{"id":"https://openalex.org/W2011447233","doi":"https://doi.org/10.1021/bi050706b","title":"Reaction Coupling through Interdomain Contacts in Imidazole Glycerol Phosphate Synthase","display_name":"Reaction Coupling through Interdomain Contacts in Imidazole Glycerol Phosphate Synthase","publication_year":2005,"publication_date":"2005-08-19","ids":{"openalex":"https://openalex.org/W2011447233","doi":"https://doi.org/10.1021/bi050706b","mag":"2011447233","pmid":"https://pubmed.ncbi.nlm.nih.gov/16142895"},"language":"en","primary_location":{"id":"doi:10.1021/bi050706b","doi":"https://doi.org/10.1021/bi050706b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi050706b","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110541487","display_name":"Rebecca S. Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca S. Myers","raw_affiliation_strings":["Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-2091, and Department of Chemistry, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-2091, and Department of Chemistry, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081468273","display_name":"Rommie E. Amaro","orcid":"https://orcid.org/0000-0002-9275-9553","observed_orcids":["https://orcid.org/0000-0002-9275-9553"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rommie E. Amaro","raw_affiliation_strings":["Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-2091, and Department of Chemistry, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-2091, and Department of Chemistry, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004867963","display_name":"Zaida Ann Luthey-Schulten","orcid":"https://orcid.org/0000-0001-9749-8367","observed_orcids":["https://orcid.org/0000-0001-9749-8367"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaida A. Luthey-Schulten","raw_affiliation_strings":["Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-2091, and Department of Chemistry, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-2091, and Department of Chemistry, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060881837","display_name":"Vincent Jo Davisson","orcid":"https://orcid.org/0000-0003-1182-0007","observed_orcids":["https://orcid.org/0000-0003-1182-0007"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V. Jo Davisson","raw_affiliation_strings":["Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-2091, and Department of Chemistry, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-2091, and Department of Chemistry, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060881837"],"corresponding_institution_ids":["https://openalex.org/I157725225","https://openalex.org/I219193219"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.3852,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.75245239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"44","issue":"36","first_page":"11974","last_page":"11985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.46779999136924744,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.46779999136924744,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.46700000762939453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imidazole-glycerol-phosphate-synthase","display_name":"imidazole glycerol phosphate synthase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/catalytic-coupling","display_name":"catalytic coupling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/glutamine-hydrolysis","display_name":"glutamine hydrolysis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/aicar","display_name":"AICAR","score":0.7450000047683716},{"id":"https://openalex.org/keywords/histidine-biosynthesis","display_name":"histidine biosynthesis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/site-directed-mutants","display_name":"site-directed mutants","score":0.5580000281333923},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.7551229000091553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5802024602890015},{"id":"https://openalex.org/C2780874372","wikidata":"https://www.wikidata.org/wiki/Q328692","display_name":"Imidazole","level":2,"score":0.5758090615272522},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.5169805288314819},{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.507178783416748},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.4239782691001892},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3644346594810486},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18901431560516357},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.14355921745300293},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000637","descriptor_name":"Transaminases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005972","descriptor_name":"Glutaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005972","descriptor_name":"Glutaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005972","descriptor_name":"Glutaminase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi050706b","doi":"https://doi.org/10.1021/bi050706b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi050706b","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:16142895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16142895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2333939654","display_name":null,"funder_award_id":"R01 GM067915","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1554616255","https://openalex.org/W1567415408","https://openalex.org/W1597265946","https://openalex.org/W1866750512","https://openalex.org/W1969264621","https://openalex.org/W1972580421","https://openalex.org/W1974525344","https://openalex.org/W1987406847","https://openalex.org/W1989219897","https://openalex.org/W1995298289","https://openalex.org/W2007936367","https://openalex.org/W2012800553","https://openalex.org/W2012839060","https://openalex.org/W2016754197","https://openalex.org/W2021566131","https://openalex.org/W2027408247","https://openalex.org/W2028066599","https://openalex.org/W2029667189","https://openalex.org/W2036931150","https://openalex.org/W2038595680","https://openalex.org/W2050265985","https://openalex.org/W2053623997","https://openalex.org/W2053686725","https://openalex.org/W2067174909","https://openalex.org/W2068994258","https://openalex.org/W2075318676","https://openalex.org/W2076635588","https://openalex.org/W2087989637","https://openalex.org/W2090837462","https://openalex.org/W2092642545","https://openalex.org/W2103815459","https://openalex.org/W2110585845","https://openalex.org/W2122471277","https://openalex.org/W2160409135","https://openalex.org/W2949174101"],"related_works":["https://openalex.org/W18188221","https://openalex.org/W1972580421","https://openalex.org/W1987406847","https://openalex.org/W2090837462","https://openalex.org/W1973991118","https://openalex.org/W2021566131","https://openalex.org/W1993971884","https://openalex.org/W3017709487","https://openalex.org/W2016754197","https://openalex.org/W2050265985"],"abstract_inverted_index":{"Imidazole":[0],"glycerol":[1],"phosphate":[2],"(IGP)":[3],"synthase,":[4],"a":[5,54,66,131,168],"triad":[6,36,158,181],"glutamine":[7,21,39,55,161,182],"amidotransferase,":[8],"catalyzes":[9],"the":[10,14,44,60,72,86,126,138,146,150,156,179],"fifth":[11],"step":[12],"in":[13,62,115,134],"histidine":[15,151],"biosynthetic":[16],"pathway,":[17],"where":[18],"ammonia":[19],"from":[20,125],"is":[22,41,75],"incorporated":[23],"into":[24],"N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide":[25],"ribonucleotide":[26,33],"(PRFAR)":[27],"to":[28,159,166,178],"yield":[29],"IGP":[30,84,116],"and":[31,53,88,103,120,152],"5'-(5-aminoimidazole-4-carboxamide)":[32],"(AICAR).":[34],"The":[35],"family":[37,64],"of":[38,46,59,100,155,171],"amidotransferases":[40],"formed":[42],"by":[43,78,94],"coupling":[45,173],"two":[47,139],"disparate":[48],"subdomains,":[49],"an":[50,79,111],"acceptor":[51,80],"domain":[52,69],"hydrolysis":[56],"domain.":[57,82],"Each":[58],"enzymes":[61],"this":[63,165],"share":[65],"common":[67],"glutaminase":[68,73,87,147],"for":[70],"which":[71],"activity":[74],"tightly":[76],"regulated":[77],"substrate":[81],"In":[83],"synthase":[85,117],"PRFAR":[89,127],"binding":[90,128],"sites":[91],"are":[92],"separated":[93],"30":[95],"A.":[96],"Using":[97],"kinetic":[98],"analyses":[99],"site-specific":[101],"mutants":[102],"molecular":[104],"dynamic":[105],"simulations,":[106],"we":[107],"have":[108],"determined":[109],"that":[110,174],"interdomain":[112,143],"salt":[113],"bridge":[114],"between":[118,137],"D359":[119],"K196":[121],"(approximately":[122],"16":[123],"A":[124],"site)":[129],"plays":[130],"key":[132],"role":[133],"mediating":[135],"communication":[136],"active":[140],"sites.":[141],"This":[142],"contact":[144],"modulates":[145],"loop":[148],"containing":[149],"glutamic":[153],"acid":[154],"catalytic":[157,172],"control":[160],"hydrolysis.":[162],"We":[163],"propose":[164],"be":[167,176],"general":[169],"principle":[170],"may":[175],"applied":[177],"entire":[180],"amidotransferase":[183],"family.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
