{"id":"https://openalex.org/W2011390056","doi":"https://doi.org/10.1359/jbmr.060821","title":"Transmigration: A New Property of Mature Multinucleated Osteoclasts","display_name":"Transmigration: A New Property of Mature Multinucleated Osteoclasts","publication_year":2006,"publication_date":"2006-09-29","ids":{"openalex":"https://openalex.org/W2011390056","doi":"https://doi.org/10.1359/jbmr.060821","mag":"2011390056","pmid":"https://pubmed.ncbi.nlm.nih.gov/17002556"},"language":"en","primary_location":{"id":"doi:10.1359/jbmr.060821","doi":"https://doi.org/10.1359/jbmr.060821","is_oa":true,"landing_page_url":"https://doi.org/10.1359/jbmr.060821","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.060821","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.060821","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008363807","display_name":"Fr\u00e9d\u00e9ric Saltel","orcid":"https://orcid.org/0000-0002-0724-9680","observed_orcids":["https://orcid.org/0000-0002-0724-9680"]},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210100775"]},{"id":"https://openalex.org/I4405253049","display_name":"Structure F\u00e9d\u00e9rative de Recherche Biosciences","ror":"https://ror.org/008e8k888","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405253049"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Saltel","raw_affiliation_strings":["CMU-Centre M\u00e9dicale Universitaire, Department of Physiologie Cellulaire et M\u00e9tabolique, Geneva, Switzerland","Laboratoire de Biologie Mol\u00e9culaire de la Cellule, IFR 128 Biosciences, Lyon-Gerland ENS/CNRS 5161, Lyon, France","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CMU-Centre M\u00e9dicale Universitaire, Department of Physiologie Cellulaire et M\u00e9tabolique, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, IFR 128 Biosciences, Lyon-Gerland ENS/CNRS 5161, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I4210100775","https://openalex.org/I4405253049"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012170361","display_name":"Anne Chabadel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210100775"]},{"id":"https://openalex.org/I4405253049","display_name":"Structure F\u00e9d\u00e9rative de Recherche Biosciences","ror":"https://ror.org/008e8k888","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405253049"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Chabadel","raw_affiliation_strings":["Laboratoire de Biologie Mol\u00e9culaire de la Cellule, IFR 128 Biosciences, Lyon-Gerland ENS/CNRS 5161, Lyon, France","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, IFR 128 Biosciences, Lyon-Gerland ENS/CNRS 5161, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I4210100775","https://openalex.org/I4405253049"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100944692","display_name":"Yingshe Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yingshe Zhao","raw_affiliation_strings":["INSERM UMR 664, Facult\u00e9 de M\u00e9decine Laennec, Lyon Cedex 08, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR 664, Facult\u00e9 de M\u00e9decine Laennec, Lyon Cedex 08, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023947803","display_name":"Marie\u2010H\u00e9l\u00e8ne Lafage\u2010Proust","orcid":"https://orcid.org/0000-0002-2091-3961","observed_orcids":["https://orcid.org/0000-0002-2091-3961"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-H\u00e9l\u00e8ne Lafage-Proust","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Laboratoire de Biologie du Tissu Osseux, E INSERM 366, Saint-\u00c9tienne Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Laboratoire de Biologie du Tissu Osseux, E INSERM 366, Saint-\u00c9tienne Cedex 2, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045029537","display_name":"Philippe Cl\u00e9zardin","orcid":"https://orcid.org/0000-0003-0149-4463","observed_orcids":["https://orcid.org/0000-0003-0149-4463"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Cl\u00e9zardin","raw_affiliation_strings":["INSERM UMR 664, Facult\u00e9 de M\u00e9decine Laennec, Lyon Cedex 08, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR 664, Facult\u00e9 de M\u00e9decine Laennec, Lyon Cedex 08, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004580613","display_name":"Pierre Jurdic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210100775"]},{"id":"https://openalex.org/I4405253049","display_name":"Structure F\u00e9d\u00e9rative de Recherche Biosciences","ror":"https://ror.org/008e8k888","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405253049"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pierre Jurdic","raw_affiliation_strings":["Laboratoire de Biologie Mol\u00e9culaire de la Cellule, IFR 128 Biosciences, Lyon-Gerland ENS/CNRS 5161, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, IFR 128 Biosciences, Lyon-Gerland ENS/CNRS 5161, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I4210100775","https://openalex.org/I4405253049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074749862","display_name":"Edith Bonnelye","orcid":"https://orcid.org/0000-0003-2574-1246","observed_orcids":["https://orcid.org/0000-0003-2574-1246"]},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210100775"]},{"id":"https://openalex.org/I4405253049","display_name":"Structure F\u00e9d\u00e9rative de Recherche Biosciences","ror":"https://ror.org/008e8k888","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405253049"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Edith Bonnelye","raw_affiliation_strings":["INSERM UMR 664, Facult\u00e9 de M\u00e9decine Laennec, Lyon Cedex 08, France","Laboratoire de Biologie Mol\u00e9culaire de la Cellule, IFR 128 Biosciences, Lyon-Gerland ENS/CNRS 5161, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR 664, Facult\u00e9 de M\u00e9decine Laennec, Lyon Cedex 08, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, IFR 128 Biosciences, Lyon-Gerland ENS/CNRS 5161, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I4210100775","https://openalex.org/I4405253049"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5004580613"],"corresponding_institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I4210100775","https://openalex.org/I4405253049"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":1.1228,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.72426066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"12","first_page":"1913","last_page":"1923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.8790000081062317},{"id":"https://openalex.org/keywords/transmigration","display_name":"transmigration","score":0.9269999861717224},{"id":"https://openalex.org/keywords/breast-cancer-bone-metastasis","display_name":"breast cancer bone metastasis","score":0.6480000019073486},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9490000009536743},{"id":"https://openalex.org/keywords/risedronate","display_name":"risedronate","score":0.9160000085830688},{"id":"https://openalex.org/keywords/bone-microenvironment","display_name":"bone microenvironment","score":0.7639999985694885},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.6460000276565552},{"id":"https://openalex.org/keywords/osteoclastic-bone-resorption","display_name":"osteoclast resorption","score":0.7699999809265137},{"id":"https://openalex.org/keywords/podosomes","display_name":"podosomes","score":0.6639999747276306},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.801876425743103},{"id":"https://openalex.org/C141073059","wikidata":"https://www.wikidata.org/wiki/Q7207063","display_name":"Podosome","level":4,"score":0.7816060781478882},{"id":"https://openalex.org/C136403682","wikidata":"https://www.wikidata.org/wiki/Q5796041","display_name":"Multinucleate","level":2,"score":0.7460899949073792},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5663762092590332},{"id":"https://openalex.org/C77076574","wikidata":"https://www.wikidata.org/wiki/Q2152526","display_name":"Giant cell","level":2,"score":0.5648255348205566},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5526858568191528},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.5011918544769287},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4600216746330261},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4499892592430115},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.4465666115283966},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32293060421943665},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29033970832824707},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22611775994300842},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21842962503433228},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20668411254882812},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.13829857110977173},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.12028604745864868},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11271408200263977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10680866241455078}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015726","descriptor_name":"Giant Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015726","descriptor_name":"Giant Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016392","descriptor_name":"Proto-Oncogene Proteins pp60(c-src)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016392","descriptor_name":"Proto-Oncogene Proteins pp60(c-src)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1359/jbmr.060821","doi":"https://doi.org/10.1359/jbmr.060821","is_oa":true,"landing_page_url":"https://doi.org/10.1359/jbmr.060821","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.060821","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:17002556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17002556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05049961v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05049961","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Bone and Mineral Research, 2006, 21 (12), pp.1913-1923. &#x27E8;10.1359/jbmr.060821&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1359/jbmr.060821","doi":"https://doi.org/10.1359/jbmr.060821","is_oa":true,"landing_page_url":"https://doi.org/10.1359/jbmr.060821","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.060821","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011390056.pdf","grobid_xml":"https://content.openalex.org/works/W2011390056.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1893383964","https://openalex.org/W1938796902","https://openalex.org/W1965511198","https://openalex.org/W1966478270","https://openalex.org/W1966677577","https://openalex.org/W1968826282","https://openalex.org/W1970259560","https://openalex.org/W1977202592","https://openalex.org/W1985744266","https://openalex.org/W2000170431","https://openalex.org/W2000983409","https://openalex.org/W2005603603","https://openalex.org/W2005716633","https://openalex.org/W2010377912","https://openalex.org/W2016411107","https://openalex.org/W2028638661","https://openalex.org/W2039353174","https://openalex.org/W2041924766","https://openalex.org/W2046945256","https://openalex.org/W2047169413","https://openalex.org/W2048578067","https://openalex.org/W2048616064","https://openalex.org/W2074467813","https://openalex.org/W2083019332","https://openalex.org/W2083730832","https://openalex.org/W2084651782","https://openalex.org/W2091579635","https://openalex.org/W2091870435","https://openalex.org/W2093252878","https://openalex.org/W2098456336","https://openalex.org/W2099281806","https://openalex.org/W2100282191","https://openalex.org/W2101386911","https://openalex.org/W2102969047","https://openalex.org/W2107860507","https://openalex.org/W2108181875","https://openalex.org/W2108725202","https://openalex.org/W2113434025","https://openalex.org/W2122647599","https://openalex.org/W2130441255","https://openalex.org/W2135415260","https://openalex.org/W2139294293","https://openalex.org/W2146833615","https://openalex.org/W2150783646","https://openalex.org/W2153801209","https://openalex.org/W2154028327","https://openalex.org/W2169061872","https://openalex.org/W2170770186","https://openalex.org/W2170843968","https://openalex.org/W2333102461","https://openalex.org/W2417656125","https://openalex.org/W2492093853","https://openalex.org/W2499881381","https://openalex.org/W4247967931","https://openalex.org/W6702665152"],"related_works":["https://openalex.org/W2028531128","https://openalex.org/W7097753630","https://openalex.org/W2045612829","https://openalex.org/W7132925729","https://openalex.org/W2030989965","https://openalex.org/W2499471665","https://openalex.org/W3188540253","https://openalex.org/W7099408229","https://openalex.org/W69352152","https://openalex.org/W2118837944"],"abstract_inverted_index":{"UNLABELLED:":[0],"Even":[1],"though":[2],"it":[3],"is":[4,39,199,209],"assumed":[5],"that":[6,21,179],"multinucleated":[7,83,95,180,242],"osteoclasts":[8,84,96,115,181,243],"are":[9,68],"migrating":[10],"cells":[11,30,126,221],"on":[12,118],"the":[13,34,75,89,193],"bone":[14,35,50,76,90,194,217,266,273],"surface":[15,77],"to":[16,74,81,86,100,143,167,244,252],"be":[17,47],"resorbed,":[18],"we":[19],"show":[20],"they":[22,79],"can":[23,46],"also":[24,98],"selectively":[25],"transmigrate":[26,101,183,245],"through":[27,102,184,246],"layers":[28,186],"of":[29,156,187,211,240],"usually":[31],"found":[32],"in":[33,192,196,225,272],"microenvironment.":[36],"This":[37,198],"activity":[38],"associated":[40,203,268],"with":[41,141,204,269],"c-src":[42,157,205],"and":[43,45,67,109,120,139,153,158,163,206],"MMPs":[44,207],"stimulated":[48],"by":[49,58,176,230,276],"metastatic":[51,218],"breast":[52,219],"cancer":[53,220],"cells,":[54],"a":[55,227,237],"process":[56,202,228,259],"blocked":[57],"bisphosphonate":[59,231],"treatment.":[60,232],"INTRODUCTION:":[61],"Osteoclasts":[62],"have":[63],"an":[64,200,270],"hematopoietic":[65],"origin":[66],"bone-resorbing":[69],"cells.":[70],"Monocytic":[71],"precursors":[72],"migrate":[73,87],"where":[78],"fuse":[80],"form":[82],"able":[85,99],"over":[88],"surface.":[91],"We":[92,174],"studied":[93],"whether":[94],"were":[97,116,127,165],"tissues.":[103],"MATERIALS":[104],"AND":[105],"METHODS:":[106],"Murine":[107],"spleen-derived":[108],"green":[110],"fluorescent":[111],"protein":[112],"(GFP)-Raw":[113],"derived":[114],"seeded":[117],"osteoblasts":[119],"several":[121],"other":[122],"cell":[123,189,248],"types.":[124,249],"The":[125,250],"fixed":[128],"for":[129,265],"20":[130],"minutes,":[131],"4":[132],"or":[133],"12":[134],"h":[135],"after":[136],"osteoclast":[137,169,223,257,278],"seeding,":[138],"stained":[140],"phalloidin":[142],"visualize":[144],"actin":[145],"using":[146],"confocal":[147,177],"microscopy.":[148],"Drugs":[149],"such":[150],"as":[151],"PP2":[152],"GM6001,":[154],"inhibitors":[155],"matrix":[159],"metalloproteinases":[160],"(MMPs),":[161],"respectively,":[162],"risedronate":[164],"used":[166],"determine":[168],"transmigration":[170,224,258],"regulating":[171],"factors.":[172],"RESULTS:":[173],"observed":[175],"microscopy":[178],"specifically":[182],"confluent":[185],"various":[188,247],"types":[190],"present":[191],"microenvironment":[195],"vitro.":[197],"efficient":[201],"but":[208],"independent":[210],"podosomes.":[212],"Moreover,":[213],"conditioned":[214],"medium":[215],"from":[216],"stimulates":[222],"vitro,":[226],"inhibited":[229],"CONCLUSIONS:":[233],"Our":[234],"data":[235],"describe":[236],"new":[238,262],"property":[239],"mature":[241],"ability":[251],"control":[253],"this":[254],"highly":[255],"regulated":[256],"may":[260],"offer":[261],"therapeutic":[263],"strategies":[264],"diseases":[267],"imbalance":[271],"remodeling":[274],"caused":[275],"excessive":[277],"resorption.":[279]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
