{"id":"https://openalex.org/W2011357096","doi":"https://doi.org/10.1073/pnas.172393399","title":"Rescue of influenza B virus from eight plasmids","display_name":"Rescue of influenza B virus from eight plasmids","publication_year":2002,"publication_date":"2002-08-09","ids":{"openalex":"https://openalex.org/W2011357096","doi":"https://doi.org/10.1073/pnas.172393399","mag":"2011357096","pmid":"https://pubmed.ncbi.nlm.nih.gov/12172012","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/123270"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.172393399","doi":"https://doi.org/10.1073/pnas.172393399","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.172393399","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/123270","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110059558","display_name":"Erich Hoffmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erich Hoffmann","raw_affiliation_strings":["MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018624996","display_name":"Kutubuddin Mahmood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kutubuddin Mahmood","raw_affiliation_strings":["MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021097468","display_name":"Chin\u2010Fen Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chin-Fen Yang","raw_affiliation_strings":["MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091454011","display_name":"Robert G. Webster","orcid":"https://orcid.org/0000-0002-1899-1856","observed_orcids":["https://orcid.org/0000-0002-1899-1856"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Webster","raw_affiliation_strings":["MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163","Department of Pathology, University of Tennessee, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Pathology, University of Tennessee, Memphis, TN 38163","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012961085","display_name":"Harry B. Greenberg","orcid":"https://orcid.org/0000-0002-2128-9080","observed_orcids":["https://orcid.org/0000-0002-2128-9080"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry B. Greenberg","raw_affiliation_strings":["MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010601658","display_name":"George\u00a0W. Kemble","orcid":"https://orcid.org/0000-0003-4225-8774","observed_orcids":["https://orcid.org/0000-0003-4225-8774"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Kemble","raw_affiliation_strings":["MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; and Department of Pathology, University of Tennessee, Memphis, TN 38163","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7316,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.96614862,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"99","issue":"17","first_page":"11411","last_page":"11416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-b","display_name":"influenza B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/recombinant-virus-rescue","display_name":"recombinant virus rescue","score":0.6949999928474426},{"id":"https://openalex.org/keywords/hemagglutinin-gene","display_name":"hemagglutinin gene","score":0.781000018119812},{"id":"https://openalex.org/keywords/neuraminidase-gene","display_name":"neuraminidase gene","score":1.0},{"id":"https://openalex.org/keywords/influenza-b-lineages","display_name":"influenza B lineages","score":0.5239999890327454},{"id":"https://openalex.org/keywords/embryonated-chicken-eggs","display_name":"embryonated chicken eggs","score":0.625}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8372935056686401},{"id":"https://openalex.org/C129470801","wikidata":"https://www.wikidata.org/wiki/Q5370234","display_name":"Embryonated","level":3,"score":0.819716215133667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8034510612487793},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6796392202377319},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.6670093536376953},{"id":"https://openalex.org/C134164806","wikidata":"https://www.wikidata.org/wiki/Q409485","display_name":"Neuraminidase","level":3,"score":0.5378943681716919},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5343396663665771},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4913693964481354},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.4634290933609009},{"id":"https://openalex.org/C25365240","wikidata":"https://www.wikidata.org/wiki/Q1897151","display_name":"Reverse genetics","level":4,"score":0.46199798583984375},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.46198540925979614},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.4352593421936035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24979719519615173},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08800733089447021},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009981","descriptor_name":"Influenza B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009981","descriptor_name":"Influenza B virus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009981","descriptor_name":"Influenza B virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D010948","descriptor_name":"Viral Plaque Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.172393399","doi":"https://doi.org/10.1073/pnas.172393399","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.172393399","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:123270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/123270","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:12172012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12172012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:123270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/123270","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1650980519","display_name":null,"funder_award_id":"N01 AI095357","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2541475296","display_name":null,"funder_award_id":"AI 95357","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3140115764","display_name":"INFLUENZA PANDEMIC PREPAREDNESS IN ASIA","funder_award_id":"n01ai095357-001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8544539060","display_name":"MOLECULAR EPIDEMIOLOGY OF PANDEMIC INFLUENZA","funder_award_id":"R01AI029680","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W76888523","https://openalex.org/W1483301458","https://openalex.org/W1494706118","https://openalex.org/W1524245131","https://openalex.org/W1579904848","https://openalex.org/W1795100282","https://openalex.org/W1935205231","https://openalex.org/W1946835238","https://openalex.org/W1965845512","https://openalex.org/W1966895511","https://openalex.org/W1977461039","https://openalex.org/W1978869747","https://openalex.org/W1985336857","https://openalex.org/W1986388571","https://openalex.org/W1997910503","https://openalex.org/W2011779891","https://openalex.org/W2012191541","https://openalex.org/W2020316997","https://openalex.org/W2020598529","https://openalex.org/W2028372889","https://openalex.org/W2032717740","https://openalex.org/W2057407542","https://openalex.org/W2057700014","https://openalex.org/W2061518004","https://openalex.org/W2073725095","https://openalex.org/W2074561865","https://openalex.org/W2077359735","https://openalex.org/W2077897437","https://openalex.org/W2083184245","https://openalex.org/W2091527885","https://openalex.org/W2100303390","https://openalex.org/W2101662353","https://openalex.org/W2105335973","https://openalex.org/W2112408527","https://openalex.org/W2126471526","https://openalex.org/W2127919461","https://openalex.org/W2128828508","https://openalex.org/W2130096583","https://openalex.org/W2133106116","https://openalex.org/W2145999102","https://openalex.org/W2146389912","https://openalex.org/W2157484446","https://openalex.org/W2163435267","https://openalex.org/W2230261403"],"related_works":["https://openalex.org/W2057700014","https://openalex.org/W7096794237","https://openalex.org/W2054449494","https://openalex.org/W3029884689","https://openalex.org/W2023534522","https://openalex.org/W1549388755","https://openalex.org/W2133106116","https://openalex.org/W2102393565","https://openalex.org/W2030226247","https://openalex.org/W2091527885"],"abstract_inverted_index":{"Influenza":[0],"B":[1,48,173,238,255],"virus":[2,49,140,239],"causes":[3],"a":[4,37],"significant":[5],"amount":[6],"of":[7,28,45,54,78,110,121,127,137,151,159,182,194,233,236,249,253],"morbidity":[8],"and":[9,64,94,113,118,186,210,218,244],"mortality,":[10],"yet":[11],"the":[12,26,43,52,58,74,138,152,157,160,177,183,199,208,224,231,250],"systems":[13],"to":[14,69,149,201],"produce":[15,70],"high":[16,84,234],"yield":[17],"inactivated":[18],"vaccines":[19,240],"for":[20,30,42,60,163,180,230],"these":[21],"viruses":[22,56],"have":[23,35],"lagged":[24],"behind":[25],"development":[27],"those":[29],"influenza":[31,47,79,172,237,254],"A":[32],"virus.":[33,256],"We":[34,72],"established":[36],"plasmid-only":[38],"reverse":[39,178],"genetics":[40],"system":[41,162,226],"generation":[44,53,232],"recombinant":[46,139],"that":[50,150,223],"facilitates":[51],"vaccine":[55],"without":[57],"need":[59],"time":[61],"consuming":[62],"coinfection":[63],"selection":[65],"procedures":[66],"currently":[67],"required":[68],"reassortants.":[71],"cloned":[73],"eight":[75],"viral":[76],"cDNAs":[77],"B/Yamanashi/166/98,":[80],"which":[81],"yields":[82,235],"relatively":[83],"titers":[85],"in":[86],"embryonated":[87,144],"chicken":[88,145],"eggs,":[89],"between":[90],"RNA":[91,95],"polymerase":[92,96],"I":[93],"II":[97],"transcription":[98],"units.":[99],"Virus":[100],"was":[101,147],"detected":[102],"as":[103,105,198],"early":[104],"3":[106],"days":[107,131],"after":[108,132,141],"transfection":[109],"cocultured":[111],"COS7":[112],"Madin-Darby":[114],"canine":[115],"kidney":[116],"cells":[117],"achieved":[119],"levels":[120],"10(6)-10(7)":[122],"plaque-forming":[123],"units":[124],"per":[125],"ml":[126],"cell":[128],"supernatant":[129],"6":[130,165,203],"transfection.":[133],"The":[134,190],"full-length":[135],"sequence":[136],"passage":[142],"into":[143],"eggs":[146],"identical":[148],"input":[153],"plasmids.":[154],"To":[155],"improve":[156],"utility":[158],"eight-plasmid":[161,225],"generating":[164],"+":[166,204],"2":[167,205],"reassortants":[168,206],"from":[169,214,247],"recently":[170],"circulating":[171],"strains,":[174],"we":[175],"optimized":[176],"transcriptase-PCR":[179],"cloning":[181],"hemagglutinin":[184],"(HA)":[185],"neuraminidase":[187],"(NA)":[188],"segments.":[189],"six":[191],"internal":[192],"genes":[193],"B/Yamanashi/166/98":[195],"were":[196],"used":[197,229],"backbone":[200],"generate":[202],"including":[207],"HA":[209,243],"NA":[211,245],"gene":[212],"segments":[213],"B/Victoria/504/2000,":[215],"B/Hong":[216],"Kong/330/2001,":[217],"B/Hawaii/10/2001.":[219],"Our":[220],"results":[221],"demonstrate":[222],"can":[227],"be":[228],"expressing":[241],"current":[242],"glycoproteins":[246],"either":[248],"two":[251],"lineages":[252]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}