{"id":"https://openalex.org/W2011319006","doi":"https://doi.org/10.1111/j.1365-2036.2011.04983.x","title":"Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation","display_name":"Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation","publication_year":2012,"publication_date":"2012-01-18","ids":{"openalex":"https://openalex.org/W2011319006","doi":"https://doi.org/10.1111/j.1365-2036.2011.04983.x","mag":"2011319006","pmid":"https://pubmed.ncbi.nlm.nih.gov/22251419"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2036.2011.04983.x","doi":"https://doi.org/10.1111/j.1365-2036.2011.04983.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2036.2011.04983.x","pdf_url":null,"source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027136649","display_name":"William D. Chey","orcid":"https://orcid.org/0000-0002-4584-4026","observed_orcids":["https://orcid.org/0000-0002-4584-4026"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. D. Chey","raw_affiliation_strings":["GI Physiology Laboratory; University of Michigan Health System; Ann Arbor; MI; USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Physiology Laboratory; University of Michigan Health System; Ann Arbor; MI; USA","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022123400","display_name":"Douglas A. Drossman","orcid":"https://orcid.org/0000-0002-8178-0453","observed_orcids":["https://orcid.org/0000-0002-8178-0453"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. A. Drossman","raw_affiliation_strings":["Division of Gastroenterology & Hepatology, University of North Carolina Center for Functional GI and Motility Disorders University of North Carolina at Chapel Hill Chapel Hill NC USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology & Hepatology, University of North Carolina Center for Functional GI and Motility Disorders University of North Carolina at Chapel Hill Chapel Hill NC USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109177295","display_name":"John F. Johanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110323","display_name":"University of Illinois Chicago, Rockford campus","ror":"https://ror.org/02437s643","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210110323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. F. Johanson","raw_affiliation_strings":["University of Illinois, College of Medicine at Rockford, Rockford, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois, College of Medicine at Rockford, Rockford, IL, USA","institution_ids":["https://openalex.org/I4210110323"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Scott","raw_affiliation_strings":["Sucampo Pharmaceuticals, Inc. Bethesda MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sucampo Pharmaceuticals, Inc. Bethesda MD USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078221692","display_name":"Raymond M. Panas","orcid":"https://orcid.org/0000-0003-0214-1926","observed_orcids":["https://orcid.org/0000-0003-0214-1926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. M. Panas","raw_affiliation_strings":["Sucampo Pharmaceuticals, Inc. Bethesda MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sucampo Pharmaceuticals, Inc. Bethesda MD USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113738093","display_name":"Ryuji Ueno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Ueno","raw_affiliation_strings":["Sucampo Pharmaceuticals, Inc. Bethesda MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sucampo Pharmaceuticals, Inc. Bethesda MD USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027136649"],"corresponding_institution_ids":["https://openalex.org/I4210114445"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":17.0327,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.9945981,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"35","issue":"5","first_page":"587","last_page":"599"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lubiprostone","display_name":"lubiprostone","score":0.9589999914169312},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome-with-constipation","display_name":"irritable bowel syndrome with constipation","score":0.996999979019165},{"id":"https://openalex.org/keywords/long-term-safety","display_name":"long-term safety","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.9660000205039978},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9279999732971191},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.6970000267028809},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7730000019073486},{"id":"https://openalex.org/keywords/symptom-severity","display_name":"symptom severity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.7160000205039978},{"id":"https://openalex.org/keywords/open-label-extension","display_name":"open-label extension","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.939117431640625},{"id":"https://openalex.org/C2781093762","wikidata":"https://www.wikidata.org/wiki/Q6695342","display_name":"Lubiprostone","level":4,"score":0.9272243976593018},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8400667309761047},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.8189080953598022},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.7864274978637695},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.7746177911758423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6744040250778198},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6249707937240601},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5674914717674255},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.505812406539917},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4700804054737091},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44854894280433655},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.42264217138290405},{"id":"https://openalex.org/C3017955636","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Chronic constipation","level":3,"score":0.16303756833076477},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068238","descriptor_name":"Lubiprostone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000203","descriptor_name":"Activities of Daily Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003248","descriptor_name":"Constipation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003672","descriptor_name":"Defecation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D065101","descriptor_name":"Chloride Channel Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2036.2011.04983.x","doi":"https://doi.org/10.1111/j.1365-2036.2011.04983.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2036.2011.04983.x","pdf_url":null,"source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:22251419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22251419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary pharmacology & therapeutics","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/90244","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2027.42/90244>","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1491518420","https://openalex.org/W1532990492","https://openalex.org/W1996621414","https://openalex.org/W1998329897","https://openalex.org/W2012442346","https://openalex.org/W2017321847","https://openalex.org/W2020525013","https://openalex.org/W2041581988","https://openalex.org/W2063916434","https://openalex.org/W2064201279","https://openalex.org/W2068114187","https://openalex.org/W2088344246","https://openalex.org/W2099768372","https://openalex.org/W2114567997","https://openalex.org/W2128650398","https://openalex.org/W2913676453","https://openalex.org/W2914483921"],"related_works":["https://openalex.org/W2088344246","https://openalex.org/W1491518420","https://openalex.org/W2316319365","https://openalex.org/W1996836360","https://openalex.org/W2258033180","https://openalex.org/W1579046272","https://openalex.org/W2978445550","https://openalex.org/W2001830981","https://openalex.org/W4300953371","https://openalex.org/W4230922432"],"abstract_inverted_index":{"BACKGROUND:":[0],"Irritable":[1],"bowel":[2,229],"syndrome":[3,230],"with":[4,34,217,227,231],"constipation":[5],"(IBS-C)":[6],"significantly":[7],"decreases":[8],"quality":[9,105],"of":[10,30,48,73,98,106,114,118,130,188,249],"life":[11],"and":[12,27,76,85,95,102,161,166,191,197,204,243],"the":[13,23,71,141,169,222],"ability":[14],"to":[15,137,184,240],"perform":[16],"daily":[17,237],"living":[18],"activities.":[19],"AIM:":[20],"To":[21],"demonstrate":[22],"long-term":[24,74],"safety,":[25],"tolerability":[26],"patient":[28,96,121],"outcomes":[29],"lubiprostone":[31,59,131,233],"in":[32,140],"patients":[33,43,56,181,226],"IBS-C.":[35],"METHODS:":[36],"This":[37],"extension":[38],"study":[39,134],"enrolled":[40,55],"522":[41],"IBS-C":[42,99],"who":[44],"had":[45,120],"completed":[46],"one":[47],"two":[49],"randomised":[50],"phase":[51,143],"3":[52,144],"studies.":[53,145],"All":[54],"received":[57],"open-label":[58],"orally":[60],"for":[61,194],"36-weeks":[62],"(8":[63],"mcg,":[64],"twice":[65,236],"daily).":[66],"The":[67,109,126,146],"primary":[68],"objective":[69],"was":[70,135,238],"assessment":[72],"safety":[75,111,128],"tolerability,":[77],"monitored":[78],"via":[79],"adverse":[80],"events":[81],"(AEs),":[82],"laboratory":[83],"parameters":[84,206],"vital":[86],"signs.":[87],"Additional":[88],"outcome":[89,123],"endpoints":[90],"included":[91],"monthly":[92],"responder":[93,202],"rates":[94,203],"evaluations":[97],"symptom":[100],"severity":[101],"impact":[103],"on":[104],"life.":[107],"RESULTS:":[108],"evaluable":[110],"population":[112],"comprised":[113],"520":[115],"patients;":[116],"476":[117],"which":[119,189],"reported":[122],"data":[124],"available.":[125],"overall":[127],"profile":[129],"during":[132],"this":[133],"similar":[136],"that":[138],"observed":[139],"preceding":[142],"most":[147,170],"common":[148,171],"AEs":[149,176],"were":[150,168,177],"diarrhoea":[151,190],"(11.0%),":[152,154],"nausea":[153,167,192],"urinary":[155],"tract":[156],"infection":[157],"(9.0%),":[158],"sinusitis":[159],"(9.0%)":[160],"abdominal":[162],"distention":[163],"(5.8%).":[164],"Diarrhoea":[165],"treatment-related":[172,186],"AEs.":[173],"No":[174],"serious":[175],"considered":[178],"treatment-related.":[179],"Seventeen":[180],"discontinued":[182],"due":[183],"a":[185],"AE,":[187],"accounted":[193],"six":[195],"(1.2%)":[196],"three":[198],"(0.6%)":[199],"respectively.":[200],"For":[201],"patient-evaluated":[205],"(n":[207],"=":[208],"476),":[209],"all":[210],"groups":[211],"experienced":[212],"significant":[213],"improvements":[214,219],"from":[215],"baseline,":[216],"initial":[218],"maintained":[220],"throughout":[221],"study.":[223],"CONCLUSION:":[224],"In":[225],"irritable":[228],"constipation,":[232],"8":[234],"mcg":[235],"found":[239],"be":[241],"safe":[242],"well":[244],"tolerated":[245],"over":[246],"9-13":[247],"months":[248],"treatment.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}