{"id":"https://openalex.org/W2011388528","doi":"https://doi.org/10.1016/j.clim.2010.05.011","title":"Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B","display_name":"Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B","publication_year":2010,"publication_date":"2010-07-21","ids":{"openalex":"https://openalex.org/W2011388528","doi":"https://doi.org/10.1016/j.clim.2010.05.011","mag":"2011388528","pmid":"https://pubmed.ncbi.nlm.nih.gov/20643584"},"language":"en","primary_location":{"id":"doi:10.1016/j.clim.2010.05.011","doi":"https://doi.org/10.1016/j.clim.2010.05.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clim.2010.05.011","pdf_url":null,"source":{"id":"https://openalex.org/S37169408","display_name":"Clinical Immunology","issn_l":"1521-6616","issn":["1521-6616","1521-7035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112922945","display_name":"Xuejun Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejun Gao","raw_affiliation_strings":["Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113867832","display_name":"Yulian Jiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yulian Jiao","raw_affiliation_strings":["Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010572699","display_name":"Laicheng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Laicheng Wang","raw_affiliation_strings":["Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115590720","display_name":"Xiaowen Liu","orcid":"https://orcid.org/0009-0003-6802-5116","observed_orcids":["https://orcid.org/0009-0003-6802-5116"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowen Liu","raw_affiliation_strings":["Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100646222","display_name":"Wenping Sun","orcid":"https://orcid.org/0000-0003-3021-6382","observed_orcids":["https://orcid.org/0000-0003-3021-6382"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenping Sun","raw_affiliation_strings":["Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bin Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Cui","raw_affiliation_strings":["Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108064842","display_name":"Zi\u2010Jiang Chen","orcid":"https://orcid.org/0000-0001-6637-6631","observed_orcids":["https://orcid.org/0000-0001-6637-6631"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zijiang Chen","raw_affiliation_strings":["Research Center for Reproductive Medicine, Shandong Provincial Hospital of Shandong University, Jinan 250021, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Reproductive Medicine, Shandong Provincial Hospital of Shandong University, Jinan 250021, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100609422","display_name":"Yueran Zhao","orcid":"https://orcid.org/0000-0002-2218-4918","observed_orcids":["https://orcid.org/0000-0002-2218-4918"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueran Zhao","raw_affiliation_strings":["Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250021, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":1.6484,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.82451299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"137","issue":"1","first_page":"139","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9789999723434448},{"id":"https://openalex.org/keywords/inhibitory-kir","display_name":"inhibitory KIR","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hla-c","display_name":"HLA-C","score":0.8489999771118164},{"id":"https://openalex.org/keywords/kir2dl1","display_name":"KIR2DL1","score":0.9449999928474426},{"id":"https://openalex.org/keywords/kir2dl3","display_name":"KIR2DL3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hla-c2","display_name":"HLA-C2","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hla-c1","display_name":"HLA-C1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7229999899864197},{"id":"https://openalex.org/keywords/genetic-protection","display_name":"genetic protection","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.7368106245994568},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6335417628288269},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5839810967445374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5774918794631958},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5154374837875366},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49875354766845703},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3214982748031616},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22346127033233643},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015236","descriptor_name":"HLA-C Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054340","descriptor_name":"Receptors, KIR","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054342","descriptor_name":"Receptors, KIR2DL1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054343","descriptor_name":"Receptors, KIR2DL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054344","descriptor_name":"Receptors, KIR2DL3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.clim.2010.05.011","doi":"https://doi.org/10.1016/j.clim.2010.05.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clim.2010.05.011","pdf_url":null,"source":{"id":"https://openalex.org/S37169408","display_name":"Clinical Immunology","issn_l":"1521-6616","issn":["1521-6616","1521-7035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:20643584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20643584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical immunology (Orlando, Fla.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G730540115","display_name":null,"funder_award_id":"ZR2009CM139","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1538843350","https://openalex.org/W1628798350","https://openalex.org/W1965779228","https://openalex.org/W1972178991","https://openalex.org/W1979261361","https://openalex.org/W1981387786","https://openalex.org/W1981657600","https://openalex.org/W1989412088","https://openalex.org/W1990569845","https://openalex.org/W1991172296","https://openalex.org/W1995310850","https://openalex.org/W1997788113","https://openalex.org/W1999878613","https://openalex.org/W2005765588","https://openalex.org/W2013956181","https://openalex.org/W2024252276","https://openalex.org/W2031293273","https://openalex.org/W2036895302","https://openalex.org/W2037763524","https://openalex.org/W2058321555","https://openalex.org/W2062581776","https://openalex.org/W2065237490","https://openalex.org/W2071267501","https://openalex.org/W2072277955","https://openalex.org/W2074197155","https://openalex.org/W2074280192","https://openalex.org/W2079722355","https://openalex.org/W2084863090","https://openalex.org/W2085722593","https://openalex.org/W2087296395","https://openalex.org/W2094608386","https://openalex.org/W2097150100","https://openalex.org/W2097363365","https://openalex.org/W2098318463","https://openalex.org/W2107749930","https://openalex.org/W2113393586","https://openalex.org/W2117003890","https://openalex.org/W2119687069","https://openalex.org/W2120128540","https://openalex.org/W2128306333","https://openalex.org/W2132268212","https://openalex.org/W2132756351","https://openalex.org/W2133854038","https://openalex.org/W2143429821","https://openalex.org/W2152095262","https://openalex.org/W2153455757","https://openalex.org/W2156015715","https://openalex.org/W2157098396","https://openalex.org/W2157861528","https://openalex.org/W2159823147","https://openalex.org/W2161027033","https://openalex.org/W2162962689","https://openalex.org/W2163751839","https://openalex.org/W2164487434","https://openalex.org/W3084142335","https://openalex.org/W4231124841"],"related_works":["https://openalex.org/W7139281692","https://openalex.org/W4416562528","https://openalex.org/W2091370926","https://openalex.org/W3024085019","https://openalex.org/W3096459024","https://openalex.org/W2588009620","https://openalex.org/W2107749930","https://openalex.org/W2084658117","https://openalex.org/W1981215706","https://openalex.org/W7020071231"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
