{"id":"https://openalex.org/W2011353889","doi":"https://doi.org/10.1016/j.jalz.2009.04.004","title":"P1\u2010001: The role of ghrelin in the hippocampal neuron plasticity","display_name":"P1\u2010001: The role of ghrelin in the hippocampal neuron plasticity","publication_year":2009,"publication_date":"2009-06-25","ids":{"openalex":"https://openalex.org/W2011353889","doi":"https://doi.org/10.1016/j.jalz.2009.04.004","mag":"2011353889"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2009.04.004","doi":"https://doi.org/10.1016/j.jalz.2009.04.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.004","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103257872","display_name":"Masako Isokawa","orcid":"https://orcid.org/0000-0001-7304-3552","observed_orcids":["https://orcid.org/0000-0001-7304-3552"]},"institutions":[{"id":"https://openalex.org/I16452829","display_name":"The University of Texas System","ror":"https://ror.org/01gek1696","country_code":"US","type":"education","lineage":["https://openalex.org/I16452829"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Masako Isokawa","raw_affiliation_strings":["University of Texas Brownsville, Brownsville, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Brownsville, Brownsville, TX, USA","institution_ids":["https://openalex.org/I16452829"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103257872"],"corresponding_institution_ids":["https://openalex.org/I16452829"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.13148936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":"4S_Part_6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.483599990606308,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.483599990606308,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.2793000042438507,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.12540000677108765,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":1.0},{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.8989213705062866},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.8756392002105713},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7685729265213013},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6472131013870239},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6288660168647766},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5867066979408264},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.5659803152084351},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.5592014193534851},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5146732926368713},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5062031149864197},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.4715538024902344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37588992714881897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3755749464035034},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26371103525161743},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2380431890487671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22490417957305908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05781072378158569},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2009.04.004","doi":"https://doi.org/10.1016/j.jalz.2009.04.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.004","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2884981276","https://openalex.org/W2154294326","https://openalex.org/W2166331003","https://openalex.org/W2634250586","https://openalex.org/W2732493371","https://openalex.org/W1785690174","https://openalex.org/W2101777754","https://openalex.org/W2891369976","https://openalex.org/W2178703453","https://openalex.org/W3043253291"],"abstract_inverted_index":{"Alzheimer's":[0,300,349],"disease":[1],"is":[2,41,289,310],"a":[3,155,161,192,265,290],"progressive":[4],"neurodegenerative":[5],"disorder":[6],"clinically":[7],"characterized":[8],"by":[9,65,76,120,205,245],"loss":[10],"of":[11,102,107,136,182,197,211,225,255,273,282,296,317,326,341],"memory":[12,29],"and":[13,17,30,59,80,91,124,133,146,158,243,277,302,339,345],"deficits":[14],"in":[15,62,174,191,195,207,229,257,299,306,347],"cognitive":[16,343],"intellectual":[18],"functions.":[19],"Steadily":[20],"developing":[21],"damage":[22],"to":[23,184,268,320],"the":[24,34,39,42,46,63,67,83,88,100,105,114,134,215,220,223,230,258,270,294,321,337,348],"neural":[25],"networks":[26],"critical":[27],"for":[28],"learning":[31,79],"possibly":[32],"underlies":[33],"devastating":[35],"symptomatology.":[36],"In":[37,127,179,219],"Alzheimer's,":[38],"hippocampus":[40,64,322],"area":[43],"that":[44,117,236,251],"shows":[45],"most":[47],"atrophy.":[48],"Recent":[49],"evidence":[50],"suggested":[51],"circulating":[52,327],"ghrelin":[53,103,183,217,237,252,308,318,328],"promoted":[54],"dendritic":[55],"spine":[56],"synapse":[57],"formation":[58,276],"long-term":[60],"potentiation":[61],"crossing":[66],"blood-brain":[68],"barrier.":[69],"The":[70,232,260],"ghrelin-induced":[71],"synaptic":[72,199,275],"changes":[73],"were":[74,139],"paralleled":[75],"enhanced":[77],"spatial":[78],"memory.":[81],"However,":[82],"cellular":[84],"signaling":[85],"mechanisms":[86],"underlying":[87],"ghrelin's":[89,271],"neurogenerative":[90],"stimulative":[92],"effects":[93],"are":[94],"not":[95],"completely":[96],"understood.":[97],"We":[98,249],"investigated":[99],"effect":[101,272],"on":[104],"phosphorylation":[106,135,254],"CREB":[108,131,137,165,247,256,262],"(c-AMP":[109],"response":[110],"element":[111],"binding":[112],"protein),":[113],"transcription":[115],"factor":[116],"consolidates":[118],"memories":[119],"inducing":[121],"gene":[122],"expression":[123,151,190,224],"protein":[125],"synthesis.":[126],"cultured":[128,185],"hippocampal":[129,176,186,240,284],"slices,":[130],"activities":[132],"(pCREB)":[138],"assayed":[140],"immunohistochemically":[141],"using":[142],"anti-pCREB":[143],"antibody":[144],"(Ser133)":[145],"fluorescence-tagged":[147],"secondary":[148],"antibody.":[149],"pCREB":[150,189,226],"was":[152,171,203,227],"analyzed":[153],"with":[154],"confocal":[156],"microscope":[157],"quantified":[159],"as":[160,279,281,331],"ratio":[162],"between":[163,293],"total":[164],"vs.":[166],"pCREB.":[167],"Ghrelin":[168],"receptor":[169],"(GHSR)":[170],"highly":[172],"expressed":[173],"our":[175,206],"slice":[177],"culture.":[178],"vitro":[180],"application":[181],"slices":[187],"up-regulated":[188],"dose-dependent":[193],"manner":[194],"isolation":[196],"extrahippocampal":[198],"contacts.":[200],"This":[201],"finding":[202],"supported":[204],"vivo":[208],"animal":[209],"model":[210],"fasting.":[212],"Fasting":[213],"up-regulates":[214],"plasma":[216],"level.":[218],"fasted":[221],"rats,":[222],"increased":[228],"hippocampus.":[231,259],"present":[233],"results":[234,313],"suggest":[235,314],"may":[238,334],"enhance":[239],"neuron":[241],"growth":[242],"plasticity":[244],"stimulating":[246],"activities.":[248],"conclude":[250],"stimulates":[253],"phosphorylated":[261],"could":[263],"be":[264],"key":[266],"molecule":[267],"exert":[269],"promoting":[274],"functions":[278],"well":[280],"protecting":[283],"neurons":[285],"from":[286],"degeneration.":[287],"There":[288],"strong":[291],"link":[292],"progression":[295],"dementia,":[297],"like":[298],"disease,":[301],"Type":[303],"II":[304],"diabetes":[305],"which":[307],"level":[309],"reduced.":[311],"Our":[312],"exogenous":[315],"administration":[316],"centrally":[319],"or":[323],"therapeutic":[324],"restoration":[325],"levels":[329],"(such":[330],"caloric":[332],"restriction)":[333],"contribute":[335],"towards":[336],"treatment":[338],"prevention":[340],"age-related":[342],"decline":[344],"dementia":[346],"disease.":[350]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
