{"id":"https://openalex.org/W2011479334","doi":"https://doi.org/10.1089/107999099313415","title":"Suppression of Late Asthmatic Response by Low-Dose Oral Administration of Interferon-beta in the Guinea Pig Model of Asthma","display_name":"Suppression of Late Asthmatic Response by Low-Dose Oral Administration of Interferon-beta in the Guinea Pig Model of Asthma","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2011479334","doi":"https://doi.org/10.1089/107999099313415","mag":"2011479334","pmid":"https://pubmed.ncbi.nlm.nih.gov/10476934"},"language":"en","primary_location":{"id":"doi:10.1089/107999099313415","doi":"https://doi.org/10.1089/107999099313415","is_oa":false,"landing_page_url":"https://doi.org/10.1089/107999099313415","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110270152","display_name":"Yu\u2010ichiro Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu-Ichiro Satoh","raw_affiliation_strings":["Department of Microbiology, Hokkaido University School of Medicine, Sapporo, Japan. satouy@med.hokudai.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Hokkaido University School of Medicine, Sapporo, Japan. satouy@med.hokudai.ac.jp","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070198444","display_name":"Kyoko Kasama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyoko Kasama","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mikiko Kuwabara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikiko Kuwabara","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029747713","display_name":"Hongyan Diao","orcid":"https://orcid.org/0000-0002-7197-4051","observed_orcids":["https://orcid.org/0000-0002-7197-4051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-Yan Diao","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hirofumi Nakajima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirofumi Nakajima","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110183801","display_name":"Masashi Kohanawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masashi Kohanawa","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Tomonori Minagawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomonori Minagawa","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5732,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.83145936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"8","first_page":"887","last_page":"894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.984000027179718},{"id":"https://openalex.org/keywords/late-asthmatic-reaction","display_name":"late asthmatic response","score":0.902999997138977},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.6589999794960022},{"id":"https://openalex.org/keywords/ovalbumin-sensitization","display_name":"ovalbumin sensitization","score":0.8420000076293945},{"id":"https://openalex.org/keywords/eosinophil-infiltration","display_name":"eosinophil infiltration","score":0.8650000095367432},{"id":"https://openalex.org/keywords/respiratory-resistance","display_name":"respiratory resistance","score":0.8930000066757202},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.7990000247955322},{"id":"https://openalex.org/keywords/subcutaneous-administration","display_name":"subcutaneous administration","score":0.8450000286102295},{"id":"https://openalex.org/keywords/2-5-oligoadenylate-synthetase","display_name":"2',5'-oligoadenylate synthetase","score":0.9430000185966492},{"id":"https://openalex.org/keywords/guinea-pig-asthma-model","display_name":"guinea pig asthma model","score":0.75}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7785569429397583},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.767922043800354},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7434887886047363},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.7374891638755798},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.6929470300674438},{"id":"https://openalex.org/C2776390293","wikidata":"https://www.wikidata.org/wiki/Q2035485","display_name":"Subcutaneous injection","level":2,"score":0.49336233735084534},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49282172322273254},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.4827263057231903},{"id":"https://openalex.org/C33362165","wikidata":"https://www.wikidata.org/wiki/Q754455","display_name":"Airway resistance","level":3,"score":0.4777849614620209},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46357208490371704},{"id":"https://openalex.org/C2776093070","wikidata":"https://www.wikidata.org/wiki/Q621636","display_name":"Route of administration","level":2,"score":0.45329540967941284},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.44351404905319214},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.432081401348114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2590280771255493},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.17392882704734802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09557509422302246},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015088","descriptor_name":"2',5'-Oligoadenylate Synthetase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/107999099313415","doi":"https://doi.org/10.1089/107999099313415","is_oa":false,"landing_page_url":"https://doi.org/10.1089/107999099313415","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},{"id":"pmid:10476934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10476934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W6601833","https://openalex.org/W29304431","https://openalex.org/W955542855","https://openalex.org/W1964331410","https://openalex.org/W1979411434","https://openalex.org/W1979492370","https://openalex.org/W1986764259","https://openalex.org/W1990762234","https://openalex.org/W1992145267","https://openalex.org/W2017660243","https://openalex.org/W2019729510","https://openalex.org/W2025463080","https://openalex.org/W2044628413","https://openalex.org/W2046403513","https://openalex.org/W2054757973","https://openalex.org/W2063172625","https://openalex.org/W2069587720","https://openalex.org/W2069947868","https://openalex.org/W2073175195","https://openalex.org/W2077715523","https://openalex.org/W2079992384","https://openalex.org/W2114151186","https://openalex.org/W2123947154","https://openalex.org/W2131227262","https://openalex.org/W2138225621","https://openalex.org/W2164713614","https://openalex.org/W2410560920","https://openalex.org/W2411053466","https://openalex.org/W2412376535","https://openalex.org/W2413631212","https://openalex.org/W2414279197","https://openalex.org/W2417904358","https://openalex.org/W2423487256","https://openalex.org/W2438369411"],"related_works":["https://openalex.org/W2015239439","https://openalex.org/W2347903178","https://openalex.org/W2616410130","https://openalex.org/W2258594614","https://openalex.org/W2323620291","https://openalex.org/W1889708850","https://openalex.org/W2468840718","https://openalex.org/W2620901334","https://openalex.org/W2014612796","https://openalex.org/W2044628413"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,30,36,39,53,60,67,73,77,84,98,118],"anti-asthmatic":[3],"effects":[4],"of":[5,11,23,27,35,50,62,66,87,115,135],"low-dose":[6,111],"oral":[7,93,112],"and":[8,18,38,72,79,92],"subcutaneous":[9,91,123],"administration":[10,26,49,94,113,124],"interferon-beta":[12],"(IFN-beta)":[13],"on":[14],"an":[15],"ovalbumin":[16],"(OVA)-sensitized":[17],"challenged":[19],"guinea":[20],"pig":[21],"model":[22],"asthma.":[24,145],"Subcutaneous":[25],"IFN-beta":[28,51,116,136],"suppressed":[29],"eosinophil":[31,74],"infiltration":[32,75],"by":[33,43,58,64,81,110,122],"14.2%":[34],"control":[37,68],"respiratory":[40],"resistance":[41],"(Rrs)":[42],"58.2%":[44],"at":[45,69,83],"2.0":[46],"MIU/kg.":[47],"Oral":[48],"inhibited":[52],"late":[54],"asthmatic":[55,100],"response":[56,101],"(LAR)":[57],"suppressing":[59],"increase":[61],"Rrs":[63],"29%":[65],"1":[70],"IU/ml":[71],"into":[76],"trachea":[78],"lung":[80],"34.6%":[82],"optimum":[85],"dosage":[86],"10":[88],"IU/ml.":[89],"Both":[90],"could":[95],"not":[96],"inhibit":[97],"early":[99],"(EAR).":[102],"Additionally":[103],"we":[104],"found":[105],"2',5'-oligoadenylate":[106],"synthetase":[107],"(2',5'-OAS)":[108],"induction":[109],"(LDOA)":[114],"to":[117],"same":[119],"extent":[120],"as":[121],"in":[125,128],"whole":[126],"blood":[127],"vivo.":[129],"These":[130],"data":[131],"suggest":[132],"that":[133],"LDOA":[134],"would":[137],"have":[138],"some":[139],"clinical":[140],"benefit":[141],"for":[142],"patients":[143],"with":[144]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}