{"id":"https://openalex.org/W2011506501","doi":"https://doi.org/10.1523/jneurosci.1328-05.2005","title":"Role of Protein Phosphatases in Estrogen-Mediated Neuroprotection","display_name":"Role of Protein Phosphatases in Estrogen-Mediated Neuroprotection","publication_year":2005,"publication_date":"2005-08-03","ids":{"openalex":"https://openalex.org/W2011506501","doi":"https://doi.org/10.1523/jneurosci.1328-05.2005","mag":"2011506501","pmid":"https://pubmed.ncbi.nlm.nih.gov/16079401","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6725236"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1328-05.2005","doi":"https://doi.org/10.1523/jneurosci.1328-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1328-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/31/7191.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/25/31/7191.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kun Don Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kun Don Yi","raw_affiliation_strings":["Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113439239","display_name":"Jaegwon Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaegwon Chung","raw_affiliation_strings":["Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041649274","display_name":"Priscilla S. Pang","orcid":"https://orcid.org/0000-0003-3650-7682","observed_orcids":["https://orcid.org/0000-0003-3650-7682"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priscilla Pang","raw_affiliation_strings":["Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111370326","display_name":"James W. Simpkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James W. Simpkins","raw_affiliation_strings":["Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107","University of North Texas Health Science Center , 3500 Camp Bowie Boulevard , Fort Worth , TX 76107 "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107","institution_ids":["https://openalex.org/I165139151"]},{"raw_affiliation_string":"University of North Texas Health Science Center , 3500 Camp Bowie Boulevard , Fort Worth , TX 76107 ","institution_ids":["https://openalex.org/I165139151"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111370326"],"corresponding_institution_ids":["https://openalex.org/I165139151"],"apc_list":null,"apc_paid":null,"fwci":1.9851,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.83106523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"25","issue":"31","first_page":"7191","last_page":"7198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.15369999408721924,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase","display_name":"protein phosphatase","score":0.9700000286102295},{"id":"https://openalex.org/keywords/estrogen-neuroprotection","display_name":"estrogen neuroprotection","score":0.8759999871253967},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/okadaic-acid","display_name":"okadaic acid","score":0.8029999732971191},{"id":"https://openalex.org/keywords/calyculin-a","display_name":"calyculin A","score":1.0},{"id":"https://openalex.org/keywords/protein-phosphatase-1","display_name":"protein phosphatase 1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":1.0},{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.7070000171661377},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7689999938011169},{"id":"https://openalex.org/keywords/protein-dephosphorylation","display_name":"protein dephosphorylation","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2776953658","wikidata":"https://www.wikidata.org/wiki/Q414042","display_name":"Okadaic acid","level":4,"score":0.9297820925712585},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.8045737743377686},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.6958826184272766},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6686747074127197},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6473994851112366},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6371957063674927},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.5501079559326172},{"id":"https://openalex.org/C2779408958","wikidata":"https://www.wikidata.org/wiki/Q7251492","display_name":"Protein phosphatase 1","level":4,"score":0.49787425994873047},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4710645079612732},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.46596789360046387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43371349573135376},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4274592697620392},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41537514328956604},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3925371766090393},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3423576354980469},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26522892713546753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24807706475257874},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.17466682195663452},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08177682757377625},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06243467330932617},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008387","descriptor_name":"Marine Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019319","descriptor_name":"Okadaic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.1328-05.2005","doi":"https://doi.org/10.1523/jneurosci.1328-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1328-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/31/7191.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5689335","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6725236","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:16079401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16079401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6725236","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6725236/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1328-05.2005","doi":"https://doi.org/10.1523/jneurosci.1328-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1328-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/31/7191.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2049917258","display_name":"Mechanisms of Cognitive Decline During Aging","funder_award_id":"P01AG022550","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8681985893","display_name":"Discovery of Novel Drugs for Alzheimer's Disease","funder_award_id":"P01AG010485","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011506501.pdf","grobid_xml":"https://content.openalex.org/works/W2011506501.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W8541533","https://openalex.org/W119907488","https://openalex.org/W171118067","https://openalex.org/W189289305","https://openalex.org/W619213375","https://openalex.org/W1595412249","https://openalex.org/W1600020348","https://openalex.org/W1647805770","https://openalex.org/W1662062786","https://openalex.org/W1674770932","https://openalex.org/W1809411463","https://openalex.org/W1818239859","https://openalex.org/W1947395210","https://openalex.org/W1966493435","https://openalex.org/W1971388737","https://openalex.org/W1972691843","https://openalex.org/W1975211445","https://openalex.org/W1975405984","https://openalex.org/W1978410273","https://openalex.org/W1978733364","https://openalex.org/W1980056037","https://openalex.org/W1981080255","https://openalex.org/W1982868475","https://openalex.org/W1984496769","https://openalex.org/W1985445048","https://openalex.org/W1988264669","https://openalex.org/W1989542226","https://openalex.org/W1991479241","https://openalex.org/W1992859245","https://openalex.org/W1992958781","https://openalex.org/W1997724028","https://openalex.org/W2003127863","https://openalex.org/W2007980908","https://openalex.org/W2009249382","https://openalex.org/W2019087786","https://openalex.org/W2021451131","https://openalex.org/W2022402045","https://openalex.org/W2022853425","https://openalex.org/W2025644637","https://openalex.org/W2031139440","https://openalex.org/W2032204255","https://openalex.org/W2032858873","https://openalex.org/W2038237876","https://openalex.org/W2042017613","https://openalex.org/W2043033966","https://openalex.org/W2043348076","https://openalex.org/W2043748431","https://openalex.org/W2044192933","https://openalex.org/W2044241508","https://openalex.org/W2045244003","https://openalex.org/W2048835444","https://openalex.org/W2048947179","https://openalex.org/W2049670422","https://openalex.org/W2055257152","https://openalex.org/W2057765023","https://openalex.org/W2063805443","https://openalex.org/W2067601393","https://openalex.org/W2070648285","https://openalex.org/W2071486760","https://openalex.org/W2073984182","https://openalex.org/W2074667468","https://openalex.org/W2076135266","https://openalex.org/W2082232769","https://openalex.org/W2082582109","https://openalex.org/W2084504852","https://openalex.org/W2087257549","https://openalex.org/W2090058810","https://openalex.org/W2091864083","https://openalex.org/W2095698264","https://openalex.org/W2098533587","https://openalex.org/W2103834862","https://openalex.org/W2115564640","https://openalex.org/W2119504151","https://openalex.org/W2123652060","https://openalex.org/W2128540699","https://openalex.org/W2130695898","https://openalex.org/W2131266318","https://openalex.org/W2135250775","https://openalex.org/W2135910109","https://openalex.org/W2148570557","https://openalex.org/W2156655462","https://openalex.org/W2159984609","https://openalex.org/W2161695527","https://openalex.org/W2167446891","https://openalex.org/W2170620326","https://openalex.org/W2342119633","https://openalex.org/W4322388716"],"related_works":["https://openalex.org/W98338516","https://openalex.org/W2121713831","https://openalex.org/W2107433841","https://openalex.org/W7100559541","https://openalex.org/W2004950881","https://openalex.org/W2075949545","https://openalex.org/W1995882426","https://openalex.org/W2064890294","https://openalex.org/W2013755949","https://openalex.org/W2067996406"],"abstract_inverted_index":{"The":[0,33],"signaling":[1,17],"pathways":[2],"that":[3,25,201],"mediate":[4],"neurodegeneration":[5],"are":[6,30],"complex":[7],"and":[8,14,18,27,53,59,75,92,105,166,180,195,210],"involve":[9],"a":[10,96,172,214],"balance":[11],"between":[12],"phosphorylation":[13],"dephosphorylation":[15],"of":[16,35,43,86,118,131,145,148,177,185,216],"structural":[19],"proteins.":[20],"We":[21],"have":[22],"shown":[23],"previously":[24],"17beta-estradiol":[26,87,137,153,186,202],"its":[28],"analogs":[29],"potent":[31],"neuroprotectants.":[32],"purpose":[34],"this":[36],"study":[37],"was":[38,158],"to":[39,66],"delineate":[40],"the":[41,67,82,129,143,190],"role":[42],"protein":[44,70,134,150,217],"phosphatases":[45],"(PPs)":[46],"in":[47,81,99,102,125,142,163,175,192],"estrogen":[48],"neuroprotection":[49],"against":[50,115,155,206],"oxidative":[51,208],"stress":[52,209],"excitotoxicity.":[54],"HT-22":[55,164],"cells,":[56,58],"C6-glioma":[57],"primary":[60,106,167],"rat":[61,107,168],"cortical":[62,108,169],"neurons":[63,170],"were":[64],"exposed":[65],"nonspecific":[68],"serine/threonine":[69,133],"phosphatase":[71,135,151],"inhibitors":[72],"okadaic":[73,120],"acid":[74,91,121],"calyculin":[76,93,123],"A":[77,94,124],"at":[78],"various":[79],"concentrations":[80,117,147],"presence":[83,144],"or":[84,122],"absence":[85,130],"and/or":[88],"glutamate.":[89],"Okadaic":[90],"caused":[95,171],"dose-dependent":[97],"decrease":[98,174,191],"cell":[100],"viability":[101],"HT-22,":[103],"C6-glioma,":[104],"neurons.":[109],"17beta-Estradiol":[110],"did":[111],"not":[112],"show":[113],"protection":[114,154],"neurotoxic":[116],"either":[119],"these":[126,132,149],"cells.":[127],"In":[128],"inhibitors,":[136,152],"attenuated":[138],"glutamate":[139,156,161,188],"toxicity.":[140],"However,":[141],"effective":[146],"toxicity":[157],"lost.":[159],"Furthermore,":[160],"treatment":[162],"cells":[165,205],"50%":[173],"levels":[176],"PP1,":[178,193],"PP2A,":[179,194],"PP2B":[181,196],"protein,":[182],"whereas":[183],"coadministration":[184],"with":[187],"prevented":[189],"levels.":[197],"These":[198],"results":[199],"suggest":[200],"may":[203],"protect":[204],"glutamate-induced":[207],"excitotoxicity":[211],"by":[212],"activating":[213],"combination":[215],"phosphatases.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}