{"id":"https://openalex.org/W2011296566","doi":"https://doi.org/10.1016/j.bbr.2015.02.002","title":"Chronic exercise dampens hippocampal glutamate overflow induced by kainic acid in rats","display_name":"Chronic exercise dampens hippocampal glutamate overflow induced by kainic acid in rats","publication_year":2015,"publication_date":"2015-02-07","ids":{"openalex":"https://openalex.org/W2011296566","doi":"https://doi.org/10.1016/j.bbr.2015.02.002","mag":"2011296566","pmid":"https://pubmed.ncbi.nlm.nih.gov/25668513"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbr.2015.02.002","doi":"https://doi.org/10.1016/j.bbr.2015.02.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2015.02.002","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042979738","display_name":"Philip V. Holmes","orcid":"https://orcid.org/0000-0002-5196-1990","observed_orcids":["https://orcid.org/0000-0002-5196-1990"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip V. Holmes","raw_affiliation_strings":["Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States. Electronic address: pvholmes@uga.edu","Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States. Electronic address: pvholmes@uga.edu","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048812604","display_name":"Jenny I. Reiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny I. Reiss","raw_affiliation_strings":["Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112261186","display_name":"Patrick S. Murray","orcid":"https://orcid.org/0000-0002-6525-2888","observed_orcids":["https://orcid.org/0000-0002-6525-2888"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick S. Murray","raw_affiliation_strings":["Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021465539","display_name":"Rod K. Dishman","orcid":"https://orcid.org/0000-0001-9213-621X","observed_orcids":["https://orcid.org/0000-0001-9213-621X"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rod K. Dishman","raw_affiliation_strings":["Department of Kinesiology, The University of Georgia, Athens, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, The University of Georgia, Athens, GA, United States","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061554517","display_name":"Jessica Marie Spradley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica M. Spradley","raw_affiliation_strings":["Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042979738"],"corresponding_institution_ids":["https://openalex.org/I165733156"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.428,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.62368058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"284","issue":null,"first_page":"19","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.859000027179718},{"id":"https://openalex.org/keywords/voluntary-wheel-running","display_name":"voluntary wheel running","score":0.9089999794960022},{"id":"https://openalex.org/keywords/kainic-acid","display_name":"kainic acid","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7229999899864197},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.9950000047683716},{"id":"https://openalex.org/keywords/seizure-susceptibility","display_name":"seizure susceptibility","score":0.671999990940094},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.3799999952316284},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7429999709129333},{"id":"https://openalex.org/keywords/sedentary-behavior","display_name":"sedentary behavior","score":0.7089999914169312},{"id":"https://openalex.org/keywords/eeg-activity","display_name":"EEG activity","score":0.6520000100135803},{"id":"https://openalex.org/keywords/in-vivo-voltammetry","display_name":"in vivo voltammetry","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2776108384","wikidata":"https://www.wikidata.org/wiki/Q390239","display_name":"Kainic acid","level":4,"score":0.971269965171814},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.8278019428253174},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.7633294463157654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5508926510810852},{"id":"https://openalex.org/C2778900099","wikidata":"https://www.wikidata.org/wiki/Q5166679","display_name":"Convulsant","level":3,"score":0.5401363372802734},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4954167604446411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46666306257247925},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44550809264183044},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.331020712852478},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33068332076072693},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.30841416120529175},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25547152757644653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22276517748832703},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14075720310211182}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006799","descriptor_name":"Housing, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007608","descriptor_name":"Kainic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012420","descriptor_name":"Running","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013686","descriptor_name":"Telemetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbr.2015.02.002","doi":"https://doi.org/10.1016/j.bbr.2015.02.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2015.02.002","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},{"id":"pmid:25668513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25668513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310010","display_name":"University of Georgia","ror":"https://ror.org/00te3t702"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W1959902108","https://openalex.org/W1970516662","https://openalex.org/W1984253712","https://openalex.org/W1989400013","https://openalex.org/W2016787304","https://openalex.org/W2019731733","https://openalex.org/W2025978099","https://openalex.org/W2045298839","https://openalex.org/W2048957533","https://openalex.org/W2058273293","https://openalex.org/W2060532219","https://openalex.org/W2061188850","https://openalex.org/W2071055836","https://openalex.org/W2074399422","https://openalex.org/W2077407548","https://openalex.org/W2084083826","https://openalex.org/W2094210565","https://openalex.org/W2103860332","https://openalex.org/W2103946141","https://openalex.org/W2108670804","https://openalex.org/W2119757776","https://openalex.org/W2122586715","https://openalex.org/W2136725788","https://openalex.org/W2155925085","https://openalex.org/W2163815564","https://openalex.org/W2164648482","https://openalex.org/W2545267061"],"related_works":["https://openalex.org/W2071055836","https://openalex.org/W2790645741","https://openalex.org/W2305337173","https://openalex.org/W2997222629","https://openalex.org/W1997636979","https://openalex.org/W1514142212","https://openalex.org/W2069293255","https://openalex.org/W2956560967","https://openalex.org/W2026204012","https://openalex.org/W2915991436"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}