{"id":"https://openalex.org/W2011241228","doi":"https://doi.org/10.1016/j.ceb.2010.10.009","title":"Chaperone-mediated autophagy in protein quality control","display_name":"Chaperone-mediated autophagy in protein quality control","publication_year":2010,"publication_date":"2010-11-20","ids":{"openalex":"https://openalex.org/W2011241228","doi":"https://doi.org/10.1016/j.ceb.2010.10.009","mag":"2011241228","pmid":"https://pubmed.ncbi.nlm.nih.gov/21094035","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3078170"},"language":"en","primary_location":{"id":"doi:10.1016/j.ceb.2010.10.009","doi":"https://doi.org/10.1016/j.ceb.2010.10.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ceb.2010.10.009","pdf_url":null,"source":{"id":"https://openalex.org/S103771297","display_name":"Current Opinion in Cell Biology","issn_l":"0955-0674","issn":["0955-0674","1879-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3078170/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048214353","display_name":"Esperanza Arias","orcid":"https://orcid.org/0000-0002-7836-5072","observed_orcids":["https://orcid.org/0000-0002-7836-5072"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esperanza Arias","raw_affiliation_strings":["Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063410689","display_name":"Ana Mar\u00eda Cuervo","orcid":"https://orcid.org/0000-0002-0771-700X","observed_orcids":["https://orcid.org/0000-0002-0771-700X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ana Maria Cuervo","raw_affiliation_strings":["Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063410689"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":1.9535,"has_fulltext":false,"cited_by_count":331,"citation_normalized_percentile":{"value":0.89191564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"23","issue":"2","first_page":"184","last_page":"189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chaperone-mediated-autophagy","display_name":"chaperone-mediated autophagy","score":1.0},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.9950000047683716},{"id":"https://openalex.org/keywords/proteotoxicity","display_name":"proteotoxicity","score":0.7360000014305115},{"id":"https://openalex.org/keywords/lysosomal-protein-degradation","display_name":"lysosomal protein degradation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/selective-autophagy","display_name":"selective autophagy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cellular-defense-mechanisms","display_name":"cellular defense mechanisms","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8984274864196777},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8097394704818726},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7295718789100647},{"id":"https://openalex.org/C2776104650","wikidata":"https://www.wikidata.org/wiki/Q2113512","display_name":"Proteotoxicity","level":3,"score":0.72198885679245},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.6521226167678833},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.582101583480835},{"id":"https://openalex.org/C99089365","wikidata":"https://www.wikidata.org/wiki/Q18034356","display_name":"BAG3","level":4,"score":0.4784714877605438},{"id":"https://openalex.org/C2777560085","wikidata":"https://www.wikidata.org/wiki/Q25105257","display_name":"Protein quality","level":2,"score":0.41251999139785767},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.2994762063026428},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2673702538013458},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23375558853149414},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.05575680732727051},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ceb.2010.10.009","doi":"https://doi.org/10.1016/j.ceb.2010.10.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ceb.2010.10.009","pdf_url":null,"source":{"id":"https://openalex.org/S103771297","display_name":"Current Opinion in Cell Biology","issn_l":"0955-0674","issn":["0955-0674","1879-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cell Biology","raw_type":"journal-article"},{"id":"pmid:21094035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21094035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3078170","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3078170/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3078170","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3078170/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2717444902","display_name":"DECREASED PROTEIN DEGRADATION IN AGING","funder_award_id":"R01AG021904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4183807675","display_name":"Decreased Protein Degradation in Aging","funder_award_id":"R37AG021904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4344833753","display_name":"Mechanisms of dopamine neuron degeneration","funder_award_id":"P50NS038370","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4784009199","display_name":"Autophagy in aging: testing geroscience in Alzheimer's disease","funder_award_id":"P01AG031782","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5547241468","display_name":null,"funder_award_id":"AG-021904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6678630482","display_name":"Liver Cell Membrane Protein-Expression and Function","funder_award_id":"P01DK041918","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1590553747","https://openalex.org/W1657935059","https://openalex.org/W1847698873","https://openalex.org/W1964976537","https://openalex.org/W1968322176","https://openalex.org/W1971023090","https://openalex.org/W1976134037","https://openalex.org/W1990012982","https://openalex.org/W1991714330","https://openalex.org/W1992951702","https://openalex.org/W1993467627","https://openalex.org/W1994823455","https://openalex.org/W2005884107","https://openalex.org/W2013944211","https://openalex.org/W2021121989","https://openalex.org/W2021492060","https://openalex.org/W2026175550","https://openalex.org/W2040253885","https://openalex.org/W2041456356","https://openalex.org/W2049613365","https://openalex.org/W2051429808","https://openalex.org/W2055039738","https://openalex.org/W2056373293","https://openalex.org/W2068288454","https://openalex.org/W2068954926","https://openalex.org/W2069276966","https://openalex.org/W2079123204","https://openalex.org/W2080666854","https://openalex.org/W2094813187","https://openalex.org/W2095683352","https://openalex.org/W2097164847","https://openalex.org/W2098561880","https://openalex.org/W2099301077","https://openalex.org/W2101962395","https://openalex.org/W2107770907","https://openalex.org/W2112693824","https://openalex.org/W2124165909","https://openalex.org/W2133548029","https://openalex.org/W2134892601","https://openalex.org/W2137275982","https://openalex.org/W2137771963","https://openalex.org/W2140664473","https://openalex.org/W2146961420","https://openalex.org/W2148396143","https://openalex.org/W2150418491","https://openalex.org/W2168326939","https://openalex.org/W2168445378"],"related_works":["https://openalex.org/W2949012796","https://openalex.org/W3147821081","https://openalex.org/W2041456356","https://openalex.org/W2009128541","https://openalex.org/W2907221099","https://openalex.org/W2119421712","https://openalex.org/W2912968393","https://openalex.org/W4238234662","https://openalex.org/W2404905481","https://openalex.org/W2152541437"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":31},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":32},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}