{"id":"https://openalex.org/W2011499790","doi":"https://doi.org/10.1590/s0074-02761987000800020","title":"Prospects for a nonliving vaccine against Schistosomiasis based on cell-mediated immune resistance mechanisms","display_name":"Prospects for a nonliving vaccine against Schistosomiasis based on cell-mediated immune resistance mechanisms","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2011499790","doi":"https://doi.org/10.1590/s0074-02761987000800020","mag":"2011499790","pmid":"https://pubmed.ncbi.nlm.nih.gov/3151085"},"language":"en","primary_location":{"id":"doi:10.1590/s0074-02761987000800020","doi":"https://doi.org/10.1590/s0074-02761987000800020","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0074-02761987000800020","pdf_url":"https://www.scielo.br/j/mioc/a/HtrcL5kGvbDJ43Fw5tb9gyJ/?lang=en&format=pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/mioc/a/HtrcL5kGvbDJ43Fw5tb9gyJ/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062935637","display_name":"Stephanie L. James","orcid":"https://orcid.org/0000-0001-9764-5435","observed_orcids":["https://orcid.org/0000-0001-9764-5435"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie L. James","raw_affiliation_strings":["The George Washington University,  USA","The George Washington University, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The George Washington University,  USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"The George Washington University, Washington, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085815766","display_name":"Edward J. Pearce","orcid":"https://orcid.org/0000-0003-1001-9656","observed_orcids":["https://orcid.org/0000-0003-1001-9656"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J. Pearce","raw_affiliation_strings":["The George Washington University,  USA","The George Washington University, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The George Washington University,  USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"The George Washington University, Washington, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016487212","display_name":"Alan Sher","orcid":"https://orcid.org/0000-0001-7053-2895","observed_orcids":["https://orcid.org/0000-0001-7053-2895"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Sher","raw_affiliation_strings":["NIH,  USA","NIH, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH,  USA","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"NIH, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.11000641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"82","issue":"suppl 4","first_page":"121","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schistosomiasis-vaccine","display_name":"schistosomiasis vaccine","score":0.9049999713897705},{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/bcg-adjuvant","display_name":"BCG adjuvant","score":0.878000020980835},{"id":"https://openalex.org/keywords/paramyosin","display_name":"paramyosin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/intradermal-vaccination","display_name":"intradermal vaccination","score":0.8489999771118164},{"id":"https://openalex.org/keywords/larval-trapping","display_name":"larval trapping","score":0.8040000200271606},{"id":"https://openalex.org/keywords/immunization-route","display_name":"immunization route","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6888784170150757},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.682105541229248},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.675064206123352},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6342126131057739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6214433312416077},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6141856908798218},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.5935268998146057},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5557959675788879},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5147573947906494},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.5024950504302979},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.4842469394207001},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4278918206691742},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.1337716281414032},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06316956877708435},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000947","descriptor_name":"Antigens, Helminth","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000947","descriptor_name":"Antigens, Helminth","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001500","descriptor_name":"BCG Vaccine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012555","descriptor_name":"Schistosomiasis mansoni","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1590/s0074-02761987000800020","doi":"https://doi.org/10.1590/s0074-02761987000800020","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0074-02761987000800020","pdf_url":"https://www.scielo.br/j/mioc/a/HtrcL5kGvbDJ43Fw5tb9gyJ/?lang=en&format=pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},{"id":"pmid:3151085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3151085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Memorias do Instituto Oswaldo Cruz","raw_type":"Journal Article"},{"id":"pmh:oai:scielo:S0074-02761987000800020","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800020","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz v.82 suppl.4 1987","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2560445","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2560445","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz v.82 suppl.4 1987","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:8b7cd28305b94b999e9ca75299b7e7c0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8b7cd28305b94b999e9ca75299b7e7c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Memorias do Instituto Oswaldo Cruz, Vol 82, Pp 121-123 (1987)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/s0074-02761987000800020","doi":"https://doi.org/10.1590/s0074-02761987000800020","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0074-02761987000800020","pdf_url":"https://www.scielo.br/j/mioc/a/HtrcL5kGvbDJ43Fw5tb9gyJ/?lang=en&format=pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2162583061","display_name":null,"funder_award_id":"AI-23269","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011499790.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2158791282","https://openalex.org/W1480853515","https://openalex.org/W2045828320","https://openalex.org/W1932452177","https://openalex.org/W1665476043","https://openalex.org/W2033724832","https://openalex.org/W1535356493","https://openalex.org/W1546632678","https://openalex.org/W2883505105","https://openalex.org/W2406971246"],"abstract_inverted_index":{"We":[0],"have":[1],"designed":[2],"a":[3,61,76,117,121,140],"vaccine":[4,141],"model":[5],"based":[6,144],"on":[7,36,145],"induction":[8,146],"of":[9,39,48,53,58,71,116,139,147],"cell-mediated":[10,148],"immunity":[11],"and":[12,42,91,105],"shown":[13],"that":[14,65,102,110],"it":[15],"protects":[16],"mice":[17],"against":[18,142],"Schistosoma":[19],"mansoni":[20],"infection.":[21],"Mice":[22],"are":[23,111],"immunized":[24],"by":[25,113,131],"intradermal":[26],"injection":[27],"with":[28,51,97],"schistosome":[29,74],"antigens":[30],"plus":[31],"BCG.":[32,98],"Resistance":[33],"is":[34,86,100],"dependent":[35],"the":[37,43,67,114,137],"route":[38],"antigen":[40],"presentation":[41],"adjuvant":[44],"chosen.":[45],"The":[46],"pattern":[47],"resistance":[49,93,150],"correlates":[50],"sensitization":[52],"T":[54,89],"lymphocytes":[55,90],"for":[56,88],"production":[57],"gamma":[59],"interferon,":[60],"macrophage":[62],"activating":[63],"lymphokine":[64],"stimulates":[66],"cellular":[68,122],"effector":[69],"mechanism":[70],"protection.":[72],"Purified":[73],"paramyosin,":[75],"muscle":[77],"cell":[78],"component":[79],"present":[80],"in":[81,126],"soluble":[82,108],"parasite":[83],"antigenic":[84],"preparations,":[85],"immunogenic":[87],"induces":[92],"when":[94],"given":[95],"intradermally":[96],"It":[99],"likely":[101],"this":[103],"protein,":[104],"possibly":[106],"other":[107],"molecules":[109],"released":[112],"parasites":[115],"challenge":[118],"infection,":[119],"induce":[120],"inflammatory":[123],"response":[124],"resulting":[125],"larval":[127],"trapping":[128],"and/or":[129],"killing":[130],"activated":[132],"macrophages.":[133],"These":[134],"results":[135],"verify":[136],"feasibility":[138],"schistosomiasis":[143],"immune":[149],"mechanisms.":[151]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}