{"id":"https://openalex.org/W2011312099","doi":"https://doi.org/10.1016/0166-3542(96)00938-2","title":"DNA polymerase activity of hepatitis B virus particles: differential inhibition by -enantiomers of nucleotide analogs","display_name":"DNA polymerase activity of hepatitis B virus particles: differential inhibition by -enantiomers of nucleotide analogs","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2011312099","doi":"https://doi.org/10.1016/0166-3542(96)00938-2","mag":"2011312099","pmid":"https://pubmed.ncbi.nlm.nih.gov/8783805"},"language":"en","primary_location":{"id":"doi:10.1016/0166-3542(96)00938-2","doi":"https://doi.org/10.1016/0166-3542(96)00938-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0166-3542(96)00938-2","pdf_url":null,"source":{"id":"https://openalex.org/S137372404","display_name":"Antiviral Research","issn_l":"0166-3542","issn":["0166-3542","1872-9096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M DAVIS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M DAVIS","raw_affiliation_strings":["Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037982412","display_name":"John T. Wilson","orcid":"https://orcid.org/0000-0002-9144-2634","observed_orcids":["https://orcid.org/0000-0002-9144-2634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J WILSON","raw_affiliation_strings":["Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098013970","display_name":"N VANDRAANEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N VANDRAANEN","raw_affiliation_strings":["Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105465814","display_name":"W MILLER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W MILLER","raw_affiliation_strings":["Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"G FREEMAN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G FREEMAN","raw_affiliation_strings":["Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010412811","display_name":"Susan M. Daluge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S DALUGE","raw_affiliation_strings":["Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111647426","display_name":"F. Leslie Boyd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F BOYD","raw_affiliation_strings":["Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062748490","display_name":"ANN E. AULABAUGH","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A AULABAUGH","raw_affiliation_strings":["Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031547878","display_name":"George R. Painter","orcid":"https://orcid.org/0000-0002-9803-8095","observed_orcids":["https://orcid.org/0000-0002-9803-8095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G PAINTER","raw_affiliation_strings":["Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111307164","display_name":"Lauren A. Boone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L BOONE","raw_affiliation_strings":["Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":3.2531,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.91482329,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"30","issue":"2-3","first_page":"133","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/viral-dna-polymerase","display_name":"viral DNA polymerase","score":0.8690000176429749},{"id":"https://openalex.org/keywords/core-particles","display_name":"core particles","score":0.7450000047683716},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.9399999976158142},{"id":"https://openalex.org/keywords/enantiomers","display_name":"enantiomers","score":0.9120000004768372},{"id":"https://openalex.org/keywords/antiviral-inhibition","display_name":"antiviral inhibition","score":0.7210000157356262},{"id":"https://openalex.org/keywords/nucleotide-incorporation","display_name":"nucleotide incorporation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.6769319772720337},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.6405653357505798},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.6254847645759583},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.6111050248146057},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5652896165847778},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5536615252494812},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.5228565335273743},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.5127466917037964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.511419951915741},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.45971205830574036},{"id":"https://openalex.org/C2777666129","wikidata":"https://www.wikidata.org/wiki/Q3503198","display_name":"Duck hepatitis B virus","level":5,"score":0.4576228857040405},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.44453510642051697},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.43586939573287964},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42846226692199707},{"id":"https://openalex.org/C2780617729","wikidata":"https://www.wikidata.org/wiki/Q1356878","display_name":"Hepadnaviridae","level":4,"score":0.4116551876068115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39952173829078674},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3985479474067688},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35165539383888245},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.272326797246933},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11610040068626404}],"mesh":[{"descriptor_ui":"D000068679","descriptor_name":"Emtricitabine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003845","descriptor_name":"Deoxycytosine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003848","descriptor_name":"Deoxyguanine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013698","descriptor_name":"Templates, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013942","descriptor_name":"Thymine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016047","descriptor_name":"Zalcitabine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D016047","descriptor_name":"Zalcitabine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019384","descriptor_name":"Nucleic Acid Synthesis Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0166-3542(96)00938-2","doi":"https://doi.org/10.1016/0166-3542(96)00938-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0166-3542(96)00938-2","pdf_url":null,"source":{"id":"https://openalex.org/S137372404","display_name":"Antiviral Research","issn_l":"0166-3542","issn":["0166-3542","1872-9096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Research","raw_type":"journal-article"},{"id":"pmid:8783805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8783805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W18186891","https://openalex.org/W597669211","https://openalex.org/W1503874190","https://openalex.org/W1512123554","https://openalex.org/W1539808745","https://openalex.org/W1569235975","https://openalex.org/W1585930597","https://openalex.org/W1853569310","https://openalex.org/W1927490337","https://openalex.org/W2010338556","https://openalex.org/W2026323517","https://openalex.org/W2029469199","https://openalex.org/W2032737565","https://openalex.org/W2035859873","https://openalex.org/W2044229573","https://openalex.org/W2044864734","https://openalex.org/W2051100798","https://openalex.org/W2054656941","https://openalex.org/W2054661137","https://openalex.org/W2058266561","https://openalex.org/W2072655313","https://openalex.org/W2073373170","https://openalex.org/W2076171352","https://openalex.org/W2095592056","https://openalex.org/W2125344913","https://openalex.org/W2129923672","https://openalex.org/W2137956846","https://openalex.org/W2144476088","https://openalex.org/W2333608621","https://openalex.org/W2950738442","https://openalex.org/W2951738192","https://openalex.org/W4236711684","https://openalex.org/W4255876370","https://openalex.org/W6652934122","https://openalex.org/W6656790492"],"related_works":["https://openalex.org/W2078863053","https://openalex.org/W2083383169","https://openalex.org/W4247891742","https://openalex.org/W4255623922","https://openalex.org/W4255876370","https://openalex.org/W2949714870","https://openalex.org/W2394824214","https://openalex.org/W2488228502","https://openalex.org/W2010408445","https://openalex.org/W2095592056"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}