{"id":"https://openalex.org/W2011302801","doi":"https://doi.org/10.1002/ibd.21386","title":"Real-time tool to display the predicted disease course and treatment response for children with Crohn\u02bcs disease","display_name":"Real-time tool to display the predicted disease course and treatment response for children with Crohn\u02bcs disease","publication_year":2010,"publication_date":"2010-09-02","ids":{"openalex":"https://openalex.org/W2011302801","doi":"https://doi.org/10.1002/ibd.21386","mag":"2011302801","pmid":"https://pubmed.ncbi.nlm.nih.gov/20812335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2998586"},"language":"en","primary_location":{"id":"doi:10.1002/ibd.21386","doi":"https://doi.org/10.1002/ibd.21386","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ibd.21386","pdf_url":"https://academic.oup.com/ibdjournal/article-pdf/17/1/30/23845773/00054725-201101000-00006.pdf","source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ibdjournal/article-pdf/17/1/30/23845773/00054725-201101000-00006.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091551190","display_name":"Corey Allan Siegel","orcid":"https://orcid.org/0000-0002-2240-6605","observed_orcids":["https://orcid.org/0000-0002-2240-6605"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corey A. Siegel","raw_affiliation_strings":["Dartmouth-Hitchcock Inflammatory Bowel Disease Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA. corey.a.siegel@hitchcock.org","Dartmouth College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth-Hitchcock Inflammatory Bowel Disease Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA. corey.a.siegel@hitchcock.org","institution_ids":["https://openalex.org/I1289422878"]},{"raw_affiliation_string":"Dartmouth College","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026340721","display_name":"Lori S. Siegel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori S. Siegel","raw_affiliation_strings":["Siegel Environmental Dynamics, LLC, Hanover, New Hampshire","Siegel Environmental Dynamics, LLC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siegel Environmental Dynamics, LLC, Hanover, New Hampshire","institution_ids":[]},{"raw_affiliation_string":"Siegel Environmental Dynamics, LLC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006726610","display_name":"Jeffrey S. Hyams","orcid":"https://orcid.org/0000-0002-9769-236X","observed_orcids":["https://orcid.org/0000-0002-9769-236X"]},"institutions":[{"id":"https://openalex.org/I4210101648","display_name":"Connecticut Children's Medical Center","ror":"https://ror.org/01a1jjn24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101648"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Hyams","raw_affiliation_strings":["Department of Pediatrics, Connecticut Children's Medical Center, Hartford, Connecticut","Connecticut Children's Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Connecticut Children's Medical Center, Hartford, Connecticut","institution_ids":["https://openalex.org/I4210101648"]},{"raw_affiliation_string":"Connecticut Children's Medical Center","institution_ids":["https://openalex.org/I4210101648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006249166","display_name":"Subra Kugathasan","orcid":"https://orcid.org/0000-0002-8686-4189","observed_orcids":["https://orcid.org/0000-0002-8686-4189"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subra Kugathasan","raw_affiliation_strings":["Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia","Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210146983"]},{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104687264","display_name":"James F. Markowitz","orcid":"https://orcid.org/0000-0002-2290-3310","observed_orcids":["https://orcid.org/0000-0002-2290-3310"]},"institutions":[{"id":"https://openalex.org/I4210165784","display_name":"Schneider Children's Hospital","ror":"https://ror.org/05p9y3e72","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800560132","https://openalex.org/I4210165784"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Markowitz","raw_affiliation_strings":["Schneider Children's Hospital, New Hyde Park, New York","Schneider Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schneider Children's Hospital, New Hyde Park, New York","institution_ids":["https://openalex.org/I4210165784"]},{"raw_affiliation_string":"Schneider Children's Hospital","institution_ids":["https://openalex.org/I4210165784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064024135","display_name":"Joel R. Rosh","orcid":"https://orcid.org/0000-0003-0042-3233","observed_orcids":["https://orcid.org/0000-0003-0042-3233","https://orcid.org/0009-0003-5108-3950"]},"institutions":[{"id":"https://openalex.org/I2802646204","display_name":"Morristown Medical Center","ror":"https://ror.org/03m6tev69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802646204","https://openalex.org/I67339987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel R. Rosh","raw_affiliation_strings":["Department of Pediatrics, Morristown Memorial Hospital, Morristown, New Jersey","Morristown Memorial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Morristown Memorial Hospital, Morristown, New Jersey","institution_ids":["https://openalex.org/I2802646204"]},{"raw_affiliation_string":"Morristown Memorial Hospital","institution_ids":["https://openalex.org/I2802646204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011889522","display_name":"Neal S. LeLeiko","orcid":"https://orcid.org/0000-0001-7699-1400","observed_orcids":["https://orcid.org/0000-0001-7699-1400"]},"institutions":[{"id":"https://openalex.org/I4210112379","display_name":"Hasbro Children's Hospital","ror":"https://ror.org/01xq02v66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210112379","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal Leleiko","raw_affiliation_strings":["Department of Pediatrics, Hasbro Children's Hospital, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hasbro Children's Hospital, Providence, Rhode Island","institution_ids":["https://openalex.org/I4210112379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112734448","display_name":"David R. Mack","orcid":"https://orcid.org/0000-0001-5604-3200","observed_orcids":["https://orcid.org/0000-0001-5604-3200"]},"institutions":[{"id":"https://openalex.org/I2799330578","display_name":"Children's Hospital of Eastern Ontario","ror":"https://ror.org/05nsbhw27","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799330578"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David R. Mack","raw_affiliation_strings":["Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I2799330578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111622519","display_name":"Wallace Crandall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wallace Crandall","raw_affiliation_strings":["Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024924640","display_name":"Jonathan Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086066","display_name":"Nemours Children\u2019s Clinic","ror":"https://ror.org/00f76x039","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086066","https://openalex.org/I4210108049"]},{"id":"https://openalex.org/I4210158181","display_name":"Nemours Children's Clinic","ror":"https://ror.org/050hscv31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210108049","https://openalex.org/I4210158181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Evans","raw_affiliation_strings":["Department of Pediatrics, Nemours Children's Clinic, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nemours Children's Clinic, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210086066","https://openalex.org/I4210158181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058101509","display_name":"David J. Keljo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Keljo","raw_affiliation_strings":["Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019018783","display_name":"Anthony R. Otley","orcid":"https://orcid.org/0000-0002-7371-9302","observed_orcids":["https://orcid.org/0000-0002-7371-9302"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anthony R. Otley","raw_affiliation_strings":["Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada","Dalhousie University#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Dalhousie University#TAB#","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051120488","display_name":"Maria M. Oliva\u2010Hemker","orcid":"https://orcid.org/0000-0002-4054-7372","observed_orcids":["https://orcid.org/0000-0002-4054-7372"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Oliva-Hemker","raw_affiliation_strings":["Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019538540","display_name":"Sharmayne Farrior","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210124153","display_name":"Phoenix Children's Hospital","ror":"https://ror.org/03ae6qy41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210124153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharmayne Farrior","raw_affiliation_strings":["Department of Pediatrics, Phoenix Children's Hospital, Phoenix, Arizona","Cedars\u2013Sinai Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Phoenix Children's Hospital, Phoenix, Arizona","institution_ids":["https://openalex.org/I4210124153"]},{"raw_affiliation_string":"Cedars\u2013Sinai Medical Center","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012227761","display_name":"Christine R. Langton","orcid":"https://orcid.org/0000-0001-8649-8863","observed_orcids":["https://orcid.org/0000-0001-8649-8863"]},"institutions":[{"id":"https://openalex.org/I4210101648","display_name":"Connecticut Children's Medical Center","ror":"https://ror.org/01a1jjn24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101648"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine R. Langton","raw_affiliation_strings":["Department of Pediatrics , Connecticut Children's Medical Center , Hartford , Connecticut ,","Connecticut Children's Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics , Connecticut Children's Medical Center , Hartford , Connecticut ,","institution_ids":["https://openalex.org/I4210101648"]},{"raw_affiliation_string":"Connecticut Children's Medical Center","institution_ids":["https://openalex.org/I4210101648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069344994","display_name":"Iwona T. Wrobel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I2802127220","display_name":"Alberta Children's Hospital","ror":"https://ror.org/00sx29x36","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802127220"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Iwona T. Wrobel","raw_affiliation_strings":["Department of Pediatrics, IBD Center, Cedars-Sinai Medical Center, Los Angeles, California","Alberta Children\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, IBD Center, Cedars-Sinai Medical Center, Los Angeles, California","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Alberta Children\u2019s Hospital","institution_ids":["https://openalex.org/I2802127220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109124941","display_name":"Ghassan T. Wahbeh","orcid":"https://orcid.org/0009-0003-1821-7689","observed_orcids":["https://orcid.org/0009-0003-1821-7689"]},"institutions":[{"id":"https://openalex.org/I2802127220","display_name":"Alberta Children's Hospital","ror":"https://ror.org/00sx29x36","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802127220"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ghassan Wahbeh","raw_affiliation_strings":["Department of Pediatrics, Alberta Children's Hospital, Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Alberta Children's Hospital, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I2802127220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003845861","display_name":"Jose Antonio Quiros","orcid":"https://orcid.org/0000-0001-9644-3604","observed_orcids":["https://orcid.org/0000-0001-9644-3604"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]},{"id":"https://openalex.org/I2801780550","display_name":"California Pacific Medical Center","ror":"https://ror.org/02bjh0167","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114073160","https://openalex.org/I2801780550"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Antonio Quiros","raw_affiliation_strings":["Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington","California Pacific Medical Center ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington","institution_ids":["https://openalex.org/I1295499534"]},{"raw_affiliation_string":"California Pacific Medical Center ,","institution_ids":["https://openalex.org/I2801780550"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110001763","display_name":"Gary H. Silber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801780550","display_name":"California Pacific Medical Center","ror":"https://ror.org/02bjh0167","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114073160","https://openalex.org/I2801780550"]},{"id":"https://openalex.org/I4210124153","display_name":"Phoenix Children's Hospital","ror":"https://ror.org/03ae6qy41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210124153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Silber","raw_affiliation_strings":["California Pacific Medical Center, San Francisco, California","Phoenix Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Pacific Medical Center, San Francisco, California","institution_ids":["https://openalex.org/I2801780550"]},{"raw_affiliation_string":"Phoenix Children's Hospital","institution_ids":["https://openalex.org/I4210124153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000419484","display_name":"Ron Bahar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210124153","display_name":"Phoenix Children's Hospital","ror":"https://ror.org/03ae6qy41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210124153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron J. Bahar","raw_affiliation_strings":["Department of Pediatrics, Phoenix Children's Hospital, Phoenix, Arizona","Cedars\u2013Sinai Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Phoenix Children's Hospital, Phoenix, Arizona","institution_ids":["https://openalex.org/I4210124153"]},{"raw_affiliation_string":"Cedars\u2013Sinai Medical Center","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017140014","display_name":"Bruce E. Sands","orcid":"https://orcid.org/0000-0001-5762-5042","observed_orcids":["https://orcid.org/0000-0001-5762-5042"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce E. Sands","raw_affiliation_strings":["Gastrointestinal Unit, MGH Crohn's and Colitis Center, Massachusetts General Hospital, Boston, Massachusetts","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Unit, MGH Crohn's and Colitis Center, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019801327","display_name":"Marla C. Dubinsky","orcid":"https://orcid.org/0000-0003-4968-5795","observed_orcids":["https://orcid.org/0000-0003-4968-5795"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210124153","display_name":"Phoenix Children's Hospital","ror":"https://ror.org/03ae6qy41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210124153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marla C. Dubinsky","raw_affiliation_strings":["Department of Pediatrics, Phoenix Children's Hospital, Phoenix, Arizona","Cedars\u2013Sinai Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Phoenix Children's Hospital, Phoenix, Arizona","institution_ids":["https://openalex.org/I4210124153"]},{"raw_affiliation_string":"Cedars\u2013Sinai Medical Center","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":25,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3862,"currency":"USD","value_usd":3862},"apc_paid":null,"fwci":6.2712,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.96254935,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"30","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12823","display_name":"Adolescent and Pediatric Healthcare","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-crohn-s-disease","display_name":"pediatric Crohn's disease","score":0.9399999976158142},{"id":"https://openalex.org/keywords/disease-progression-prediction","display_name":"disease progression prediction","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8046778440475464},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6762166023254395},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.6363769769668579},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.5798807144165039},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.5682894587516785},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5347826480865479},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5202652215957642},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.5035938620567322},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.4368704855442047},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4219483733177185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38885846734046936},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33497917652130127},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.08027151226997375}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/ibd.21386","doi":"https://doi.org/10.1002/ibd.21386","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ibd.21386","pdf_url":"https://academic.oup.com/ibdjournal/article-pdf/17/1/30/23845773/00054725-201101000-00006.pdf","source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},{"id":"pmid:20812335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20812335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory bowel diseases","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2253134","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2998586","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2998586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2998586","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Inflamm Bowel Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/ibd.21386","doi":"https://doi.org/10.1002/ibd.21386","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ibd.21386","pdf_url":"https://academic.oup.com/ibdjournal/article-pdf/17/1/30/23845773/00054725-201101000-00006.pdf","source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8568640227","display_name":"The Natural History of Pediatric Crohn's Disease","funder_award_id":"K23DK066248","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8623779135","display_name":"Risk Communication in Crohn's Disease","funder_award_id":"K23DK078678","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320306493","display_name":"Abbott Laboratories","ror":"https://ror.org/0052svj16"},{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011302801.pdf","grobid_xml":"https://content.openalex.org/works/W2011302801.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1975976726","https://openalex.org/W1995864537","https://openalex.org/W2029028359","https://openalex.org/W2042203075","https://openalex.org/W2043780895","https://openalex.org/W2056225184","https://openalex.org/W2062369130","https://openalex.org/W2106733239","https://openalex.org/W2135795051","https://openalex.org/W2146975269","https://openalex.org/W2148567965","https://openalex.org/W2152381563","https://openalex.org/W2166041617","https://openalex.org/W2978802083","https://openalex.org/W3175417087"],"related_works":["https://openalex.org/W2977988157","https://openalex.org/W2172519764","https://openalex.org/W2009611686","https://openalex.org/W2586215708","https://openalex.org/W1986704746","https://openalex.org/W2606869702","https://openalex.org/W4297960682","https://openalex.org/W3087015594","https://openalex.org/W2969430619","https://openalex.org/W3211241155"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immunomodulators":[1],"and":[2,22,27,57,97,112,149,179,212,223,230],"biologics":[3],"are":[4,198],"effective":[5],"treatments":[6],"for":[7,133,158,186],"children":[8],"with":[9,21,170],"Crohn's":[10],"disease":[11,19,98,135,210],"(CD).":[12],"The":[13,39,81,183],"challenge":[14],"of":[15,36,41,55,60,88,101,161,173,194,209,227],"communicating":[16],"the":[17,33,52,86,107,129,156,187,195,244],"anticipated":[18],"course":[20],"without":[23],"therapy":[24],"to":[25,32,45,49,114,166,221,246],"patients":[26,71],"parents":[28],"is":[29,85,189,233],"a":[30,47,74,90,125,134,150,167,201,205,219],"barrier":[31],"timely":[34],"use":[35,160,172],"these":[37],"agents.":[38],"aim":[40],"this":[42,232],"project":[43],"was":[44],"develop":[46],"tool":[48,220],"graphically":[50],"display":[51],"predicted":[53],"risks":[54,226],"CD":[56,70,228],"expected":[58],"benefits":[59],"therapy.":[61,182],"METHODS:":[62],"Using":[63,191],"prospectively":[64],"collected":[65],"data":[66],"from":[67],"796":[68],"pediatric":[69],"we":[72],"developed":[73,218],"model":[75,83,188],"using":[76],"system":[77],"dynamics":[78],"analysis":[79],"(SDA).":[80],"primary":[82],"outcome":[84],"probability":[87,208],"developing":[89],"CD-related":[91],"complication.":[92],"Input":[93],"variables":[94,123],"include":[95,137],"patient":[96,248],"characteristics,":[99],"magnitude":[100],"serologic":[102],"immune":[103],"responses":[104],"expressed":[105],"as":[106],"quartile":[108],"sum":[109],"score":[110],"(QSS),":[111],"exposure":[113],"medical":[115],"treatments.":[116],"RESULTS:":[117],"Multivariate":[118],"Cox":[119,196],"proportional":[120],"analyses":[121,197],"show":[122],"contributing":[124],"significant":[126],"increase":[127],"in":[128,164],"hazard":[130],"ratio":[131],"(HR)":[132],"complication":[136,211],"female":[138],"gender,":[139],"older":[140],"age":[141],"at":[142,243],"diagnosis,":[143],"small":[144],"bowel":[145],"or":[146,176],"perianal":[147],"disease,":[148],"higher":[151],"QSS.":[152],"As":[153],"QSS":[154],"increases,":[155,163],"HR":[157,169],"early":[159,171,175,180],"corticosteroids":[162],"contrast":[165],"decreasing":[168],"immunomodulators,":[174],"late":[177],"biologics,":[178],"combination":[181],"concordance":[184],"index":[185],"0.81.":[190],"SDA,":[192],"results":[193],"transformed":[199],"into":[200],"simple":[202],"graph":[203],"displaying":[204],"real-time":[206],"individualized":[207,225],"treatment":[213],"response.":[214],"CONCLUSIONS:":[215],"We":[216],"have":[217],"predict":[222],"communicate":[224],"complications":[229],"how":[231],"modified":[234],"by":[235],"treatment.":[236],"Once":[237],"validated,":[238],"it":[239],"can":[240],"be":[241],"used":[242],"bedside":[245],"facilitate":[247],"decision":[249],"making.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}