{"id":"https://openalex.org/W2011307544","doi":"https://doi.org/10.1097/00007691-199410000-00002","title":"Pharmacokinetics and Pharmacodynamics of Famotidine in Children with Gastroduodenal Ulcers","display_name":"Pharmacokinetics and Pharmacodynamics of Famotidine in Children with Gastroduodenal Ulcers","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W2011307544","doi":"https://doi.org/10.1097/00007691-199410000-00002","mag":"2011307544","pmid":"https://pubmed.ncbi.nlm.nih.gov/7846741"},"language":"en","primary_location":{"id":"doi:10.1097/00007691-199410000-00002","doi":"https://doi.org/10.1097/00007691-199410000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007691-199410000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085582238","display_name":"Akira Nagita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Nagita","raw_affiliation_strings":["Department of Pediatrics, Osaka Medical College, Japan","Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Osaka Medical College, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073563495","display_name":"Mitsuhiro Manago","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhiro Manago","raw_affiliation_strings":["Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shigeyuki Aoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeyuki Aoki","raw_affiliation_strings":["Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110307880","display_name":"Makoto Mino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Mino","raw_affiliation_strings":["Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101823057","display_name":"Kaoru Suzuki","orcid":"https://orcid.org/0000-0001-6672-8959","observed_orcids":["https://orcid.org/0000-0001-6672-8959"]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru Suzuki","raw_affiliation_strings":["Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]}]},{"author_position":"last","author":{"id":null,"display_name":"Kiyoshi Ashida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Ashida","raw_affiliation_strings":["Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205143321"],"apc_list":null,"apc_paid":null,"fwci":1.4233,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.80133214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"16","issue":"5","first_page":"444","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.7099999785423279,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.7099999785423279,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.21400000154972076,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/famotidine","display_name":"famotidine","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8489999771118164},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9940000176429749},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.8980000019073486},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.7850000262260437},{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.8450000286102295},{"id":"https://openalex.org/keywords/gastric-acid-suppression","display_name":"gastric acid suppression","score":0.8109999895095825},{"id":"https://openalex.org/keywords/intragastric-ph","display_name":"gastric pH","score":0.8579999804496765},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9350000023841858},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.7749999761581421},{"id":"https://openalex.org/keywords/ulcer-healing","display_name":"ulcer healing","score":0.6389999985694885},{"id":"https://openalex.org/keywords/h2-receptor-antagonists","display_name":"H2 receptor antagonists","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2781263782","wikidata":"https://www.wikidata.org/wiki/Q411159","display_name":"Famotidine","level":2,"score":0.9976050853729248},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8249337673187256},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.8241239190101624},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6569302082061768},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6474336385726929},{"id":"https://openalex.org/C2777504413","wikidata":"https://www.wikidata.org/wiki/Q846270","display_name":"Gastric acid","level":3,"score":0.582962691783905},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.552129864692688},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5217350721359253},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.4682382643222809},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38894686102867126},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34204402565956116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3338870406150818}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005744","descriptor_name":"Gastric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015738","descriptor_name":"Famotidine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015738","descriptor_name":"Famotidine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015738","descriptor_name":"Famotidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007691-199410000-00002","doi":"https://doi.org/10.1097/00007691-199410000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007691-199410000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},{"id":"pmid:7846741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7846741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic drug monitoring","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060293793","https://openalex.org/W2347582599","https://openalex.org/W2382580916","https://openalex.org/W1952903320","https://openalex.org/W1528502471","https://openalex.org/W2514877583","https://openalex.org/W2007192610","https://openalex.org/W2151789828","https://openalex.org/W2094575249","https://openalex.org/W2013103899"],"abstract_inverted_index":{"We":[0],"treated":[1],"14":[2],"boys,":[3],"six":[4],"with":[5,10,160],"gastric":[6,21,110],"ulcers":[7,126],"and":[8,17,53,73,89,105,155],"eight":[9],"duodenal":[11],"ulcers,":[12],"to":[13,116,151],"determine":[14],"famotidine":[15,100,108,138,146],"pharmacokinetics":[16],"its":[18],"inhibition":[19],"of":[20,37,69,99,143,158],"acid":[22],"secretion":[23],"(pharmacodynamics).":[24],"Famotidine":[25],"(1":[26],"mg/kg/day)":[27],"was":[28,101],"administered":[29,107],"either":[30],"intravenously":[31,104],"or":[32],"orally":[33,106],"at":[34],"a":[35,41,65,153],"dose":[36],"0.5":[38,144],"mg/kg":[39,145],"twice":[40],"day":[42],"(maximum:":[43],"40":[44],"mg/day).":[45],"Blood":[46],"samples":[47],"were":[48,62,80,132],"collected":[49],"from":[50],"all":[51],"subjects":[52],"the":[54,76,119],"intragastric":[55,120],"pH":[56,121],"monitored":[57],"in":[58],"eight.":[59],"Pharmacokinetic":[60],"parameters":[61],"calculated":[63],"assuming":[64],"one-compartment":[66],"model.":[67],"Volume":[68],"distribution,":[70],"elimination":[71],"half-life,":[72],"area":[74],"under":[75],"serum":[77],"concentration-time":[78],"curve":[79],"1.52":[81],"+/-":[82,86,91],"0.37":[83],"l/kg,":[84],"2.29":[85],"0.38":[87],"h,":[88],"1.14":[90],"0.32":[92],"ng.h/ml,":[93],"respectively.":[94],"The":[95],"mean":[96],"oral":[97],"bioavailability":[98],"50.6%.":[102],"Both":[103],"neutralized":[109],"acidity":[111],"during":[112,137],"sleep":[113],"but":[114],"failed":[115],"continuously":[117],"maintain":[118],">":[122],"5.0.":[123],"All":[124],"subjects'":[125],"healed":[127],"within":[128],"8":[129,148],"weeks.":[130],"There":[131],"no":[133],"side":[134],"effects":[135],"noted":[136],"treatment.":[139],"Twice":[140],"daily":[141],"administration":[142],"for":[147],"weeks":[149],"appears":[150],"be":[152],"tolerated":[154],"effective":[156],"treatment":[157],"children":[159],"gastroduodenal":[161],"ulcers.":[162]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
