":[10],"including":[11],"diabetes,":[12],"Parkinson's,":[13],"Alzheimer's,":[14],"neural":[15],"degeneration,":[16],"and":[17,59,164,180,191,196,218],"cardiomyopathies.":[18],"This":[19],"research":[20,149,202,216],"is":[21,93,208],"controversial":[22],"to":[23,106,168,181,210,229],"some":[24,38,113],"because":[25],"producing":[26],"ES":[27,65,77,99,115,138,154,163,200,226],"requires":[29],"destroying":[30],"embryos,":[31],"which":[32,213],"generally":[33],"means":[34],"human":[35,42,98,162,205,233],"embryos.":[36],"However,":[37],"of":[39,56,176,225,232],"the":[40,170,174,222,230],"surplus":[41],"embryos":[43,105,125],"available":[44],"from":[45,102,127],"in":[46,76,103,122,157],"vitro":[47],"fertilization":[48],"(IVF)":[49],"clinics":[50],"may":[51,86],"have":[52,87,118],"a":[53,133,145],"high":[54],"rate":[55],"genetic":[57],"errors":[58,71],"therefore":[60],"would":[61],"be":[62,74,211],"unsuitable":[63],"cell":[66,116,201,206,227],"research.":[67],"Although":[68],"gross":[69],"chromosome":[70],"can":[72,131],"readily":[73],"detected":[75],"cells,":[78,155,167,194],"other":[79],"anomalies":[80],"such":[81],"as":[82],"mitochondrial":[83],"DNA":[84],"defects":[85],"gone":[88],"unrecognized.":[89],"An":[90],"insurmountable":[91],"problem":[92],"that":[94],"there":[95],"are":[96],"no":[97],"derived":[101],"vivo-produced":[104],"provide":[107],"normal":[108,124,177],"comparative":[109],"data.":[110],"In":[111,140,198],"contrast,":[112,199],"monkey":[114,153],"lines":[117,207],"been":[119],"produced":[120],"using":[121,151,203],"vivo-generated,":[123],"obtained":[126],"fertile":[128],"animals;":[129],"these":[130],"represent":[132],"\"gold":[134],"standard\"":[135],"primate":[137],"cells.":[139],"this":[141],"review,":[142],"we":[143],"argue":[144],"need":[146],"strong":[148],"programs":[150],"rhesus":[152],"conducted":[156],"parallel":[158],"with":[159],"studies":[160],"on":[161],"adult":[165],"derive":[169],"maximum":[171],"information":[172],"about":[173],"biology":[175],"produce":[182],"technical":[183],"protocols":[184],"their":[186],"directed":[187],"differentiation":[188],"into":[189],"safe":[190],"functional":[192],"replacement":[193],"tissues,":[195],"organs.":[197],"only":[204],"likely":[209],"incomplete,":[212],"could":[214],"hinder":[215],"progress,":[217],"delay":[219],"or":[220],"diminish":[221],"effective":[223],"application":[224],"technology":[228],"treatment":[231],"diseases.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
