{"id":"https://openalex.org/W2011243715","doi":"https://doi.org/10.1021/bi101165p","title":"Characterization and Comparison of Two Binding Sites on Obscurin for Small Ankyrin 1","display_name":"Characterization and Comparison of Two Binding Sites on Obscurin for Small Ankyrin 1","publication_year":2010,"publication_date":"2010-10-15","ids":{"openalex":"https://openalex.org/W2011243715","doi":"https://doi.org/10.1021/bi101165p","mag":"2011243715","pmid":"https://pubmed.ncbi.nlm.nih.gov/20949908","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3000613"},"language":"en","primary_location":{"id":"doi:10.1021/bi101165p","doi":"https://doi.org/10.1021/bi101165p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi101165p","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3000613","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000476255","display_name":"Ben Busby","orcid":"https://orcid.org/0000-0001-5267-4988","observed_orcids":["https://orcid.org/0000-0001-5267-4988"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Busby","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology","Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore,Baltimore, Maryland 21201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore,Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010767261","display_name":"Chris D. Willis","orcid":"https://orcid.org/0000-0002-6639-6568","observed_orcids":["https://orcid.org/0000-0002-6639-6568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris D. Willis","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050623823","display_name":"Maegen A. Ackermann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maegen A. Ackermann","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013084655","display_name":"Aikaterini Kontrogianni\u2010Konstantopoulos","orcid":"https://orcid.org/0000-0003-3948-1959","observed_orcids":["https://orcid.org/0000-0003-3948-1959"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aikaterini Kontrogianni-Konstantopoulos","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042232757","display_name":"Robert J. Bloch","orcid":"https://orcid.org/0000-0002-4933-3469","observed_orcids":["https://orcid.org/0000-0002-4933-3469"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert J. Bloch","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology","Department of Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042232757"],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.4247,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.54262359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"49","issue":"46","first_page":"9948","last_page":"9956"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.3495999872684479,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.03790000081062317,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-protein-binding-sites","display_name":"protein-protein binding sites","score":0.7490000128746033},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.7250000238418579},{"id":"https://openalex.org/keywords/binding-site-competition","display_name":"binding site competition","score":0.6269999742507935},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":0.847000002861023},{"id":"https://openalex.org/keywords/striated-muscle","display_name":"striated muscle","score":0.8820000290870667},{"id":"https://openalex.org/keywords/alpha-helix","display_name":"alpha-helix","score":0.5680000185966492},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.7960000038146973},{"id":"https://openalex.org/keywords/site-directed-mutants","display_name":"site-directed mutants","score":0.7450000047683716},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"homology modeling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5903993844985962},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.5558762550354004},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5181640386581421},{"id":"https://openalex.org/C37140074","wikidata":"https://www.wikidata.org/wiki/Q18047361","display_name":"Obscurin","level":5,"score":0.48871898651123047},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.41042348742485046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36967945098876953},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3537837266921997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2932595908641815},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0593734085559845},{"id":"https://openalex.org/C90671521","wikidata":"https://www.wikidata.org/wiki/Q74314","display_name":"Titin","level":4,"score":0.0},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.0},{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/bi101165p","doi":"https://doi.org/10.1021/bi101165p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi101165p","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:20949908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20949908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:2221658","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3000613","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3000613","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3000613/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2221658","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3000613","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4059526509","display_name":"Organization of Sarcoplasmic Reticulum in Skeletal Muscle","funder_award_id":"R01AR056330","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5126050644","display_name":"Training Program in Integrative Membrane Biology","funder_award_id":"T32GM008181","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G89372756","display_name":"M-Line Proteins and A-Band Assembly in Skeletal Muscle","funder_award_id":"R01AR052768","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000901414","display_name":"Interdisciplinary Training Program in Muscle Biology","funder_award_id":"T32AR007592","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W858052349","https://openalex.org/W1491040459","https://openalex.org/W1525531613","https://openalex.org/W1963550288","https://openalex.org/W1966460261","https://openalex.org/W1977922844","https://openalex.org/W1979761077","https://openalex.org/W1989270637","https://openalex.org/W1995972219","https://openalex.org/W1996073320","https://openalex.org/W2014776147","https://openalex.org/W2039373032","https://openalex.org/W2042540616","https://openalex.org/W2048908753","https://openalex.org/W2085277871","https://openalex.org/W2086422517","https://openalex.org/W2096039018","https://openalex.org/W2099388247","https://openalex.org/W2099944913","https://openalex.org/W2108376995","https://openalex.org/W2111975407","https://openalex.org/W2118817344","https://openalex.org/W2120618651","https://openalex.org/W2121652706","https://openalex.org/W2131255875","https://openalex.org/W2132659731","https://openalex.org/W2133142974","https://openalex.org/W2133841550","https://openalex.org/W2138387305","https://openalex.org/W2149010450","https://openalex.org/W2155102198","https://openalex.org/W2157046483","https://openalex.org/W2170476464","https://openalex.org/W4210400672"],"related_works":["https://openalex.org/W2048908753","https://openalex.org/W2015833217","https://openalex.org/W2030640974","https://openalex.org/W2000821818","https://openalex.org/W2027060041","https://openalex.org/W3005226465","https://openalex.org/W49986325","https://openalex.org/W2008516669","https://openalex.org/W1580396120","https://openalex.org/W2789404145"],"abstract_inverted_index":{"Obscurin":[0],"A,":[1],"an":[2,18,79],"\u223c720":[3],"kDa":[4],"modular":[5],"protein":[6,20],"of":[7,21,69,88,104,124,128,147,151,157,190,207,227,240],"striated":[8],"muscles,":[9],"binds":[10,60,76,95],"to":[11,61,65,71,86,135,145,235],"small":[12],"ankyrin":[13],"1":[14],"(sAnk1,":[15],"Ank":[16],"1.5),":[17],"integral":[19],"the":[22,46,55,89,119,148,158,236],"sarcoplasmic":[23],"reticulum,":[24],"through":[25],"two":[26],"distinct":[27],"carboxy-terminal":[28],"sequences,":[29],"Obsc(6316-6436)":[30,58,90],"and":[31,179,199],"Obsc(6236-6260).":[32],"We":[33,52],"hypothesized":[34],"that":[35,42,54,59,74,87,142,184,200],"these":[36,174],"sequences":[37,226],"differ":[38,229],"in":[39,133,167,223,231,242],"affinity":[40,80,98],"but":[41,233],"they":[43,143],"compete":[44,107],"for":[45,108],"same":[47,149],"binding":[48,109,134,137],"site":[49,138],"on":[50,139],"sAnk1.":[51,152],"show":[53],"sequence":[56,106],"within":[57],"sAnk1":[62,77,129,241],"is":[63],"limited":[64],"residues":[66,150,209],"6316-6345.":[67],"Comparison":[68],"Obsc(6231-6260)":[70,94,201],"Obsc(6316-6345)":[72,75,185],"reveals":[73],"with":[78,96,110,118,220],"(133":[81],"\u00b1":[82,100],"43":[83],"nM)":[84],"comparable":[85],"fusion":[91],"protein,":[92],"whereas":[93],"lower":[97],"(384":[99],"53":[101],"nM).":[102],"Oligopeptides":[103],"each":[105,136],"both":[111,225],"sites":[112],"at":[113],"half-maximal":[114],"inhibitory":[115],"concentrations":[116],"consistent":[117,219],"affinities":[120],"measured":[121],"directly.":[122],"Five":[123],"six":[125],"site-directed":[126],"mutants":[127],"showed":[130],"similar":[131,244],"reductions":[132],"obscurin,":[140],"suggesting":[141],"dock":[144],"many":[146],"Circular":[153],"dichroism":[154],"(CD)":[155],"analysis":[156],"synthetic":[159],"oligopeptides":[160],"revealed":[161],"a":[162,187,203,212,221,243],"2-fold":[163],"greater":[164],"\u03b1-helical":[165],"content":[166],"Obsc(6316-6346),":[168],"\u223c35%,":[169],"than":[170],"Obsc(6231-6260,)":[171],"\u223c17%.":[172],"Using":[173],"data,":[175],"structural":[176],"prediction":[177],"algorithms,":[178],"homology":[180],"modeling,":[181],"we":[182],"predict":[183],"contains":[186],"bent":[188],"\u03b1-helix":[189,206],"12":[191],"amino":[192],"acids,":[193],"flanked":[194],"by":[195,211],"short":[196],"disordered":[197,214],"regions,":[198],"has":[202],"short,":[204],"N-terminal":[205],"4-5":[208],"followed":[210],"long":[213],"region.":[215],"Our":[216],"results":[217],"are":[218],"model":[222],"which":[224],"obscurin":[228],"significantly":[230],"structure":[232],"bind":[234],"ankyrin-like":[237],"repeat":[238],"motifs":[239],"though":[245],"not":[246],"identical":[247],"manner.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
