{"id":"https://openalex.org/W2011461336","doi":"https://doi.org/10.1146/annurev-cellbio-100109-104131","title":"Membrane Fusion: Five Lipids, Four SNAREs, Three Chaperones, Two Nucleotides, and a Rab, All Dancing in a Ring on Yeast Vacuoles","display_name":"Membrane Fusion: Five Lipids, Four SNAREs, Three Chaperones, Two Nucleotides, and a Rab, All Dancing in a Ring on Yeast Vacuoles","publication_year":2010,"publication_date":"2010-10-07","ids":{"openalex":"https://openalex.org/W2011461336","doi":"https://doi.org/10.1146/annurev-cellbio-100109-104131","mag":"2011461336","pmid":"https://pubmed.ncbi.nlm.nih.gov/20521906"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-cellbio-100109-104131","doi":"https://doi.org/10.1146/annurev-cellbio-100109-104131","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-cellbio-100109-104131","pdf_url":null,"source":{"id":"https://openalex.org/S93285647","display_name":"Annual Review of Cell and Developmental Biology","issn_l":"1081-0706","issn":["1081-0706","1530-8995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017690454","display_name":"William T. Wickner","orcid":"https://orcid.org/0000-0001-8431-0468","observed_orcids":["https://orcid.org/0000-0001-8431-0468"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William Wickner","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755-3844;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755-3844;","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017690454"],"corresponding_institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"],"apc_list":null,"apc_paid":null,"fwci":1.9969,"has_fulltext":false,"cited_by_count":283,"citation_normalized_percentile":{"value":0.89867841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"26","issue":"1","first_page":"115","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.9729999899864197},{"id":"https://openalex.org/keywords/homotypic-fusion","display_name":"homotypic fusion","score":0.9459999799728394},{"id":"https://openalex.org/keywords/yeast-vacuole","display_name":"yeast vacuole","score":0.9679999947547913},{"id":"https://openalex.org/keywords/snare-proteins","display_name":"SNARE proteins","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hops-complex","display_name":"HOPS complex","score":0.8899999856948853},{"id":"https://openalex.org/keywords/rab-gtpases","display_name":"Rab GTPases","score":0.9570000171661377},{"id":"https://openalex.org/keywords/protein-lipid-interactions","display_name":"protein-lipid interactions","score":0.5989999771118164},{"id":"https://openalex.org/keywords/exocytic-pathway","display_name":"exocytic pathway","score":0.597000002861023},{"id":"https://openalex.org/keywords/endocytic-pathway","display_name":"endocytic pathway","score":0.875}],"concepts":[{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.8282151222229004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7860302925109863},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.7735192775726318},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.7276198863983154},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6661151051521301},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.6568816304206848},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.5313388109207153},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.5209854245185852},{"id":"https://openalex.org/C2910636507","wikidata":"https://www.wikidata.org/wiki/Q4082043","display_name":"Vesicular Transport Proteins","level":5,"score":0.45814627408981323},{"id":"https://openalex.org/C92488253","wikidata":"https://www.wikidata.org/wiki/Q56592403","display_name":"Cell fusion","level":3,"score":0.4108917713165283},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36147814989089966},{"id":"https://openalex.org/C2777867350","wikidata":"https://www.wikidata.org/wiki/Q7908031","display_name":"Vacuolar protein sorting","level":4,"score":0.28780418634414673},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.131788969039917},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.1226503849029541},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11805999279022217},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.11509531736373901},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0974448025226593}],"mesh":[{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050600","descriptor_name":"SNARE Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev-cellbio-100109-104131","doi":"https://doi.org/10.1146/annurev-cellbio-100109-104131","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-cellbio-100109-104131","pdf_url":null,"source":{"id":"https://openalex.org/S93285647","display_name":"Annual Review of Cell and Developmental Biology","issn_l":"1081-0706","issn":["1081-0706","1530-8995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:20521906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20521906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of cell and developmental biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G682116551","display_name":"Protein Compartmentation","funder_award_id":"R01GM023377","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W1496054948","https://openalex.org/W1498832295","https://openalex.org/W1502422391","https://openalex.org/W1506518340","https://openalex.org/W1598680533","https://openalex.org/W1618106381","https://openalex.org/W1654890776","https://openalex.org/W1942671396","https://openalex.org/W1969054503","https://openalex.org/W1971603103","https://openalex.org/W1976127915","https://openalex.org/W1978349247","https://openalex.org/W1978391620","https://openalex.org/W1978698410","https://openalex.org/W1983906692","https://openalex.org/W1984974677","https://openalex.org/W1987388155","https://openalex.org/W1987600267","https://openalex.org/W1990942267","https://openalex.org/W1994218245","https://openalex.org/W1994275810","https://openalex.org/W1996286203","https://openalex.org/W2001928918","https://openalex.org/W2006525803","https://openalex.org/W2008735381","https://openalex.org/W2008909409","https://openalex.org/W2010112989","https://openalex.org/W2013673237","https://openalex.org/W2014135378","https://openalex.org/W2014222535","https://openalex.org/W2014703631","https://openalex.org/W2018622809","https://openalex.org/W2019897261","https://openalex.org/W2020978927","https://openalex.org/W2022525315","https://openalex.org/W2022704511","https://openalex.org/W2025059188","https://openalex.org/W2027775552","https://openalex.org/W2030468686","https://openalex.org/W2031231011","https://openalex.org/W2036523243","https://openalex.org/W2039990417","https://openalex.org/W2040411500","https://openalex.org/W2045405284","https://openalex.org/W2045466386","https://openalex.org/W2047808133","https://openalex.org/W2051103934","https://openalex.org/W2058569591","https://openalex.org/W2058981056","https://openalex.org/W2060225027","https://openalex.org/W2061601101","https://openalex.org/W2063224834","https://openalex.org/W2066613474","https://openalex.org/W2067546702","https://openalex.org/W2070593103","https://openalex.org/W2071094219","https://openalex.org/W2071651805","https://openalex.org/W2077549723","https://openalex.org/W2077745609","https://openalex.org/W2079368124","https://openalex.org/W2080226687","https://openalex.org/W2080228510","https://openalex.org/W2080878773","https://openalex.org/W2082851502","https://openalex.org/W2089483770","https://openalex.org/W2091298684","https://openalex.org/W2092654348","https://openalex.org/W2094866780","https://openalex.org/W2098607413","https://openalex.org/W2100671512","https://openalex.org/W2106770504","https://openalex.org/W2107726605","https://openalex.org/W2108157396","https://openalex.org/W2109345429","https://openalex.org/W2111499388","https://openalex.org/W2111620983","https://openalex.org/W2117199571","https://openalex.org/W2119401439","https://openalex.org/W2125335261","https://openalex.org/W2125562692","https://openalex.org/W2126003136","https://openalex.org/W2127688327","https://openalex.org/W2130155363","https://openalex.org/W2130301962","https://openalex.org/W2130691377","https://openalex.org/W2131273633","https://openalex.org/W2132005005","https://openalex.org/W2136635037","https://openalex.org/W2140324218","https://openalex.org/W2141730317","https://openalex.org/W2141781497","https://openalex.org/W2144892927","https://openalex.org/W2149451120","https://openalex.org/W2150109115","https://openalex.org/W2154195767","https://openalex.org/W2157633843","https://openalex.org/W2157704580","https://openalex.org/W2164345143","https://openalex.org/W2164433356","https://openalex.org/W2167510623","https://openalex.org/W2170117855","https://openalex.org/W2171798772","https://openalex.org/W2171920896","https://openalex.org/W2292886181"],"related_works":["https://openalex.org/W2125561686","https://openalex.org/W2067546702","https://openalex.org/W2100671512","https://openalex.org/W2150052026","https://openalex.org/W4389019462","https://openalex.org/W2067512458","https://openalex.org/W2471664890","https://openalex.org/W7052048045","https://openalex.org/W1978349247","https://openalex.org/W4211119360"],"abstract_inverted_index":{"Although":[0],"fusion":[1,20,33,38,48,74,84,89,112,120],"mechanisms":[2],"are":[3],"highly":[4],"conserved":[5],"in":[6,30,114],"evolution":[7],"and":[8,14,35,49,70,83,102,107],"among":[9],"organelles":[10],"of":[11,37,78,81,110],"the":[12,79,98,103,108],"exocytic":[13],"endocytic":[15],"pathways,":[16],"yeast":[17],"vacuole":[18,50],"homotypic":[19],"offers":[21],"unique":[22],"technical":[23],"advantages:":[24],"excellent":[25],"genetics,":[26],"clear":[27],"organelle":[28],"cytology,":[29],"vitro":[31],"colorimetric":[32],"assays,":[34],"reconstitution":[36],"from":[39],"all-pure":[40],"components,":[41],"including":[42],"a":[43,88],"Rab":[44],"GTPase,":[45],"HOPS":[46,101],"(homotypic":[47],"protein":[51,113],"sorting":[52],"complex),":[53],"four":[54],"SNAREs":[55],"[soluble":[56],"N-ethylmaleimide-sensitive":[57],"factor":[58],"(NSF)":[59],"attachment":[60],"receptors]":[61],"that":[62],"snare":[63],"(bind)":[64],"each":[65,111],"other,":[66],"SNARE-complex":[67],"disassembly":[68,105],"chaperones,":[69,106],"vacuolar":[71],"lipids.":[72],"Vacuole":[73],"studies":[75],"offer":[76],"paradigms":[77],"interdependence":[80],"lipids":[82],"proteins":[85],"to":[86],"assemble":[87],"microdomain,":[90],"distinct":[91],"lipid":[92],"functions,":[93],"SNARE":[94,104],"complex":[95],"proofreading":[96],"through":[97],"synergy":[99],"between":[100],"role":[109],"promoting":[115],"radical":[116],"bilayer":[117],"restructuring":[118],"for":[119],"without":[121],"lysis.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":30},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
