{"id":"https://openalex.org/W2011439532","doi":"https://doi.org/10.1089/scd.2012.0417","title":"Mesenchymal Stem Cells and the Treatment of Conditions and Diseases: The Less Glittering Side of a Conspicuous Stem Cell for Basic Research","display_name":"Mesenchymal Stem Cells and the Treatment of Conditions and Diseases: The Less Glittering Side of a Conspicuous Stem Cell for Basic Research","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2011439532","doi":"https://doi.org/10.1089/scd.2012.0417","mag":"2011439532","pmid":"https://pubmed.ncbi.nlm.nih.gov/23025629"},"language":"en","primary_location":{"id":"doi:10.1089/scd.2012.0417","doi":"https://doi.org/10.1089/scd.2012.0417","is_oa":false,"landing_page_url":"https://doi.org/10.1089/scd.2012.0417","pdf_url":null,"source":{"id":"https://openalex.org/S120158623","display_name":"Stem Cells and Development","issn_l":"1525-8165","issn":["1525-8165","1547-3287","1557-8534","2168-6580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells and Development","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054549463","display_name":"Jos\u00e9 J. Minguell","orcid":"https://orcid.org/0000-0001-5962-6540","observed_orcids":["https://orcid.org/0000-0001-5962-6540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose J. Minguell","raw_affiliation_strings":["TCA Cellular Therapy","TCA Cellular Therapy, 101 Judge Tanner Boulevard, Covington, LA 70433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TCA Cellular Therapy","institution_ids":[]},{"raw_affiliation_string":"TCA Cellular Therapy, 101 Judge Tanner Boulevard, Covington, LA 70433, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056645769","display_name":"Carolina Allers","orcid":"https://orcid.org/0000-0001-8576-770X","observed_orcids":["https://orcid.org/0000-0001-8576-770X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolina Allers","raw_affiliation_strings":["TCA Cellular Therapy","TCA Cellular Therapy, Covington, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TCA Cellular Therapy","institution_ids":[]},{"raw_affiliation_string":"TCA Cellular Therapy, Covington, Louisiana","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056340582","display_name":"Gabriel P. Lasala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel P. Lasala","raw_affiliation_strings":["TCA Cellular Therapy","TCA Cellular Therapy, Covington, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TCA Cellular Therapy","institution_ids":[]},{"raw_affiliation_string":"TCA Cellular Therapy, Covington, Louisiana","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.521,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.44350759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"2","first_page":"193","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":1.0},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mesoderm-differentiation","display_name":"mesoderm differentiation","score":0.5389999747276306},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7900000214576721},{"id":"https://openalex.org/keywords/alternative-stem-cell-sources","display_name":"alternative stem cell sources","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8583700656890869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7462706565856934},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6630385518074036},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.6169299483299255},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5778215527534485},{"id":"https://openalex.org/C143441281","wikidata":"https://www.wikidata.org/wiki/Q5133858","display_name":"Clinical uses of mesenchymal stem cells","level":5,"score":0.493673175573349},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.4667292833328247},{"id":"https://openalex.org/C13685319","wikidata":"https://www.wikidata.org/wiki/Q7607302","display_name":"Stem cell transplantation for articular cartilage repair","level":5,"score":0.4141031503677368},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38901054859161377},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36570465564727783},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.3563210964202881},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2920287251472473},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2821989059448242},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.19922035932540894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1869211494922638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057905","descriptor_name":"Stem Cell Research","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/scd.2012.0417","doi":"https://doi.org/10.1089/scd.2012.0417","is_oa":false,"landing_page_url":"https://doi.org/10.1089/scd.2012.0417","pdf_url":null,"source":{"id":"https://openalex.org/S120158623","display_name":"Stem Cells and Development","issn_l":"1525-8165","issn":["1525-8165","1547-3287","1557-8534","2168-6580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells and Development","raw_type":"journal-article"},{"id":"pmid:23025629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23025629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":148,"referenced_works":["https://openalex.org/W1241557","https://openalex.org/W1487779806","https://openalex.org/W1491777786","https://openalex.org/W1521707994","https://openalex.org/W1545896785","https://openalex.org/W1548244064","https://openalex.org/W1555788107","https://openalex.org/W1613946354","https://openalex.org/W1804670053","https://openalex.org/W1912601661","https://openalex.org/W1965425745","https://openalex.org/W1967833960","https://openalex.org/W1970089076","https://openalex.org/W1971218073","https://openalex.org/W1974276124","https://openalex.org/W1976662121","https://openalex.org/W1978455833","https://openalex.org/W1978492568","https://openalex.org/W1979388177","https://openalex.org/W1980563065","https://openalex.org/W1981043866","https://openalex.org/W1982388152","https://openalex.org/W1983259364","https://openalex.org/W1986451583","https://openalex.org/W1987081782","https://openalex.org/W1987795135","https://openalex.org/W1988904745","https://openalex.org/W1989560466","https://openalex.org/W1990491925","https://openalex.org/W1991062038","https://openalex.org/W1996485697","https://openalex.org/W1998111995","https://openalex.org/W1999070656","https://openalex.org/W1999728896","https://openalex.org/W2000225716","https://openalex.org/W2001868663","https://openalex.org/W2003595336","https://openalex.org/W2003996125","https://openalex.org/W2005349078","https://openalex.org/W2005928896","https://openalex.org/W2007383919","https://openalex.org/W2010177121","https://openalex.org/W2011004393","https://openalex.org/W2015679500","https://openalex.org/W2015867161","https://openalex.org/W2016707632","https://openalex.org/W2017743514","https://openalex.org/W2018013954","https://openalex.org/W2018392368","https://openalex.org/W2019123554","https://openalex.org/W2020959877","https://openalex.org/W2024292129","https://openalex.org/W2025371271","https://openalex.org/W2026342859","https://openalex.org/W2033435500","https://openalex.org/W2035065708","https://openalex.org/W2035176325","https://openalex.org/W2037212024","https://openalex.org/W2038022281","https://openalex.org/W2039533211","https://openalex.org/W2040190589","https://openalex.org/W2041629505","https://openalex.org/W2045903915","https://openalex.org/W2049446122","https://openalex.org/W2050365141","https://openalex.org/W2051172891","https://openalex.org/W2052172161","https://openalex.org/W2054248603","https://openalex.org/W2055778894","https://openalex.org/W2056963249","https://openalex.org/W2057625720","https://openalex.org/W2061409836","https://openalex.org/W2063558730","https://openalex.org/W2065226637","https://openalex.org/W2067694074","https://openalex.org/W2069681400","https://openalex.org/W2070356929","https://openalex.org/W2071078660","https://openalex.org/W2071426740","https://openalex.org/W2071904806","https://openalex.org/W2076491580","https://openalex.org/W2077510301","https://openalex.org/W2078467122","https://openalex.org/W2079316697","https://openalex.org/W2081225883","https://openalex.org/W2082586271","https://openalex.org/W2083731843","https://openalex.org/W2084293556","https://openalex.org/W2084721303","https://openalex.org/W2086332063","https://openalex.org/W2087353148","https://openalex.org/W2087578260","https://openalex.org/W2091780386","https://openalex.org/W2092746470","https://openalex.org/W2092885226","https://openalex.org/W2095085916","https://openalex.org/W2095212193","https://openalex.org/W2096025394","https://openalex.org/W2097220529","https://openalex.org/W2098385948","https://openalex.org/W2100207849","https://openalex.org/W2100221605","https://openalex.org/W2102545161","https://openalex.org/W2103097226","https://openalex.org/W2103696333","https://openalex.org/W2105151699","https://openalex.org/W2107402669","https://openalex.org/W2107989515","https://openalex.org/W2108181330","https://openalex.org/W2108915141","https://openalex.org/W2110289202","https://openalex.org/W2115005758","https://openalex.org/W2115256958","https://openalex.org/W2116500923","https://openalex.org/W2118788475","https://openalex.org/W2118934189","https://openalex.org/W2120267080","https://openalex.org/W2120487028","https://openalex.org/W2122125669","https://openalex.org/W2122659446","https://openalex.org/W2125632594","https://openalex.org/W2126957024","https://openalex.org/W2129409686","https://openalex.org/W2130520407","https://openalex.org/W2130794824","https://openalex.org/W2135652919","https://openalex.org/W2138946470","https://openalex.org/W2140137066","https://openalex.org/W2141248581","https://openalex.org/W2142912967","https://openalex.org/W2145041062","https://openalex.org/W2147159837","https://openalex.org/W2151942524","https://openalex.org/W2152037725","https://openalex.org/W2153949260","https://openalex.org/W2154867085","https://openalex.org/W2156969855","https://openalex.org/W2157811993","https://openalex.org/W2158775094","https://openalex.org/W2158780936","https://openalex.org/W2159417266","https://openalex.org/W2159999899","https://openalex.org/W2167556063","https://openalex.org/W2169389686","https://openalex.org/W2169459855","https://openalex.org/W2170507244","https://openalex.org/W2278906020","https://openalex.org/W2417593607"],"related_works":["https://openalex.org/W1988284851","https://openalex.org/W3095950657","https://openalex.org/W2280266201","https://openalex.org/W2381375755","https://openalex.org/W1998650056","https://openalex.org/W2950854031","https://openalex.org/W2942091494","https://openalex.org/W3087130475","https://openalex.org/W2030187900","https://openalex.org/W1970368333"],"abstract_inverted_index":{"Not":[0],"too":[1],"long":[2],"ago,":[3],"several":[4,185],"motivated":[5],"and":[6,14,30,140,187],"forward-looking":[7],"articles":[8,134],"were":[9],"published":[10],"describing":[11],"the":[12,55,74,97,104,137,150,154,166,173,199],"cellular":[13,139],"molecular":[15,141],"properties":[16],"of":[17,40,57,83,99,120,133,143,169,202],"mesenchymal":[18],"stem":[19,45],"cells":[20,85],"(MSCs),":[21],"specially":[22],"highlighting":[23],"their":[24,176],"potential":[25,87],"for":[26,73,126],"self-renewal,":[27],"commitment,":[28],"differentiation,":[29],"maturation":[31],"into":[32,115],"specific":[33],"mesoderm-derived":[34],"lineages.":[35],"A":[36],"very":[37],"influential":[38],"publication":[39],"that":[41,59,77,112],"period":[42],"entitled":[43],"\"Mesenchymal":[44],"cells:":[46],"No":[47],"longer":[48],"second":[49],"class":[50],"marrow":[51,78],"citizens\"":[52],"[1]":[53],"raised":[54],"point":[56],"view":[58],"\"\u2026challenges":[60],"to":[61,66,71,165,172,183,198],"harness":[62],"MSC":[63],"cell":[64],"therapy":[65],"treat":[67],"diseases":[68],"\u2026":[69],"need":[70],"wait":[72],"full":[75],"comprehension":[76],"is":[79,88],"a":[80,118,123,130],"rich":[81],"source":[82],"mesenchyme-derived":[84],"whose":[86],"still":[89],"far":[90],"from":[91,146],"fully":[92],"appreciated.\"":[93],"Whether":[94],"or":[95],"not":[96,190],"prophecy":[98],"Gerson":[100],"was":[101],"fulfilled,":[102],"in":[103,193],"last":[105],"8":[106],"years":[107],"it":[108],"has":[109],"become":[110],"evident":[111],"infusing":[113],"MSCs":[114,144,170],"patients":[116],"suffering":[117],"variety":[119],"disorders":[121],"represents":[122],"viable":[124],"option":[125],"medical":[127],"treatment.":[128],"Accordingly,":[129],"vast":[131],"number":[132],"have":[135],"explored":[136],"privileged":[138],"features":[142],"prepared":[145],"sources":[147],"other":[148],"than":[149],"canonical,":[151],"represented":[152],"by":[153],"bone":[155],"marrow.":[156],"This":[157],"review":[158],"will":[159],"provide":[160],"more":[161],"information":[162],"neither":[163],"related":[164],"biological":[167],"attractiveness":[168],"nor":[171],"success":[174],"after":[175],"clinical":[177,200],"use.":[178],"Rather,":[179],"we":[180],"would":[181],"like":[182],"underscore":[184],"\"critical":[186],"tangential\"":[188],"issues,":[189],"always":[191],"discussed":[192],"biomedical":[194],"publications,":[195],"but":[196],"relevant":[197],"utilization":[201],"bone-marrow-derived":[203],"MSCs.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}