{"id":"https://openalex.org/W2011429694","doi":"https://doi.org/10.1111/j.1432-1033.1975.tb02173.x","title":"Identification of Chloride\u2010Binding Sites in Hemoglobin by Nuclear\u2010Magnetic\u2010Resonance Quadrupole\u2010Relaxation Studies of Hemoglobin Digests","display_name":"Identification of Chloride\u2010Binding Sites in Hemoglobin by Nuclear\u2010Magnetic\u2010Resonance Quadrupole\u2010Relaxation Studies of Hemoglobin Digests","publication_year":1975,"publication_date":"1975-07-01","ids":{"openalex":"https://openalex.org/W2011429694","doi":"https://doi.org/10.1111/j.1432-1033.1975.tb02173.x","mag":"2011429694","pmid":"https://pubmed.ncbi.nlm.nih.gov/236"},"language":"en","primary_location":{"id":"doi:10.1111/j.1432-1033.1975.tb02173.x","doi":"https://doi.org/10.1111/j.1432-1033.1975.tb02173.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1975.tb02173.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1975.tb02173.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1975.tb02173.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013872202","display_name":"Emilia Chiancone","orcid":"https://orcid.org/0000-0002-4203-5194","observed_orcids":["https://orcid.org/0000-0002-4203-5194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emilia CHIANCONE","raw_affiliation_strings":["Centro di Biologia Molecolare del C.N.R., lstituto di Chimica Riologica dell'Universiti, Citti Universitaria, 1-00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro di Biologia Molecolare del C.N.R., lstituto di Chimica Riologica dell'Universiti, Citti Universitaria, 1-00185 Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090015641","display_name":"Maurizio Brunori","orcid":"https://orcid.org/0000-0002-7795-1635","observed_orcids":["https://orcid.org/0000-0002-7795-1635"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maurizio BRUNORI","raw_affiliation_strings":["Centro di Biologia Molecolare del C.N.R., lstituto di Chimica Riologica dell'Universiti, Citti Universitaria, 1-00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro di Biologia Molecolare del C.N.R., lstituto di Chimica Riologica dell'Universiti, Citti Universitaria, 1-00185 Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073641797","display_name":"Eraldo Antonini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eraldo ANTONINI","raw_affiliation_strings":["Centro di Biologia Molecolare del C.N.R., lstituto di Chimica Riologica dell'Universiti, Citti Universitaria, 1-00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro di Biologia Molecolare del C.N.R., lstituto di Chimica Riologica dell'Universiti, Citti Universitaria, 1-00185 Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111606091","display_name":"Jeffries Wyman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffries WYMAN","raw_affiliation_strings":["Centro di Biologia Molecolare del C.N.R., lstituto di Chimica Riologica dell'Universiti, Citti Universitaria, 1-00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro di Biologia Molecolare del C.N.R., lstituto di Chimica Riologica dell'Universiti, Citti Universitaria, 1-00185 Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063138592","display_name":"Jan Erik Norne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Erik NORNE","raw_affiliation_strings":["Fysikalisk Kemi 2, Kemicentrum, Lunds Universitet, Box 740, S-22007 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fysikalisk Kemi 2, Kemicentrum, Lunds Universitet, Box 740, S-22007 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029499060","display_name":"Sture Fors\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sture FORS\u00c9N","raw_affiliation_strings":["Fysikalisk Kemi 2, Kemicentrum, Lunds Universitet, Box 740, S-22007 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fysikalisk Kemi 2, Kemicentrum, Lunds Universitet, Box 740, S-22007 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107412810","display_name":"Joseph Bonaventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph BONAVENTURA","raw_affiliation_strings":["Marine Laboratory, Duke University, Beaufort, North Carolina, U.S.A. 28516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Laboratory, Duke University, Beaufort, North Carolina, U.S.A. 28516","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5835,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.92693483,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"55","issue":"2","first_page":"385","last_page":"390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/chloride-binding-site","display_name":"chloride binding site","score":0.9629999995231628},{"id":"https://openalex.org/keywords/35cl-nmr","display_name":"35Cl NMR","score":0.8560000061988831},{"id":"https://openalex.org/keywords/carboxypeptidase-a","display_name":"carboxypeptidase A","score":0.9319999814033508},{"id":"https://openalex.org/keywords/carboxypeptidase-b","display_name":"carboxypeptidase B","score":1.0},{"id":"https://openalex.org/keywords/protein-digestion","display_name":"protein digestion","score":0.6320000290870667},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.8999999761581421},{"id":"https://openalex.org/keywords/phytic-acid","display_name":"phytic acid","score":0.9449999928474426},{"id":"https://openalex.org/keywords/histidine-residues","display_name":"histidine residues","score":0.414000004529953},{"id":"https://openalex.org/keywords/amino-acid-residues","display_name":"amino acid residues","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8151541948318481},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.7389980554580688},{"id":"https://openalex.org/C136398272","wikidata":"https://www.wikidata.org/wiki/Q83164201","display_name":"Carboxypeptidase A","level":4,"score":0.7141972184181213},{"id":"https://openalex.org/C108477463","wikidata":"https://www.wikidata.org/wiki/Q426367","display_name":"Carboxypeptidase","level":3,"score":0.561061680316925},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.4394160807132721},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.43119797110557556},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.41082507371902466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3226727247238159},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20817029476165771},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1491052210330963}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002268","descriptor_name":"Carboxypeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010833","descriptor_name":"Phytic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1432-1033.1975.tb02173.x","doi":"https://doi.org/10.1111/j.1432-1033.1975.tb02173.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1975.tb02173.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1975.tb02173.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1432-1033.1975.tb02173.x","doi":"https://doi.org/10.1111/j.1432-1033.1975.tb02173.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1975.tb02173.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1975.tb02173.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011429694.pdf","grobid_xml":"https://content.openalex.org/works/W2011429694.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W585914646","https://openalex.org/W1495666670","https://openalex.org/W1603979102","https://openalex.org/W1966011695","https://openalex.org/W1973243449","https://openalex.org/W1980039548","https://openalex.org/W2001809047","https://openalex.org/W2005436544","https://openalex.org/W2013862948","https://openalex.org/W2025747003","https://openalex.org/W2026911129","https://openalex.org/W2045253574","https://openalex.org/W2129097776","https://openalex.org/W2322315864"],"related_works":["https://openalex.org/W1973243449","https://openalex.org/W2013862948","https://openalex.org/W2410588081","https://openalex.org/W2082331471","https://openalex.org/W2064585953","https://openalex.org/W1966011695","https://openalex.org/W1971819074","https://openalex.org/W2503733367","https://openalex.org/W2037364620","https://openalex.org/W1991930129"],"abstract_inverted_index":{"35Cl":[0,66],"minus-nuclear":[1],"magnetic":[2],"resonance":[3],"(NMR)":[4],"studies":[5],"indicate":[6],"that":[7,71],"various":[8],"digests":[9,75],"of":[10,21,30,46,50,54,60,64,104,134,146],"human":[11],"hemoglobin":[12,40,153],"with":[13,76,85,119],"carboxypeptidase":[14,78,121],"A":[15,79,122],"and":[16,92,123,154],"B,":[17,81],"or":[18,80,89,94],"a":[19,108],"combination":[20],"the":[22,28,35,52,61,65,73,102,105,116,132,147,156,165],"two,":[23],"may":[24,127],"be":[25,129],"used":[26],"for":[27,144],"identification":[29],"chloride":[31,82,149],"binding":[32,47,150],"sites.":[33],"All":[34],"digestion":[36],"products":[37],"contain,":[38],"like":[39,139],"itself,":[41],"at":[42,88,93],"least":[43],"two":[44],"classes":[45],"sites,":[48],"one":[49],"high,":[51],"others":[53],"low":[55],"affinity.":[56],"The":[57,97],"pH":[58],"dependence":[59],"excess":[62],"linewidth":[63],"minus":[67],"NMR":[68],"signal":[69],"indicates":[70],"in":[72,101,115,152,155,164],"simple":[74,106,157],"either":[77],"is":[83,113,161],"bound":[84],"high":[86],"affinity":[87],"near":[90,95],"His-beta146-Asp-beta94":[91],"Val-alpha1-Arg-alpha141.":[96],"high-affinity":[98,148],"sites":[99,151],"show,":[100],"case":[103],"digests,":[107],"strong":[109],"oxygen":[110],"linkage":[111,126],"which":[112],"lost":[114,163],"forms":[117],"digested":[118,167],"both":[120],"B;":[124],"this":[125],"thus":[128],"correlated":[130],"to":[131],"presence":[133],"conformational":[135],"changes.":[136],"Organic":[137],"phosphates,":[138],"inositol":[140],"hexaphosphate,":[141],"show":[142],"competition":[143,160],"some":[145],"digests.":[158],"This":[159],"likewise":[162],"doubly":[166],"hemoglobins.":[168]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
